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Market Research Report
Product code
1043373
Metastatic Renal Cell Carcinoma (mRCC) | Primary Research (KOL's Insight) | Market Intelligence | Epidemiology & Market Forecast - 2030 |
Metastatic Renal Cell Carcinoma (mRCC) | Primary Research (KOL's Insight) | Market Intelligence | Epidemiology & Market Forecast - 2030 |
Published: November 30, 2021
Mellalta Meets LLP
Content info: 293 Pages
Delivery time: 1-2 business days
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Currently, tyrosine kinase inhibitors (TKIs) and anti-VEGF antibodies are widely used in first- and second-line treatments for mRCC. Despite the current treatments, there remains the unmet need for early diagnosis and treatment options. Emerging drugs in development like Dovitinib (Allarity Therapeutics) and Savolitinib/ AZD6094 (Astrazeneca), and others will expand the first-line and second-line settings for patients with mRCC and likely to address the current unmet needs for the treatment of mRCC. The upcoming treatment options for mRCC can drive market competition, contributing to budget sustainability and improving patient access to biologic treatments.
Renal cell carcinoma (RCC) is a type of kidney cancer which originates within the renal cortex and are responsible for 80% to 85% of all primary renal neoplasms. It is the most common form of kidney cancer found in adults. RCC metastasizes in approximately 20-30% of the cases. According to National Cancer Institute, Metastatic renal cell carcinoma (mRCC) is a heterogeneous disease with wide variations in its clinical presentation, natural history, and response to therapy. The most common sites for metastases of RCC are the lungs, bones, liver, and brain. The recurrence of RCC after initial care is relatively high and certain subtypes such as clear cell RCC are more likely to metastasize. A more recent discovery with new immune checkpoint inhibitors heralded a further paradigm shift from TKI monotherapy to immunotherapy-based combinations.
Renal Cell Carcinoma diagnosis majorly depends on abdominal imaging or upon presentation of invasive disease at common metastatic sites, such as the lung, bone, and liver. Computerized tomography (CT) remains the gold standard for the diagnosis of Renal cell carcinoma (RCC). Abdominal ultrasonography (USG), MRI, blood test and urine analysis are common diagnostic tools being used for the diagnosis. Core biopsy and pathological examination are performed to confirm the diagnosis in case of renal cell carcinoma identified in both kidney and at distant metastatic sites. More than 50% of patients with renal cell carcinoma are asymptomatic and diagnosed incidentally during thoracoabdominal imaging ordered for unrelated issues.
Despite the availability of several optimal imaging strategies and guidelines, the diagnosis of recurrent and mRCC is still a challenge which is generally confounded by various factors, such as the ability of RCC to metastasize to virtually any part of the human body, atypical patterns of manifestation, and limitations in technique.
RCC occurs mostly in adults and often in men ages 50 to 70. The incidence of RCC varies with the highest rates observed in the North America. In the United States, there are approximately 63,000 new cases and almost 14,000 deaths each year. In the United States, incidence rates of RCC have been on the rise through the mid-2000s.
The renal cell carcinoma market has witnessed a substantial change, largely fueled by label expansions of immune checkpoint inhibitor therapies. Combination regimens, including Opdivo plus Yervoy (Bristol Myers Squibb / Ono Pharmaceutical), Keytruda (Merck & Co.) plus Inlyta (Pfizer), and Bavencio (Pfizer / Merck KGaA) plus Inlyta, are revolutionizing the treatment of advanced disease. The recent approval and uptake of the Opdivoplus Cabometyx (Exelixis / Ipsen) and axitinib plus pembrolizumab combination will also drive fierce competition in this setting. Multiple immune checkpoint inhibitors are also anticipated to enter the early-stage setting over the forecast period. Additionally, the anticipated entry of other agents such as bempegaldesleukin (NektarTherapeutics) and belzutifan (Merck & Co.) will further diversify treatment options and create a highly competitive and dynamic market.
The current treatment market has long been dominated by targeted treatments, including mTOR and angiogenesis inhibitors. However, the introduction of immune checkpoint inhibitors has diversified treatment options and the treatment landscape for renal cell carcinoma market is rapidly moving toward combination combinatorial approaches. The introduction of diagnostic companions could offer the possibility of providing better outcomes and reducing the cost-burden of patients that are less likely to respond to the therapy.
Metastatic Renal cell Carcinoma (mRCC) is expected to see a high growth during our forecast period. The market in the G7 countries is expected to reach USD 7.9 billion in 2030 with a CAGR of 7.5%. Primary drivers of this growth will be the uptake of the emerging drugs i.e., Belzutifan (Merck/Peloton Therapeutics), Bempegaldesleukin (Bristol-Myers Squibb/Nektar Therapeutics), and others.