Market Research Report
Natural Killer Cell Therapies: Pipeline Review
|Published by||ROOTS ANALYSIS||Product code||858729|
|Published||Content info||80 Pages
Delivery time: 1-2 business days
|Natural Killer Cell Therapies: Pipeline Review|
|Published: June 30, 2019||Content info: 80 Pages||
Presently, over 150 research studies, evaluating various types of NK cell based therapy candidates for oncological indications, are underway.
The NK cell therapy pipeline features both off-the-shelf and personalized therapy candidates, with several leads being developed in combination with other drugs; the contribution of older companies is worth recognizing.
Both North America and Asia are currently leading in terms of number of clinical research initiatives focused on NK cells; the field has an elaborate early stage pipeline with several promising product candidates.
Natural killer (NK) cells, or killer (K) cells, represent an important subset of cellular mediators of the innate immune system. These cells are known to be instrumental in containing viral infections and regulating tumor development, while the adaptive immune system generates an antigen-specific response. Technically, they are classified as group I innate lymphocytes. Although they share a common progenitor, NK cells are very different from B-lymphocytes and T-lymphocytes, and do not require specific antigen-based activation in order to function. The cytotoxic effects of these cells are mediated using perforin and granzymes, which is somewhat similar to the mode of action of cytotoxic T cells. Additionally, studies have demonstrated that NK cells can also secrete certain cytokines and chemokines, such as IFNy and TNFα, through which they can recruit other immune components to augment and sustain an immune response. For instance, IFNy secreted by NK cells has been shown to be involved in T-helper (TH1) cell based immune response, and the activation of certain antigen-presenting cells and macrophages. Alternatively, NK cells have been shown to respond to certain types of interferons and macrophage-derived cytokines.
Several studies have demonstrated the various benefits of NK cells as a therapeutic tool. Currently, these cells are being evaluated across multiple clinical trials to treat various types of cancer and infectious diseases. Further, the genetic modification of NK cells has demonstrated additional benefits, and many companies are also working on developing allogenic product candidates that can be used as off-the-shelf therapies.
The “Natural Killer Cell Therapies: Pipeline Review” report features an extensive study of the current market landscape and clinical research scenario related to all NK cell-based products / product candidates. The information in this report has been presented in the form of interactive dashboards, aiming to provide a comprehensive overview of the ongoing activity in this domain, and offering insights on a number of important parameters, including:
All information has been sourced and analyzed from company websites, press releases, reliable clinical trial data repositories (such as clinicaltrials.gov), and other publicly available information platforms.
Dashboard 1 is an interactive MS Excel dashboard that provides a detailed review of the contemporary developer landscape, featuring the identities and details of various innovator companies and their respective NK cell therapy candidates. The dashboard offers insights on current (highest) phase of development, source of NK cells (autologous and allogenic), target disease indication (hematological malignancies, solid tumors and others), type of therapy (monotherapy and combination therapy), route of administration and other relevant details (wherever available).
Dashboard 2 is an interactive MS Excel dashboard featuring an analysis of both completed and active clinical trials, which were registered starting from January 2009 to May 2019, featuring detailed charts on (primary) developer company (year of establishment, location of headquarters, and company size), type of developer (industry and non-industry), name of therapy, source of NK cells (autologous and allogenic), and other trial related details (collaborating sponsors, trial title, study objectives, location of trial, current status, availability of results, target therapeutic indication, study type, current / anticipated enrolment, study start / end date and key outcomes / results).
Dashboard 3 is another interactive MS Excel dashboard that offers a retrospective analysis of the various clinical development programs of NK cell based therapies clinical trials that have been discontinue for various reasons (highlighted wherever available). It is worth mentioning that in this analysis we have we have designated the “unknown” status to certain clinical development program that have not been updated from a long time, assuming that such trials are either terminated or indefinitely suspended. The analysis presented in this dashboard has been based on the identity and key details of developer company, (such as type of developer, geographical location), name of therapy, source of NK cells (autologous and allogenic), other trial related details (collaborating sponsors, trial title, study objectives, target therapeutic indication and study type) and reason for termination (wherever available).
The following companies and organizations have been mentioned in the report.