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PUBLISHER: Stratistics Market Research Consulting | PRODUCT CODE: 1133409

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PUBLISHER: Stratistics Market Research Consulting | PRODUCT CODE: 1133409

Cell Culture Market Forecasts to 2028 - Global Analysis By Product, Consumables, Application, End userand By Geography

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According to Stratistics MRC, the Global Cell Culture Market is accounted for $ 26.13 billion in 2022 and is expected to reach $59.18 billion by 2028 growing at a CAGR of 14.6 % during the forecast period. The technique of taking cells from an animal or plant source and growing them subsequently under controlled circumstances is known as cell culture. In addition, this artificial environment contains nutrients that are necessary for cell growth and multiplication, such as the right temperature, gases, pH, and humidity. Before culture, cells from the tissues can be removed mechanically or enzymatically. The cells that need to be cultivated can also come from an established cell line or cell strain.

According to the WHO, there were 271,963,258 confirmed cases of COVID-19, including 5,331,019 deaths (as of December 17, 2021). The highest number of deaths was in the Americas, followed by Europe and Southeast Asia. According to the National Institutes of Health (NIH) alone spends about US$ 41.7 billion annually in medical research for the American people. According to the American Cancer Society's 2022 statistics, there will be an estimated 1,918,030 new cases of cancer in the United States in 2022. Such an increasing burden of diseases such as cancer creates the need for precision medicine, which leads to the increase in demand for cell culture products and consumables for their development and hence drives the growth of the market.

Market Dynamics:

Driver:

Growing awareness about the benefits of cell-based vaccines

The threat of new virus epidemics has grown as a result of population growth, climate change, and more animal-human contact. Global demand for vaccines is anticipated to be fueled by the rising prevalence of infectious illnesses and the rising risk of pandemics. Cell culture has emerged as a significant component of vaccine development in the pharmaceutical business. To create vaccinations against rotavirus, polio, smallpox, hepatitis, rubella, and chickenpox, cell culture technology was employed. Flu vaccinations made from cells have also received approval for use in other nations. The main elements anticipated to boost the growth of the cell culture market during the forecast period are rising awareness of the advantages of cell culture-based vaccinations and the regulatory approval of numerous cell culture-based vaccines globally.

Restraint:

High cost of cell biology research

Intensive research and development is put into developing novel treatments including gene and stem cell therapies. For accurate results, the tools, reagents, and other products used in research must be of the highest calibre. The cost of cell biology research has significantly increased as a result of the growing necessity to uphold high standards through the use of high-quality products and comply with regulations established by regulatory organisations. As a result, small businesses and academic institutions with restricted funding are unable to carry out cell biology research. Since micro carriers are used in stem cell biology, this factor is probably going to limit market expansion.

Opportunity:

Growing demand for 3D cell culture

3D cell cultures are gaining demand over 2D cell cultures due to multiple reasons. 2D cell culture methods involve growing cells on flat surfaces as 2D monolayers. However, these cells adhere only to cell culture vessels and attach only to cells at the periphery; this limits multi-dimensional cell cultures. Researchers have come up with 3D cell cultures to resolve these issues. These cultures have proven to be efficient in several studies of basic biological mechanisms, such as cell number monitoring, cell viability, cell proliferation, and cell morphology. In addition, 3D cell cultures are more stable and last longer than 2D cultures. The advantages of 3D cell cultures have drawn various participants to make investments in this area. The focus has also shifted more toward items like 3D micro fluidic cell culture chips called micro fluidic organ-on-a-chip models, which are designed to simulate the physiology of an organ.

Threat:

Plastic waste disposal

One versatile research technique is cell culture. However, a lot of its consumables are plastic. Due to this, there is now an issue with the annual development of significant amounts of plastic waste. The environment has suffered as a result. Additionally, given the numerous benefits associated with single-use bio processing equipment and consumables, including cost savings, a quicker time to process development, and cheaper capital expenditures, biopharmaceutical businesses are rapidly adopting them. They decrease batch changeover time and utility and water costs associated with cleaning and sterilising. However, there are still significant worries about how this new method will dispose of solid waste. Such products can't be recycled because it takes a lot of work to separate the components into homogeneous parts. The majority of single-use systems and their parts are therefore unsuitable for recycling. However, as there has been a substantial increase in research and innovation to develop environmentally friendly bio processing methods, the impact of this difficulty would diminish in the future.

COVID-19 Impact

Infectious disease COVID-19 is brought on by the most recent corona virus discovery. The COVID-19 epidemic has evolved from a localised crisis. The COVID-19 epidemic has put more strain on the world's healthcare systems. As a result of the COVID-19 pandemic, major pharmaceutical and biotechnology companies have developed or are now manufacturing a number of COVID-19 vaccines and antiviral medications. The need for cell culture goods has increased since cell culture is essential to medication development and production. Viral vaccines based on cell culture are used to immunise people against illnesses all over the world.

The centrifuges segment is expected to be the largest during the forecast period

The centrifuges segment is estimated to have a lucrative growth, due to bench top centrifuges' increasing operational efficiency and reliability for routine laboratory use, centrifuges. Additionally, high-quality, quick, and high-yield cell separation using bio processing centrifuges is commercially accessible, which may help the approach become more widely used. In the near future, it is anticipated that demand for the product will increase due to the increased need for centrifuges for the manufacturing of gene treatments, antibodies, and vaccines.

The reagents segment is expected to have the highest CAGR during the forecast period

The reagents segment is anticipated to witness the fastest CAGR growth during the forecast period, due to the rising importance of albumin for transporting serum-derived compounds that sustain mammalian cultures, the reagents category. To maintain a sterile and nutrient-rich environment in the culture systems, additional reagents like antibiotics and amino acids are being utilised more frequently in primary cultures. These elements should considerably accelerate segment growth.

Region with highest share:

North America projected to hold the largest market share during the forecast period owing to the substantial expenditures in research and development, the availability of an established scientific infrastructure, the sizeable demand for media devoid of animal components, and other considerations, North America maintained the greatest revenue share. Due to the rising incidence of cancer and the increased funding for cancer-related research, North America had the lion's share of the global market for cell culture, and this trend is predicted to continue. Additionally, the region's industry is growing since cell culture equipment and consumables are readily available thanks to the presence of most of the major manufacturers.

Region with highest CAGR:

Asia-Pacific projected to have the highest CAGR over the forecast period, owing to rising healthcare costs, increased public awareness of regenerative therapies, and a significant potential for clinical research applications, the Asia Pacific region is anticipated to develop at the quickest rate over the projected period. Due to a rise in awareness of the usage of cell culture techniques, the development of the R&D industry, and a rise in research funding, Asia-Pacific is anticipated to have the quickest growth rate. The region's cell culture market is anticipated to increase as a result of leading manufacturers concentrating on increasing their geographic presence in developing Asia-Pacific nations in order to secure a significant market share.

Key players in the market

Some of the key players profiled in the Cell Culture Market include Merck, Bio-Techne Corporation, KromaTiD, Sartorius Stedim Biotech, BioIVT, Cytiva (Danaher Corporation), Sartorius AG, BioSpherix, Ltd., CELLINK, Thermo Fisher Scientific, Inc., Asahi Breweries, Ltd., Evonik, Avantor, Inc., HiMedia Laboratories, Agilent Technologies, CellulaREvolution, Corning Incorporated, Becton, PromoCell GmbH, Corning Incorporated.

Key Developments:

In June 2022, Evonik launched the cQrex portfolio of cell culture ingredients to increase efficiency and productivity in bioprocesses for producing monoclonal antibodies, vaccines, viral vectors, and therapeutic cells.

In March 2022, CELLINK launched its BIO CELLX bio-dispensing platform for the automation of 3D cell-based assays for drug discovery and cancer research. Such product launches are likely to broaden the growth prospects for the segment.

In February 2022, KromaTiD expanded its service offerings with the launch of cell and blood culture isolation, processing, and quality control services.

In January 2022, Cytiva (Danaher Corporation) collaborated with Nucleus Biologics for the development of custom culture media for cell and gene therapies. Furthermore, expansion of the existing service offerings is being undertaken by emerging players to enhance their market presence.

In January 2022, BioIVT launched its GMP Grade Human AB Serum specialized for gene therapy manufacturing.

In May 2019, Sartorius Stedim Biotech launched a new generation of Ambr 15 cell culture automated microbioreactor system that can significantly increase lab productivity.

Products Covered:

  • Equipment
  • Pipetting Instruments
  • Other Products

Consumables Covered:

  • Accessories
  • Vessels
  • Media
  • Cells and Cell Lines
  • Reagents
  • Sera

Applications Covered:

  • Drug Screening & Development
  • Stem Cell Research
  • Tissue Engineering & Regenerative Medicine
  • Cancer Research
  • Biopharmaceuticals
  • Vaccine Production
  • Diagnostics
  • Bioproduction
  • Other Applications

End Users Covered:

  • Hospital & Diagnostic Laboratories
  • Pharmaceutical & Biotechnology Companies
  • Academic and Research Institutes
  • Other End Users

Regions Covered:

  • North America
    • US
    • Canada
    • Mexico
  • Europe
    • Germany
    • UK
    • Italy
    • France
    • Spain
    • Rest of Europe
  • Asia Pacific
    • Japan
    • China
    • India
    • Australia
    • New Zealand
    • South Korea
    • Rest of Asia Pacific
  • South America
    • Argentina
    • Brazil
    • Chile
    • Rest of South America
  • Middle East & Africa
    • Saudi Arabia
    • UAE
    • Qatar
    • South Africa
    • Rest of Middle East & Africa

What our report offers:

  • Market share assessments for the regional and country-level segments
  • Strategic recommendations for the new entrants
  • Covers Market data for the years 2020, 2021, 2022, 2025, and 2028
  • Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
  • Strategic recommendations in key business segments based on the market estimations
  • Competitive landscaping mapping the key common trends
  • Company profiling with detailed strategies, financials, and recent developments
  • Supply chain trends mapping the latest technological advancements

Free Customization Offerings:

All the customers of this report will be entitled to receive one of the following free customization options:

  • Company Profiling
    • Comprehensive profiling of additional market players (up to 3)
    • SWOT Analysis of key players (up to 3)
  • Regional Segmentation
    • Market estimations, Forecasts and CAGR of any prominent country as per the client's interest (Note: Depends on feasibility check)
  • Competitive Benchmarking
    • Benchmarking of key players based on product portfolio, geographical presence, and strategic alliances
Product Code: SMRC21896

Table of Contents

1 Executive Summary

2 Preface

  • 2.1 Abstract
  • 2.2 Stake Holders
  • 2.3 Research Scope
  • 2.4 Research Methodology
    • 2.4.1 Data Mining
    • 2.4.2 Data Analysis
    • 2.4.3 Data Validation
    • 2.4.4 Research Approach
  • 2.5 Research Sources
    • 2.5.1 Primary Research Sources
    • 2.5.2 Secondary Research Sources
    • 2.5.3 Assumptions

3 Market Trend Analysis

  • 3.1 Introduction
  • 3.2 Drivers
  • 3.3 Restraints
  • 3.4 Opportunities
  • 3.5 Threats
  • 3.6 Product Analysis
  • 3.7 Application Analysis
  • 3.8 End User Analysis
  • 3.9 Emerging Markets
  • 3.10 Impact of Covid-19

4 Porters Five Force Analysis

  • 4.1 Bargaining power of suppliers
  • 4.2 Bargaining power of buyers
  • 4.3 Threat of substitutes
  • 4.4 Threat of new entrants
  • 4.5 Competitive rivalry

5 Global Cell Culture Market, By Product

  • 5.1 Introduction
  • 5.2 Equipment
    • 5.2.1 Biosafety Equipment
    • 5.2.2 Cryostorage Equipment
    • 5.2.3 Water Baths
    • 5.2.4 Cryopreservative Containers
    • 5.2.5 Sterilizers
    • 5.2.6 Refrigerators and Freezers
    • 5.2.7 Carbon dioxide Incubators
    • 5.2.8 Culture Systems/Bioreactors
    • 5.2.9 Centrifuges
    • 5.2.10 Microscopes
    • 5.2.11 Cell Counters
    • 5.2.12 Cryogenic Tanks
  • 5.3 Pipetting Instruments
  • 5.4 Other Products

6 Global Cell Culture Market, By Consumables

  • 6.1 Introduction
  • 6.2 Accessories
  • 6.3 Vessels
    • 6.3.1 Multiwell Plates
    • 6.3.2 Petri Dishes
    • 6.3.3 Roller/Roux Bottles
    • 6.3.4 Flasks
    • 6.3.5 Cell Factory Systems/Cell Stacks
  • 6.4 Media
    • 6.4.1 Source
      • 6.4.1.1 Classical Media
      • 6.4.1.2 Xeno-free/Animal Component Free
      • 6.4.1.3 Serum-free Media
      • 6.4.1.4 Chemically Defined Media
      • 6.4.1.5 Other Cell Culture Media
    • 6.4.2 Physical form
      • 6.4.2.1 Liquid Media
      • 6.4.2.2 Dry Powder Media
    • 6.4.3 Type
      • 6.4.3.1 Custom Media
      • 6.4.3.2 Off-the-Shelf Media
  • 6.5 Cells and Cell Lines
  • 6.6 Reagents
    • 6.6.1 Attachment & Matrix Factors
    • 6.6.2 Supplements
    • 6.6.3 Buffers & Chemicals
    • 6.6.4 Cell Dissociation Reagents
    • 6.6.5 Antibiotics/Antimycotics
    • 6.6.6 Balanced Salt Solutions
    • 6.6.7 Cryoprotective Agents
    • 6.6.8 Contamination Detection Kits
    • 6.6.9 Growth Factors and Cytokines
    • 6.6.10 Other Cell Culture Reagents
  • 6.7 Sera
    • 6.7.1 Adult Bovine Sera (ABS)
    • 6.7.2 Fetal Bovine Sera (FBS)
    • 6.7.3 Other Animal Sera

7 Global Cell Culture Market, By Application

  • 7.1 Introduction
  • 7.2 Drug Screening & Development
  • 7.3 Stem Cell Research
  • 7.4 Tissue Engineering & Regenerative Medicine
  • 7.5 Cancer Research
  • 7.6 Biopharmaceuticals
  • 7.7 Vaccine Production
  • 7.8 Diagnostics
  • 7.9 Bioproduction
    • 7.9.1 Vaccine Production
    • 7.9.2 Therapeutic Protein Production
    • 7.9.3 Cell and Gene therapy
    • 7.9.4 Monoclonal Antibody Production
  • 7.10 Other Applications

8 Global Cell Culture Market, By End user

  • 8.1 Introduction
  • 8.2 Hospital & Diagnostic Laboratories
  • 8.3 Pharmaceutical & Biotechnology Companies
  • 8.4 Academic and Research Institutes
  • 8.5 Other End users

9 Global Cell Culture Market, By Geography

  • 9.1 Introduction
  • 9.2 North America
    • 9.2.1 US
    • 9.2.2 Canada
    • 9.2.3 Mexico
  • 9.3 Europe
    • 9.3.1 Germany
    • 9.3.2 UK
    • 9.3.3 Italy
    • 9.3.4 France
    • 9.3.5 Spain
    • 9.3.6 Rest of Europe
  • 9.4 Asia Pacific
    • 9.4.1 Japan
    • 9.4.2 China
    • 9.4.3 India
    • 9.4.4 Australia
    • 9.4.5 New Zealand
    • 9.4.6 South Korea
    • 9.4.7 Rest of Asia Pacific
  • 9.5 South America
    • 9.5.1 Argentina
    • 9.5.2 Brazil
    • 9.5.3 Chile
    • 9.5.4 Rest of South America
  • 9.6 Middle East & Africa
    • 9.6.1 Saudi Arabia
    • 9.6.2 UAE
    • 9.6.3 Qatar
    • 9.6.4 South Africa
    • 9.6.5 Rest of Middle East & Africa

10 Key Developments

  • 10.1 Agreements, Partnerships, Collaborations and Joint Ventures
  • 10.2 Acquisitions & Mergers
  • 10.3 New Product Launch
  • 10.4 Expansions
  • 10.5 Other Key Strategies

11 Company Profiling

  • 11.1 Merck
  • 11.2 Bio-Techne Corporation
  • 11.3 KromaTiD
  • 11.4 Sartorius Stedim Biotech
  • 11.5 BioIVT
  • 11.6 Cytiva (Danaher Corporation)
  • 11.7 Sartorius AG
  • 11.8 BioSpherix, Ltd.
  • 11.9 CELLINK
  • 11.10 Thermo Fisher Scientific, Inc.
  • 11.11 Asahi Breweries, Ltd.
  • 11.12 Evonik
  • 11.11 Avantor, Inc.
  • 11.14 HiMedia Laboratories
  • 11.15 Agilent Technologies
  • 11.16 CellulaREvolution
  • 11.17 Corning Incorporated
  • 11.18 Becton
  • 11.19 PromoCell GmbH
  • 11.20 Corning Incorporated
Product Code: SMRC21896

List of Tables

  • Table 1 Global Cell Culture Market Outlook, By Region (2020-2028) ($MN)
  • Table 2 Global Cell Culture Market Outlook, By Product (2020-2028) ($MN)
  • Table 3 Global Cell Culture Market Outlook, By Equipment (2020-2028) ($MN)
  • Table 4 Global Cell Culture Market Outlook, By Biosafety Equipment (2020-2028) ($MN)
  • Table 5 Global Cell Culture Market Outlook, By Cryostorage Equipment (2020-2028) ($MN)
  • Table 6 Global Cell Culture Market Outlook, By Water Baths (2020-2028) ($MN)
  • Table 7 Global Cell Culture Market Outlook, By Cryopreservative Containers (2020-2028) ($MN)
  • Table 8 Global Cell Culture Market Outlook, By Sterilizers (2020-2028) ($MN)
  • Table 9 Global Cell Culture Market Outlook, By Refrigerators and Freezers (2020-2028) ($MN)
  • Table 10 Global Cell Culture Market Outlook, By Carbon dioxide Incubators (2020-2028) ($MN)
  • Table 11 Global Cell Culture Market Outlook, By Culture Systems/Bioreactors (2020-2028) ($MN)
  • Table 12 Global Cell Culture Market Outlook, By Centrifuges (2020-2028) ($MN)
  • Table 13 Global Cell Culture Market Outlook, By Microscopes (2020-2028) ($MN)
  • Table 14 Global Cell Culture Market Outlook, By Cell Counters (2020-2028) ($MN)
  • Table 15 Global Cell Culture Market Outlook, By Cryogenic Tanks (2020-2028) ($MN)
  • Table 16 Global Cell Culture Market Outlook, By Pipetting Instruments (2020-2028) ($MN)
  • Table 17 Global Cell Culture Market Outlook, By Other Products (2020-2028) ($MN)
  • Table 18 Global Cell Culture Market Outlook, By Consumables (2020-2028) ($MN)
  • Table 19 Global Cell Culture Market Outlook, By Accessories (2020-2028) ($MN)
  • Table 20 Global Cell Culture Market Outlook, By Vessels (2020-2028) ($MN)
  • Table 21 Global Cell Culture Market Outlook, By Multiwell Plates (2020-2028) ($MN)
  • Table 22 Global Cell Culture Market Outlook, By Petri Dishes (2020-2028) ($MN)
  • Table 23 Global Cell Culture Market Outlook, By Roller/Roux Bottles (2020-2028) ($MN)
  • Table 24 Global Cell Culture Market Outlook, By Flasks (2020-2028) ($MN)
  • Table 25 Global Cell Culture Market Outlook, By Cell Factory Systems/Cell Stacks (2020-2028) ($MN)
  • Table 26 Global Cell Culture Market Outlook, By Media (2020-2028) ($MN)
  • Table 27 Global Cell Culture Market Outlook, By Source (2020-2028) ($MN)
  • Table 28 Global Cell Culture Market Outlook, By Classical Media (2020-2028) ($MN)
  • Table 29 Global Cell Culture Market Outlook, By Xeno-free/Animal Component Free (2020-2028) ($MN)
  • Table 30 Global Cell Culture Market Outlook, By Serum-free Media (2020-2028) ($MN)
  • Table 31 Global Cell Culture Market Outlook, By Chemically Defined Media (2020-2028) ($MN)
  • Table 32 Global Cell Culture Market Outlook, By Other Cell Culture Media (2020-2028) ($MN)
  • Table 33 Global Cell Culture Market Outlook, By Physical form (2020-2028) ($MN)
  • Table 34 Global Cell Culture Market Outlook, By Liquid Media (2020-2028) ($MN)
  • Table 35 Global Cell Culture Market Outlook, By Dry Powder Media (2020-2028) ($MN)
  • Table 36 Global Cell Culture Market Outlook, By Type (2020-2028) ($MN)
  • Table 37 Global Cell Culture Market Outlook, By Custom Media (2020-2028) ($MN)
  • Table 38 Global Cell Culture Market Outlook, By Off-the-Shelf Media (2020-2028) ($MN)
  • Table 39 Global Cell Culture Market Outlook, By Cells and Cell Lines (2020-2028) ($MN)
  • Table 40 Global Cell Culture Market Outlook, By Reagents (2020-2028) ($MN)
  • Table 41 Global Cell Culture Market Outlook, By Attachment & Matrix Factors (2020-2028) ($MN)
  • Table 42 Global Cell Culture Market Outlook, By Supplements (2020-2028) ($MN)
  • Table 43 Global Cell Culture Market Outlook, By Buffers & Chemicals (2020-2028) ($MN)
  • Table 44 Global Cell Culture Market Outlook, By Cell Dissociation Reagents (2020-2028) ($MN)
  • Table 45 Global Cell Culture Market Outlook, By Antibiotics/Antimycotics (2020-2028) ($MN)
  • Table 46 Global Cell Culture Market Outlook, By Balanced Salt Solutions (2020-2028) ($MN)
  • Table 47 Global Cell Culture Market Outlook, By Cryoprotective Agents (2020-2028) ($MN)
  • Table 48 Global Cell Culture Market Outlook, By Contamination Detection Kits (2020-2028) ($MN)
  • Table 49 Global Cell Culture Market Outlook, By Growth Factors and Cytokines (2020-2028) ($MN)
  • Table 50 Global Cell Culture Market Outlook, By Other Cell Culture Reagents (2020-2028) ($MN)
  • Table 51 Global Cell Culture Market Outlook, By Sera (2020-2028) ($MN)
  • Table 52 Global Cell Culture Market Outlook, By Adult Bovine Sera (ABS) (2020-2028) ($MN)
  • Table 53 Global Cell Culture Market Outlook, By Fetal Bovine Sera (FBS) (2020-2028) ($MN)
  • Table 54 Global Cell Culture Market Outlook, By Other Animal Sera (2020-2028) ($MN)
  • Table 55 Global Cell Culture Market Outlook, By Application (2020-2028) ($MN)
  • Table 56 Global Cell Culture Market Outlook, By Drug Screening & Development (2020-2028) ($MN)
  • Table 57 Global Cell Culture Market Outlook, By Stem Cell Research (2020-2028) ($MN)
  • Table 58 Global Cell Culture Market Outlook, By Tissue Engineering & Regenerative Medicine (2020-2028) ($MN)
  • Table 59 Global Cell Culture Market Outlook, By Cancer Research (2020-2028) ($MN)
  • Table 60 Global Cell Culture Market Outlook, By Biopharmaceuticals (2020-2028) ($MN)
  • Table 61 Global Cell Culture Market Outlook, By Vaccine Production (2020-2028) ($MN)
  • Table 62 Global Cell Culture Market Outlook, By Diagnostics (2020-2028) ($MN)
  • Table 63 Global Cell Culture Market Outlook, By Bioproduction (2020-2028) ($MN)
  • Table 64 Global Cell Culture Market Outlook, By Vaccine Production (2020-2028) ($MN)
  • Table 65 Global Cell Culture Market Outlook, By Therapeutic Protein Production (2020-2028) ($MN)
  • Table 66 Global Cell Culture Market Outlook, By Cell and Gene therapy (2020-2028) ($MN)
  • Table 67 Global Cell Culture Market Outlook, By Monoclonal Antibody Production (2020-2028) ($MN)
  • Table 68 Global Cell Culture Market Outlook, By Other Applications (2020-2028) ($MN)
  • Table 69 Global Cell Culture Market Outlook, By End user (2020-2028) ($MN)
  • Table 70 Global Cell Culture Market Outlook, By Hospital & Diagnostic Laboratories (2020-2028) ($MN)
  • Table 71 Global Cell Culture Market Outlook, By Pharmaceutical & Biotechnology Companies (2020-2028) ($MN)
  • Table 72 Global Cell Culture Market Outlook, By Academic and Research Institutes (2020-2028) ($MN)
  • Table 73 Global Cell Culture Market Outlook, By Other End users (2020-2028) ($MN)

Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.

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