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Chiral Technology

Abstract

This report analyzes the worldwide markets for Chiral Technology in US$ Million by the following Chiral Technology Enabling Products - Intermediates, Analytical, and Others. The End Use markets also analyzed in the report include Pharmaceuticals, and Agrochemicals. The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2009 through 2017. Also, a six-year historic analysis is provided for these markets. The report profiles 38 companies including many key and niche players such as Albemarle Corporation, BASF SE, Cambrex Corp., Chiral Quest Inc., Dalco ChromTech AB, Daicel Corporation., Chiral Technologies, Inc., Chiral Technologies Europe, DSM Pharmaceutical Products, Johnson Matthey PLC, Regis Technologies Inc., Shasun Pharmaceuticals Limited, Solvias, Sigma Aldrich Corp, and Suven Life Sciences Ltd. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain.

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Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

  • Study Reliability and Reporting Limitations
  • Disclaimers
  • Data Interpretation & Reporting Level
    • Quantitative Techniques & Analytics
  • Product Definitions and Scope of Study
    • Chiral Technology Enabling Products
      • Chiral Intermediates
      • Analytical Products
      • Other Products
    • Chiral Technology End-Use Markets
      • Pharmaceuticals
      • Agrochemicals

II. EXECUTIVE SUMMARY

1. MARKET OVERVIEW

  • Bright Outlook for the Global Chiral Technology Market
    • Table 1: World Chiral Technology Enabling Products Market by Segment (2011): Percentage Share Breakdown by Value Sales for Chiral Intermediates, Chiral Analytical Products, and Others (includes corresponding Graph/Chart)
  • Good Tidings for Chiral Technology
  • Market Drivers
  • Demand for Chiral-based Therapeutic Drugs Augments Growth
    • New Legislations Push Chiral Technology Demand
  • Key Market Trends
  • Organizations Extend Approaches
  • Companies' Association with Universities
  • Trends in Chiral Processes
  • Increasing Reliance on Generic Approaches
  • Predominant Use of Polysaccharides Derivatives as CSPs
  • Automation: Introduction of Instruments Supporting Chiral Processes, a Growing Trend

2. CHIRAL TECHNOLOGY

  • An Insight into Chiral Technology
  • Techniques Used for Achieving Single-Isomers
    • Table 2: World Chiral Technology Market (2011): Percentage Breakdown of Revenues by Techniques- Traditional Methods, Asymmetric Methods, and Biological Methods (includes corresponding Graph/Chart)
  • Importance and Advancements

3. CHIRAL TECHNOLOGY - AN OVERVIEW

  • Definitions
  • Chiral Technology Enabling Products
    • Chiral Intermediates
    • Analytical Products
    • Other Products
  • Chiral Technology End-Use Markets
    • Pharmaceuticals
    • Agrochemicals
  • Description
  • Functioning of Chiral Molecules
  • Chiral Preparation Process
  • Traditional Methods
  • Biological Methods
  • Asymmetric Methods
  • Chiral Separation
  • Factors Influencing the Efficacy of Chiral Separations
  • Recent Approaches in Chiral Separations
  • Extensive Use of Supercritical Fluid Chromatography (SFC)
  • Chromatography - The Widely Used Method for Separation
    • How it Works?
      • Chiral Mobile Phase Additive (CMPA)
      • Chiral Stationary Phase (CSP)
      • List of Newly Introduced Generic Versions of Derivatized Amylose and Cellulose Phases
      • Challenges and Novel Concepts in the Development of Chiral Stationary Phases
      • Novel Concepts
      • Chiral Recognition
      • Protein Chiral Stationary Phases
      • Carbohydrate Columns
      • Pirkle Columns
  • Crystallization
  • Solvent Extraction
  • Kinetic Resolution
  • Capillary Electrophoresis
  • Receptor Based Resolution
  • Miscellaneous Separative Techniques
  • Chiral Synthesis

4. CHIRAL TECHNOLOGY - DEVELOPMENT VIS-A-VIS ACQUISITION

  • In-House Creation & Development
  • Acquisition of Technology
  • "Economics" of Chiral Technology

5. CHIRAL ANALYSIS

  • Chiral Analysis: A Primer
  • Chiral Analysis Products
  • Chiral Analytical Chromatography
  • Chiral Liquid Chromatography
  • Supercritical Fluid Chromatography - Substitute to LC for Enantiomer Separations
  • Chiral Gas Chromatography
  • Chiral Simulated Moving Bed Chromatography
  • Partition Chromatography
  • Adsorption Chromatography
  • Computer Assisted Resolution
  • Chiral Polarimetry
  • Other Chiral Analytical Techniques
  • Calorimetry
    • Differential Scanning Calorimetry (DSC)
  • Enzymatic Assay
  • Immunoassay
  • Isotope Dilution
  • Nuclear Magnetic Resonance (NMR)
  • X-Ray Crystallography

6. APPLICATION MARKETS

  • Pharmaceuticals - The Largest Market
  • Changing Face of the Pharmaceutical Industry: A Review
  • Analysis of Chiral Drugs
    • Select Companies Involved in Chiral Technology Market
      • Single-Enantiomer Drugs Worldwide
  • Drugs Built on Chiral Technology
    • Analgesics
    • Anesthetics
    • Anti-Infective Products
    • Cardiovascular System (CVS) Products
    • Angiotensin-Converting Enzyme (ACE) Inhibitors
    • Beta-Blockers
    • Calcium Channel Blockers
    • Diuretics
    • Vasodilators
    • Central Nervous System (CNS) Agents
    • Anticonvulsants
    • Sedatives and Tranquilizers
    • Stimulants and Antidepressants
    • Oncogenic (Cancer-Treatment) Products
  • Biochemicals
  • Oligonucleotides
  • Oxyacids
  • Amino Acids
  • Sugars and Other Oligosaccharides
  • Vitamins
  • Peptides
  • Pesticides - A Thriving Market
  • Herbicides
  • Insecticides
  • Fungicides
  • Other Products
  • Liquid Crystals
  • Flavor and Aroma Chemicals

7. CHIRAL ISOMERISM

  • Organic Chemical Isomerism Types
  • Structural Isomerism
    • Chain Isomerism
    • Position Isomerism
    • Functional Group Isomerism
  • Stereoisomerism
  • Dynamic Isomerism (Tautomerism)
  • Patents

8. REGULATORY & ENVIRONMENTAL ISSUES - A REVIEW

9. PRODUCT INTRODUCTIONS/INNOVATIONS

  • Phenomenex Introduces Chiral Screening Service
  • AminoLogics Develops a Novel Chiral Converting Molecule for Amino Acids
  • Chiral Technologies Worldwide to Display 3-im and Protein-based Reversed Phase Columns
  • Chiral Technologies Introduces 3µm Chiral Stationary Phases for Rapid Analysis
  • Chiral Technologies Introduces 5µm Versions of Polysaccharide-Based Chiral Stationary
  • Semba Launches Semba Octave(tm) Chromatography System
  • Modular SFC to Launch Chiral Centrifugal Fraction Collector and Sample Concentration System
  • Chiral Technologies Introduces New Versions of Immobilized IC and IA Chiral Phases
  • PDR-Chiral Develops AutoMDS for Automated Screening of Chiral and Achiral Substances

10. PRODUCT INTRODUCTIONS/INNOVATIONS - A HISTORIC PERSPECTIVE BUILDER

  • Waters Introduces New Products Under the UPLC Line
  • Sigma-Aldrich/Supelco Introduces Astec CHIROBIOTIC(tm) Chiral HPLC Columns
  • Sigma-Aldrich/Supelco Introduces Astec CYCLOBOND(tm) Chiral HPLC Columns
  • Chiral Technologies Introduces CHIRALPAK(r) IC Columns Under Polysaccharide Product Range
  • Degussa Develops Novel Processes to Synthesize (S) CAP
  • Regis Technologies, Inc. Launches RegisPack Chiral Columns
  • Sigma-Aldrich Introduces ChiroSolv(tm) Kits
  • Sigma-Aldrich Launches Ascentis Express HPLC Columns
  • Evolved Nanomaterial Releases Revolutionary Analytical Chiral Column
  • BASF Develops Novel Process to Produce Chiral Intermediates
  • Sepiatech Launches Sepmatix Parallel HPLC system
  • MACHEREY-NAGEL Launches Novel NUCLEOCEL CSP Columns

11. RECENT INDUSTRY ACTIVITY

  • Daicel Chemical Industries Announces Renaming to Daicel Corp.
  • WR Grace Takes Over Synthetech
  • Daicel Chiral to Start a New Branch in Beijing
  • Saltigo Concludes Process Development Agreement with Reuter Chemische
  • Chiral Technologies Europe Inks Global Licensing Agreement with University of Vienna
  • Shasun Announces Change of Name
  • CT Worldwide Announces the Launch of a Novel Microsite
  • Chiral Technologies Partners with Vanderbilt University's Program in Drug Discovery
  • DSM Renews Co-Operation Agreement with Fudan University
  • Chiral Technologies Europe Inks Distribution Agreement with HICHROM

12. STRATEGIC CORPORATE DEVELOPMENTS - A HISTORIC PERSPECTIVE BUILDER

  • Dow Sells Dowpharma Small Molecules Business
  • Daicel Chemical Establishes New Subsidiary in China
  • Chiral Technologies Europe Takes Over ChromTech
  • Cambrex to Buy ProSyntest AS
  • Johnson Matthey and X-Zyme Sign Licensing Agreement
  • Chiral Quest Starts a New Production Facility
  • Chiral Quest Completes Reverse Merger with Surg II
  • DSM and IEP Extend Partnership
  • Shasun Chemicals Acquires Rhodia Pharma Solutions
  • Sigma-Aldrich Corp Acquires Astec
  • Solvias Receives License for MeOBIPHEP Catalyst Technology
  • Codexis Acquires Juelich Fine Chemicals

13. FOCUS ON SELECT PLAYERS

  • Albemarle Corporation (USA)
  • BASF SE (Germany)
  • Cambrex Corp. (USA)
  • Chiral Quest Inc. (US)
  • Dalco ChromTech AB (Sweden)
  • Daicel Corporation (Japan)
  • Chiral Technologies Worldwide
  • Chiral Technologies, Inc. (USA)
  • Chiral Technologies Europe (France)
  • DSM Pharmaceutical Products (The Netherlands)
  • Johnson Matthey PLC (UK)
  • Regis Technologies, Inc. (USA)
  • Shasun Pharmaceuticals Limited (India)
  • Solvias (Switzerland)
  • Sigma Aldrich Corp. (USA)
  • Suven Life Sciences Ltd. (USA)

14. GLOBAL MARKET PERSPECTIVE

    • Table 3: World Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 4: World Historic Review for Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 5: World 15-Year Perspective for Chiral Technology Enabling Products by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)
    • Table 6: World Recent Past, Current & Future Analysis for Chiral Intermediates by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 7: World Historic Review for Chiral Intermediates by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 8: World 15-Year Perspective for Chiral Intermediates by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)
    • Table 9: World Recent Past, Current & Future Analysis for Chiral Analytical Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 10: World Historic Review for Chiral Analytical Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 11: World 15-Year Perspective for Chiral Analytical Products by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)
    • Table 12: World Recent Past, Current & Future Analysis for Other* Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 13: World Historic Review for Other* Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 14: World 15-Year Perspective for Other* Chiral Technology Enabling Products by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)
    • Table 15: World Recent Past, Current & Future Analysis for Chiral Technology in Pharmaceuticals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 16: World Historic Review for Chiral Technology in Pharmaceuticals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 17: World 15-Year Perspective for Chiral Technology in Pharmaceuticals by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)
    • Table 18: World Recent Past, Current & Future Analysis for Chiral Technology in Agrochemicals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 19: World Historic Review for Chiral Technology in Agrochemicals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 20: World 15-Year Perspective for Chiral Technology in Agrochemicals by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)

III. MARKET

1. THE UNITED STATES

  • A. Market Analysis
    • Overview
  • B. Market Analytics
    • Table 21: The US Recent Past, Current and Future Analysis for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 22: The US Historic Review for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 23: The US 15-Year Perspective for Chiral Technology Enabling Products by Product Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)
    • Table 24: The US Recent Past, Current & Future Analysis for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 25: The US Historic Review for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 26: The US 15-Year Perspective for Chiral Technology by End-Use Segment - Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)

2. JAPAN

  • Market Analytics
    • Table 27: Japanese Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 28: Japanese Historic Review for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 29: Japanese 15-Year Perspective for Chiral Technology Enabling Products by Product Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)
    • Table 30: Japanese Recent Past, Current & Future Analysis for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 31: Japanese Historic Review for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 32: Japanese 15-Year Perspective for Chiral Technology by End-Use Segment - Percentage Breakdown of Value Sales for Pharmaceuticals and Agrochemicals Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)

3. EUROPE

  • A. Market Analysis
    • Overview
  • B. Market Analytics
    • Table 33: European Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 34: European Historic Review for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 35: European 15-Year Perspective for Chiral Technology Enabling Products by Product Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)
    • Table 36: European Recent Past, Current and Future Analysis for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 37: European Historic Review for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 38: European 15-Year Perspective for Chiral Technology by End-Use Segment - Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)

4. REST OF WORLD

  • A. Market Analysis
    • India
      • Chiral Drugs in the Indian Market
    • China-A Hub for Pharmaceutical Manufacturing
  • B. Market Analytics
    • Table 39: Rest of World Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 40: Rest of World Historic Review for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 41: Rest of World 15-Year Perspective for Chiral Technology Enabling Products by Product Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)
    • Table 42: Rest of World Recent Past, Current & Future Analysis for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2009 through 2017 (includes corresponding Graph/Chart)
    • Table 43: Rest of World Historic Review for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2008 (includes corresponding Graph/Chart)
    • Table 44: Rest of World 15-Year Perspective for Chiral Technology by End-Use Segment - Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2003, 2011 & 2017 (includes corresponding Graph/Chart)

IV. COMPETITIVE LANDSCAPE

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