PUBLISHER: AnalystView Market Insights | PRODUCT CODE: 1877398
PUBLISHER: AnalystView Market Insights | PRODUCT CODE: 1877398
The Retinitis Pigmentosa (RP) Market size was valued at US$ 14,789.90 Million in 2024, expanding at a CAGR of 7.4% from 2025 to 2032.
Retinitis Pigmentosa (RP) is a group of inherited retinal disorders that cause progressive vision loss by damaging the retina, the light-sensitive tissue in the back of the eye. Individuals with RP typically have reduced night vision, gradual peripheral vision loss, and, in the advanced stages, complete blindness. The RP market is primarily driven by improved diagnosis of inherited retinal diseases, increased access to genetic testing, and rapid advances in gene therapy, stem-cell therapy, and optogenetic approaches that allow for more targeted and personalized treatment options. However, market growth is limited by the high cost of gene therapies and the scarcity of approved treatments beyond Luxturna. Key market trends include increased investment in AAV- and CRISPR-based therapeutic platforms, as well as a greater emphasis on early genetic screening.
Retinitis Pigmentosa (RP) Market- Market Dynamics
Rising Healthcare Expenditure Drives Growth In The Retinitis Pigmentosa Market
The increase in healthcare expenditure is expected to drive future growth in the retinitis pigmentosa market. Healthcare expenditure is the total amount of money spent on healthcare goods and services, such as medical treatments, medications, hospitalizations, and preventive care, over a given time period, indicating the overall cost of healthcare provision within a population. Healthcare spending is increasing as the cost of advanced medical technologies rises, populations age, and chronic diseases become more prevalent. Healthcare spending for retinitis pigmentosa is concentrated on improving diagnostic methods, developing effective treatments, and providing supportive care to manage vision loss. For example, according to the National Institutes of Health, a US-based government agency, healthcare spending in the United States increased by 4.1% in 2022 to $4.5 trillion, representing a faster growth rate than the 3.2% increase observed in 2021. As a result, rising healthcare costs are fueling the growth of the retinitis pigmentosa industry.
The worldwide market is segmented on the basis of Route of Administration, Diagnosis, Treatment Type, Disease Type, End-Users, and Region.
In treatment type segment, the gene therapy category is expected to remain a key growth driver throughout the forecast period. Gene therapy for retinitis pigmentosa focuses on delivering functional genes to patient cells to combat disease-causing mutations. Luxturna (voretigene neparvovec-rzyl) is the only FDA-approved therapy for biallelic RPE65 mutations, which restores functional gene expression in retinal cells. Beyond Luxturna, several candidates are making progress in clinical trials, utilizing AAV and other vector technologies to target a broader range of mutations. Continued investment from leading biopharmaceutical companies is boosting development activity and shaping the segment's upward trajectory. For instance, in May 2025, Beacon Therapeutics Holdings Limited reported 6-month interim safety and efficacy results from the Phase 2 DAWN trial of the Company's lead program, laru-zova (laruparetigene zovaparvovec), in patients with X-linked retinitis pigmentosa (XLRP).
Based on Treatment Type segment, Vitamin A supplements remain an essential and historically significant segment of the RP market because vitamin A (specifically, retinol palmitate) has long been studied for its ability to slow photoreceptor degeneration in some RP patients. In the absence of broadly approved gene therapies (for many genetic subtypes), vitamin A has provided a relatively simple, low-tech supplement that may delay the decline in retinal function. Because RP is genetically heterogeneous, nutritional interventions such as vitamin A provide patients with a low-cost, scalable option, especially in settings where advanced therapies are unavailable or as a complementary measure. Vitamin A supplementation exemplifies how more traditional, non-gene-based treatments remain part of the therapeutic mix, even in a market dominated by sophisticated therapies. According to the NEI, a trial supported by the institute (1984-1992) discovered that taking 15,000 IU of vitamin A palmitate daily could slow the rate of functional retinal decline (measured using ERG).
Retinitis Pigmentosa (RP) Market- Geographical Insights
In 2025, North America emerged as a significant region, accounting for more than 45.2% of the market. The region benefits from advanced healthcare infrastructure, significant R&D investments, and a rising incidence of retinal disease. Regulatory support from agencies such as the FDA expedites the approval of innovative therapies, resulting in market growth. The growing awareness of genetic disorders, as well as the demand for effective treatments, are driving this expansion. The United States is the primary contributor, with key players including Regeneron Pharmaceuticals and Spark Therapeutics leading the way. Canada also plays an important role, focusing on R&D initiatives. Collaborations between biotech firms and academic institutions characterize the competitive landscape, thereby expanding the pipeline of novel therapies. The presence of major pharmaceutical companies ensures a strong market environment that promotes innovation and accessibility.
United States Retinitis Pigmentosa (RP) Market- Country Insights
North America, particularly the United States, Canada is known for its large concentration of major players such as pharmaceutical companies, which actively pursue the development of novel therapies for better treatment. For instance, in August 2024, Ocugen, Inc., a biotechnology company focused on discovering, developing, and commercializing novel gene and cell therapies and vaccines, announced that Health Canada has issued a "No Objection Letter" to begin the OCU400 Phase 3 liMeliGhT clinical trial in Canada. OCU400 is a modifier gene therapy product candidate for retinitis pigmentosa (RP). These are focused on the development of novel therapeutics, which will boost regional market growth.
The Retinitis Pigmentosa market is competitive, with a diverse range of stakeholders including pharmaceutical companies, biotechnology firms, academic institutions, research organizations, and healthcare providers. These organizations are involved in a variety of activities, including research and development of new therapies, manufacturing and commercialization of existing treatments, and providing healthcare services to retinitis pigmentosa patients. Government agencies, including the National Institutes of Health (NIH) in the United States and the European Commission's Horizon 2020 program, fund and support retinitis pigmentosa research and development initiatives. These organizations play an important role in encouraging innovation, facilitating collaborations, and advancing therapeutic discoveries in the field of ophthalmology.
In December 2024, Bausch + Lomb, a subsidiary of Bausch Health, has acquired Elios Vision Inc., the developer of the ELIOS system, a minimally invasive glaucoma surgery (MIGS) procedure that uses an excimer laser. This acquisition demonstrates Bausch + Lomb's commitment to providing advanced glaucoma treatment solutions, thereby improving patient care around the world.
In May, 2024, The EYE-RD Global Registry was introduced by Johnson & Johnson at the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO). This non-interventional global registry is the first of its kind and aims to collect longitudinal clinical data on patients with inherited retinal diseases (IRDs), such as X-linked retinitis pigmentosa. The registry's goal is to fill knowledge gaps by providing real-world insights into disease progression and patient experiences, which will aid in IRD research, diagnosis, and treatment strategies.
In August 2025, Novartis (CH) has announced a strategic collaboration with a leading biotechnology company to co-develop a novel gene therapy to treat Retinitis Pigmentosa. This collaboration is expected to leverage both companies' genetic research expertise, potentially shortening the development timeline and expanding the therapeutic options available to patients. Such collaborations not only strengthen Novartis' research capabilities, but also reflect an industry-wide trend toward collaborative innovation.