PUBLISHER: AnalystView Market Insights | PRODUCT CODE: 2073746
PUBLISHER: AnalystView Market Insights | PRODUCT CODE: 2073746
Nucleic Acid Therapeutics CDMO market size was valued at US$ 17,508.3 Million in 2025, expanding at a CAGR of 14.3% from 2026 to 2033.
The nucleic acid drugs represent a family of artificial oligonucleotides (DNA, RNA, or analogs of nucleotide bases) with a well-defined sequence that will be able to bind with the target DNA sequence through Watson-Crick base pairing. The nucleic acid drug structure, which can undergo modifications to its backbone (phosphorothioate bonds) or sugar units (2'-O-methyl or locked nucleic acids), enables the manipulation of the gene expression of the target DNA by antisense binding, RNA interference, or splice modulation. Thus, nucleic acid therapeutics offer highly specific genetic regulation for advanced targeted treatment strategies.
Nucleic Acid Therapeutics CDMO Market- Market Dynamics
Rapid Expansion of RNA-Based Therapeutics to Drive Market Growth
The rise in RNA-based therapeutic drugs is among the main reasons that impact the development of the Nucleic Acid Therapeutics CDMO market owing to growing demands in the development and manufacturing of these RNA-based drugs. For instance, in 2026, according to a comprehensive review published in the U.S. National Library of Medicine (PMC), because of the advancements in mRNAs, siRNAs, ASOs, and RNA editing as described in detail in the review made by the U.S. National Library of Medicine (PMC). Already over 20 RNA-based drugs have been approved worldwide, while others are at different stages of clinical trials; that is, Phase I, II, and III, for treatments of cancer, genetic diseases, infectious diseases, and metabolic diseases. This accelerating clinical progress is significantly increasing demand for specialized CDMO capabilities worldwide.
The Global Nucleic Acid Therapeutics CDMO market is segmented on the basis of Type, Service, End Use, Application, and Region.
Among the given applications, infectious diseases account for a prominent share because of the growing need for nucleic acid drugs for viral, bacterial, and novel infections owing to the advances made in the field of RNA- and DNA-based drug manufacturing. In May 2025, Aldevron, which is a part of Danaher, partnered with Integrated DNA Technologies to introduce the first personalized CRISPR therapy using mRNA through advanced manufacturing technologies for DNA and RNA, contributing to the development of next generation nucleic acid medicines for genetic and infectious diseases. This trend is expected to further accelerate innovation and adoption of nucleic acid therapeutics globally.
Nucleic Acid Therapeutics CDMO Market- Geographical Insights
North America dominated the Nucleic Acid Therapeutics CDMO market due to its supportive regulatory environment, increasing investment and funding activities, and a rising number of product approvals. For instance, in 2026, according to the National Academies of Sciences, Engineering, and Medicine's initiative on aligning investments in therapeutic innovation with disease burden and unmet needs, growing attention is being directed toward increasing investment in therapeutics that address high-priority health challenges and underserved patient populations. The study brings together a multidisciplinary committee of 16 experts from healthcare, biopharmaceuticals, and policy to evaluate how research and development funding can be more effectively allocated toward areas with the greatest unmet medical need. This investment momentum is expected to accelerate innovation and strengthen regional market growth.
India Nucleic Acid Therapeutics CDMO market - Country Insights
The India Nucleic Acid Therapeutics CDMO market is expected to see high levels of growth owing to its cost-effective manufacturing infrastructure, high-caliber workforce, and the presence of high-end WHO-cGMP-compliant manufacturing plants. For instance, according to CDSCO Gov, there are 2,006 WHO-cGMP-certified pharmaceutical manufacturing facilities in India spread throughout different states in the list up till now, which means that India is blessed with many top-class WHO-cGMP manufacturing facilities. Gujarat stands first with 684 WHO-cGMP-certified manufacturing plants, followed by Maharashtra with 229, Himachal Pradesh with 202, Telangana with 172, and Uttarakhand with 128 WHO-cGMP manufacturing facilities. This strong manufacturing base positions India as a preferred hub for nucleic acid therapeutics CDMO services.
Leading companies in the global market, including LGC Limited, Merck KGaA, WuXi AppTec, BIOSPRING, and Univercells Inc., are putting all their efforts into strategic growth. Such companies have been concentrating on collaborations, acquisitions, capacity expansion, and other service launches that could prove beneficial for their market shares, technologies, and worldwide presence. In October 2025, BIOSPRING launched manufacturing services for Luxna Biotech's unique XNA amidite portfolio that includes AmNA(TM), scpBNA(TM), and 5'-CP(TM) chemistries. The launch of this product line will improve the therapeutic oligonucleotide contract development and manufacturing organization services provided by BIOSPRING due to the advanced nucleic acid medicines with improved affinity, increased stability, and lower toxicity. These moves will increase the speed of innovations of companies operating in the global market.
In June 2026, Merck KGaA agreed to acquire Bio-Techne Corporation for approximately USD 11.3 billion, significantly expanding its life science business. The acquisition strengthens Merck's portfolio of research reagents, proteins, antibodies, and analytical tools supporting biopharmaceutical and nucleic acid therapeutics development.
In March 2026, Agilent Technologies launched Agilent Advanced Therapeutics, integrating its nucleic acid manufacturing and CDMO capabilities to provide end-to-end oligonucleotide development and production services supporting advanced therapeutic programs, including infectious disease-focused nucleic acid therapies.