Global Hydrophobic Interaction Chromatography Market Size study & Forecast, by Product and Service by Sample Type by End-User and Regional Forecasts 2022-2032

Description

The Global Hydrophobic Interaction Chromatography (HIC) Market, valued at nearly USD 0.24 billion in 2024, is projected to expand at a notable CAGR of 7.70% between 2025 and 2035, ultimately reaching approximately USD 0.54 billion. Hydrophobic interaction chromatography, a pivotal separation technique in bioprocessing, leverages hydrophobic interactions between proteins and specialized resins to achieve high-purity separations without denaturing sensitive biomolecules. As the pharmaceutical and biotechnology sectors accelerate the production of complex biologics-ranging from monoclonal antibodies to next-generation vaccines-the adoption of HIC has emerged as a cornerstone in downstream purification workflows. Its capacity to maintain protein functionality while delivering high yield has positioned it as an indispensable method in the manufacturing of advanced therapeutics. The surge in biologics demand, coupled with intensifying regulatory requirements for purity and process validation, is propelling the global HIC market forward.

Expanding R&D expenditure in life sciences, alongside the explosive growth of the biopharmaceutical pipeline, has significantly bolstered the market's momentum. An increasing number of blockbuster biologics are nearing patent expiry, triggering a wave of biosimilar development that heavily depends on robust and cost-effective purification processes such as HIC. Technological advancements-such as the development of high-capacity resins, automation-enabled chromatography systems, and integration with multi-modal purification strategies-are reshaping operational efficiencies for research institutions and manufacturers alike. Additionally, the widespread focus on vaccine production in the wake of global health emergencies has spotlighted HIC's role in ensuring product safety and consistency, further anchoring its demand. However, the high cost of resins and consumables, coupled with the technical complexity of optimization, may present short-term adoption barriers, particularly for smaller research facilities.

North America currently leads the global hydrophobic interaction chromatography market, buoyed by its extensive biopharmaceutical manufacturing infrastructure, strong academic research base, and sustained government funding for life sciences innovation. The United States, home to a significant number of contract development and manufacturing organizations (CDMOs) and biotech startups, serves as the market's epicenter. Europe follows closely, supported by robust regulatory frameworks, thriving biosimilar pipelines, and well-established biotech hubs in Germany, Switzerland, and the UK. Meanwhile, the Asia Pacific region is forecast to register the fastest growth rate, driven by escalating biopharma investments in China, India, and South Korea, increasing adoption of advanced purification technologies, and rising collaborations between local players and global pharmaceutical giants. Latin America and the Middle East & Africa are steadily emerging, with gradual improvements in research infrastructure and expanding clinical trial activities.

Major market players included in this report are:

GE Healthcare
Sartorius AG
Bio-Rad Laboratories, Inc.
Thermo Fisher Scientific Inc.
Merck KGaA
Tosoh Corporation
Danaher Corporation
Agilent Technologies, Inc.
Waters Corporation
Mitsubishi Chemical Corporation
PerkinElmer Inc.
Novasep Holding SAS
Shimadzu Corporation
Repligen Corporation
Purolite Corporation

Global Hydrophobic Interaction Chromatography Market Report Scope:

Historical Data - 2023, 2024
Base Year for Estimation - 2024
Forecast period - 2025-2035
Report Coverage - Revenue forecast, Company Ranking, Competitive Landscape, Growth factors, and Trends
Regional Scope - North America; Europe; Asia Pacific; Latin America; Middle East & Africa
Customization Scope - Free report customization (equivalent up to 8 analysts' working hours) with purchase. Addition or alteration to country, regional & segment scope*

The objective of the study is to define market sizes of different segments & countries in recent years and to forecast the values for the coming years. The report is designed to incorporate both qualitative and quantitative aspects of the industry within the countries involved in the study. The report also provides detailed information about crucial aspects, such as driving factors and challenges, which will define the future growth of the market. Additionally, it incorporates potential opportunities in micro-markets for stakeholders to invest, along with a detailed analysis of the competitive landscape and product offerings of key players. The detailed segments and sub-segments of the market are explained below:

By Product and Service:

Resins
Columns
Services
Others

By Sample Type:

Monoclonal Antibodies
Vaccines
Others

By End-User:

Research & Academic Institutes

By Region:

North America
U.S.
Canada
Europe
UK
Germany
France
Spain
Italy
ROE
Asia Pacific
China
India
Japan
Australia
South Korea
RoAPAC
Latin America
Brazil
Mexico
Middle East & Africa
UAE
Saudi Arabia
South Africa
Rest of Middle East & Africa

Key Takeaways:

Market Estimates & Forecast for 10 years from 2025 to 2035.
Annualized revenues and regional level analysis for each market segment.
Detailed analysis of geographical landscape with Country level analysis of major regions.
Competitive landscape with information on major players in the market.
Analysis of key business strategies and recommendations on future market approach.
Analysis of competitive structure of the market.
Demand side and supply side analysis of the market.

Chapter 1. Global Hydrophobic Interaction Chromatography Market Report Scope & Methodology

1.1. Research Objective
1.2. Research Methodology
- 1.2.1. Forecast Model
- 1.2.2. Desk Research
- 1.2.3. Top Down and Bottom-Up Approach
1.3. Research Attributes
1.4. Scope of the Study
- 1.4.1. Market Definition
- 1.4.2. Market Segmentation
1.5. Research Assumption
- 1.5.1. Inclusion & Exclusion
- 1.5.2. Limitations
- 1.5.3. Years Considered for the Study (Historical Data - 2023, 2024; Base Year - 2024; Forecast Period - 2025-2035)

Chapter 2. Executive Summary

2.1. CEO/CXO Standpoint
2.2. Strategic Insights
2.3. ESG Analysis
2.4. Key Findings

Chapter 3. Global Hydrophobic Interaction Chromatography Market Forces Analysis

3.1. Market Forces Shaping The Global Hydrophobic Interaction Chromatography Market (2024-2035)
3.2. Drivers
- 3.2.1. (Growing Biologics & Biosimilars Production Driving Demand for HIC)
- 3.2.2. (Technological Advancements in High-Capacity Resins, Automation & Single-Use Systems)
3.3. Restraints
- 3.3.1. (High Cost of Resins and Consumables Increasing Operational Expenditure)
- 3.3.2. (Technical Complexity of Process Optimization and Competition from Alternative Purification Methods)
3.4. Opportunities
- 3.4.1. (Integration with Continuous Bioprocessing and Multi-Modal Purification Workflows)
- 3.4.2. (Rapid Expansion in Asia Pacific and Emerging Biopharma Manufacturing Hubs)

Chapter 4. Global Hydrophobic Interaction Chromatography Industry Analysis

4.1. Porter's 5 Forces Model
- 4.1.1. Bargaining Power of Buyer
- 4.1.2. Bargaining Power of Supplier
- 4.1.3. Threat of New Entrants
- 4.1.4. Threat of Substitutes
- 4.1.5. Competitive Rivalry
4.2. Porter's 5 Force Forecast Model (2024-2035)
4.3. PESTEL Analysis
- 4.3.1. Political
- 4.3.2. Economical
- 4.3.3. Social
- 4.3.4. Technological
- 4.3.5. Environmental
- 4.3.6. Legal
4.4. Top Investment Opportunities
4.5. Top Winning Strategies (2025)
4.6. Market Share Analysis (2024-2025)
4.7. Global Pricing Analysis And Trends 2025
4.8. Analyst Recommendation & Conclusion

Chapter 5. Global Hydrophobic Interaction Chromatography Market Size & Forecasts by Product & Service 2025-2035

5.1. Market Overview
5.2. Global Hydrophobic Interaction Chromatography Market Performance - Potential Analysis (2025)
5.3. Product & Service: Resins
- 5.3.1. Top Countries Breakdown Estimates & Forecasts, 2024-2035
- 5.3.2. Market size analysis, by region, 2025-2035
5.4. Product & Service: Columns
- 5.4.1. Top Countries Breakdown Estimates & Forecasts, 2024-2035
- 5.4.2. Market size analysis, by region, 2025-2035
5.5. Product & Service: Services
- 5.5.1. Top Countries Breakdown Estimates & Forecasts, 2024-2035
- 5.5.2. Market size analysis, by region, 2025-2035
5.6. Product & Service: Others
- 5.6.1. Top Countries Breakdown Estimates & Forecasts, 2024-2035
- 5.6.2. Market size analysis, by region, 2025-2035

Chapter 6. Global Hydrophobic Interaction Chromatography Market Size & Forecasts by Sample Type 2025-2035

6.1. Market Overview
6.2. Global Hydrophobic Interaction Chromatography Market Performance - Potential Analysis (2025)
6.3. Monoclonal Antibodies
- 6.3.1. Top Countries Breakdown Estimates & Forecasts, 2024-2035
- 6.3.2. Market size analysis, by region, 2025-2035
6.4. Vaccines
- 6.4.1. Top Countries Breakdown Estimates & Forecasts, 2024-2035
- 6.4.2. Market size analysis, by region, 2025-2035
6.5. Others (Biologics & Specialty Proteins)
- 6.5.1. Top Countries Breakdown Estimates & Forecasts, 2024-2035
- 6.5.2. Market size analysis, by region, 2025-2035

Chapter 7. Global Hydrophobic Interaction Chromatography Market Size & Forecasts by Region 2025-2035

7.1. Hydrophobic Interaction Chromatography Market, Regional Market Snapshot
7.2. Top Leading & Emerging Countries
7.3. North America Hydrophobic Interaction Chromatography Market
- 7.3.1. U.S. Hydrophobic Interaction Chromatography Market
  - 7.3.1.1. Product & Service (Resins, Columns, Services) breakdown size & forecasts, 2025-2035
  - 7.3.1.2. Sample Type (Monoclonal Antibodies, Vaccines, Others) breakdown size & forecasts, 2025-2035
- 7.3.2. Canada Hydrophobic Interaction Chromatography Market
  - 7.3.2.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.3.2.2. Sample Type breakdown size & forecasts, 2025-2035
7.4. Europe Hydrophobic Interaction Chromatography Market
- 7.4.1. UK Hydrophobic Interaction Chromatography Market
  - 7.4.1.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.4.1.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.4.2. Germany Hydrophobic Interaction Chromatography Market
  - 7.4.2.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.4.2.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.4.3. France Hydrophobic Interaction Chromatography Market
  - 7.4.3.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.4.3.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.4.4. Spain Hydrophobic Interaction Chromatography Market
  - 7.4.4.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.4.4.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.4.5. Italy Hydrophobic Interaction Chromatography Market
  - 7.4.5.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.4.5.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.4.6. Rest of Europe Hydrophobic Interaction Chromatography Market
  - 7.4.6.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.4.6.2. Sample Type breakdown size & forecasts, 2025-2035
7.5. Asia Pacific Hydrophobic Interaction Chromatography Market
- 7.5.1. China Hydrophobic Interaction Chromatography Market
  - 7.5.1.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.5.1.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.5.2. India Hydrophobic Interaction Chromatography Market
  - 7.5.2.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.5.2.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.5.3. Japan Hydrophobic Interaction Chromatography Market
  - 7.5.3.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.5.3.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.5.4. Australia Hydrophobic Interaction Chromatography Market
  - 7.5.4.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.5.4.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.5.5. South Korea Hydrophobic Interaction Chromatography Market
  - 7.5.5.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.5.5.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.5.6. Rest of APAC Hydrophobic Interaction Chromatography Market
  - 7.5.6.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.5.6.2. Sample Type breakdown size & forecasts, 2025-2035
7.6. Latin America Hydrophobic Interaction Chromatography Market
- 7.6.1. Brazil Hydrophobic Interaction Chromatography Market
  - 7.6.1.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.6.1.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.6.2. Mexico Hydrophobic Interaction Chromatography Market
  - 7.6.2.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.6.2.2. Sample Type breakdown size & forecasts, 2025-2035
7.7. Middle East and Africa Hydrophobic Interaction Chromatography Market
- 7.7.1. UAE Hydrophobic Interaction Chromatography Market
  - 7.7.1.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.7.1.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.7.2. Saudi Arabia (KSA) Hydrophobic Interaction Chromatography Market
  - 7.7.2.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.7.2.2. Sample Type breakdown size & forecasts, 2025-2035
- 7.7.3. South Africa Hydrophobic Interaction Chromatography Market
  - 7.7.3.1. Product & Service breakdown size & forecasts, 2025-2035
  - 7.7.3.2. Sample Type breakdown size & forecasts, 2025-2035

Chapter 8. Competitive Intelligence

8.1. Top Market Strategies
8.2. GE Healthcare
- 8.2.1. Company Overview
- 8.2.2. Key Executives
- 8.2.3. Company Snapshot
- 8.2.4. Financial Performance (Subject to Data Availability)
- 8.2.5. Product/Services Port
- 8.2.6. Recent Development
- 8.2.7. Market Strategies
- 8.2.8. SWOT Analysis
8.3. Sartorius AG
8.4. Bio-Rad Laboratories, Inc.
8.5. Thermo Fisher Scientific Inc.
8.6. Merck KGaA
8.7. Tosoh Corporation
8.8. Danaher Corporation
8.9. Agilent Technologies, Inc.
8.10. Waters Corporation
8.11. Mitsubishi Chemical Corporation
8.12. PerkinElmer Inc.
8.13. Novasep Holding SAS
8.14. Shimadzu Corporation
8.15. Repligen Corporation
8.16. Purolite Corporation