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PUBLISHER: DelveInsight | PRODUCT CODE: 1226534

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PUBLISHER: DelveInsight | PRODUCT CODE: 1226534

TOCTINO Drug Insight and Market Forecast - 2032

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PAGES: 30 Pages
DELIVERY TIME: 2-10 business days
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"TOCTINO Drug Insight and Market Forecast - 2032" report provides comprehensive insights about TOCTINO for Hand Eczema (HE) in EU4 and the UK. A detailed picture of the TOCTINO for Hand Eczema in EU4 (Germany, France, Italy, and Spain) and the United Kingdom for the study period 2019-2032 is provided in this report along with a detailed description of the TOCTINO for Hand Eczema. The report provides insight about mechanism of action, dosage and administration, as well as research and development activity including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments inclusive of the TOCTINO market forecast, analysis for Hand Eczema inEU4 and the UK, descriptive analysis such as SWOT, analyst views, comprehensive overview of market competitors, and brief about other emerging therapies in Hand Eczema.

Drug Summary:

TOCTINO (alitretinoin) is an endogenous metabolite of vitamin A and belongs to the retinoid, a class of drugs that have been used to treat many skin disorders, including acne vulgaris, psoriasis, etc., for around two decades.

Alitretinoin is an approved and marketed product in multiple European countries and is indicated for use in adults with severe chronic HE that is unresponsive to treatment with potent topical corticosteroids. Patients in whom eczema has hyperkeratotic features predominantly are more likely to respond to treatment than those in whom eczema predominantly presents as pompholyx. However, it is not approved in the US and Japan.

Dosage and administration

TOCTINO is available as red-brown soft gelatin capsules containing 10 or 30 mg of alitretinoin. TOCTINO (alitretinoin) is a convenient once-daily capsule to be taken with food. The recommended dose for TOCTINO is 10 mg or 30 mg once daily. The recommended starting dose is 30 mg in most patients, and a treatment course lasts up to 12-24 weeks, depending on response. A dose reduction to 10 mg once daily may be considered in patients with unacceptable adverse reactions to the 30 mg dose.

Mechanism of action

Alitretinoin has a distinct uniqueness among all retinoids in that it has the ability to bind to all subclasses of retinoic acid receptors (RARs) and retinoid X receptors (RXRs). The pharmacological action of retinoids may be explained by their effects on cell proliferation, cell differentiation, apoptosis, angiogenesis, keratinization, sebum secretion, and immunomodulation. The mechanism by which alitretinoin alleviates the signs and symptoms of CHE is unclear. It has, however, been suggested that by activating RXRs, alitretinoin may stimulate TH2 immune functions, thus ameliorating the pathology encountered in CHE. Alitretinoin has demonstrated immunomodulatory and anti-inflammatory effects that are relevant to skin inflammation. It suppresses the production of chemokines that are involved in the recruitment of leukocytes to sites of skin inflammation, reduces the expansion of T lymphocytes and antigen-presenting cells, and inhibits the effect on cell differentiation. CXCR3 ligands and CCL20 chemokines, expressed in eczematous skin lesions, are downregulated by alitretinoin in cytokine-stimulated keratinocytes and dermal endothelial cells. In addition, alitretinoin suppresses the expansion of cytokine-activated leucocyte subsets and antigen-presenting cells. It has been observed that in humans, alitretinoin only minimally affects sebum secretion.

Scope of the Report:

The report provides insights into:

  • A comprehensive product overview including the TOCTINO description, mechanism of action, dosage and administration, research and development activities in Hand Eczema (HE).
  • Elaborated details on TOCTINO regulatory milestones and other development activities have been provided in this report.
  • The report also highlights the TOCTINO research and development activity in Hand Eczema (HE) in detail across the Europe.
  • The report also covers the patents information with expiry timeline around TOCTINO.
  • The report contains forecasted sales of TOCTINO for Hand Eczema (HE) till 2032.
  • Comprehensive coverage of the late-stage emerging therapies for Hand Eczema (HE).
  • The report also features the SWOT analysis with analyst views for TOCTINO in Hand Eczema (HE).


The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by DelveInsight's team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.

TOCTINO Analytical Perspective by DelveInsight

  • In-depth TOCTINO Market Assessment

This report provides a detailed market assessment of TOCTINO in Hand Eczema (HE) in EU4 (Germany, France, Italy, and Spain) and the United Kingdom. This segment of the report provides forecasted sales data from 2023 to 2032.

  • TOCTINO Clinical Assessment

The report provides the clinical trials information of TOCTINO in Hand Eczema (HE) covering trial interventions, trial conditions, trial status, start and completion dates.

Report Highlights:

  • In the coming years, the market scenario for Hand Eczema (HE) is set to change due to the extensive research and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
  • The companies are developing therapies that focus on novel approaches to treat/improve the disease condition, assess challenges, and seek opportunities that could influence TOCTINO dominance.
  • Other emerging products for Hand Eczema (HE) are expected to give tough market competition to TOCTINO and launch of late-stage emerging therapies in the near future will significantly impact the market.
  • A detailed description of regulatory milestones, and developmental activities, provide the current development scenario of TOCTINO in Hand Eczema (HE).
  • Our in-depth analysis of the forecasted sales data from 2023 to 2032 will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the TOCTINO in Hand Eczema (HE).

Key Questions

  • What is the product type, route of administration and mechanism of action of TOCTINO?
  • What is the clinical trial status of the study related to TOCTINO in Hand Eczema (HE) and study completion date?
  • What are the key collaborations, mergers and acquisitions, licensing and other activities related to the TOCTINO development?
  • What are the key designations that have been granted to TOCTINO for Hand Eczema (HE)?
  • What is the forecasted market scenario of TOCTINO for Hand Eczema (HE)?
  • What are the forecasted sales of TOCTINO in the five major countries, including Europe (Germany, France, Italy, Spain, and the United Kingdom)?
  • What are the other emerging products available in Hand Eczema (HE) and how are they giving competition to TOCTINO for Hand Eczema (HE)?
  • Which are the late-stage emerging therapies under development for the treatment of Hand Eczema (HE)?
Product Code: DIDM0742

Table of Contents

1 Report Introduction

2 TOCTINO Overview

  • 2.1 Product Detail
  • 2.2 Clinical Development
    • 2.2.1 Clinical Studies
    • 2.2.2 Clinical Trials Information
  • 2.3 Other Developmental Activities
  • 2.4 Product Profile

3 Competitive Landscape (Late-stage Emerging Therapies) *

4 TOCTINO Market Assessment

  • 4.1 Market Outlook of TOCTINO in Hand Eczema (HE)
  • 4.2 EU4 and the UK Market Analysis
    • 4.2.1 Market Size of TOCTINO in EU4 and the UK for Hand Eczema (HE)
  • 4.3 Country-wise Market Analysis
    • 4.3.1 Market Size of TOCTINO in Germany for Hand Eczema (HE)
    • 4.3.2 Market Size of TOCTINO in France for Hand Eczema (HE)
    • 4.3.3 Market Size of TOCTINO in Italy for Hand Eczema (HE)
    • 4.3.4 Market Size of TOCTINO in Spain for Hand Eczema (HE)
    • 4.3.5 Market Size of TOCTINO in the United Kingdom for Hand Eczema (HE)

5 SWOT Analysis

7 Analysts' Views

8 Appendix

  • 8.1 Bibliography
  • 8.2 Report Methodology

9 DelveInsight Capabilities

10 Disclaimer

11 About DelveInsight

12 Report Purchase Options

Product Code: DIDM0742

List of Tables

  • Table 1: TOCTINO, Clinical Trial Description, 2023
  • Table 2: TOCTINO : General Description
  • Table 3: Competitive Landscape (Late -stage Emerging Therapies)
  • Table 4: TOCTINO Market Size in EU4 and the UK, in USD million (2019-2032)
  • Table 5: TOCTINO Market Size in Germany, in USD million (2019-2032)
  • Table 6: TOCTINO Market Size in France, in USD million (2019-2032)
  • Table 7: TOCTINO Market Size in Italy, in USD million (2019-2032)
  • Table 8: TOCTINO Market Size in Spain, in USD million (2019-2032)
  • Table 9: TOCTINO Market Size in the United Kingdom, in USD million (2019-2032)

List of Figures

  • Figure 1: TOCTINO Market Size in EU4 and the UK, USD million (2019-2032)
  • Figure 2: TOCTINO Market Size in Germany, USD million (2019-2032)
  • Figure 3: TOCTINO Market Size in France, USD million (2019-2032)
  • Figure 4: TOCTINO Market Size in Italy, USD million (2019-2032)
  • Figure 5: TOCTINO Market Size in Spain, USD million (2019-2032)
  • Figure 6: TOCTINO Market Size in the United Kingdom, USD million (2019-2032)
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Jeroen Van Heghe

Manager - EMEA



Christine Sirois

Manager - Americas


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