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PUBLISHER: DelveInsight | PRODUCT CODE: 1376853

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PUBLISHER: DelveInsight | PRODUCT CODE: 1376853

Retinopathy of Prematurity - Epidemiology Forecast- 2032

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Key Highlights:

  • In the United States, there were around 18,000 incident cases of Retinopathy of Prematurity in 2022. These cases are projected to increase during the study period of 2019-2032.
  • The risk factor for developing Retinopathy of Prematurity (ROP) is the baby's age and weight at birth. Especially children with gestational age at birth below 31 weeks or a birth weight of less than 1,500 g are in danger of developing Retinopathy of Prematurity.
  • Research indicates that the incidence of Retinopathy of Prematurity has been increasing over the years and tends to rise consistently in the US.
  • In France, approximately 30% of preterm infants by birth weight (=1,500g) develop Retinopathy of Prematurity.
  • Advancements in life-preserving technologies have led to increased survival of premature and low birth weight (LBW) babies. As estimated, gestational age (EGA) and LBW are well-known to be inversely related to Retinopathy of Prematurity risk, these developments in neonatal care have increased the population of babies at risk for Retinopathy of Prematurity.
  • The studies examining the incidence of Retinopathy of Prematurity have focused on various groups of premature infants, leading to variations in the calculated ROP incidence rates. This is due to differences in the worldwide screening guidelines, ranging from infants born before 30 to 37 weeks of gestational age (GA) and weighing between 1,000 g and 2,500 g. These divergent criteria make it challenging to compare ROP incidence rates across different studies directly.
  • Approximately 30% of patients require treatment for Retinopathy of Prematurity in Japan.

DelveInsight's "Retinopathy of Prematurity (Retinopathy of Prematurity) - Epidemiology - 2032" report delivers an in-depth understanding of Retinopathy of Prematurity historical and forecasted epidemiology in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

Geography Covered:

  • The United States
  • EU4 (Germany, France, Italy, and Spain) and the United Kingdom
  • Japan

Study Period: 2019-2032

Retinopathy of Prematurity Disease Understanding

Retinopathy of Prematurity Overview

Retinopathy of Prematurity (Retinopathy of Prematurity) is an eye disease that can happen in premature babies (born early) - or who weigh less than 1,500 g at birth. Retinopathy of Prematurity happens when abnormal blood vessels grow in the retina (the light-sensitive layer of tissue in the back of your eye). Some babies with Retinopathy of Prematurity have mild cases and get better without treatment. However, some babies need treatment to protect their vision and prevent blindness.

Retinopathy of Prematurity Diagnosis

Retinopathy of Prematurity is diagnosed through a comprehensive eye exam by a specialized ophthalmologist. This exam involves dilating the infant's pupils to assess the retina's blood vessels. The disease is categorized into stages based on severity, location, and extent of abnormal vessel growth. Retinal imaging may aid in monitoring. Treatment options such as laser therapy or medication are considered depending on the severity. Regular follow-up exams are crucial for timely intervention and to prevent vision loss.

Further details related to diagnosis are provided in the report…

Retinopathy of Prematurity Epidemiology

The report provides historical as well as forecasted epidemiology segmented by total incident cases of preterm infants by birth weight (=1,500 g), total incident cases of Retinopathy of Prematurity, and total treated cases (patients who went for initial treatment, patients who went for retreatment) of Retinopathy of Prematurity in the 7MM covering the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan from 2019 to 2032.

  • The total number of incident cases of preterm infants by birth weight (=1,500 g) in the 7MM was ~94,000 in 2022. As per the estimate, the incident cases of preterm infants by birth weight (=1,500 g) in the 7MM are anticipated to increase during the study period of 2019-2032.
  • Approximately 9% of the total incident cases of ROP in the US went for initial treatment out of which 36% of cases required retreatment.
  • There is a decreasing trend in preterm births (=1,500 g) in Germany, Italy, and Spain.
  • The total number of incident cases of Retinopathy of Prematurity in the US was ~18,000 in 2022 and is expected to increase during the forecast period.
  • Among the EU4, Germany accounted for the highest number of incident cases of Retinopathy of Prematurity, followed by France, whereas Spain accounted for the lowest number of cases in 2022.
  • The total number of incident cases of Retinopathy of Prematurity in Japan was ~5,000 in 2022 and is expected to increase during the forecast period.

KOL Views

To keep up with current epidemiology trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry Experts contacted for insights on the retinopathy of prematurity evolving preventive treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, drug uptake, along with challenges related to accessibility, including ophthalmologists, HCPs, Physicians, and others.

DelveInsight's analysts connected with 10+ KOLs to gather insights; however, interviews were conducted with 5+ KOLs in the 7MM. Centers such as National Eye Institute, National Institutes of Health, Bethesda, USA, Stanley Manne Children's Research Institute, United Kingdom, MD, Ophthalmology - Oakland, USA, North Shore University Health System, MD, Lurie Children's Hospital of Chicago, etc., were contacted. Their opinion helps understand and validate retinopathy of prematurity epidemiology trends.

Scope of the Report:

  • The report covers a segment of key events, an executive summary, and a descriptive overview of retinopathy of prematurity, explaining its causes, signs and symptoms, pathogenesis, and currently available therapies.
  • Comprehensive insight into the epidemiology segments and forecasts, disease progression, and treatment guidelines has been provided.
  • The report provides an edge while developing business strategies, understanding trends, expert insights/KOL views, and patient journeys in the 7MM.
  • A detailed review of current challenges in establishing the diagnosis.

Retinopathy of Prematurity Report Insights

  • Patient Population
  • Country-wise Epidemiology Distribution
  • Incident cases of retinopathy of prematurity

Retinopathy of Prematurity Report Key Strengths

  • Ten Years Forecast
  • The 7MM Coverage
  • Retinopathy of Prematurity Epidemiology Segmentation

Retinopathy of Prematurity Report Assessment

  • Current Diagnostic Practices

Epidemiology Insights

  • What are the disease risk, burdens, and unmet needs of Retinopathy of Prematurity?
  • What will be the growth opportunities across the 7MM concerning the patient population with Retinopathy of Prematurity?
  • What is the historical and forecasted Retinopathy of Prematurity patient pool in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan?
  • Why are incident cases of preterm infants by birth weight (=1,500 g) declining in some European countries?

Reasons to Buy:

  • Insights on patient burden/disease incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • A detailed overview of preterm infants by birth weight (=1,500 g) cases of retinopathy of prematurity.
  • To understand the perspective of key opinion leaders around the current challenges with establishing the diagnosis and insights on the recurrent and treatment-eligible patient pool.
  • Detailed insights on various factors hampering disease diagnosis and other existing diagnostic challenges.
Product Code: DIEI1779

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary of Retinopathy of Prematurity

4. Key Events

5. Epidemiology Forecast Methodology

6. Retinopathy of Prematurity Epidemiology Overview at a Glance

  • 6.1. Patient Share (%) Distribution by Therapies in the 7MM in 2019
  • 6.2. Patient Share (%) Distribution by Therapies in the 7MM in 2032

7. Disease Background and Overview

  • 7.1. Introduction
  • 7.2. Causes
  • 7.3. Sign and Symptoms
  • 7.4. Pathophysiology
  • 7.5. Pathogenesis
  • 7.6. Diagnosis
  • 7.7. Treatment Management of Retinopathy of Prematurity
  • 7.8. Guidelines for Retinopathy of Prematurity
    • 7.8.1. American Academy of Pediatrics (AAP): 2018
      • 7.8.1.1. Screening Guidelines
      • 7.8.1.2. Treatment Guidelines
    • 7.8.2. Royal College of Pediatrics and Child Health (RCPCH): 2022
      • 7.8.2.1. Screening Guidelines
      • 7.8.2.2. Treatment Guidelines
    • 7.8.3. Screening Guidelines in England, Germany, France, and Italy
    • 7.8.4. Japanese Ophthalmological Society: 2020
      • 7.8.4.1. Guidelines for Follow-up after Intravitreal Injection of Ranibizumab

8. Epidemiology and Patient Population of the 7MM

  • 8.1. Key Findings
  • 8.2. Assumptions and Rationale
  • 8.3. Total Incident Cases of Retinopathy of Prematurity in the 7MM
  • 8.4. United States
    • 8.4.1. Total Incident Cases of Preterm Infants by Birth Weight (=1,500g) in the United States
    • 8.4.2. Total Incident Cases of Retinopathy of Prematurity in the United States
    • 8.4.3. Total Treated Cases of Retinopathy of Prematurity in the United States
  • 8.5. EU4 and the UK
    • 8.5.1. Total Incident Cases of Preterm Infants by Birth Weight (=1,500g) in EU4 and the UK
    • 8.5.2. Total Incident Cases of Retinopathy of Prematurity in EU4 and the UK
    • 8.5.3. Total Treated Cases of Retinopathy of Prematurity in EU4 and the UK
  • 8.6. Japan
    • 8.6.1. Total Incident Cases of Preterm Infants by Birth Weight (=1,500g) in Japan
    • 8.6.2. Total Incident Cases of Retinopathy of Prematurity in Japan
    • 8.6.3. Total Treated Cases of Retinopathy of Prematurity in Japan

9. Patient Journey

10. Appendix

  • 10.1. Bibliography
  • 10.2. Report Methodology

11. DelveInsight Capabilities

12. Disclaimer

Product Code: DIEI1779

List of Tables

  • Table 1: Summary of Retinopathy of Prematurity Market and Epidemiology (2019-2032)
  • Table 2: Recommended Timing of the First Exam Based on Gestational Age in the United States
  • Table 3: Screening Guidelines of Retinopathy of Prematurity in England, Germany, France, and Italy
  • Table 4: Comparison of Laser and Anti-VEGF Retreatment Rate
  • Table 5: Treatment and Retreatment Rate of Retinopathy of Prematurity in the 7MM
  • Table 6: Total Incident Cases of Retinopathy of Prematurity in the 7MM (2019-2032)
  • Table 7: Total Incident Cases of Preterm Infants by Birth Weight (=1,500g) in the US (2019-2032)
  • Table 8: Total Incident Cases of Retinopathy of Prematurity in the US (2019-2032)
  • Table 9: Total Treated Cases of Retinopathy of Prematurity in the US (2019-2032)
  • Table 10: Total Incident Cases of Preterm Infants by Birth Weight (=1,500g) in EU4 and the UK (2019-2032)
  • Table 11: Total Incident Cases of Retinopathy of Prematurity in EU4 and the UK (2019-2032)
  • Table 12: Total Treated Cases of Retinopathy of Prematurity in EU4 and the UK (2019-2032)
  • Table 13: Total Incident Cases of Preterm Infants by Birth Weight (=1,500g) in Japan (2019-2032)
  • Table 14: Total Incident Cases of Retinopathy of Prematurity in Japan (2019-2032)
  • Table 15: Total Treated Cases of Retinopathy of Prematurity in Japan (2019-2032)

List of Figures

  • Figure 1: Pathophysiology of Retinopathy of Prematurity
  • Figure 2: VEGF in the Pathogenesis of Retinopathy of Prematurity
  • Figure 3: Retinopathy of Prematurity Progression in Premature Infants
  • Figure 4: Total Incident Cases of Retinopathy of Prematurity in the 7MM (2019-2032)
  • Figure 5: Total Incident Cases of Preterm Infants by Birth Weight (=1,500g) in the US (2019-2032)
  • Figure 6: Total Incident Cases of Retinopathy of Prematurity in the US (2019-2032)
  • Figure 7: Total Treated Cases of Retinopathy of Prematurity in the US (2019-2032)
  • Figure 8: Total Incident Cases of Preterm Infants by Birth Weight (=1,500g) in EU4 and the UK (2019-2032)
  • Figure 9: Total Incident Cases of Retinopathy of Prematurity in EU4 and the UK (2019-2032)
  • Figure 10: Total Treated Cases of Retinopathy of Prematurity in EU4 and the UK (2019-2032)
  • Figure 11: Total Incident Cases of Preterm Infants by Birth Weight (=1,500g) in Japan (2019-2032)
  • Figure 12: Total Incident Cases of Retinopathy of Prematurity in Japan (2019-2032)
  • Figure 13: Total Treated Cases of Retinopathy of Prematurity in Japan (2019-2032)
Have a question?
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Jeroen Van Heghe

Manager - EMEA

+32-2-535-7543

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Christine Sirois

Manager - Americas

+1-860-674-8796

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