PUBLISHER: DelveInsight | PRODUCT CODE: 1397524
PUBLISHER: DelveInsight | PRODUCT CODE: 1397524
"XPOVIO Drug Insight and Market Forecast - 2032" report provides comprehensive insights about XPOVIO for Diffuse Large B-cell lymphoma (DLBCL) in the seven major markets. A detailed picture of the XPOVIO for DLBCL in the 7MM, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan for the study period 2019 -2032 is provided in this report along with a detailed description of the XPOVIO for DLBCL. The report provides insights about mechanism of action, dosage and administration, as well as research and development including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments inclusive of the XPOVIO market forecast analysis for DLBCL in the 7MM, SWOT, analysts' views, comprehensive overview of market competitors, and brief about other emerging therapies in DLBCL.
XPOVIO (selinexor) is a first-in-class, oral selective inhibitor of nuclear export (SINE) compound. It functions by binding with and inhibiting the nuclear export protein XPO1 (also called CRM1), leading to the accumulation of tumor suppressor proteins in the cell nucleus. This reinitiates and amplifies their tumor suppressor function and is believed to lead to the selective induction of apoptosis in cancer cells while largely sparing normal cells.
XPOVIO is also being studied in patients with R/R DLBCL and reported positive top-line results from the Phase IIb SADAL study evaluating XPOVIO in patients with relapsed or refractory DLBCL after at least two prior multi-agent therapies and who are ineligible for transplantation, including high dose chemotherapy with stem cell rescue.
Recently, the FDA granted accelerated approval to XPOVIO for adult patients with R/R DLBCL, not otherwise specified, including DLBCL arising from follicular lymphoma, after at least two lines of systemic therapy. This indication was approved under accelerated approval based on the response rate. Continued approval for these indications may be contingent upon verifying and describing clinical benefits in confirmatory trials.
The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by DelveInsight's team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.
This report provides a detailed market assessment of XPOVIO for Diffuse Large B-cell lymphoma (DLBCL) in the seven major markets, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan. This segment of the report provides forecasted sales data from 2023 to 2032.
The report provides the clinical trials information of XPOVIO for DLBCL covering trial interventions, trial conditions, trial status, start and completion dates.