Acute Coronary Syndrome - Epidemiology Forecast - 2036

Acute Coronary Syndrome (ACS) Insights and Trends

• Acute Coronary Syndrome (ACS) comprises acute myocardial infarction and Unstable Angina together. The total incidence cases of ACS in the 7MM were ~2.2 million in 2025, of which the highest incidence cases of this disease were in the United States.
• ACS arise from a sudden blockage in a coronary artery and include Unstable Angina, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), and ST-Segment Elevation Myocardial Infarction (STEMI). Unstable angina presents with chest pain without ECG or blood test evidence of heart damage, NSTEMI shows elevated cardiac biomarkers without ST-segment elevation, while STEMI involves both biomarker elevation and ST-segment elevation on ECG.
• Secondary findings suggest that unstable angina accounts for roughly 10-30% of overall ACS cases.
• The incidence of ACS is higher in men, but certain risk factors have a stronger association with ACS in women. Although these sex-specific differences lessen with age, women often retain a relatively higher risk where differences persist. With aging populations and rising lifestyle-related risk factors, ACS incidence in women is expected to approach that of men.

Acute Coronary Syndrome (ACS) Epidemiology Forecast in the 7MM

• 2025 ACS Incident Cases: ~2.2 million
• ACS Growth Rate (2026-2036): ~0.6% CAGR

DelveInsight's 'Acute Coronary Syndrome (ACS) - Epidemiology Forecast - 2036' report delivers an in-depth understanding of the ACS, historical and forecasted epidemiology in the United States, EU4 (Germany, Spain, Italy, and France), and the United Kingdom, and Japan.

Acute Coronary Syndrome (ACS) Understanding and Diagnosis Algorithm

Acute Coronary Syndrome (ACS) is a group of conditions caused by a sudden reduction or blockage of blood flow to the heart. It includes unstable angina, NSTEMI, and STEMI, representing varying degrees of severity. ACS commonly presents with chest pain or discomfort, though symptoms can differ across patients. Chest pain or discomfort is the immediate signal for heart problems like ACS. Chest pain caused by ACS can come on suddenly, as is the case with a heart attack. Other times, the pain can be unpredictable or get worse even with rest-both hallmark symptoms of unstable angina. People who experience chronic chest pain resulting from decreased blood flow to the heart due to years of cholesterol buildup in their arteries can develop ACS if a blood clot forms on top of the plaque buildup. It is primarily triggered by plaque rupture and clot formation in the coronary arteries. Risk factors include hypertension, diabetes, smoking, obesity, and a sedentary lifestyle. The condition is more common in older adults and men, though the incidence in women is rising.

Acute Coronary Syndrome (ACS) Diagnosis

Diagnosis of ACS is based on a combination of clinical evaluation, electrocardiogram (ECG), and cardiac biomarkers. Patients are assessed for symptoms such as chest pain, shortness of breath, and radiating discomfort. ECG is performed immediately to identify changes such as ST-segment elevation or depression. Cardiac biomarkers, particularly troponins, are measured to detect heart muscle damage. Serial testing is often required to confirm a diagnosis. Additional tools such as echocardiography or coronary angiography may be used to assess heart function and identify the site of blockage. Early and accurate diagnosis is critical to guide timely treatment and improve outcomes.

Acute Coronary Syndrome (ACS) Epidemiology

Key Findings from Acute Coronary Syndrome (ACS) Epidemiological Analysis and Forecast

• According to DelveInsight's estimates, the total incident cases of ACS in the 7MM were approximately 2.2 million in 2025.
• In 2025, Acute Myocardial Infarction (AMI) accounted for a higher proportion of ACS cases; ~835,000 in the United States compared to Unstable Angina, indicating a shift toward more severe clinical presentations.
• Approximately three-quarters of AMI cases were NSTEMI (~75%), while STEMI accounted for about one-quarter, indicating a clear predominance of NSTEMI presentations.
• ACS cases were predominantly observed in males (~75%), while females accounted for a smaller proportion, indicating male predominance.

Scope of the Report:

• The report covers a segment of an executive summary, a descriptive overview of ACS, explaining its causes, signs, and symptoms, and pathogenesis.
• Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression.

Report Insights

Acute Coronary Syndrome (ACS) Patient Population Forecast

Report Key Strengths

• Epidemiology-based (Epi-based) Bottom-up Forecasting
• 11-year Forecast
• Patient Burden Trends (by geography)

FAQs:

• What are the disease risks, burdens, and unmet needs of ACS? What will be the growth opportunities across the 7MM concerning the patient population with ACS?
• What is the historical and forecasted ACS patient pool in the US, EU4 (Germany, France, Italy, and Spain), the UK, and Japan?

Reasons to Buy:

• Insights on patient burden/disease prevalence/incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• To understand key opinion leaders' perspectives on the diagnostic challenges to overcome barriers in the future.
• Detailed insights into various factors hampering disease diagnosis and other existing diagnostic challenges.