PUBLISHER: DelveInsight | PRODUCT CODE: 1083577
PUBLISHER: DelveInsight | PRODUCT CODE: 1083577
DelveInsight's, 'Major Depressive Disorder (MDD) - Market Insights, Epidemiology, and Market Forecast - 2032' report deliver an in-depth understanding of the historical and forecasted epidemiology as well as the market trends of major depressive disorder (MDD) in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.
The major depressive disorder (MDD) market report provides current treatment practices, emerging drugs, market share of the individual therapies, and current and forecasted major depressive disorder (MDD) market size from 2019 to 2032, segmented by seven major markets. The report also covers the current major depressive disorder (MDD) treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying market potential.
Study Period: 2019-2032.
Major depressive disorder (MDD), also referred to as depression, is a serious medical illness that disrupts a person's mood, behavior, and thought processes, apart from degrading physical health. It should not be mistaken for the passing feelings of unhappiness that everyone experiences, nor should it be confused with the intense grief brought about by the death of a loved one. Sadness and grief are normal reactions to life stresses. With time, and usually, without medical treatment, sadness and grief lift, and people go on with their lives. By contrast, without specialized medical treatment, depression often persists. But with effective treatment, a large majority of people improve significantly. In most instances, MDD is a recurrent, episodic illness. This means that a person who has been depressed once and has recovered is likely to have one or more episodes of depression in the future, often within two to three years. When depression is not treated or is treated inappropriately, it is potentially fatal: nearly one in six people with severe, untreated depression commits suicide. However, seeking help and receiving an accurate diagnosis from a psychiatrist or other health care professional is a crucial and often decisive step toward recovery.
MDD is one form of depressive illness or mood disorder. Other forms include bipolar disorder (manic-depressive illness) and dysthymia. In bipolar disorder, episodes of depression alternate with episodes of mania, a condition in which inappropriate or extreme "high" feelings may lead to dangerous, destructive behavior. Dysthymia involves symptoms similar to those of major depressive disorder. The symptoms are milder but longer-lasting, and although they might not be disabling, they prevent a person from feeling good or operating at "full steam." Occasionally, a person with dysthymia may also have a major depressive disorder, a condition referred to as double depression.
According to the World Health Organization (WHO), unipolar depression is one of the leading causes of disability-adjusted life year (DALY) and approximately 350 million people worldwide are said to suffer from this mental disorder. As described in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM- V), the hallmark of major depressive disorder is the occurrence of depressed mood (dysphoria) and loss of interest in activities that were rather pleasurable in the past (anhedonia) for a duration of at least two weeks. These symptoms must also be accompanied by at least four of the following manifestations such as changes in appetite or weight, sleep patterns, altered psychomotor activity, feelings of worthlessness or guilt, difficulty concentrating or making decisions, and recurrent thoughts of death or suicidal ideation. Even though there are plenty of drugs developed for the management of depression, one of the challenges in dealing with this disease is that a significant portion of the patients taking antidepressants fails to attain full remission. Some patients also develop treatment-resistant depression in which the patients fail to respond to the available drugs or other therapeutic approaches.
The DelveInsight Major Depressive Disorder (MDD) Market Report gives a thorough understanding of major depressive disorder (MDD) by including details of disease definition, symptoms, causes, pathophysiology, and diagnosis.
It covers the details of conventional and current medical therapies and diagnoses available in the major depressive disorder (MDD) market to treat the condition. It also provides the country-wise treatment guidelines and algorithms across the United States, Europe, and Japan.
The major depressive disorder (MDD) epidemiology division provides insights into the historical and current patient pool and the forecasted trend for every seven major countries. It helps recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the report also provides the diagnosed incident patient pool, trends, and assumptions.
The disease epidemiology covered in the report provides historical and forecasted major depressive disorder (MDD) epidemiology segmented as the 12-month prevalent cases of major depressive disorder, gender-specific cases of major depressive disorder, severity specific cases of major depressive disorder, and relapse/refractory cases of major depressive disorder. The report includes the diagnosed prevalent scenario of major depressive disorder (MDD) symptoms in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2019 to 2032.
The epidemiology segment also provides the major depressive disorder (MDD) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
The total 12-month prevalent patient population of MDD in the 7MM countries was over 48 million cases in 2021.
The drug chapter segment of the major depressive disorder (MDD) report encloses the detailed analysis of major depressive disorder (MDD) marketed drugs and late stage (Phase-III, Phase-II/III, Phase-II, and Phase-I/II) pipeline drugs. It also helps understand the major depressive disorder (MDD) clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.
The evidence-based guideline summarizes recommendations on the use of antidepressants and other drug therapies; psychotherapy, including cognitive behavior therapy; and Electroconvulsive Therapy (ECT). Because many patients with major depressive disorder have co-occurring psychiatric disorders, including substance use disorders, physicians should also consider appropriate treatments for these diagnoses. Patients with mild to moderate depression should be treated with antidepressants or psychotherapy. Combined pharmacotherapy and psychotherapy may be useful in patients with psychosocial or interpersonal problems, intrapsychic conflict, or a co-occurring axis II disorder. ECT can be used in selective patients.
To meet the current demands of the patient pool and to counter the unmet needs of the therapeutic market, drug developers are gradually shifting their attention toward MDD as a possible indication for new targeted therapies.
Several companies are working robustly on many new therapies, such as AXS-05 (Axsome Therapeutics), Vraylar (AbbVie), Zuranolone (SAGE Therapeutics), and LY03005 (Luye Pharma). The mid-stage pipeline is crowded, with several potential therapies with the imminent attention of big pharmaceutical companies for this market space.
AXS-05 (Axsome Therapeutics), is a novel, oral, patent-protected, investigational NMDA receptor antagonist with multimodal activity under development to treat MDD and other central nervous systems (CNS) disorders. AXS-05 utilizes a proprietary formulation and dose of dextromethorphan and bupropion and Axsome's metabolic inhibition technology to modulate the delivery of the components. The dextromethorphan component of AXS-05 is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, also known as a glutamate receptor modulator, which is a novel mechanism of action, meaning it works differently than currently approved therapies for major depressive disorder. The dextromethorphan component of AXS-05 is also a sigma-1 receptor agonist. The bupropion component of AXS-05 serves to increase the bioavailability of dextromethorphan and is a norepinephrine and dopamine reuptake inhibitor.
Vraylar (AbbVie) is an oral, once-daily atypical antipsychotic approved for the acute treatment of adult patients with manic or mixed episodes associated with bipolar I disorder, with a recommended dose range of 3-6 mg/day, and for the treatment of schizophrenia in adults, with a recommended dose range of 1.5-6 mg/day.
While the mechanism of action of Vraylar in schizophrenia and bipolar I disorder is unknown, the efficacy of VRAYLAR could be mediated through a combination of partial agonist activity at central dopamine D and serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors. Pharmacodynamic studies with cariprazine have shown that it acts as a partial agonist with high binding affinity at dopamine D3, dopamine D2, and serotonin 5-HT1A receptors. Cariprazine demonstrated up to ~eightfold greater in vitro affinity for dopamine D3 vs. D2 receptors. Cariprazine also acts as an antagonist at serotonin 5-HT2B and 5-HT2A receptors with high and moderate binding affinity, respectively, as well as it binds to the histamine H1 receptors. Cariprazine shows lower binding affinity to the serotonin 5-HT2C and 1A- adrenergic receptors and has no appreciable affinity for cholinergic muscarinic receptors. The clinical significance of these in vitro data is unknown. The company has announced the submission of the Supplemental New Drug Application to US FDA for cariprazine (Vraylar) for the adjunctive treatment of MDD.
The major depressive disorder (MDD) market outlook of the report builds a detailed comprehension of the historical, current, and forecasted major depressive disorder (MDD) market trends by analyzing the impact of current therapies on the market, unmet needs, and demand for better technology.
This segment gives a thorough detail of the major depressive disorder (MDD) market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria's, mechanism of action, compliance rate, growing need for the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.
According to DelveInsight, the major depressive disorder (MDD) market in the 7MM is expected to change in the study period 2019-2032.
This section includes a glimpse of the major depressive disorder (MDD) market in the 7MM. The major depressive disorder (MDD) market size in the seven major markets was approximately USD 5,600 million in 2021.
This section provides the total major depressive disorder (MDD) market size and market size of major depressive disorder (MDD) by therapies in the United States.
Depression is a common mental disorder that presents with depressed mood, loss of interest or pleasure in regular activities, decreased energy, feelings of guilt or low self-worth, disturbed sleep or appetite, and poor concentration. Major depressive disorder is the most prevalent and disabling form of depression. In addition to the immediate symptoms of depression, MDD results in poor quality of life and overall decreased productivity and can increase mortality from suicide. Social difficulties including stigma, loss of employment, and marital conflict as a result of depression can also occur. Anxiety Posttraumatic Stress Disorder (PTSD), and substance misuse are common co-occurring conditions that may worsen the existing depression and complicate treatment. Depression is considered to be a largely biological illness but can result from a combination of genetic, biological, environmental, and psychological factors. Trauma, loss of a loved one, a difficult relationship, or any stressful situation may trigger depression, but depression can also occur without an obvious trigger.
In cases of MDD severity, if it is determined to be mild to moderate then, the initial treatment is consist of an evidence-based mono-therapy. When the patient prefers psychotherapy, one of the following evidence-based interventions can be offered based on patient preference and availability: Cognitive Behavior Therapy (CBT), Interpersonal Therapy (IPT), Mindfulness-Based Cognitive Therapy (MBCT), Behavioral therapy/behavioral activation (BT/BA), Acceptance and commitment therapy (ACT), and Problem-solving therapy (PST). Further, patients and providers may want to consider that there is some evidence that treatment benefits for CBT and possibly BA may be more enduring than for pharmacotherapy. If the shared decision is made to initiate antidepressant monotherapy, then recommend starting with a Selective serotonin reuptake inhibitor (except fluvoxamine), Serotonin-norepinephrine reuptake inhibitor, mirtazapine, or bupropion. Their efficacies are comparable, and therefore selection should be based on the antidepressant's safety and side effect profile.
The United States accounts for the highest market size of major depressive disorder (MDD) compared to the EU5 (the United Kingdom, Germany, Italy, France, and Spain) and Japan.
The total major depressive disorder (MDD) market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are also mentioned.
The total major depressive disorder (MDD) market size and market size by therapies of major depressive disorder (MDD) in Japan are also mentioned.
This section focuses on the rate of uptake of the potential drugs recently launched or expected to get launched in the market during the study period 2019-2032. The analysis covers major depressive disorder (MDD) market uptake by drugs, patient uptake by therapies, and sales of each drug.
This helps in understanding the drugs with the most rapid uptake, and the reasons behind the maximal use of new drugs and allows the comparison of the drugs based on market share and size, which again will be useful in investigating factors important in the market uptake and in making financial and regulatory decisions.
The report provides insights into different therapeutic candidates in Phase III, Phase II/III, Phase II, and Phase I/II stages. It also analyses major depressive disorder (MDD)'s key players involved in developing targeted therapeutics.
Major players include Axsome Therapeutics, AbbVie, SAGE Therapeutics, and others whose key products are expected to get launched in the US market by 20XX.
The report covers detailed information on collaborations, acquisitions and mergers, licensing, and patent details for major depressive disorder (MDD) emerging therapies.
To keep up with current market trends, we take KOLs and SMEs' opinions working in the major depressive disorder (MDD) domain through primary research to fill the data gaps and validate our secondary research. Their opinion helps understand and validate current and emerging therapy treatment patterns or major depressive disorder (MDD) market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.
We perform a Competitive and Market Intelligence analysis of the major depressive disorder (MDD) market using various Competitive Intelligence tools: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.