PUBLISHER: DelveInsight | PRODUCT CODE: 1074049
PUBLISHER: DelveInsight | PRODUCT CODE: 1074049
DelveInsight's 'focal segmental glomerulosclerosis (FSGS) - Epidemiology Forecast - 2032' report delivers an in-depth understanding of the historical and forecasted epidemiology of focal segmental glomerulosclerosis (FSGS) in the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.
Focal segmental glomerulosclerosis (FSGS) is a well-defined histologic pattern of injury characterized by sclerosis, hyalinosis, foam-cell infiltration, vacuolization of podocytes, and podocyte precursor proliferation between glomeruli tuft and Bowman's capsule. It is "focal" in that only some glomeruli are affected and "segmental" where only a portion of the affected glomerulus is sclerosed. It typically presents with nephrotic syndrome with characterized proteinuria and obliteration or failure of glomerular capillary loops by increased extracellular matrix in glomeruli capillary tufts. However, the capillary injury does not occupy the entire glomerulus.
The clinical features of FSGS are the features of nephrotic syndrome and include peripheral edema, marked proteinuria (with or without a nephrotic range), hypertension, hypoalbuminemia, hyperlipidemia, and progressive loss of renal function. It may be found either in primary or secondary forms.
Primary FSGS sometimes has no identifiable cause or known etiology (idiopathic) and is linked to genetic mutations in podocyte-specific proteins (e.g., membrane and podocyte slit diaphragm proteins), while secondary FSGS may occur in response to previous glomerular injury, glomerular hypertension, hypertrophy, drug toxicity (e.g., pamidronate, Adriamycin), some malignancies or viral infections (e.g., HIV infection), obesity, and reduced renal mass. FSGS is one of the most common causes of primary glomerular disease in children and adults, which may progress to end-stage renal disease (ESRD) with a relatively high risk.
FSGS is further classified as collapsing, tip, cellular, perihilar, and not otherwise specified variants according to the location and character of the sclerotic lesion. Primary or idiopathic FSGS is considered to be related to podocyte injury, and the pathogenesis of podocyte injury has been actively investigated. Several circulating factors affecting the podocyte permeability barrier have been proposed but not proven to cause FSGS. Genetic alterations may also cause FSGS. These genes mainly regulate the slit diaphragm structure, actin cytoskeleton of podocytes, and foot process structure. The mode of inheritance and age of onset is different according to the gene involved.
The focal segmental glomerulosclerosis (FSGS) epidemiology division provides insights into the historical and current patient pool, along with the forecast trend for every seven major countries. It helps recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the report also provides the diagnosed patient pool and their trends, along with assumptions undertaken.
The disease epidemiology covered in the report provides historical and forecasted focal segmental glomerulosclerosis (FSGS) epidemiology segmented as the Diagnosed Prevalence of focal Segmental Glomerulosclerosis, Gender-specific cases of Focal Segmental Glomerulosclerosis, and Type-specific cases of Focal Segmental Glomerulosclerosis. The report includes the prevalent scenario of Focal segmental glomerulosclerosis (FSGS) in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2019-2032.
The epidemiology segment also provides the focal segmental glomerulosclerosis (FSGS) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
The total diagnosed population of focal segmental glomerulosclerosis (FSGS) in the 7MM countries was close to 220,000 cases in 2021.
As per the estimates, the United States had the highest diagnosed prevalence focal segmental glomerulosclerosis (FSGS) population in 2021. Among the EU5 countries, Germany had the highest diagnosed prevalent population of Focal segmental glomerulosclerosis (FSGS) with more than 23,000 cases, followed by France in 2021. On the other hand, Spain had the lowest diagnosed prevalent population of ~13,000 cases in 2021.
We interview KOLs and obtain SME's opinions through primary research to fill the data gaps and validate our secondary research. The opinion helps understand the total patient population and current treatment pattern. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the indications.
Study Period: 2019-2032.