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PUBLISHER: FirstWord Group | PRODUCT CODE: 1355795

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PUBLISHER: FirstWord Group | PRODUCT CODE: 1355795

Non-Small Cell Lung Cancer - Immunotherapies - KOL Insight

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How do KOLs interpret data from Checkmate-816, and how does this now inform the treatment of patients with early-stage resectable NSCLC without EGFR or ALK genomic alterations? Why do oncologists say the KEYNOTE-671 findings for Merck & Co.'s Keytruda will likely impact NSCLC treatment practice? How do experts assess the potential to re-challenge with IO-based therapy? KOLs critically assess the prospects of launched and pipeline therapies.

In addition to the full report, licensed users have access to KOL Bulletins via the Attachments area.

Table of Contents

Executive summary (9)

Current and future treatment algorithm

Research objectives (2)

PD-1/L1 and CTLA-4-based regimens (40)

  • Approved/pipeline programmes (40)
    • Advanced NSCLC (Merck & Co.; BMS; Roche; AstraZeneca; Regeneron; Daiichi Sankyo) (11)
    • Stage III non-resectable NSCLC (Merck & Co.; BMS; AstraZeneca) (6)
    • Early-stage NSCLC (Merck & Co.; BMS; Roche; AstraZeneca) (13)
    • Post-ICI settings (10)

Anti-PD1/VEGF bispecific antibody (7)

  • Pipeline therapy (7)
    • Ivonescimab (SMT112; Summit) (7)

Anti-TIGIT monoclonal antibodies (10)

  • Pipeline therapies (10)
    • Tiragolumab (RG6058; Roche), vibostolimab (MK-7684; Merck & Co.), ociperlimab (BGB-A1217; BeiGene) and domvanalimab (AB154; Arcus/Gilead) (10)

LAG3 agents (5)

  • Pipeline therapies (5)
    • Eftilagimod alpha (IMP321; Immutep) (5)

Future treatment trends (7)

  • Key insights summary (7)

Appendix (6)

  • KOL details (6)
    • KOLs from the USA (2)
    • KOLs from Europe (3)
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