Global Head and Neck Squamous Cell Carcinoma Market - 2023-2030

Overview

Global Head and Neck Squamous Cell Carcinoma Market reached US$ 2.2 billion in 2022 and is expected to reach US$ 4.3 billion by 2030 growing with a CAGR of 8.8% during the forecast period 2023-2030. The head and neck squamous cell carcinoma market is driven by factors such as increasing incidence and prevalence, advancements in research, increased research and development activities, and government initiatives.

Squamous cells that line the mucosal surfaces of the head and neck region, including the mouth, throat, and nasal passages, are where head and neck squamous cell carcinoma develops. The HNSCC market covers a wide range of topics, including supportive care, research, and therapy. It includes a variety of therapeutic methods, including operations, radiation, chemotherapy, targeted therapy, and immunotherapy.

Market Dynamics

The Increasing Research Activities are Driving the Global Head and Neck Squamous Cell Carcinoma Market Growth

For instance, on July 10, 2023, new data from the ASP-1929-181 study was presented at the American Head and Neck Society's (AHNS) 11th International Conference on Head and Neck Cancer (AHNS 2023), according to Rakuten Medical, Inc., a global biotechnology company developing and marketing precision, cell targeting therapies based on its proprietary AlluminoxTM platform.

The preliminary analysis of 19 patients with locoregional and/or metastatic head and neck squamous cell carcinoma (HNSCC) who were enrolled in the ASP-1929-181 study suggested that the novel treatment strategy of Alluminox treatment using ASP-1929 in combination with anti-PD-1 therapy showed encouraging early results in patients.

Head and neck cancers are among the tumor types that are treated with PD-1 treatment. The preliminary findings of this study call for further investigation to assess its potential as a novel, cutting-edge therapy for recurrent head and neck cancer. The antitumor immune response is projected to lead to enhanced tumor-shrinking that is lasting compared to either treatment alone when targeting both EGFR + tumors and PD-1 blocking.

The Active Major Players are Driving the Global Head and Neck Squamous Cell Carcinoma Market Growth

For instance, in June 2023, LianBio, a biotechnology company committed to bringing paradigm-shifting medicines to patients in China and other major Asian markets, and NANOBIOTIX, a late-stage clinical biotechnology company pioneering physics-based approaches to expand treatment options for cancer patients, announced the randomization of the first patient in Asia in NANORAY-312, a global Phase 3 registrational trial evaluating NBTXR3 for the treatment of elderly patients with locally advanced cancer and neck squamous cell carcinoma ("LA-HNSCC") who are ineligible for platinum-based chemotherapy.

In high-risk, chemotherapy-ineligible elderly patients with LA, NANORAY-312 is a global, two-arm, randomized, Investigator's Choice Phase 3 registrational study that aims to compare the effectiveness and safety of radiotherapy-activated NBTXR3 with or without cetuximab to radiotherapy with or without cetuximab.-HNSCC.

Side Effects Associated with Head and Neck Squamous Cell Carcinoma Therapy are Hampering the Market Growth

Side effects associated with head and neck squamous cell carcinoma medication therapy restraining the market growth. Chemotherapy's side effects include vomiting and nauseous, Fatigue, loss of hair lowered blood cell counts, which raises the risk of bleeding, anemia, infection mouth ulcers, and sores decrease in appetite, constipation, or diarrhea.

Targeted Treatment side effects include skin responses, such as rashes, gastrointestinal issues like diarrhea Fatigue, elevated blood pressure alterations in liver function, and increased chance of clotting or bleeding joint or muscle aches.

Immunotherapy Fatigue, responses on the skin (rash, itching), signs of the flu (such as fever, chills, and body aches), coughing, breathlessness, either diarrhea or colitis adverse effects relating to the endocrine system (hormone imbalances, thyroid malfunction).

Segment Analysis

The global head and neck squamous cell carcinoma market is segmented based on type, drug class, route of administration, treatment, end-user and region.

The Radiotherapy Segment is Expected to Hold a Dominant Position in the Market Over the Forecast Period

The radiotherapy segment accounted for the highest market stake accounting for approximately 45.4% of the head and neck squamous cell carcinoma market in 2022. The recommended course of treatment is high-dose cisplatin 100 mg/m2 administered concurrently with radiotherapy (RT) on days 1, 22, and 43. Alternative chemotherapy regimens with equivalent efficacy but less toxicity are preferred because this one has significant toxicity.

Recently, the prospective randomized phase II/III JCOG1008 research compared the effectiveness and safety of bolus cisplatin 100 mg/m2 administered every three weeks against weekly cisplatin 40 mg/m2 in 261 high-risk Asian LA-HNSCC patients planned for postoperative chemoradiation. Weekly cisplatin was found to be non-inferior with respect to the main endpoint OS at 3 years after a median follow-up of 2.2 years.

Geographical Penetration

North America Holds a Dominant Position in the Global Head and Neck Squamous Cell Carcinoma Market

North America is estimated to hold around 39.7% of the total market share in 2023. The active major players are driving the market in the North American region. For instance, in July 2022, Pliant stated that PLN-74809, an oral, dual-selective vB6/vB1 integrin inhibitor, has been given Fast Track designation by the U.S. Food and Drug Administration (FDA) for the possible treatment of Head and Neck squamous Cell Carcinoma (PSC).

The core treatment candidate of the Company, PLN-74809, is being evaluated in the INTEGRIS-PSC Phase 2a clinical trial (NCT04480840). In the first half of 2023, topline results from this randomized, double-blind, placebo-controlled trial in PSC patients are anticipated. As a result, the aforementioned elements support market expansion in the region.

Competitive Landscape

The major global players in the market include: Sanofi, F. Hoffmann-La Roche Ltd., Boehringer Ingelheim International GmbH., GSK plc, Novartis AG, Bayer AG, Merck & Co., Inc., AstraZeneca, Eli Lilly and Co, and Cipla Inc. among others.

COVID-19 Impact Analysis

Russia-Ukraine Conflict Analysis

The Russia-Ukraine war may affect the head and neck squamous cell carcinoma market due to a lack of facilities being impacted during times of geopolitical instability and economic uncertainty. Access to medical knowledge and healthcare facilities may be hampered in areas that are directly affected by the conflict. This might affect our capacity to deliver efficient and timely HNSCC treatments.

If either Russia or Ukraine makes a substantial contribution to the study and development of HNSCC, the conflict may impede ongoing research and clinical trials, possibly delaying the release of novel and more effective therapies.

Artificial Intelligence Analysis:

Artificial intelligence (AI) is increasingly being used in the head and neck squamous cell carcinoma market to improve various aspects of data analysis. To find new therapeutic molecules and forecast their effectiveness against HNSCC, AI is employed in the drug discovery process. It can mimic molecular interactions and forecast potential interactions between new medications and cancer cells.

Medical imaging data from CT scans, MRIs, and PET scans can be analyzed by AI algorithms to look for minute patterns and anomalies that can point to HNSCC. This can help with accurate diagnosis and early discovery, enabling prompt intervention.

By Type

• Salivary Gland
• Oral and Oropharyngeal
• Nasal Cavity &Paranasal Sinuses
• Nasopharyngeal
• Laryngeal
• Hypo Pharyngeal

By Drug Class

• EGFR Inhibitors
• Immune Checkpoint Inhibitors
• Others

By Route of Administration

• Intravenous
• Oral
• Others

By Treatment

• Radiation
• Chemotherapy
• Immunotherapy

By End-user

• Hospitals
• Specialty Clinics
• Ambulatory Surgical Centers

By Region

• North America

U.S.

Canada

Mexico

• Europe

Germany

U.K.

France

Italy

Spain

Rest of Europe

• South America

Brazil

Argentina

Rest of South America

• Asia-Pacific

China

India

Japan

Australia

Rest of Asia-Pacific

• Middle East and Africa

Key Developments

• In December 2022, NANOBIOTIX, a late-clinical-stage biotechnology company that has pioneered physics-based approaches to expand treatment options for cancer patients reported that the first patient in the United States has been randomized in NANORAY-312, a global Phase 3 registrational trial evaluating NBTXR3 for the treatment of elderly patients with locally advanced head and neck squamous cell carcinoma ("LA-HNSCC") who are ineligible for platinum-based chemotherapy.

Why Purchase the Report?

• To visualize the global head and neck squamous cell carcinoma market segmentation based on the type, drug class, route of administration, treatment, end-user and region and understand key commercial assets and players.
• Identify commercial opportunities by analyzing trends and co-development.
• Excel data sheet with numerous data points of head and neck squamous cell carcinoma market-level with all segments.
• PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
• Product mapping available as excel consisting of key products of all the major players.

The global head and neck squamous cell carcinoma market report would provide approximately 69 tables, 72 figures, and 195 Pages.

Target Audience 2023

• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies