Global Necrotizing Enterocolitis Drugs Market - 2023-2030

Overview

The necrotizing enterocolitis market trends show rising research owing to the rising technological advancements and research studies. Several antibiotics are being launched for the treatment of necrotizing enterocolitis. Antifungals are also utilized for prevention of necrotizing enterocolitis in pediatrics.

Furthermore, rising treatment for necrotizing enterocolitis due to the rising availability of approved antibiotics and increase in the number of necrotizing enterocolitis cases in the market, and an increase in the research and development is driving up the necrotizing enterocolitis market size.

The market is experiencing a growth in demand for drugs from North America areas as a result of the rising advancements in this field. With significant competitors like Noveome Biotherapeutics, Inc., Pfizer Inc., Endo Pharmaceuticals Inc., and Sanofi actively operating in the market, the market will grow in upcoming time.

Dynamics

Growing Research and Development by the Researchers Drive the Growth of the Necrotizing Enterocolitis Market

One of the most common neonatal gastrointestinal illnesses is necrotizing enterocolitis (NEC). The prevalence and death of NEC remain high despite ongoing advances in prevention and treatment. The prevention and treatment of NEC have lately advanced due to new therapeutic approaches such administering breast milk composition, immunotherapy, stem cell therapy, and fecal microbiota transplantation (FMT).

Composition of breast milk, including oligosaccharides, lactoferrin, exosomes generated from breast milk, and other components, has been shown in numerous studies to be one of the most efficient ways to prevent and cure NEC. The most prevalent protein in colostrum (5-6.7 g/L) and the most significant protein in breast milk are both lactoferrin. Intestinal inflammation can be decreased by lactoferrin by preventing the production of pro-inflammatory cytokines including IL-6 and TNF-. In addition to preserving the gut's barrier function, lactoferrin affects the proliferation and death of intestinal epithelial cells.

Numerous preclinical investigations and clinical trials have proven lactoferrin's efficiency in both preventing and treating NEC. By reducing TLR4 expression and boosting crypt cell turnover, oligosaccharides shield intestinal epithelial cells from harm. Exosomes produced from breast milk promote gut growth and have favorable effects on experimental NEC. Intestinal stem cells are vulnerable to oxidative damage, which was controlled via the Wnt/-catenin signaling pathway, but exosomes from breast milk protect them.

Rising Investments and Funding by Companies Creates Opportunities for the Growth of the Market

Noveome Biotherapeutics, Inc., a biopharmaceutical company based in Pittsburgh that is in the clinical stages of developing next-generation biological products for the improvement and reconstruction of cellular structure in inflamed or injured tissues, has closed the first tranche of its $40.2 million Series E financing for a total of $20.7 million. MAK Capital oversaw the funding, and additional funds were contributed by current investors.

Noveome has previously raised $170 million in funding from individual investors along with non-dilutive investment from the Pennsylvania Commonwealth, Allegheny County, and the U.S. Department of Defense. The financing's proceeds will be principally put to use advancing the Company's clinical stage program looking at its patented, ST266, cell-free platform biologic, to treat symptoms of the uncommon pediatric condition necrotizing enterocolitis (NEC).

A unique population composed of human amnion-derived cell cultured into ST266. These cells produce a special collection of cytokines and growth factors termed as the secretome using a patented culture technique, which aids in cellular survival and lowers inflammation.

High Cost of Necrotizing Enterocolitis Surgery will Hamper the Growth of the Market

The management of NEC is very expensive. According to studies, a surgical NEC case in the United States typically costs between $400 000 and $500 000. According to a prospective study that took hospital expenditures into account, the price of surgery NEC ranged from $300,000 to $660,000. The surgical procedure chosen to treat NEC could have a big impact on hospital expenses. A formal laparotomy, which necessitates operating room time and specialist personnel, may be more expensive than the installation of a peritoneal drain, which is normally a quick bedside procedure.

Laparotomy followed by peritoneal drainage may cost considerably more money than each treatment by itself. Despite the fact that NEC places a considerable burden on child health and healthcare spending, the most effective solution has never been found. These side effects may restrain the growth of market.

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Segment Analysis

The global necrotizing enterocolitis drugs market is segmented based on type, drugs, route of administration and distribution channel.

Owing to High Prevalence, the Classic Necrotizing Enterocolitis from Type Segment Accounted for Approximately 43.4% of the Necrotizing Enterocolitis Market Share

The classic necrotizing enterocolitis category from type held the largest market share in 2022 and is expected to maintain its dominance over the forecast period due to a growth in incidence of necrotizing enterocolitis worldwide. Infants born prior to pregnancy of 28 weeks are typically affected by this most prevalent kind of NEC. Three - six weeks following birth is when classic NEC manifests. The infant is typically stable and performing well. The condition then develops unexpectedly and without prior notice.

A potentially fatal condition known as necrotizing enterocolitis (NEC) nearly exclusively affects newborns. The mortality rate at NEC can reach 50%. The pathophysiology of NEC is intestinal inflammation that results in bacterial invasion, cell death, and colon or intestine necrosis. As NEC worsens, there may be an intestinal perforation, which could result in sepsis, peritonitis, and even death. Bacterial invasion through the intestinal wall is the primary cause of necrotizing enterocolitis.

As a result, the intestine's wall becomes inflamed and loses cells. An intestinal perforation can result in the spilling of intestinal contents in the peritoneum and peritonitis if it is not diagnosed and treated. Low birth weight, prematurity, and formula feeding were identified as the main risk factors among a number of others. Formula feeding with a high osmotic strength has specifically been linked to danger. A function for genetic variables is also possible.

Geographical Penetration

North America Accounted for Approximately 34.2% of the Market Share in 2022, Owing to the Strong Presence of Major Players and Increasing Healthcare Infrastructure Investment

Due to the rising need for necrotizing enterocolitis treatment in healthcare, manufacturers in North America have chances of increasing their operations. There are many producers and suppliers in North America and owing to the quick economic growth of the region, industrial production has expanded, driving the demand for drugs for necrotizing enterocolitis.

Increasing expenditure on healthcare and rising research studies, advancement of technologies for treatment of infectious disease, and increase in pharmaceutical and biotechnology business establishment across the region are also contributing to the growth of necrotizing enterocolitis market share of this region.

It is also anticipated that the main healthcare organizations' and enterprises' collaborative research projects as well as new product development, which constantly seeks to improve available alternatives, will contribute to the expanding demand. Individuals are becoming more aware of various drugs such as antibiotics for intravenous usage for management purposes, leading to the expansion of the market in this region. The above-mentioned factors further proves the dominance of North America on a global scale.

Competitive Landscape

The major global players in the necrotizing enterocolitis drugs market include Noveome Biotherapeutics, Inc., Pfizer Inc., Endo Pharmaceuticals Inc., Par Pharmaceutical, AdvaCare Pharma, Sanofi, Aden Healthcare, Mallinckrodt Pharmaceuticals, Samex Overseas and Anant Pharmaceuticals Pvt. Ltd. Among others.

COVID-19 Impact Analysis

By Type

• Classic Necrotizing Enterocolitis
• Transfusion-associated Necrotizing Enterocolitis
• Atypical Necrotizing Enterocolitis
• Term Infant Necrotizing Enterocolitis

By Drugs

• Antibiotics
  • Ampicillin
  • Gentamycin
  • Cefotaxime
  • Vancomycin
  • Metronidazole

• Vasopressors
  • Vasopressin
  • Epinephrine

• Opioid Analgesics
  • Morphine sulfate
  • Fentanyl

• Antifungal Agents
  • Fluconazole

By Route of Administration

• Oral
• Intravenous
• Others

By Distribution Channel

• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies

By Region

• North America
  • U.S.
  • Canada
  • Mexico

• Europe
  • Germany
  • U.K.
  • France
  • Spain
  • Italy
  • Rest of Europe

• South America
  • Brazil
  • Argentina
  • Rest of South America

• Asia-Pacific
  • China
  • India
  • Japan
  • Australia
  • Rest of Asia-Pacific

• Middle East and Africa

Key Developments

• On May 24, 2022, the U.S. Food and Drug Administration (FDA) has designated rare pediatric diseases (RPDD) and orphan drugs (ODD) for the company's main product ST266 for the management of necrotizing enterocolitis (NEC), according to a press release from Noveome Biotherapeutics, Inc. The company is currently in stages of preparing for clinical trials to look into ST266 treatment for NEC. ST266 is currently being assessed in a number of preclinical animal models.
• On February 7, 2022, Endo International plc announced the company's Par Sterile Products division has started selling VASOSTRICT, a ready-to-use 100 mL pre-mix bottle of vasopressin injection, USP. The drug's only and first ready-to-use formulation is this one. By removing the requirement to prepare or transport the product prior to patient administration, ready-to-use, or RTU, goods assist in streamlining operations. By lowering the likelihood of a preparation error, this might save waste and expenses, improve convenience and workflow, increase accuracy and compliance, and promote the provision of high-quality patient care.

DMI Opinion:

The global necrotizing enterocolitis market is going to see moderate growth in upcoming years owing to rising usage of antibiotics for necrotizing enterocolitis. Several researches are taking place worldwide for antibiotics development. Numerous advances are taking place leading to the growth of market such as novel antibiotics. According to DMI the necrotizing enterocolitis market will see a decent growth with several novel therapies in the market.

Why Purchase the Report?

• To visualize the global necrotizing enterocolitis drugs market segmentation based on type, drugs, route of administration, distribution channel and region as well as understand key commercial assets and players.
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• Excel data sheet with numerous data points of necrotizing enterocolitis market-level with all segments.
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The global necrotizing enterocolitis drugs market report would provide approximately 69 tables, 69 figures and 195 Pages.

Target Audience 2023

• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies