Global Membranous Nephropathy Market - 2023-2030

Overview

The membranous nephropathy market trends show rising research owing to the rising technological advancements and research studies. Several alkylating agents are being launched for the treatment of membranous nephropathy. Immunosuppressants are also utilized for prevention of membranous nephropathy.

Furthermore, rising treatment for membranous nephropathy due to the rising availability of approved alkylating agents and increase in the number of membranous nephropathy cases in the market, and an increase in the research and development is driving up the membranous nephropathy market size.

The market is experiencing a growth in demand for drugs from North American areas as a result of the rising advancements in this field. With significant competitors like Novartis AG, SynAct Pharma, Roxane Laboratories, Inc, and Genentech Inc. actively operating in the market, the market will grow in upcoming time.

Dynamics

Growing Clinical Trials and Regulatory Approvals Drive the Growth of the Membranous Nephropathy Market

There are several factors driving the growth of the market one of which is rising research and development by the major key companies currently developing therapies for the treatment of membranous nephropathy. Various novel products are being developed by the companies for treatment purpose. Several approvals are taking place which are enhancing the growth of the market.

For instance, on August 16, 2022, Resomelagon, a name for the AP1189 chemical structure, has been added to the list of suggested International Nonproprietary Names (INN) Proposed List 127, according to a statement from SynAct Pharma AB. The structure of AP1189 has the particular systematic name (2E)-2-(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]prop-2-en-1-ylidenehydrazine-1-carboximidamide. If the name is included to the WHO's list of suggested INNs, it will be known as resomelagon.

Resomelagon has been suggested as a name for AP1189 in order to represent the fact that it promotes the resolution of inflammation via functioning as a melanocortin receptor agonist as well as the fact it adheres to WHO guidelines for naming INNs for the unique chemical structures.

Rising Research and Development by Key Players Creates Opportunities for the Growth of the Market

Membranous nephropathy (MN) is mostly caused by podocyte destruction, which is mediated by in situ activation of complement in the glomeruli, but the exact molecular process is still unclear. Pyroptosis is a specific form of programmed cell death that can cause tissue damage, trigger inflammatory reactions, and kill off cells. It is unclear, though, whether pyroptosis plays a role in the onset and course of MN. In MN, pyroptosis is a significant factor in the promotion of podocyte damage.

To confirm that complement stimulation caused pyroptosis in podocytes and that suppressing pyroptosis corrected complement-induced podocyte degradation in vitro, researchers first noticed the development of pyroptosis in the MN patient's kidneys. Podocytes' mitochondrial depolarization and formation of reactive oxygen species (ROS) were also generated by complement stimulation, and their pyroptosis was restored by inhibiting ROS. It's interesting to note that suppressing pyroptosis attenuated some of these effects.

In addition, they discovered that pyroptosis was present in the kidneys of rats with passive Heymann nephritis (PHN), and that PHN-induced kidney damage was alleviated in vivo by molecules that inhibit pyroptosis. These results show that mitochondrial dysfunction is a key mechanism underpinning complement-induced podocyte destruction in MN and that pyroptosis plays a significant role in this process. It sheds new light on the possibility that pyroptosis could be used as a brand-new target for therapy for MN therapy in the future.

Side Effects Associated with the Drugs will Hamper the Growth of the Market

A greater likelihood of infection is the most important adverse effect of immunosuppressive medications. Other, less severe adverse effects may include vomiting, nausea, excessive hair growth, and trembling in the hands. Usually, these adverse effects go away when the body becomes used to the immunosuppressant medications.

The following side symptoms require quick attention: feeling especially weak or weary, temperature over 100 degrees or shivers, frequently peeing or burning while trying to pass pee, persistent cold, or cough. These side effects may restrain the growth of market.

Segment Analysis

The global membranous nephropathy market is segmented based on type, drugs, route of administration and distribution channel.

Owing to High Utilization, the Immunosuppressive Agents from Treatment Segment Accounted for Approximately 40.4% of the Membranous Nephropathy Market Share

The immunosuppressive agents category from drugs held the largest market share in 2022 and is expected to maintain its dominance over the forecast period due to a growth in incidence of membranous nephropathy worldwide. Adults with primary membranous nephropathy frequently develop nephrotic syndrome. Without therapy, one-third of patients would have persistent proteinuria and about 30% of patients will undergo spontaneous remission. Within ten years, one-third of patients advance to end-stage kidney disease (ESKD).

Due to the increased risk of developing ESKD, immunosuppressive therapy is advised for patients with serious nephrotic syndrome at present and for those whose proteinuria does not improve with supportive therapy. Different immunosuppressive regimens' efficacy and toxicity are unknown. Inducing remission and lowering the number of patients who proceed towards ESKD, immunosuppressive medication likely outperforms non-immunosuppressive therapy. These advantages must be weighed against the negative effects of immunosuppressive medications, though.

Geographical Penetration

North America Accounted for Approximately 33.6% of the Market Share in 2022, Owing to the Strong Presence of Major Players and Increasing Healthcare Infrastructure Investment

Due to the rising need for membranous nephropathy treatment in healthcare, manufacturers in North America have chances of increasing their operations. There are many producers and suppliers in North America and owing to the quick economic growth of the region, industrial production has expanded, driving the demand for drugs for membranous nephropathy.

Increasing expenditure on healthcare and rising research studies, advancement of technologies for treatment of infectious disease, and increase in pharmaceutical and biotechnology business establishment across the region are also contributing to the growth of membranous nephropathy market share of this region.

It is also anticipated that the main healthcare organizations' and enterprises' collaborative research projects as well as new product development, which constantly seeks to improve available alternatives, will contribute to the expanding demand. Individuals are becoming more aware of various drugs such as alkylating agents for management purposes, leading to the expansion of the market in this region. The above-mentioned factors further proves the dominance of North America on a global scale.

Competitive Landscape

The major global players in the membranous nephropathy market include F. Hoffman La Roche, SynAct Pharma, Roxane Laboratories, Inc, Dr. Reddy's Laboratories Ltd., Genentech, Inc., Novartis AG, Anant Pharmaceuticals Pvt. Ltd, Merck KGaA, Panacea Biotec among others.

COVID-19 Impact Analysis

Russia Ukraine Conflict Analysis

Due to the low prevalence as well as absence of major market participants in this region, it is predicted that the Russia-Ukraine conflict will not have a significant effect on the worldwide membranous nephropathy market. The growth of the global membranous nephropathy market, however, is anticipated to be relatively unaffected by the import and export of raw materials over the forecast period.

By Type

• Primary Membranous Nephropathy
• Secondary Membranous Nephropathy

By Drugs

• Alkylating Agents
  • Chlorambucil
  • Cyclophosphamide
  • Cisplatin
  • Ethyleneimines
  • Triazines

• Immunosuppressive Agents
  • Methylprednisolone
  • Cyclophosphamide
  • Mycophenolate Mofetil

• Calcineurin Inhibitors
  • Tacrolimus
  • Cyclosporine

• Adrenocorticotropic Hormone (ACTH) Analogs
• Rituximab

By Route of Administration

• Oral
• Intravenous
• Others

By Distribution Channel

• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies

By Region

• North America
  • U.S.
  • Canada
  • Mexico

• Europe
  • Germany
  • U.K.
  • France
  • Spain
  • Italy
  • Rest of Europe

• South America
  • Brazil
  • Argentina
  • Rest of South America

• Asia-Pacific
  • China
  • India
  • Japan
  • Australia
  • Rest of Asia-Pacific

• Middle East and Africa

Key Developments

• On January 30, 2023, According to Kidney International Reports, Obinutuzumab may be used in refractory MN, mostly in patients with normal kidney function, according to recent research. Obinutuzumab's effectiveness in treating refractory phospholipase A2 receptor-associated MN along with severe CKD is currently being reported by a number of studies. Despite having severe kidney dysfunction and/or advanced chronicity, the patients are benefiting with obinutuzumab therapy. The legacy impact of immunosuppressive medications in reaching remission is another issue that requires careful consideration.
• On April 6, 2022, the drugmaker Dr Reddy's introduces methylprednisolone sodium succinate generic version for injection in the US. Methylprednisolone Sodium Succinate administered via Injection by Dr. Reddy is offered in single-dose vials of 40 mg and 125 mg, each carton of which contains 25 vials, and multi-dose vials of 500 mg and 1 gm, each carton of which contains one vial.

DMI Opinion:

The global membranous nephropathy market is going to see moderate growth in upcoming years owing to rising usage of immunosuppressents for membranous nephropathy. Several researches are taking place worldwide for alkylating agents development. Numerous advances are taking place leading to the growth of market such as novel alkylating agents. According to DMI the membranous nephropathy market will see a decent growth with several novel therapies in the market.

Why Purchase the Report?

• To visualize the global membranous nephropathy market segmentation based on type, drugs, route of administration, distribution channel and region as well as understand key commercial assets and players.
• Identify commercial opportunities by analyzing trends and co-development.
• Excel data sheet with numerous data points of membranous nephropathy market-level with all segments.
• PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
• Product mapping available as excel consisting of key products of all the major players.

The global membranous nephropathy market report would provide approximately 53 tables, 54 figures and 195 Pages.

Target Audience 2023

• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies