Global Angiotensin-Converting Enzyme Inhibitors (ACE) Market

Description

Overview

ACE inhibitors are a class of medication used for treating cardiovascular diseases, renal diseases, diabetes mellitus, etc. They are used to treat hypertension in combination with other drugs. The FDA-approved uses include adjunctive therapy in systolic heart failure. It is also used for myocardial infection.

The mechanism of action involves the blockage of the angiotensin-converting enzyme that lowers the blood pressure. Besides treating hypertension, these inhibitors treat several kidney diseases like nephrotic syndrome, glomerular infections, and other kidney inflammations. Lisinopril and benazepril are famous examples of ACE inhibitors.

Market Dynamics: Drivers & Restraints

Increasing prevalence of cardiovascular diseases

Cardiovascular diseases are one of the leading causes of death around the world. According to the World Health Organisation, 2023, an estimated 17 million people die annually due to cardiovascular diseases, mainly stroke and heart attacks. It affects men and women equally due to unhealthy diet habits and underlying health ailments like diabetes, hypertension, etc, which lead to heart strokes in many individuals.

Furthermore, according to the British Heart Foundation, 2023, nearly 620 million people live with cardiac diseases. Globally, it is estimated that 1 in 13 individuals currently suffer from heart or circulatory disease. Each year, more than 60 million people develop cardiac diseases, which are almost the same as the population of the UK.

In March 2023, according to Harvard Business School 2023, the study revealed an increased risk of cardiovascular diseases along with diabetes and hypertension among young adults.

Side effects of ACE inhibitor therapy

ACE inhibitors are used to treat hypertension, but sometimes, when given with other anti-hypertensive agents, it leads to hypotension. Excessive usage of ACE inhibitors leads to hyperkalemia, where increased potassium levels are seen. Adverse drug reaction is possible, leading to angioedema, a rare but life-threatening situation. Patients with heart failure and poor renal perfusion lead to further reduction of glomerular filtration rate with ACE inhibitor therapy.

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Segment Analysis

The global angiotensin-converting enzyme inhibitors (ACE) are segmented based on drug type, application, route of administration, distribution channel, and region.

The Dicarboxylic-containing agents segment accounted for approximately 47.1% of the market share

Dicarboxylic-containing ACE inhibitors are expected to hold the largest share of the market. ACE inhibitors are under clinical trial for treating diseases like cardiovascular, lung, renal, etc. A combination therapy containing ACE inhibitors is given to patients suffering from cardiac ailments and other diseases.

In September 2023, Pharmascience Inc. launched PERINDOPRIL-INDAPAMIDE, a combination of an angiotensin-converting enzyme (ACE) inhibitor and diuretic to lower blood pressure in hypertensive patients of all ages.

The Centre for Chronic Disease Control, India, along with Imperial College London, All India Institute of Medical Sciences, New Delhi, is conducting phase 4 clinical trials to compare the efficacy of three single-pill combinations of two anti-hypertensive agents, Amlodipine and Perindopril. The study start date is August 30, 2022. The estimated completion date is December 31, 2023.

Geographical Analysis

North America accounted for approximately 39.6% of the market share in 2022

North America is expected to hold the largest market share due to the prevalence of diabetes mellitus in the US and Canada. ACE inhibitors are used to treat diabetes mellitus, hypertension, etc., due to their efficacy in blocking the angiotensin enzyme in the body.

For instance, according to the Pan American Health Organization, 62 million people live with diabetes in the Americas, which is expected to be much higher given that around 40% of those without any symptoms. Diabetes is America's sixth leading cause of mortality and was responsible for over 284,000 deaths in 2019. The prevalence of type 2 diabetes is increasing drastically due to unhealthy food habits and sedentary lifestyles in America.

According to the USC Schaeffer Center for Health Policy & Economics, in 2023, about 70% of Americans will have high blood pressure in their lifetimes. Only 1 in 4 patients with hypertension were in control, and others are asymptomatic.

COVID-19 Impact Analysis:

COVID-19 moderately impacted the angiotensin enzyme inhibitor market. Disruption in the supply chain was observed during the pandemic. People who contracted COVID-19 mainly have underlying co-morbidities like diabetes, hypertension, and heart ailments. As there is no termination in the drug intake by people suffering from heart ailments, there is not much impact observed on ACE inhibitors market. The implementation of lockdowns worldwide made testing and diagnosing cardiovascular diseases difficult because there is a high fear of contracting the disease.

Competitive Landscape

The major global players in the angiotensin-converting enzyme inhibitors (ACE) market include: Camber Pharmaceuticals, Inc., Pfizer Inc, Merck & Co., Inc, Biogaran, Lupin Pharmaceuticals, Inc., Crescent Pharma Limited, Global Pharma Pvt Ltd, SCHWITZ BIOTECH, Steris Healthcare PVT Ltd, Auro Pharma Inc among others.

Key Developments

In February 2021, Novartis received US Food and Drug Administration approval for Entresto for the treatment of chronic heart failure.
In January 2021, Merck & Co, Inc., received US Food and Drug Administration approval for VERQUVO for the treatment of chronic heart failure specifically approved for patients following a hospitalization for heart failure. It is jointly developed with Bayer AG.

Why Purchase the Report?

To visualize the global angiotensin-converting enzyme inhibitors market segmentation based on drug type, application, route of administration, distribution channel and region as well as understand key commercial assets and players.
Identify commercial opportunities by analyzing trends and co-development.
Excel data sheet with numerous data points of angiotensin-converting enzyme inhibitors market-level with all segments.
PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
Product mapping available as excel consisting of key products of all the major players.

The global angiotensin-converting enzyme inhibitors (ACE) market report would provide approximately 69 tables, 70 figures, and 195 Pages.

Target Audience 2023

Manufacturers/ Buyers
Industry Investors/Investment Bankers
Research Professionals
Emerging Companies

Product Code: PH2029

1. Methodology and Scope

1.1. Research Methodology
1.2. Research Objective and Scope of the Report

2. Definition and Overview

3. Executive Summary

3.1. Snippet by Drug Type
3.2. Snippet by Application
3.3. Snippet by Route of Administration
3.4. Snippet by Distribution Channel
3.5. Snippet by Region

4. Dynamics

4.1. Impacting Factors
- 4.1.1. Driver
  - 4.1.1.1. Increasing prevalence of cardiovascular diseases
  - 4.1.1.2.
- 4.1.2. Restraints
  - 4.1.2.1. Side effects of ACE inhibitor therapy
  - 4.1.2.2.
- 4.1.3. Opportunity
- 4.1.4. Impact Analysis

5. Industry Analysis

5.1. Porter's Five Force Analysis
5.2. Supply Chain Analysis
5.3. Pricing Analysis
5.4. Cardiovascular disease statistics
5.5. Regulatory Analysis
5.6. DMI Opinion

6. COVID-19 Analysis

6.1. Analysis of COVID-19
- 6.1.1. Scenario Before COVID
- 6.1.2. Scenario During COVID
- 6.1.3. Scenario Post COVID
6.2. Pricing Dynamics Amid COVID-19
6.3. Demand-Supply Spectrum
6.4. Government Initiatives Related to the Market During Pandemic
6.5. Manufacturers Strategic Initiatives
6.6. Conclusion

7. By Drug Type

7.1. Introduction
- 7.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
- 7.1.2. Market Attractiveness Index, By Drug Type
7.2. Dicarboxylate-containing Agents *
- 7.2.1. Introduction
- 7.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
  - 7.2.2.1. Enalapril
  - 7.2.2.2. Ramipril
  - 7.2.2.3. Quinapril
  - 7.2.2.4. Others
7.3. Phosphonate-containing Agents
- 7.3.1. Fosinopril
- 7.3.2. Others
7.4. Sulfhydryl-containing Agents
- 7.4.1. Alacepril
- 7.4.2. Captopril
- 7.4.3. Others
7.5. Others

8. By Application

8.1. Introduction
- 8.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 8.1.2. Market Attractiveness Index, By Application
8.2. Cardiovascular Diseases*
- 8.2.1. Introduction
- 8.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
8.3. Renal Diseases
8.4. Diabetes
8.5. Hypertension
8.6. Others

9. By Route of Administration

9.1. Introduction
- 9.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Route of Administration
- 9.1.2. Market Attractiveness Index, By Route of Administration
9.2. Oral*
- 9.2.1. Introduction
- 9.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
9.3. Parenteral
9.4. Others

10. By Distribution Channel

10.1. Introduction
- 10.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel
- 10.1.2. Market Attractiveness Index, By Distribution Channel
10.2. Hospital Pharmacies*
- 10.2.1. Introduction
- 10.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
10.3. Retail Pharmacies
10.4. Online Pharmacies

11. By Region

11.1. Introduction
- 11.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Region
- 11.1.2. Market Attractiveness Index, By Region
11.2. North America
- 11.2.1. Introduction
- 11.2.2. Key Region-Specific Dynamics
- 11.2.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
- 11.2.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 11.2.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Route of Administration
- 11.2.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel
- 11.2.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 11.2.7.1. U.S.
  - 11.2.7.2. Canada
  - 11.2.7.3. Mexico
11.3. Europe
- 11.3.1. Introduction
- 11.3.2. Key Region-Specific Dynamics
- 11.3.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
- 11.3.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 11.3.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Route of Administration
- 11.3.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel
- 11.3.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 11.3.7.1. Germany
  - 11.3.7.2. UK
  - 11.3.7.3. France
  - 11.3.7.4. Italy
  - 11.3.7.5. Spain
  - 11.3.7.6. Rest of Europe
11.4. South America
- 11.4.1. Introduction
- 11.4.2. Key Region-Specific Dynamics
- 11.4.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
- 11.4.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 11.4.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Route of Administration
- 11.4.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel
- 11.4.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 11.4.7.1. Brazil
  - 11.4.7.2. Argentina
  - 11.4.7.3. Rest of South America
11.5. Asia-Pacific
- 11.5.1. Introduction
- 11.5.2. Key Region-Specific Dynamics
- 11.5.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
- 11.5.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 11.5.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Route of Administration
- 11.5.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel
- 11.5.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 11.5.7.1. China
  - 11.5.7.2. India
  - 11.5.7.3. Japan
  - 11.5.7.4. Australia
  - 11.5.7.5. Rest of Asia-Pacific
11.6. Middle East and Africa
- 11.6.1. Introduction
- 11.6.2. Key Region-Specific Dynamics
- 11.6.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
- 11.6.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 11.6.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Route of Administration
- 11.6.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel

12. Competitive Landscape

12.1. Competitive Scenario
12.2. Market Positioning/Share Analysis
12.3. Mergers and Acquisitions Analysis

13. Company Profiles

13.1. Camber Pharmaceuticals, Inc.
- 13.1.1. Company Overview
- 13.1.2. Product Portfolio and Description
- 13.1.3. Financial Overview
- 13.1.4. Key Developments
13.2. Pfizer Inc
13.3. Merck & Co., Inc
13.4. Biogaran
13.5. Lupin Pharmaceuticals, Inc.
13.6. Crescent Pharma Limited
13.7. Global Pharma Pvt Ltd
13.8. SCHWITZ BIOTECH
13.9. Steris Healthcare PVT Ltd
13.10. Auro Pharma Inc

LIST NOT EXHAUSTIVE.

14. Appendix

14.1. About Us and Services
14.2. Contact Us

Global Angiotensin-Converting Enzyme Inhibitors (ACE) Market - 2023-2030