PUBLISHER: Fortune Business Insights Pvt. Ltd. | PRODUCT CODE: 1887156
PUBLISHER: Fortune Business Insights Pvt. Ltd. | PRODUCT CODE: 1887156
The global prostate cancer hormone therapy market is witnessing robust growth as prostate cancer prevalence continues to rise and treatment innovations advance rapidly. According to the latest industry estimates, the market was valued at USD 16.07 billion in 2024, is expected to reach USD 20.44 billion in 2025, and is projected to surge to USD 79.93 billion by 2032, demonstrating the strong demand for hormone-based treatment options across global healthcare systems. In 2024, North America dominated the market with a 51.71% share, supported by advanced healthcare infrastructure, strong reimbursement policies, and high awareness of early cancer diagnosis.
Hormone therapy remains a cornerstone of prostate cancer management. Also known as Androgen Deprivation Therapy (ADT), this treatment reduces hormone levels that fuel tumor growth and is widely used in metastatic and advanced-stage cancers. With global cancer burden intensifying-GLOBOCAN 2022 recorded 1.47 million prostate cancer cases, making it the 4th most common cancer-there is rising dependence on hormone therapy as a core treatment approach.
Market Drivers
The development of advanced hormonal therapies is a major market driver. Leading pharmaceutical companies are introducing new androgen receptor inhibitors and next-generation GnRH-based therapies to overcome resistance and improve patient outcomes. In November 2023, Astellas Pharma and Pfizer received FDA approval for XTANDI for non-metastatic Castration-Sensitive Prostate Cancer, enabling broader treatment use.
Strong R&D pipelines and increasing clinical trials continue to accelerate therapeutic innovation. The rising global incidence of prostate cancer, coupled with expanding access to advanced therapies in developed nations, also supports continuous market growth.
Market Restraints
A significant restraint is the growing resistance to conventional ADT. Over time, prostate cancer cells may mutate and continue producing androgens, diminishing therapeutic effectiveness. For instance, research in January 2024 by Sylvester Comprehensive Cancer Center revealed that the enzyme 3BHSD1 enables tumors to regenerate androgens even during hormone suppression therapy, accelerating disease progression. This resistance challenges treatment efficacy and limits long-term therapy adoption.
Market Challenges
Patients undergoing hormonal therapy often experience substantial side effects, making treatment adherence challenging. Erectile dysfunction and libido loss are common complications. A study published by Elsevier in 2020 reported that 82% of ADT patients experienced erectile problems, while 64% reported loss of sexual desire, negatively affecting quality of life. Such adverse effects remain a major barrier to therapy continuation.
Market Opportunities
Combination therapies offer significant future opportunities. Pharmaceutical companies are increasingly exploring combinations of PARP inhibitors with ADT to address resistance and extend survival. In February 2025, the TALAPRO-2 trial demonstrated that combining talazoparib (Talzenna) with enzalutamide (Xtandi) provided a 14-month improvement in overall survival for HRR-deficient metastatic prostate cancer patients, with a 38% reduction in mortality risk. These outcomes highlight the strong potential of combination therapy in shaping the future treatment landscape.
By Drug Class
In 2024, GnRH agonists held the leading share due to high effectiveness in testosterone suppression. Regulatory approvals for products like CAMCEVI continue strengthening this segment. GnRH receptor antagonists and androgen receptor inhibitors are expected to grow substantially due to multiple new approvals and expanded clinical indications.
By Disease State
The metastatic castration-resistant prostate cancer (mCRPC) segment dominated in 2024, driven by rising incidence and increased approvals of targeted therapies. The non-metastatic CRPC segment is set for strong growth as companies broaden their indications.
By Route of Administration
The oral segment held the largest share due to ease of administration and growing generic launches, such as Amneal's FDA-approved generic Abiraterone Acetate. The parenteral segment continues to expand with new injectable formulations under trial.
By Distribution Channel
Hospital pharmacies lead due to specialized cancer treatment centers and physician-supervised therapy administration. Retail and online pharmacies are growing steadily due to improved drug accessibility.
North America
The market reached USD 8.31 billion in 2024, driven by high prostate cancer incidence and advanced therapeutic adoption. Strong R&D presence and FDA approvals contribute to regional dominance.
Europe
Europe holds the second-largest share, supported by healthcare authority endorsements. In 2024, NICE recommended ORGOVYX as a cost-effective treatment option.
Asia Pacific
Expected to be the fastest-growing region due to rising aging populations and increasing therapy approvals. In July 2024, China's NMPA approved XTANDI for metastatic disease.
Latin America & Middle East/Africa
Moderate growth is expected, driven by rising collaborations and gradual improvements in prostate cancer treatment access.
Conclusion
The global prostate cancer hormone therapy market is on a strong growth trajectory, rising from USD 16.07 billion in 2024 to USD 20.44 billion in 2025, and projected to reach USD 79.93 billion by 2032. With expanding treatment innovations, increasing approvals, and strong R&D momentum, hormone therapy remains central to the future of prostate cancer care.
Segmentation By Drug Class
By Route of Administration
By Disease State
By Distribution Channel
By Region
Figure 57: Global Prostate Cancer Hormone Therapy Market Share (%), By Company, 2024