PUBLISHER: Global Industry Analysts, Inc. | PRODUCT CODE: 1742795
PUBLISHER: Global Industry Analysts, Inc. | PRODUCT CODE: 1742795
Global Plasma-Derived Medicines Market to Reach US$25.1 Billion by 2030
The global market for Plasma-Derived Medicines estimated at US$17.9 Billion in the year 2024, is expected to reach US$25.1 Billion by 2030, growing at a CAGR of 5.7% over the analysis period 2024-2030. Immunoglobulin, one of the segments analyzed in the report, is expected to record a 4.6% CAGR and reach US$9.7 Billion by the end of the analysis period. Growth in the Coagulation Factors segment is estimated at 7.1% CAGR over the analysis period.
The U.S. Market is Estimated at US$4.9 Billion While China is Forecast to Grow at 8.8% CAGR
The Plasma-Derived Medicines market in the U.S. is estimated at US$4.9 Billion in the year 2024. China, the world's second largest economy, is forecast to reach a projected market size of US$5.0 Billion by the year 2030 trailing a CAGR of 8.8% over the analysis period 2024-2030. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at a CAGR of 2.9% and 5.6% respectively over the analysis period. Within Europe, Germany is forecast to grow at approximately 3.7% CAGR.
Global Plasma-Derived Medicines Market - Key Trends & Drivers Summarized
Why Are Plasma-Derived Medicines Critical in Treating Rare and Chronic Disorders?
Plasma-derived medicines, obtained through fractionation of donated human plasma, play a vital role in managing a range of life-threatening and chronic conditions, including hemophilia, primary immunodeficiencies, hereditary angioedema, and autoimmune disorders. These biologics include immunoglobulins (IVIG/SCIG), clotting factors (Factor VIII, Factor IX), albumin, and hyperimmune globulins used in post-exposure prophylaxis. Unlike synthetic drugs, plasma-derived therapies are complex biologics that cannot be replaced with small-molecule alternatives, and in many cases, they remain the only therapeutic option available for patients.
Their importance has grown with the increasing global prevalence of immunodeficiencies and rare bleeding disorders, particularly as diagnostic capabilities expand and newborn screening programs identify affected individuals earlier. Additionally, plasma-based therapies are being increasingly used in off-label and critical care settings, such as septic shock, Guillain-Barre syndrome, and post-transplant immunomodulation. With a growing global population living longer with chronic immune conditions, the medical reliance on plasma proteins continues to intensify, creating upward pressure on both demand and supply chains.
What Are the Technological and Operational Challenges Shaping the Supply Landscape?
The production of plasma-derived medicines is a highly specialized, resource-intensive process involving rigorous donor screening, plasma collection, pathogen inactivation, and cold-chain logistics. Fractionation, the process of separating plasma proteins, takes 7-12 months from collection to final product due to multiple purification and validation steps. This extended lead time, combined with strict biological standards and batch variability, makes the industry highly capital- and compliance-intensive. Any disruption in donor availability or facility operations can result in downstream supply bottlenecks, as witnessed during the COVID-19 pandemic when plasma donations declined significantly worldwide.
Technological advances in chromatography, virus filtration, and nanofiltration are improving the yield, purity, and safety of plasma derivatives. Automated plasmapheresis systems and digital donor engagement tools are enhancing collection efficiency. However, the scalability of these advancements is constrained by the biological nature of plasma-each batch is unique, and consistent manufacturing outcomes require continuous quality control. Moreover, pathogen safety remains a top priority; regulatory mandates necessitate multiple virus inactivation steps, including solvent-detergent treatment and heat pasteurization, which add cost and complexity to every product. These operational realities have led to a global plasma supply imbalance, with developed markets heavily reliant on a few large-scale donor networks, especially in the U.S.
How Are Market Leaders and Governments Responding to Rising Global Demand?
To address growing demand, biopharmaceutical companies are investing heavily in expanding plasma collection centers, upgrading fractionation capacities, and regionalizing manufacturing to ensure better access and supply resilience. Industry leaders such as CSL Behring, Grifols, Takeda, and Octapharma are acquiring independent collection networks, building plasma banks, and integrating donor outreach with digital health platforms. These companies are also forming public-private partnerships to improve plasma access in underrepresented geographies, such as Southeast Asia, Latin America, and Eastern Europe.
Governments and regulatory bodies are taking steps to safeguard national plasma supply security. Initiatives such as the European Commission’s Blood and Plasma Initiative and the U.S. HHS-supported Plasma Protein Therapeutics Association (PPTA) are encouraging voluntary donation, improving reimbursement models, and incentivizing local collection infrastructure. The World Health Organization has called for the development of national self-sufficiency strategies, particularly in low- and middle-income countries, where reliance on imported products leaves patients vulnerable to shortages and price shocks. Meanwhile, emerging biotech firms are exploring recombinant alternatives and synthetic biology approaches to reduce dependency on human plasma, although such products are still in early clinical phases.
What’s Powering the Long-Term Growth of the Plasma-Derived Medicines Market?
The growth in the global plasma-derived medicines market is driven by several factors, including rising prevalence of immunodeficiencies and rare hematological disorders, improved global diagnostic capabilities, and expanding off-label applications. The increasing use of IVIG in neurology and autoimmune therapies, alongside growing demand for albumin in liver disease and critical care, is significantly expanding the market beyond its traditional hematology base. Aging populations, particularly in developed countries, are also contributing to higher treatment volumes, as older patients require immunoglobulin therapies for age-associated immune decline.
Furthermore, strong regulatory support for plasma safety, increasing public awareness of donation, and strategic investments by major biopharma companies are reinforcing supply chains. Growth in contract plasma fractionation services, digital donor engagement tools, and personalized therapy regimens is enabling better production planning and treatment customization. Additionally, the entry of emerging economies into the plasma collection and manufacturing space is expected to improve global accessibility and reduce regional disparities. As chronic disease management becomes more biologics-centric, and as global health systems prioritize continuity of care in rare disorders, plasma-derived medicines are poised for robust, sustained growth in the years ahead.
SCOPE OF STUDY:
The report analyzes the Plasma-Derived Medicines market in terms of units by the following Segments, and Geographic Regions/Countries:
Segments:
Product (Immunoglobulin, Coagulation Factors, Albumin, Other Products); Distribution Channel (Hospital Pharmacies, Retail Pharmacies, Online Pharmacies); Application (Pelvic Inflammatory Disease, Bleeding Disorders, Alpha-1 Antitrypsin Deficiency, Hereditary Angioedema, Chronic Inflammatory Demyelinating Polyneuropathy, Guillain-Barre Syndrome, Multifocal Motor Neuropathy, Liver Diseases, Primary Immune Thrombocytopenia, Other Applications)
Geographic Regions/Countries:
World; United States; Canada; Japan; China; Europe (France; Germany; Italy; United Kingdom; Spain; Russia; and Rest of Europe); Asia-Pacific (Australia; India; South Korea; and Rest of Asia-Pacific); Latin America (Argentina; Brazil; Mexico; and Rest of Latin America); Middle East (Iran; Israel; Saudi Arabia; United Arab Emirates; and Rest of Middle East); and Africa.
Select Competitors (Total 34 Featured) -
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