PUBLISHER: Grand View Research | PRODUCT CODE: 1363371
PUBLISHER: Grand View Research | PRODUCT CODE: 1363371
The global rat model market size is expected to reach USD 2.41 billion by 2030, according to a new report by Grand View Research, Inc.., expanding at a CAGR of 7.06% from 2023 to 2030. Genetically modified organisms are extensively used in research for identifying potential therapeutic targets and further validation of the same. The extensive healthcare-based research has driven the market for understanding diseases and genetic illnesses of humans.
During the COVID-19 outbreak, researchers were focused on understanding the pathogenesis and transmission of the SARS-CoV2 virus by using the readily available animal model in addition to in-vitro and ex-vivo culture systems. These models also helped in the evaluation of vaccines and antivirals for the treatment. Companies creating transgenic animals used this as a perfect opportunity to provide the scientific community with genetically modified rats for evaluation of SARS-Cov2 entry. For example, in 2020,Envigo created the hACE2 knockinrat model through CRISPR-based technology. ACE2 serving as a primary receptor facilitates the entry of the SARS-CoV2 virus and is being investigated as a potential preventative target.
Animal models continue to be significant tools for preclinical testing of potential therapeutics and understanding disease mechanisms. Increased spending on research and growing number of clinical trials are the key factors contributing to the market growth. The rising incidence of genetic diseases globally and the surge in the use of animal species to advance various groundbreaking therapies are expected to further propel the market growth. Post completion of The Human Genome Project in 2003, there have been evident advancements in synthetic and molecular biology for understanding the genetic basis of diseases. These advanced technologies and products have also made it easier to create genetically engineered models (GEM) of rats, wherein different types such as knockout, outbred, inbred, and conditioned are now available in the market.
The market is expected to observe direct competition from the mouse/mice model. The mice models have been long preferred due to their small sizes and they offer economic as well as more established choices for discovery and early stage research. However, the vast use of gene editing tools in rats and the similarity of rat and human genomes make the rat model suitable for genetic manipulation and handling of experiments, thus fueling the market expansion.