PUBLISHER: Grand View Research | PRODUCT CODE: 1842186
PUBLISHER: Grand View Research | PRODUCT CODE: 1842186
The global hepatitis therapeutics market size was estimated at USD 16.80 billion in 2024 and is projected to reach USD 23.62 billion by 2033, growing at a CAGR of 3.9% from 2025 to 2033. The global market is expanding as the prevalence of hepatitis B and C infections continues to pose a significant health challenge.
Improved screening and rising clinical awareness have accelerated early diagnosis, supporting timely treatment initiation. Demand for antivirals, direct-acting antivirals, and immunomodulators remains strong, forming the backbone of current therapies. For instance, the Hepatitis B Foundation reported FDA approval of seven medications for chronic hepatitis B, including five oral antivirals: Viread, Vemlidy, Baraclude, Epivir-HBV, and Hepsera, along with two injectable immune modulators: Pegasys and Intron A. The foundation emphasized that treatment decisions should consider liver disease activity and cirrhosis, with regular specialist monitoring recommended. Rising adoption of curative hepatitis C therapies further strengthens growth prospects.
Another key driver is the rise in liver-related complications associated with untreated hepatitis infections, such as cirrhosis and hepatocellular carcinoma, which is pushing demand for advanced therapeutic approaches. The increasing burden of comorbid conditions in aging populations has heightened reliance on antiviral regimens with proven efficacy and safety. Pharmaceutical companies are actively investing in clinical research to address these needs through therapies with higher cure rates and improved tolerability. For instance, in August 2025, Applied Clinical Trials Online reported that Aligos Therapeutics had initiated dosing in its Phase II B-SUPREME trial of ALG-000184, a first-in-class oral capsid assembly modulator, in approximately 200 treatment-naive adults with chronic hepatitis B, including both HBeAg-positive and HBeAg-negative patients. The randomized, double-masked study was designed to compare ALG-000184 monotherapy with tenofovir disoproxil fumarate over 48 weeks, with primary endpoints focusing on HBV DNA suppression and secondary outcomes assessing safety, pharmacokinetics, and antigen reductions. Interim findings were expected in 2026, and topline results in 2027, while earlier Phase I data had already demonstrated sustained antiviral activity, favorable safety, and no new safety signals, reinforcing the momentum of clinical innovation in hepatitis therapeutics.
The emergence of cell-based immunotherapies is driving growth in the hepatitis therapeutics market, particularly for patients with advanced liver complications from chronic infections. For instance, in May 2025, OncLive reported that SCG101, an autologous HBV-specific T-cell therapy, delivered antiviral and antitumor activity in advanced HBV-related hepatocellular carcinoma. In a Phase I trial, 94% of patients achieved notable HBsAg reductions within 28 days, with sustained control for up to one year, while 23.5% achieved complete HBsAg loss. Tumor responses were observed in 47% of patients, and median overall survival had not been reached. Safety remained manageable, with transient ALT elevations and cytokine release syndrome being the most common events. These outcomes underscore the role of innovative immunotherapies in addressing unmet needs and strengthening market expansion.
Global Hepatitis Therapeutics Market Report Segmentation
This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global hepatitis therapeutics market report based on disease, distribution channel, and region: