PUBLISHER: Grand View Research | PRODUCT CODE: 1869720
PUBLISHER: Grand View Research | PRODUCT CODE: 1869720
The global preparative and process chromatography market size was estimated at USD 12.42 billion in 2024 and is projected to reach USD 21.15 billion by 2033, growing at a CAGR of 5.50% from 2025 to 2033. The market growth is driven by the rising demand and approval of monoclonal antibodies in the pharmaceutical and biotechnology sectors.
In addition, the preparative and process chromatography market is driven by the expanding biopharmaceutical industry, the demand for advanced purification techniques, and the need for more efficient and cost-effective processes. For instance, in September 2025, Samsung Biologics expanded biopharma partnerships through end-to-end CDMO services. The key highlights are end-to-end support from early development to commercial production, robust quality systems that strengthen supply chain resilience, and Samsung Biologics' continued capacity expansion and enhanced flexibility to accommodate complex modalities. Moreover, technological advancements and the development of innovative products are expected to boost market growth. For instance, in October 2021, CEM launched the prodigy preparative high-performance liquid chromatography (HPLC) system. The system offers an elevated temperature capability, resulting in enhanced resolution and separation capabilities.
The COVID-19 pandemic had a positive impact on the preparative and process chromatography market due to the increased demand for COVID-19 vaccines and treatment drugs. Similarly, the pharmaceutical and biotechnology industries are expected to grow significantly in the coming years, owing to increased production and demand for preparative and process chromatography. The separation process and preparative chromatography can be used to analyze materials for the coronavirus vaccine.
Further, a chromatography system is a scientific technique that separates specific components from sample mixtures. Analytical and preparative chromatography systems are widely used in both qualitative and quantitative analyses of biotechnological, pharmaceutical, and other elements. The market for chromatography systems is expanding due to a number of factors, including increased demand for insulin and omega-3 fatty acids, growing concerns about food quality and safety, and an aging population.
Furthermore, ongoing research paradigms focusing on the separation and analysis of monoclonal antibodies via mild reverse-phase chromatography are expected to drive growth in the market. Companies are actively developing flexible and robust platforms for the continuous production of monoclonal antibody products, resulting in a greater demand for quality control measures. The industry is expanding due to increased demand for preparative techniques, technological advancements, and the widespread integration of liquid chromatographic methods in downstream processing.
Moreover, affinity chromatography has emerged as an important tool for protein purification. It relies on highly specific interactions between the protein of interest and an immobilized ligand. The Downstream Process (DSP), also known as the product purification process, is one of the most expensive aspects of modern bioprocess protocols, especially for proteins. As a result, in these cases, chromatography is an essential tool throughout the DSP process, from early initial capture to final polishing or finishing.
Preparative techniques have gained widespread acceptance for purifying APIs, with key drivers including increased throughput, cost-effectiveness, and purity. These techniques provide users with adequate material volume at the desired quality for the start of clinical and preclinical trials. This, in turn, opens up new avenues for commercialization with minimal time investment in product development.
Global Preparative And Process Chromatography Market Report Segmentation
This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global preparative and process chromatography market report on the basis of product, type, end use, and region: