PUBLISHER: Grand View Research | PRODUCT CODE: 2152221
PUBLISHER: Grand View Research | PRODUCT CODE: 2152221
The global mammalian cell fermentation technology market size was valued at USD 50.4 billion in 2025 and is projected to grow from USD 54.7 billion in 2026 to USD 97.8 billion in 2033, at a CAGR of 8.6% from 2026 to 2033. North America dominated the market, accounting for a revenue share of 37.0% in 2025. Mammalian cells are commonly used to manufacture therapeutic proteins such as monoclonal antibodies, vaccines, and other biologics, along with several cell lines, including Chinese Hamster Ovary (CHO) cells, Human Embryonic Kidney (HEK) cells, and others. The increasing prevalence of chronic diseases, coupled with the growing demand for biologics, is fueling the demand for fermentation technologies.
By end-use, the CMOs & CDMOs segment dominated the market with a share of approximately 51.0% in 2025.
The market for mammalian cell fermentation technology is experiencing a significant surge due to the rising demand for biologics and biosimilars. These treatments have become crucial in managing various ailments, including cancer, autoimmune conditions, and infectious diseases. As pharmaceutical companies increasingly invest in developing new biologics, interest in mammalian cell fermentation technology continues to grow. For instance, in June 2025, WuXi Biologics announced plans to construct a new commercial biomanufacturing facility in Chengdu, China. The site will feature advanced biologics production capabilities, including a 15,000 L fermentation system with the potential for future expansion to 60,000 L, supporting the growing global demand for biologics and recombinant therapeutics. This investment highlights the increasing adoption of advanced cell culture and fermentation technologies to expand biologics manufacturing capacity worldwide.
Technological developments in cell culture are another driver boosting the market for mammalian cell fermentation. Higher yields of recombinant proteins and other biologics can now be achieved with serum-free media and advances in bioreactor technologies, which have fundamentally transformed the industry.
The market for mammalian cell fermentation technology has expanded due to the rise in chronic diseases such as diabetes, heart disease, and cancer. There is a constant need for mammalian cell fermentation tools because many illnesses necessitate long-term therapy, frequently with biologics. Overall, it is anticipated that the market for mammalian cell fermentation technology will expand over the next several years due to the ongoing need for biologics and biosimilars and advances in the treatment of chronic diseases.
Global Mammalian Cell Fermentation Technology Market Report Segmentation
This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global mammalian cell fermentation technology market report based on type, application, end use, and region:
Chinese Hamster Ovary (CHO) Cell Fermentation
Human Embryonic Kidney (HEK) Cell Fermentation
Baby Hamster Kidney (BHK) Cell Fermentation
Murine Myeloma Cell Fermentation
Others
Monoclonal Antibodies
Recombinant Proteins
Vaccines
Hormones
Enzymes
Others
Biopharmaceutical Companies
CMOs & CDMOs
Academic & Research Institutes
North America
Europe
Asia Pacific
Latin America
Middle East & Africa