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Market Research Report

Immuno-Oncology Diagnostics, The Race for Biomarkers, Market Forecasts for Immuno-Oncology Diagnostics. With Executive and Consultant Guides and including Customized Forecasting and Analysis 2019 to 2023

Published by Howe Sound Research Product code 804234
Published Content info 216 Pages
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Immuno-Oncology Diagnostics, The Race for Biomarkers, Market Forecasts for Immuno-Oncology Diagnostics. With Executive and Consultant Guides and including Customized Forecasting and Analysis 2019 to 2023
Published: March 5, 2019 Content info: 216 Pages
Description

New report for listing from Howe Sound Research.

Revolution in cancer therapy to be driven by new diagnostics. Histology, genomics and liquid biopsy converge.

This is a complex area but this readable report will bring the entire management team up to speed, on both the technology and the opportunity.

A revolution in cancer therapy is underway. New therapy based on using the body's natural immune defenses is having unprecedented success. But diagnostics, especially biomarkers are desperately needed to help select the right therapy.

The technology is moving faster than the market. The impact on the health care industry is enormous. Tumor Mutational Burden? Checkpoint Inhibitors? Cytokines? Find out about the technology in readily understood terms that explain the jargon. Find the opportunities and the pitfalls. Understand growth expectations and the ultimate potential market size.

ABOUT THE LEAD AUTHOR

Mr. Greg Powell, B.SC., M.B.A is the President of Howe Sound Research. He is an experienced business and clinical professional. He is co-author of the paper "The Radioimmunoassay of Angiotensinogen by Antibody Trapping." He has worked in laboratory testing and management for over 20 years. Mr. Powell is a member of The American Association for Clinical Chemistry. Mr. Powell's education includes:

B.Sc. (Chemistry) University of BC

M.B.A. (Finance and Policy) University of BC

Market Research Seminar - Burke Institute

Finance for Senior Executives - Harvard Business School

Table of Contents

Table of Contents

i. Market Guides

  • iA. Situation Analysis
  • iB. Guide for Executives and Marketing Staff
  • iC. Guide for Investment Analysts and Management Consultants
  • iD. Impact of the Nobel Prize

1. Introduction and Market Definition

  • 1.1 What are Immuno-Oncology Diagnostics?
  • 1.2 Immuno-oncology - the looming cure
    • 1.2.1 Immuno-oncology Diagnostics Takes a Leading Role
  • 1.3 Market Definition
    • 1.3.1 Market Size
    • 1.3.2 Currency
    • 1.3.3 Years
  • 1.4 Methodology
    • 1.4.1 Authors
    • 1.4.2 Sources
  • 1.5 U.S. Medical Market and laboratory Testing - Perspective
    • 1.4.1 U.S. Medicare Expenditures for Laboratory Testing

2. Immunotherapy - Guide to Immune Technologies

  • 2.0 The Immune System
    • 2.0.1 Innate immune system
      • 2.0.1.1 Surface barriers
      • 2.0.1.2 Inflammation
      • 2.0.1.3 Complement system
      • 2.0.1.4 Cellular barriers
      • 2.0.1.5 Natural killer cells
    • 2.0.2 Adaptive immune system
      • 2.0.2.1 Lymphocytes
      • 2.0.2.2 Killer T cells
      • 2.0.2.3 Helper T cells
      • 2.0.2.4 Gamma delta T cells
      • 2.0.2.5 B lymphocytes and antibodies
    • 2.0.3 Tumor immunology - the immune surveillance system
  • 2.1 Immuno OncologyDiagnostics
    • 2.1.1 Checkpoint Assays
      • 2.1.1.1 Outlook for Checkpoint Assays
    • 2.1.2 Cytokine Assays
      • 2.1.2.1 Outlook for Cytokine Assays
    • 2.1.3 Genomic Germline
      • 2.1.3.1 Outlook for Genomic Germline
    • 2.1.4 Genomic Tumour
      • 2.1.4.1 Outlook for Genomic Tumour
    • 2.1.5 Tumor Microenviroment
      • 2.1.5.1 Outlook for Tumor Micro Environment
    • 2.1.6 Others
      • 2.1.6.1 Outlook for Other Diagnostics

3. Industry Overview

  • 3.1 Players in a Dynamic Market
    • 3.1.1 Academic Research Lab
    • 3.1.2 Diagnostic Test Developer
    • 3.1.3 Genomic Instrumentation Supplier
    • 3.1.3.1 Cell Separation and Viewing Instrumentation Supplier
    • 3.1.4 Pharmaceutical/Reagent Supplier
    • 3.1.5 Independent Testing Lab
    • 3.1.6 Public National/regional lab
    • 3.1.7 Hospital lab
    • 3.1.8 Physician Lab
    • 3.1.9 Audit Body
    • 3.1.10 Certification Body

4. Market Trends

  • 4.1 Factors Driving Growth
    • 4.1.1 Outcome potential
    • 4.1.2 Companion Diagnostics
    • 4.1.3 Funding
    • 4.1.4 Technology Environment
    • 4.1.5 Target Solutions
  • 4.2 Factors Limiting Growth
    • 4.2.1 Complex Role of Diagnostics
    • 4.2.2 Clinical Trials Role
    • 4.2.3 Protocols
  • 4.3 Diagnostic Technology Development
    • 4.3.1 Combinations - Issues and Complexity
    • 4.3.2 Shifting Role of Diagnostics
    • 4.3.3 Multiplexing and Foundation One
    • 4.3.4 The Disruption Dynamic
    • 4.3.5 The Race for Biomarkers
    • 4.3.6 The Next Five Years

5. Cancer Immunotherapy Recent Developments

  • 5.1 Recent Developments - Importance and How to Use This Section
    • 5.1.1 Importance of These Developments
    • 5.1.2 How to Use This Section
    • Icon Acquires MolecularMD
    • Guardant Health to Develop Companion Diagnostic Tests for AstraZeneca
    • Tumor Mutational Burden as Predictor of Immunotherapy Success
    • Foundation Medicine and Merck to Develop Diagnostic Tests for Keytruda
    • Cancer Genetics and NovellusDx to Merge
    • ApoCell Expands Immuno-Oncology Biomarker Services
    • MRM Proteomics Inc and Exactis Innovation Partner
    • Agilent Companion Diagnostic Gains FDA Approval in Urothelial Carcinoma
    • Fluidigm Partners with GenomOncology to Provide Immuno-Oncology Solution
    • MolecularMD Launches Validated Tumor Mutation Burden Assay
    • Minomic Secures Key Patent in the United States and China
    • Biocartis and Wondfo Announce Joint Venture
    • Five Prime Therapeutics Announces Collaboration with Roche to Develop Companion Diagnostics
    • Cancer Genetics Expands Immuno-Oncology Panel
    • 10x Genomics Acquires Epinomics, To Launch ATAC-Seq Product
    • Qiagen, Freenome Partner to Improve Companion Diagnostic Development
    • Personal Genome Diagnostics to Develop Companion Diagnostic for Five Prime
    • Thermo Fisher Expands Oncomine Immuno-Oncology Assay Portfolio
    • Bristol-Myers Squibb and Illumina to Develop Companion Diagnostics for Oncology Immunotherapies
    • HalioDx announces high capacity IHC multiplex technology
    • MolecularMD to Implement Promega's Technology
    • NCI, NanoString Collaborate to Evaluate Utility of PanCancer Gene Expression Panel
    • MIODx to Develop Immune Repertoire Sequencing Assay to Predict Immunotherapy Response
    • Personal Genome Diagnostics Licenses Tumor Mutation Burden from MSKCC
    • HalioDx Closes €18.5M Series B Round
    • Announcement of the 2018 Nobel Prize in Physiology or Medicine

6. Profiles of Key Immunotherapy Companies

  • 10X Genomics
  • Abbott Laboratories
  • Adaptive Biotechnologies
  • Aethlon Medical
  • Agena Bioscience
  • Angle plc
  • Apocell
  • ARUP Laboratories
  • Beckman Coulter
  • Becton Dickinson
  • Bioarray Genetics
  • BioCartis
  • Biocept
  • Biodesix Inc.
  • BioFluidica
  • BioGenex
  • bioMérieux
  • Bio-Rad
  • Bio-Techne
  • Bristol-Myers Squibb
  • Cancer Genetics
  • Caris Molecular Diagnostics
  • CellMax Life
  • Charles River
  • Chronix Biomedical
  • Circulogene
  • Clearbridge BioMedics
  • Clinical Genomics
  • Cynvenio
  • Cytolumina Technologies Corp.
  • CytoTrack
  • Dako (Agilent)
  • Diagnologix LLC
  • Epic Sciences
  • Exosome Diagnostics
  • Fluidigm Corp
  • Fluxion Biosciences
  • Foundation Medicine
  • Freenome
  • Genomic Health
  • GenomOncology
  • GRAIL
  • Guardant Health
  • HalioDx
  • Horizon Discovery
  • HTG Molecular Diagnostics
  • iCellate
  • Illumina
  • Incell Dx
  • Inivata
  • Integrated Diagnostics
  • Invivoscribe
  • Leica Biosystems
  • Luminex
  • MDx Health
  • Merck & Co., Inc
  • MIODx
  • Molecular MD
  • MRM Proteomics Inc
  • Myriad Genetics/Myriad RBM
  • Nanostring
  • Natera
  • Neogenomics
  • New Oncology
  • Oncocyte
  • Ortho Clinical Diagnostics
  • Perkin Elmer
  • Personal Genome Diagnostics
  • Pfizer
  • Promega
  • Protagen Diagnostics
  • Qiagen
  • Quanterix
  • Rarecells SAS
  • Roche Diagnostics
  • Siemens
  • Silicon Biosystems
  • SkylineDx
  • SRI International
  • Sysmex
  • Thermo Fisher
  • Trovagene
  • Vortex Biosciences

7. Global Market Size

  • 7.1 Immuno-oncology Diagnostics Global Market Size by Country with Charts
  • 7.2 Immuno-oncology Diagnostics Global Market Size by Type with Charts

8. Global Market by Type

  • 8.1 Checkpoint Assay Market
    • 8.1.1 Checkpoint Assay Market by Country with Chart
  • 8.2 Cytokine Assay Market
    • 8.2.1 Cytokine Assay Market by Country with Chart
  • 8.3 Genome Germline Market
    • 8.3.1 Genome Germline Market by Country with Chart
  • 8.4 Genome Tumour Market
    • 8.4.1 Genome Tumour Market by Country with Chart
  • 8.5 Tumour Micro Environment Market
    • 8.5.1 Tumour Micro Environment Market by Country with Chart
  • 8.6 Other Market
    • 8.6.1 Other Market by Country with Chart

9. Appendices

  • 9.1 FDA Cancer Drug Approvals by Year
  • 9.2 Clinical Trials Started 2010 to 2016
  • 9.3 Prevalence of Cancer Treatments - 2015

Table of Tables

  • Table 1 List of Cancers by Mortality
  • Table 2 Lab Spending 2014 to 2024
  • Table 3 Overview of Innate and Adaptive Immunity
  • Table 4 FDA Approved Monoclonal Antibodies in Cancer treatment
  • Table 5 FDA Approved Companion diagnostics in Cancer treatment
  • Table 6 Market Players by Type
  • Table 7 Five Factors Driving Growth
  • Table 8 Three Factors Limiting Growth
  • Table 9 Immuno-oncology Diagnostics Global Market by Country/Region
  • Table 10 Immuno-oncology Diagnostics Global Market by Type
  • Table 11 Checkpoint Assay Market by Country
  • Table 12 Cytokine Assay Market by Country
  • Table 13 Genome Germline Market by Country
  • Table 14 Genome Tumour Market by Country
  • Table 15 Tumour Micro Environment Market by Country
  • Table 16 Other Market by Country

Table of Figures

  • Figure 1 Cancer Death Rates - USA, CDC
  • Figure 2 Clinical Lab Spending 2014 to 2024
  • Figure 3 Helper T Cell Roles
  • Figure 4 Antibody Diagram
  • Figure 5 Macrophages attack a Cancer Cell
  • Figure 6 The Tumour Micro Environment
  • Figure 7 Comparing IO Diagnostic and Traditional Testing
  • Figure 8 Growth rates of IO DiagnosticTechnologies
  • Figure 9 Market Size by Country - Key Countries
  • Figure 10 Global Market by Country
  • Figure 11 Chart of Global Market by Type
  • Figure 12 Growth Rates of Diagnostic Segments
  • Figure 13 IO Diagnostics Share Change by Type
  • Figure 14 Chart - Checkpoint Assay Market by Country
  • Figure 15 Chart - Cytokine Assay Market by Country
  • Figure 16 Chart - Genome Germline Market by Country
  • Figure 17 Chart - Genome Tumour Market by Country
  • Figure 18 Chart - Tumour Micro Environment Market by Country
  • Figure 19 Chart - Other Market, Global Size
  • Figure 20 FDA Cancer Drug Approvals by Year
  • Figure 21 Clinical Trials for Immunotherapy by Year
  • Figure 22 Pie Chart of Prevalence of Cancer Treatments
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