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PUBLISHER: KuicK Research | PRODUCT CODE: 1336826

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PUBLISHER: KuicK Research | PRODUCT CODE: 1336826

Global mRNA Cancer Vaccines Market Opportunity & Clinical Pipeline Insight 2023

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“Global mRNA Cancer Vaccines Market Opportunity & Clinical Pipeline Insight 2023” Report Highlights:

  • mRNA Cancer Vaccines Clinical Pipeline Insight: > 40 Vaccines In Trials
  • Highest Phase Of Clinical Development: Phase 3 (August 2023)
  • Till Now (August 2023) No Vaccines Is Commercially Approved In Market
  • mRNA Cancer Vaccines Clinical Pipeline Insight By Indication, Company, Country & Phase
  • RNA Cancer Vaccines Proprietary Technologies By Companies
  • Market Collaborations & Investments Insight

The clinical and commercial landscape of the global mRNA cancer vaccines market is undergoing a transformative shift marked by a surge in investment, strategic collaborations, and the anticipation of groundbreaking advancements in cancer treatment. As pharmaceutical and biotechnology companies recognize the potential of mRNA technology, a fierce competition is slowly unfolding, fuelled by the prospect of developing innovative therapies that target cancer with unprecedented precision.

Pharmaceutical companies are devoting significant resources into pushing mRNA cancer vaccines from the experimental stage to feasible therapeutic options, therefore the market is expanding as a result of research and development investments. Both start-ups and established market players are pursuing the various advantages of mRNA cancer vaccines, such as their fast adaptability and potential to trigger strong immune responses against cancer cells presenting a particular antigen.

Moreover, strategic partnerships between global pharmaceutical giants and biotechnology innovators are shaping the commercial trajectory of mRNA cancer vaccines. The collaborations between BioNTech and Genentech, and Moderna and Merck are prime examples of successful collaboration ventures aimed at the development of novel mRNA vaccines for cancer indications. Such collaborations aim to combine the expertise of both parties, accelerating the development, manufacturing and distribution of these novel therapies. Moreover, the inclusion of mRNA vaccines in diversified oncology pipelines is enhancing companies' overall competitiveness in the rapidly evolving cancer therapeutics market.

The allure of mRNA cancer vaccines has driven a wave of market entrants seeking to establish a strong foothold. The influx of players has led to heightened competition, fostering innovation. Companies are focusing on developing proprietary mRNA platforms, targeting not only established cancers but also exploring applications in rarer cancer indications. For instance, BioNTech's FixVac platform has been used to develop 5 of the company's mRNA cancer vaccines. The company has another platform, called the iNeST platform. Both platforms allow the developed of individualized cancer vaccines. In addition, the competition has also increased the efficiency in production processes, pricing strategies and distribution networks.

However, commercialization of mRNA cancer vaccines presents challenges that necessitate careful consideration. Pricing strategies must strike a delicate balance between ensuring patient accessibility and providing a return on the substantial investments required for research and development. Several factors influence the cost of a cancer therapeutic. These include research and development costs, manufacturing complexities, production scale and volume, supply chain logistics, intellectual property and licensing. However, it is also expected the competition resulting from increasing market entry of different mRNA cancer vaccines will help these vaccines be sold at affordable prices.

In addition, navigating regulatory pathways, securing intellectual property rights and addressing potential safety concerns are also critical components in successfully bringing mRNA cancer vaccines to the market. The approval of the first mRNA-based COVID-19 vaccines has paved the way for a smoother regulatory process for subsequent mRNA therapies, including those for cancer. As regulatory agencies around the world become more familiar with mRNA technology, the time and resources required for market entry may potentially decrease, expediting commercialization efforts.

Lastly, the global mRNA cancer vaccines market is not confined by geographical boundaries. Market expansion strategies involve penetrating diverse healthcare ecosystems and collaborating with regional stakeholders. As these vaccines contribute to demonstrate their efficacy and safety, their adoption across different markets holds the promise of changing treatment paradigms and contributing to the fight against cancer on a global scale.

The global market for mRNA cancer vaccines has a promising future but it also has different aspects that need to be addressed. Even while the potential for a substantial clinical impact of mRNA cancer vaccines is obvious, their commercialization will be dependent on factors such as regulatory clearance, market acceptance, reimbursement policies, and the ability to manage complex supply chain networks. Therefore, the global market for mRNA cancer vaccines is a mosaic of tactical planning, collaborations, and discoveries. Understanding the complex interactions between global expansion strategies, competitive dynamics, pricing strategies and investment trends in critical to be able to grab a sizeable market share in the global market.

Table of Contents

1. mRNA Vaccines as Next Generation Cancer Immunotherapy

  • 1.1 mRNA Vaccines Overview
  • 1.2 mRNA Vaccines v/s Other Cancer Therapeutic Approaches
  • 1.3 mRNA Vaccines v/s Other Vaccines

2. Global mRNA Cancer Vaccines Market Overview

  • 2.1 Current Market Landscape
  • 2.2 Future Clinical & Commercialization Opportunities

3. Global mRNA Cancer Vaccines Market Trends by Country

  • 3.1 US
  • 3.2 China
  • 3.3 Australia
  • 3.4 Europe
  • 3.5 Canada

4. Global mRNA Cancer Vaccines Market Collaborations, Deals & Investments

5. Global mRNA Cancer Vaccines Market Clinical Landscape by Indication

  • 5.1 Breast Cancer
  • 5.2 Brain Cancer
  • 5.3 Melanoma
  • 5.4 Colorectal Cancer
  • 5.5 Head & Neck Cancers

6. Global mRNA Cancer Vaccines Clinical Pipeline Overview

  • 6.1 By Company
  • 6.2 By Country
  • 6.3 By Patient Segment
  • 6.4 By Phase
  • 6.5 By Priority Status

7. Global mRNA Cancer Vaccines Clinical Pipeline By Company, Indication & Phase

  • 7.1 Research
  • 7.2 Preclinical
  • 7.3 Phase-I
  • 7.4 Phase-I/II
  • 7.5 Phase-II
  • 7.6 Phase-II/III
  • 7.7 Phase-III

8. Proprietary Technologies & Methodologies for RNA Cancer Vaccines Development

  • 8.1 FixVac - BioNTech
  • 8.2 iNeST - BioNTech
  • 8.3 NanoReady - Samyang Holdings
  • 8.4 CureVac Method - CureVac
  • 8.5 mRNA platform - Moderna
  • 8.6 NeoCura Ag - NeoCura

9. Competitive Landscape

  • 9.1 Avstera Therapeutics
  • 9.2 BioNTech
  • 9.3 Combined Therapeutics
  • 9.4 CureVac
  • 9.5 EpiVax
  • 9.6 Immorna
  • 9.7 Immune Design
  • 9.8 MDimune
  • 9.9 Moderna Therapeutics
  • 9.10 NeoCura
  • 9.11 Orna Therapeutics
  • 9.12 pHion Therapeutics
  • 9.13 Regen BioPharma
  • 9.14 RNAimmune
  • 9.15 TransCode Therapeutics

List of Figures

  • Figure 5-1: KEYNOTE-603 Phase I Study - Initiation & Completion Years
  • Figure 5-2: GO39733 Phase I Study - Initiation & Completion Years
  • Figure 5-3: ATTAC-II Phase II Study - Initiation & Completion Years
  • Figure 5-4: CV-GBLM-001 Phase I Study - Initiation & Completion Years
  • Figure 5-5: GO39733 Phase II Study - Initiation & Completion Years
  • Figure 5-6: BNT111-01 Phase II Study - Initiation & Completion Years
  • Figure 5-7: BNT122-01 Phase II Study - Initiation & Completion Years
  • Figure 5-8: AHEAD-MERIT Phase II Study - Initiation & Completion Years
  • Figure 5-9: KEYNOTE-603 Phase II Study - Initiation & Completion Years
  • Figure 6-1: Global - mRNA Cancer Vaccines Clinical Pipeline by Company (Numbers), 2023
  • Figure 6-2: Global - mRNA Cancer Vaccines Clinical Pipeline by Country (Numbers), 2023
  • Figure 6-3: Global - mRNA Cancer Vaccines Clinical Pipeline by Patient Segment (Numbers), 2023
  • Figure 6-4: Global - mRNA Cancer Vaccines Clinical Pipeline by Phase (Numbers), 2023
  • Figure 6-5: Global - mRNA Cancer Vaccines Clinical Pipeline by Priority Status (Numbers), 2023
  • Figure 8-1: BioNTech - uRNA products
  • Figure 8-2: BioNTech - iNeST technology
  • Figure 8-3: CureVac - CureVac Method for Generation of mRNA Therapeutics
  • Figure 8-4: Moderna - mRNA Technology
  • Figure 8-5: NeoCura - NeoCura Ag Platform

List of Tables

  • Table 1-1: mRNA Vaccines v/s Other Cancer Therapeutic Approaches
  • Table 1-2: mRNA-Based Cancer Vaccines vs. Other Cancer Vaccines
  • Table 2-1: Recent Designations Granted to Investigational mRNA Cancer Vaccines
  • Table 5-1: Breast Cancer mRNA Vaccines in Clinical Trials
  • Table 5-2: Brain Cancer mRNA Vaccines in Clinical Trials
  • Table 5-3: Melanoma mRNA Vaccines in Clinical Trials
  • Table 5-4: Colorectal Cancer mRNA Vaccines in Clinical Trials
  • Table 5-5: Head & Neck Cancer mRNA Vaccines in Clinical Trials
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