Chiral Chromatography Columns - Market Share Analysis, Industry Trends & Statistics, Growth Forecasts (2024 - 2029)

The Chiral Chromatography Columns Market size is estimated at USD 104.17 million in 2024, and is expected to reach USD 132.13 million by 2029, growing at a CAGR of 4.87% during the forecast period (2024-2029).

The COVID-19 pandemic is likely to have a slightly positive effect on the market. Robust analytical techniques were used by researchers worldwide in the creation of efficient COVID-19 treatments. As per the study report published by Scientific Reports in April 2021, the normal phase chiral high-performance liquid chromatography (HPLC) method provides an essential analytical tool for the preclinical and clinical evaluation of hydroxychloroquine that was tested in the clinics for the potential treatment of COVID-19. Hence the advanced techniques in chiral chromatography were expected to have a positive impact on the market during the pandemic. As the trials are still ongoing for the treatment of COVID-19 it is expected to have a significant impact on the market over the coming years.

The major factors attributing to the growth of the chiral chromatography columns market are the advancement in the technology of chromatography instruments and the significance of chromatography-based studies in drug approval. Higher government expenditure, funding, and subsidies have encouraged pharmaceutical and biotechnology industries to use the advanced chromatographic method that is propelling market growth.

For instance, as per the report published by the Multidisciplinary Digital Publishing Institute in December 2021, on five distinct polysaccharide-type chiral selectors, four phthalimide-analog thalidomide derivatives were successfully separated through enantioseparation in a polar organic mobile phase mode which opens up the possibility of a new type of chiral screening strategy. Hence new types of strategies can be identified through the chiral chromatography on the drug molecules and are expected to drive the market to grow.

Moreover, new collaborations and acquisitions among the major players are also expected to have a positive impact on the market. For instance, in February 2022, Sartorius closed the acquisition of the Novasep chromatography division following approval by the United States Federal Trade Commission. The portfolio acquired comprises chromatography systems primarily suited for smaller biomolecules, such as oligonucleotides, peptides, and insulin, as well as innovative systems for the continuous manufacturing of biologics. Thus, due to the above-mentioned factors, the studied market is expected to be significantly driven.

However, the rising price of the equipment is expected to hinder the market growth.

Chiral Chromatography Columns Market Trends

Prepacked Column Segment Expected to Dominate the Market Over the Forecast Period

• Prepacked columns help to manage the time-consuming, laborious process of packing chromatography columns, leaving more time for processing the product. The prepacked column is expected to dominate the market over the forecast period, attributed to augmenting demand for analytical volumes in industries and laboratories. Virus titer reduced testing, increased demand for antibody purification and vaccines, and recombinant proteins have surged the pre-packaged column chromatography market.
• Cost-effective purification and process development of biological drugs are also attributed to the growth of this segment. Another main factor affecting the dynamics of the industry is the fast growth of the pharmaceutical, biotechnology, proteomics & life science market with new product approvals and launches. For instance, in June 2022, Bio-Rad Laboratories, Inc launched its CHT-prepacked Foresight Pro Columns, designed to support downstream process-scale chromatography applications across different stages of biological drug development and production. The standardized design and format of prepacked columns offer a more cost-effective and flexible solution than customer-packed options.
• Furthermore, the new advancements in prepacked column performance help the market grow. As per the report published by Wiley Analytical Science in March 2022, the machine learning model offered excellent predictive capabilities for the plate height and the asymmetry, with packing quality strongly influenced by backbone and functional mode. Hence with these new machine learning methods, the performance of prepacked columns can be predicted, which is expected to have significant growth in the market.
• Therefore, owing to the above factors, the growth of the chiral chromatography columns market is expected to grow through the prepacked columns segment over the forecast period.

North America Expected to Dominate the Market Over the Forecast Period

• North America is expected to dominate the overall chiral chromatography columns market over the forecast period. It accounts for the largest share of the chromatography market due to growing government investments and funding for research.
• The United States holds the largest market share in the North American region owing to different factors, such as novel advancements, a significant rise in unique product approvals, and launches driving chromatography market growth. For instance, in June 2022, Tosoh Bioscience LLC, based in Pennsylvania, United States, introduced 2.5 and 5.0 cm ID SkillPak pre-packed columns (SkillPak 50 and SkillPak 200). These columns are designed for the process development of monoclonal antibodies, antibody fragments, antibody-drug conjugates, oligonucleotides, and viruses. Similarly, in November 2021, Daicel Chiral Technologies launched its CHIRALPAK IK, which is a new immobilized selector built on the success of CHIRALPAK IG, one of the most effective chiral chromatography phases used in laboratories.
• Furthermore, the distribution and collaboration agreements among the major chromatography players are expected to positively impact the market. For instance, in June 2021, Orochem Technologies Inc, a United States-based advanced chemical technology and chromatography company, signed a distribution agreement with Altmann Analytik GmbH & Co. KG for the worldwide marketing & sales of sample preparation, chromatography, and proteomics products except for China and India.
• Therefore, owing to the above factors, the growth of the chiral chromatography columns market in North America is expected to drive over the forecast period.

Chiral Chromatography Columns Industry Overview

The chiral chromatography columns market is moderately competitive and consists of major players. In terms of market share, a few major players are currently dominating the market. Some prominent players are vigorously making acquisitions and new product launches with other companies to consolidate their market positions across the globe. Some of the companies which are currently dominating the market are Merck KGaA, Shimadzu Corporation, Daicel Corporation, Thermo Fisher Scientific Inc., Bio-Rad Laboratories, Danaher Corporation (Phenomenex Inc.), General Electric Company (GE Healthcare), and Agilent Technologies.

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