PUBLISHER: Roots Analysis | PRODUCT CODE: 1723658
PUBLISHER: Roots Analysis | PRODUCT CODE: 1723658
As per Roots Analysis, the global non-viral drug delivery systems market size is valued at $8.6 billion in the current year and is projected to reach $20.4 billion by 2035, growing at a CAGR of 9.0% during the forecast period.
The opportunity for non-viral drug delivery systems market has been distributed across the following segments:
Type of Molecule Delivered
Type of Biologics Delivered
Type of Vehicle Used
Target Therapeutic Area
Type of Payment Employed
Key Geographical Regions
Non-viral drug delivery represents an innovative approach that serves as a promising alternative to viral vectors for delivering genetic material or biotherapeutics to cells, tissues or organs. Notably, in recent years, several intracellular non-viral drug delivery methods have gained significant traction owing to their efficiency in delivering drugs. This growing interest of stakeholders in intracellular non-viral drug delivery methods can be attributed to the various advantages associated with non-viral vectors over viral vectors, including enhanced safety, higher specificity towards the target cells and a reduced risk of activating immune responses. Moreover, non-viral vectors lower the likelihood of mutagenesis, making them a preferred option for gene delivery. They can also carry larger payloads compared to the viral vectors, such as adeno-associated viral vectors, increasing their applications in targeted drug delivery. Notable examples of non-viral vectors include nanoparticles (particularly lipid nanoparticles), cell penetrating peptides (CPPs) and exosome-based drug delivery systems. These non-viral vectors leverage specialized mechanisms to target intracellular proteins and enzymes, typically employing conjugation and / or encapsulation techniques to deliver RNA, peptides, antibodies, proteins and DNA into cells. Targeted drug delivery ensures that an adequate concentration of therapeutic agents reaches the intended physiological site of action, maximizing the clinical benefits while minimizing off-targets effects and systemic toxicity. Additionally, it is important to highlight that the ongoing advancements in cell biology and drug delivery systems have uncovered several potential therapeutic targets that were previously considered incurable owing to their localization within the cell membrane.
In September 2024, NanoSyrinx secured $13 million in seed funding to advance its intracellular nanosyringe technology, designed to target biologics in hard-to-reach sites within cells. Reflecting on the development, Dr. Edwin Moses (Chairman of Board of Directors, NanoSyrinx), quoted that "NanoSyrinx's technology promises to make a positive difference to the existing challenges associated with intracellular delivery of therapeutics. I am delighted to join the Board and help build on the momentum of this latest fundraise, to support the company and its leadership team in the further development of this unique platform which has the potential to create enormous value and make a real difference to patients' lives".
Research suggests that over 20% of the human proteome, including oncogenic proteins, cell metabolism regulators, and components of key signaling pathways are localized within the cell membrane. Given that only 10% of the human genome can be effectively targeted with small molecule drugs, industry experts see intracellular therapies, particularly gene delivery, as a compelling alternative to conventional treatments. Given the increasing demand for targeted non-viral drug delivery coupled with the ongoing pace of innovation in the development of non-viral drug delivery systems, the overall market is anticipated to witness substantial market growth during the forecast period.
The report delves into the current state of the non-viral drug delivery systems market and identifies potential growth opportunities within the industry. The key takeaways of the report are:
Biologics are Likely to Hold the Largest Share of the Non-Viral Drug Delivery Systems Market During the Forecast Period
Based on the type of molecule, the global market is segmented into small molecules and biologics. Amongst these types, the biologics segment occupies the largest share of the current overall market. This can be attributed to their ability to target specific, complex biological pathways, offering greater precision and efficacy.
Based on the Type of Biologic Delivered, RNA Segment Captures the Majority of the Current Market Share
Based on the type of biologic delivered, the global non-viral drug delivery systems market is segmented into RNA, DNA, proteins / peptides and antibodies. Presently, the RNA segment occupies the highest share of the overall market. However, it is important to note that the antibodies' segment is anticipated to grow at a relatively higher CAGR during the forecast period.
Nanoparticles Segment is Likely to Hold the Largest Share in the Non-Viral Drug Delivery Systems Market During the Forecast Period
Based on the type of vehicle used, the global non-viral drug delivery systems market is segmented into nanoparticles, extracellular vesicles, polymers, oligonucleotides and cell penetrating peptides. Currently, nanoparticles segment leads the non-viral drug delivery systems market. It is important to highlight that this trend is unlikely to change in the future as well. This is due to the unique size and large surface area-to-volume ratio of nanoparticles which enables them to be precisely engineered in order to target specific tissues, allowing for controlled drug release as compared to other drug delivery vehicles.
Non-Viral Drug Delivery Systems Market for Oncological Disorders is Likely to Grow at a Relatively Faster Pace During the Forecast Period
Based on the target therapeutic area, the global non-viral drug delivery systems market is segmented across oncological disorders, infectious diseases, cardiovascular disorders, genetic disorders, hepatic disorders, metabolic disorders, neurological disorders, pulmonary disorders, rare disorders and other disorders. Presently, the market is dominated by the revenues generated through the systems intended for the treatment of oncological disorders. However, the market for infectious disease is anticipated to witness a higher growth rate during the forecast period owing to the pressing need for effective targeted treatments against rapidly evolving pathogens.
Upfront Payments are Likely to Dominate the Non-Viral Drug Delivery Systems Market During the Forecast Period
Based on the type of payment employed, the global non-viral delivery systems market is distributed across upfront payments and milestone payments. Presently, the upfront segment occupies the highest share in the non-viral drug delivery systems market. Further, it is important to highlight that this trend is unlikely to change in the future as well.
North America Accounts for the Largest Share in the Market
Based on key geographical regions, the market is segmented into North America, Europe, and Asia Pacific. In the current scenario, North America is likely to capture the largest market share. Further, it is worth highlighting that Asia-Pacific is expected to grow at a relatively high CAGR during the forecast period.
The report on non-viral drug delivery systems market features insights into various sections, including:
FRAMEWORK AND BCG MATRIX