MICROBIAL FERMENTATION CMO MARKET: OVERVIEW
As per Roots Analysis, the global microbial fermentation CMO market is estimated to grow from USD 3.6 billion in the current year to USD 9.1 billion by 2035, at a CAGR of 8.7% during the forecast period, till 2035.
The market sizing and opportunity analysis has been segmented across the following parameters:
Type of Expression System
- Bacterial Expression Systems
- Yeast Expression Systems
- Other Expression Systems
Type of Biologic
- Recombinant Proteins
- Enzymes
- Plasmid DNA
- Antibodies
- Other Biologics
Company Size
- Small
- Mid-Sized
- Large and Very Large
End Users
- Pharma / Biotech Companies
- Academic / Research Institutes
Key Geographical Regions
- North America
- Europe
- Asia-Pacific
- Rest of the World
MICROBIAL FERMENTATION CMO MARKET: GROWTH AND TRENDS
In recent years, the field of microbial fermentation has experienced a renaissance, with the microbial biopharmaceutical industry increasingly focusing on the production of biologics through advanced microbial expression systems. The modification and innovation in microbial fermentation-based expression systems for the production of various biologics have sidelined some of the earlier concerns associated with them like improper 3D folding of the biologics that can lead to inactive or even harmful proteins. As a result, microbial fermentation systems have facilitated the contract manufacturing of high-quality biologics in larger quantity. Further, the increasing adoption of microbial fermentation for the production of biologics has been driven by the advancements in innovative technologies and platforms offered by leading microbial fermentation companies. Over time, the microbial fermentation domain has significantly evolved and has led to the production of various biologics, primarily proteins.
Currently, a wide range of traditional and advanced microbial expression systems / platforms, utilizing bacteria, fungi, and yeast, are employed to produce diverse biologics, particularly smaller molecules such as cytokines, growth factors, plasmid DNA, nucleic acids, single-domain antibodies, and non-glycosylated antibody fragments. Consequently, microbial fermentation is likely to present lucrative market growth opportunities for contract service providers and the microbial fermentation CMO market is anticipated to grow faster in the coming years.
MICROBIAL FERMENTATION CMO MARKET: KEY INSIGHTS
The report delves into the current state of the microbial fermentation CMO market and identifies potential growth opportunities within the industry. Some key findings from the report include:
- Presently, more than 120 players are engaged in offering microbial fermentation contract manufacturing services across the globe; most of these players are headquartered in Europe.
- The current market landscape of microbial fermentation CMOs is fragmented, featuring the presence of both new entrants and established players; majority of these players offer process development services.

- Owing to the rise in demand for biologics, service providers and drug innovators are upgrading their technical expertise to efficiently manufacture high-quality products using microbial expression systems.
- The growing interest in this domain is evident from the rise in partnership activity; in fact, the maximum number of collaborations related to microbial fermentation were inked in the last two years.
- Industry players are making extensive efforts to expand their existing capacities and capabilities for both clinical and commercial scale microbial fermentation.
- The microbial fermentation CMO market is likely to grow at a CAGR of 8.7%, till 2035; presently, majority of the market share is occupied by upstream bacterial expression system.
- The microbial fermentation contract manufacturing market is anticipated to be primarily driven by the rising demand for biologics; Europe is expected to capture a larger share (over 40%) of the market by 2035
MICROBIAL FERMENTATION CMO MARKET: KEY SEGMENTS
Bacterial Expression System Segment Occupies the Largest Share of the Microbial Fermentation CMO Market
Based on the type of expression system, the market is segmented into bacterial expression systems, yeast expression systems and other expression systems. At present, the bacterial expression systems segment holds the maximum share of the global microbial fermentation CMO market owing to its cost-effectiveness in culturing, ease of genetic manipulation, and fast production of recombinant proteins. Additionally, the yeast expression systems segment is likely to grow at a faster pace during the forecasted period.
By Type of Biologic, Plasmid DNA is the Fastest Growing Segment of the Global Microbial Fermentation CMO Market
Based on the type of biologic, the market is segmented into recombinant proteins, enzymes, plasmid DNA, antibodies and other biologics. Currently, the recombinant proteins segment captures the highest proportion of the global microbial fermentation CMO market. Further, the microbial fermentation CMO market for plasmid DNA is likely to grow at a relatively higher CAGR during the forecast period. This can be attributed to the increasing demand for the next- generation therapeutics.
Large and Very Large Contract Manufacturers Occupy the Largest Share of the Microbial Fermentation CMO Market by Company Size
Based on the company size, the market is segmented into small, mid-sized, large and very large companies. At present, large and very large contract manufacturers hold the maximum share of the microbial fermentation CMO market. Further, it is worth highlighting that the microbial fermentation CMO market for the mid-sized players segment is likely to grow at a relatively higher CAGR.
Currently, the Pharma / Biotech Companies Segment Holds the Largest Share of the Microbial Fermentation CMO Market
Based on the end users, the global market is segmented into pharma / biotech companies and academic / research institutes. Currently, the pharma / biotech companies segment holds the largest market share. In fact, this trend is likely to remain the same in the coming future.
Europe Accounts for the Largest Share of the Market
Based on key geographical regions, the market is segmented into North America, Europe, Asia-Pacific and Rest of the World. Currently, Europe dominates the global microbial fermentation CMO market and accounts for the largest revenue share. Further, the market in Asia-Pacific is expected to grow at a higher CAGR in the coming years.
Example Players in the Microbial Fermentation CMO Market
- AbbVie
- BOC Sciences
- Eurofins
- FUJIFILM Diosynth Biotechnologies
- GSK
- Lonza
- Sandoz
MICROBIAL FERMENTATION CMO MARKET: RESEARCH COVERAGE
- Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the global microbial fermentation CMO market, focusing on key market segments, including [A] type of expression system, [B] type of biologic, [C] company size, [D] end users and [E] key geographical regions.
- Market Landscape: A comprehensive evaluation of the companies engaged in microbial fermentation CMO market, based on several relevant parameters, such as [A] year of establishment, [B] company size, [C] location of headquarters, [D] types of services offered, [E] affiliated services, [F] AI support, [G] analytical techniques used, [H] therapeutic areas and [I] regulatory certifications / accreditations.
- Company Competitiveness Analysis: A comprehensive competitive analysis of service providers in the microbial fermentation industry, examining factors, such as [A] developer strength and [B] product portfolio strength.
- Company Profiles: In-depth profiles of key service providers engaged in the microbial fermentation market, focusing on [A] overview of the company, [B] financial information (if available), [C] service portfolio, and [D] recent developments and an informed future outlook.
- Partnerships and Collaborations: An insightful analysis of the deals inked by stakeholders in the microbial fermentation market, based on several parameters, such as [A] year of partnership, [B] type of biologic, [D] type of partner, [E] most active players (in terms of the number of partnerships signed) and [F] geographical distribution of partnership activity.
- Recent Expansions: In-depth analysis of the various expansion initiatives undertaken by contract biomanufacturers in this domain, based on several parameters, such as [A] year of expansion, [B] type of expansion, [C] microbial fermentation capacity, [D] type of biologic manufactured, [E] location of expanded facility, [F] type of expansion, [G] most active players and [H] geography.
- Big Pharma Initiatives in Microbial Manufacturing: An insightful analysis of big pharma players initiatives, based on several parameters, such as [A] number of initiatives, [B] year of initiative, and [C] types of initiatives.
- Attractiveness Competition Matrix: A detailed discussion on proprietary 2X2 representation to assess the current market scenario across emerging and established market segments.
- Make Versus Buy Decision Making Framework: An insightful analysis of the various factors that biopharmaceutical therapeutics / drug developers should consider while deciding whether to manufacture their respective products in-house or engage the services of CMOs.
- Case Study 1: A detailed discussion on the microbial fermentation technology / platforms that are available in the market. Additionally, a detailed discussion on emerging microbial fermentation technologies.
- Case Study 2: A detailed discussion on the key characteristics of large and small molecule drugs, along with information on the steps involved in their respective manufacturing processes.
- Market Impact Analysis: A thorough analysis of various factors, such as drivers, restraints, opportunities, and existing challenges that are likely to impact market growth.
KEY QUESTIONS ANSWERED IN THIS REPORT
- How many companies are currently engaged in this market?
- Which are the leading companies in this market?
- What factors are likely to influence the evolution of this market?
- What is the current and future market size?
- What is the CAGR of this market?
- How is the current and future market opportunity likely to be distributed across key market segments?
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