PUBLISHER: The Business Research Company | PRODUCT CODE: 1720895
PUBLISHER: The Business Research Company | PRODUCT CODE: 1720895
Sphingosine 1 phosphate receptor (S1PR) modulator drugs are a class of therapeutic agents that specifically target sphingosine-1-phosphate (S1P) receptors, a family of G-protein-coupled receptors involved in essential cellular processes. These drugs regulate the activity of S1P receptors, which play a crucial role in immune cell trafficking, vascular function, and inflammation.
The primary types of sphingosine 1 phosphate receptor (S1PR) modulator drugs include fingolimod and ozanimod. Fingolimod is an oral medication used for treating multiple sclerosis (MS) by modulating the immune system to prevent nerve damage associated with the disease. These drugs are available in different routes of administration, including oral, injectable, and topical forms, and are used for treating multiple sclerosis, cardiovascular diseases, and transplant rejection. Their primary end-users include hospitals, rehabilitation centers, and retail pharmacies.
The sphingosine 1 phosphate receptor (S1PR) modulator drugs market research report is one of a series of new reports from The Business Research Company that provides sphingosine 1 phosphate receptor (S1PR) modulator drugs market statistics, including the sphingosine 1 phosphate receptor (S1PR) modulator drugs industry global market size, regional shares, competitors with the sphingosine 1 phosphate receptor (S1PR) modulator drugs market share, detailed sphingosine 1 phosphate receptor (S1PR) modulator drugs market segments, market trends, and opportunities, and any further data you may need to thrive in the sphingosine 1 phosphate receptor (S1PR) modulator drugs industry. This sphingosine 1 phosphate receptor (S1PR) modulator drugs market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.
The sphingosine 1 phosphate receptor (S1PR) modulator drugs market size has grown strongly in recent years. It will grow from $2.44 billion in 2024 to $2.60 billion in 2025 at a compound annual growth rate (CAGR) of 6.3%. The growth in the historic period can be attributed to the increasing prevalence of autoimmune diseases, greater investment in autoimmune drug development, the expansion of treatment indications, rising awareness of autoimmune disease management, and higher healthcare expenditure.
The sphingosine 1 phosphate receptor (S1PR) modulator drugs market size is expected to see strong growth in the next few years. It will grow to $3.28 billion in 2029 at a compound annual growth rate (CAGR) of 6.0%. The growth in the forecast period can be attributed to growing demand for oral therapies over injectables, increasing prevalence of autoimmune diseases, rising healthcare expenditure globally, growth in awareness and diagnosis of conditions such as multiple sclerosis, and rising geriatric population prone to autoimmune diseases. Major trends in the forecast period include advancements in receptor selectivity, regulatory approvals for new indications, integration of real-world evidence (RWE), technological advancements in drug delivery, a shift toward oral therapies, strategic collaborations, and acquisitions.
The increasing prevalence of autoimmune diseases is expected to drive the expansion of the sphingosine 1-phosphate receptor (S1PR) modulator drugs market. Autoimmune diseases occur when the immune system mistakenly attacks the body's healthy cells, leading to inflammation and tissue damage. Factors such as genetics, environmental triggers, lifestyle changes, and improved diagnostic capabilities contribute to the growing incidence of these conditions. S1PR modulator drugs help regulate immune cell migration, reducing inflammation in autoimmune diseases such as multiple sclerosis and ulcerative colitis. For example, in May 2024, data published by the National Center for Health Statistics (NCHS), a US-based health statistics agency, indicated that the prevalence of current asthma among adults aged 18 and over in the United States increased from 8.4% in 2021 to 8.7% in 2022. Additionally, the incidence of asthma episodes within the past 12 months for adults in the same age group rose from 3.3% in 2021 to 3.7% in 2022. As a result, the rising prevalence of autoimmune diseases is fueling the growth of the S1PR modulator drugs market.
Leading companies in the S1PR modulator drugs market are emphasizing the development of innovative therapies, such as oral treatments, to improve patient compliance, enhance drug efficacy, and expand the therapeutic potential of these medications in managing autoimmune diseases. Oral therapy involves administering medications in pill or tablet form, providing a convenient and non-invasive treatment option for patients. For instance, in March 2022, Pfizer, a US-based pharmaceutical and biotechnology company, announced positive phase 3 trial results for etrasimod in ulcerative colitis patients. The drug met its primary and key secondary endpoints, demonstrating significant improvements in remission rates, endoscopic outcomes, and symptom relief. These results highlight etrasimod's potential as a new treatment option for moderate-to-severe ulcerative colitis. Pfizer plans to advance regulatory submissions, reinforcing its immuno-inflammatory disease portfolio and commitment to innovative healthcare solutions.
In December 2023, Vanda Pharmaceuticals, a US-based pharmaceutical company, acquired the U.S. and Canadian rights to PONVORY from Actelion Pharmaceuticals Ltd. for an undisclosed amount. This acquisition strengthens Vanda's portfolio by adding an innovative therapy for relapsing multiple sclerosis (MS), a condition with increasing prevalence and a significant unmet medical need. Actelion Pharmaceuticals Ltd., a Switzerland-based biopharmaceutical company, specializes in developing sphingosine 1-phosphate receptor (S1PR) modulator drugs for various diseases.
Major players in the sphingosine 1 phosphate receptor (s1pr) modulator drugs market are Pfizer Inc., Johnson & Johnson, Merck & Co. Inc., AbbVie Inc., Bristol Myers Squibb Company, Novartis International AG, Biogen Inc., Eisai Co. Ltd., Sun Pharmaceutical Industries Ltd., Ono Pharmaceutical Co. Ltd., Actelion Pharmaceuticals Ltd., KYORIN Pharmaceutical Co. Ltd., Vanda Pharmaceuticals Inc., Celgene Corporation, Ventyx Biosciences Inc., Idorsia Pharmaceuticals Ltd., Cayman Chemical Company, Juvise Pharmaceuticals, Priothera Limited, and Arena Pharmaceuticals.
Asia-Pacific was the largest region in the sphingosine 1 phosphate receptor (S1PT) modulator drugs market in 2024. The regions covered in sphingosine 1 phosphate receptor (S1PR) modulator drugs report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the sphingosine 1 phosphate receptor (S1PR) modulator drugs market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The sphingosine 1 phosphate receptor (S1PR) modulator drugs market consists of sales of non-selective S1PR modulators, selective S1PR1 modulators, and next-generation and experimental S1PR modulators. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Sphingosine 1 Phosphate Receptor (S1PR) Modulator Drugs Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on sphingosine 1 phosphate receptor (s1pr) modulator drugs market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for sphingosine 1 phosphate receptor (s1pr) modulator drugs ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The sphingosine 1 phosphate receptor (s1pr) modulator drugs market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.