PUBLISHER: The Business Research Company | PRODUCT CODE: 1730994
PUBLISHER: The Business Research Company | PRODUCT CODE: 1730994
PARP inhibitors (poly(ADP-ribose) polymerase inhibitors) are a class of drugs primarily used in cancer treatment. These medications work by inhibiting DNA repair in cancer cells, especially in cancers with BRCA mutations. They are commonly prescribed for ovarian and breast cancers and are typically taken orally. PARP inhibitors help lower the risk of cancer recurrence after chemotherapy, though they may cause side effects such as fatigue and low blood cell counts.
The main types of PARP inhibitors include olaparib, rucaparib, niraparib, talazoparib, and others. Olaparib is a well-known PARP inhibitor used to treat BRCA-mutated ovarian, breast, pancreatic, and prostate cancers by blocking DNA repair in cancer cells, which leads to cell death. These drugs are used for various indications, including ovarian cancer, breast cancer, prostate cancer, and pancreatic cancer. They are distributed via hospital pharmacies, retail pharmacies, and online platforms, and are utilized by hospitals, specialty clinics, research institutions, and other healthcare settings.
The poly (ADP-Ribose) polymerase (PARP) inhibitors market research report is one of a series of new reports from The Business Research Company that provides poly (ADP-Ribose) polymerase (PARP) inhibitors market statistics, including the poly (ADP-Ribose) polymerase (PARP) inhibitors industry global market size, regional shares, competitors with the poly (ADP-Ribose) polymerase (PARP) inhibitors market share, detailed poly (ADP-Ribose) polymerase (PARP) inhibitors market segments, market trends, and opportunities, and any further data you may need to thrive in the poly (ADP-Ribose) polymerase (PARP) inhibitors industry. This poly (ADP-Ribose) polymerase (PARP) inhibitors market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.
The poly(ADP-ribose) polymerase (PARP) inhibitors market size has grown rapidly in recent years. It will grow from $6.53 billion in 2024 to $7.56 billion in 2025 at a compound annual growth rate (CAGR) of 15.7%. The growth during the historic period can be attributed to factors such as the rising incidence of cancer, increased genetic testing, higher success rates in clinical trials, expanding insurance coverage, and growth in cancer research.
The poly(ADP-ribose) polymerase (PARP) inhibitors market size is expected to see rapid growth in the next few years. It will grow to $13.45 billion in 2029 at a compound annual growth rate (CAGR) of 15.5%. The growth during the forecast period can be attributed to factors such as the increasing production and supply of drugs, the rising prevalence of BRCA-mutated cancers, the growing incidence of breast cancer, the expanding use of monoclonal antibodies, and rising healthcare expenditure. Key trends in the forecast period include advancements in biomarker research, the use of combination therapies, the integration of artificial intelligence in drug development, progress in biomarker-driven therapies, and the development of next-generation PARP inhibitors.
The increasing prevalence of breast cancer is expected to drive the growth of the poly(ADP-ribose) polymerase (PARP) inhibitors market. Breast cancer is a disease where breast cells grow uncontrollably, forming malignant tumors that can spread to other areas of the body. Factors contributing to the rising prevalence include aging populations, lifestyle changes, genetic factors, hormonal imbalances, obesity, alcohol consumption, and exposure to environmental risks. PARP inhibitors help breast cancer patients by blocking the PARP enzyme's ability to repair DNA damage in cancer cells, causing cell death, particularly in tumors with BRCA1 or BRCA2 mutations. According to the National Breast Cancer Foundation, in January 2025, one in eight women in the United States will be diagnosed with breast cancer in their lifetime. In 2024, 310,720 women and 2,800 men were diagnosed with invasive breast cancer. As a result, the increasing prevalence of breast cancer is fueling the growth of the PARP inhibitors market.
Companies in the PARP inhibitors market are focused on advancing cancer treatments, such as anticancer medications, to target specific genetic mutations found in some cancers. These medicines work by inhibiting the growth of cancer cells, preventing their spread, or destroying them through various mechanisms, such as interfering with cell division, blocking proteins necessary for tumor growth, or stimulating the immune system to combat cancer. For instance, in March 2024, Zydus Lifesciences Limited, a pharmaceutical company based in India, launched IBYRA, a generic version of the PARP inhibitor olaparib. This drug offers an affordable and targeted treatment option for patients with HRD-positive and BRCA-positive cancers, significantly reducing treatment costs compared to the original medication.
In June 2023, Ariceum Therapeutics GmbH, a biotechnology company based in Germany, acquired Theragnostics Ltd. for an undisclosed amount. This acquisition aims to expand Ariceum Therapeutics' radiopharmaceutical pipeline by incorporating Theragnostics' next-generation PARP inhibitor radiation therapies, while also strengthening its U.S. operations. Theragnostics Ltd, a U.K.-based biopharmaceutical company, specializes in developing radio-labeled PARP inhibitors.
Major players in the poly(ADP-ribose) polymerase (PARP) inhibitors market are Pfizer Inc., Johnson & Johnson Services Inc., AbbVie Inc., Merck & Co. Inc., Bayer AG, AstraZeneca plc, Bristol-Myers Squibb Company, GSK plc, Takeda Pharmaceutical Company Limited, Boehringer Ingelheim, Vertex Pharmaceuticals Inc., Jiangsu Hengrui Pharmaceuticals Co. Ltd., BeiGene LTD, Karyopharm Therapeutics Inc., Clovis Oncology Inc., Repare Therapeutics Inc., Ribon Therapeutics, Artios Pharma, IMPACT Therapeutics Inc., BiPar Sciences Inc., and Allarity Therapeutics Inc.
North America was the largest region in the poly(ADP-ribose) polymerase (PARP) inhibitors market in 2024. Asia Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in poly(ADP-ribose) polymerase (PARP) inhibitors report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the poly(ADP-ribose) polymerase (PARP) inhibitors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The poly(ADP-ribose) polymerase (PARP) inhibitors market consists of sales of rubraca, zejula, and talzenna. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Poly(ADP-Ribose) Polymerase (PARP) Inhibitors Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on poly(adp-ribose) polymerase (parp) inhibitors market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for poly(adp-ribose) polymerase (parp) inhibitors ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The poly(adp-ribose) polymerase (parp) inhibitors market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.