PUBLISHER: The Business Research Company | PRODUCT CODE: 1750933
PUBLISHER: The Business Research Company | PRODUCT CODE: 1750933
C5 complement inhibitors are a class of targeted immunomodulatory biologic agents that specifically block the cleavage of complement component 5 (C5) into its active fragments, C5a and C5b. By doing so, they prevent the formation of the membrane attack complex (MAC) and mitigate the downstream inflammatory and cytolytic processes linked to the overactivation of the complement system. These inhibitors are used to treat complement-mediated disorders such as paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and certain forms of generalized myasthenia gravis, where excessive complement activity contributes to disease pathology.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The main products in C5 complement inhibitors are long-acting C5 inhibitors and short-acting C5 inhibitors. Long-acting C5 complement inhibitors are therapeutic agents designed to provide prolonged suppression of C5 activity, thereby reducing the frequency of administration while maintaining effective control over immune-mediated conditions. The drugs included in this category are eculizumab, ravulizumab, and others, which can be administered via intravenous, subcutaneous, or oral routes. These inhibitors are distributed through channels such as hospital pharmacies, retail pharmacies, and online pharmacies, with applications in conditions such as paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, generalized myasthenia gravis, neuromyelitis optica spectrum disorder, and others.
The C5 complement inhibitors market research report is one of a series of new reports from The Business Research Company that provides C5 complement inhibitors market statistics, including C5 complement inhibitors industry global market size, regional shares, competitors with a C5 complement inhibitors market share, detailed C5 complement inhibitors market segments, market trends and opportunities, and any further data you may need to thrive in the C5 complement inhibitors industry. This C5 complement inhibitors market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The C5 complement inhibitors market size has grown rapidly in recent years. It will grow from$6.91 billion in 2024 to $7.91 billion in 2025 at a compound annual growth rate (CAGR) of 14.4%. The growth during the historic period can be attributed to the rising prevalence of rare and chronic diseases, the growing demand for targeted therapies, increased awareness among healthcare providers, higher investments in research and development, and favorable reimbursement policies.
The C5 complement inhibitors market size is expected to see rapid growth in the next few years. It will grow to$13.45 billion in 2029 at a compound annual growth rate (CAGR) of 14.2%. The growth during the forecast period can be attributed to collaborations between drug manufacturers, advancements in healthcare infrastructure, high healthcare expenditure, increasing demand for innovative treatments, and the rising prevalence of complement-mediated illnesses. Key trends during the forecast period include advancements in biotechnology, growing investment in RNA-based methods and gene therapy, improvements in diagnostic tools, the emergence of novel therapies, and developments in monoclonal antibody therapies.
The increasing prevalence of chronic diseases is expected to significantly propel the growth of the C5 complement inhibitors market. Chronic diseases are long-term medical conditions that progress slowly and often require continuous management to prevent complications. The rise in chronic diseases is largely driven by lifestyle factors such as poor diet, physical inactivity, smoking, and stress, which contribute to long-term health deterioration. C5 complement inhibitors play a key role in treating chronic diseases by blocking the overactivation of the complement system, reducing inflammation, preventing tissue damage, and improving disease outcomes in conditions such as paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and other complement-mediated disorders. For example, in October 2022, the World Heart Federation reported that cardiovascular disease-related deaths are projected to rise from around 22.2 million by 2030 to 32.3 million by 2050, highlighting the growing burden of chronic diseases. This rising prevalence of chronic diseases is a major driver for the expansion of the C5 complement inhibitors market.
Companies in the C5 complement inhibitors market are focusing on developing innovative treatments, such as self-administered C5 inhibitors, to provide more convenient and effective options for patients with generalized myasthenia gravis and other conditions. Self-administered C5 inhibitors are designed for patient use and work by targeting and blocking the complement C5 protein, reducing inflammation and immune-mediated damage. A notable example is the approval of Zilbrysq (zilucoplan) by the U.S. Food and Drug Administration (FDA) in October 2023. This once-daily subcutaneous C5 complement inhibitor, developed by Union Chimique Belge (UCB) SA, provides a new treatment option for adults with generalized myasthenia gravis who are anti-acetylcholine receptor (AChR) antibody-positive. The approval of Zilbrysq strengthens UCB's neurology portfolio, expanding treatment choices for individuals suffering from autoimmune neuromuscular disorders and improving the convenience of treatment.
In July 2023, Astellas Pharma Inc., a Japan-based pharmaceutical company, acquired Iveric Bio Inc. for $5.9 billion to enhance its ophthalmology pipeline and strengthen its presence in the retinal disease market. This acquisition grants Astellas access to Iveric Bio's lead asset, Zimura, a complement C5 inhibitor designed to treat geographic atrophy secondary to age-related macular degeneration (AMD). Iveric Bio, a US-based biopharmaceutical company, is developing novel treatments in the complement C5 inhibitor space. The acquisition positions Astellas to further expand its offerings in retinal diseases, potentially improving patient outcomes for those suffering from vision loss associated with complement-mediated conditions.
Major players in the c5 complement inhibitors market are F. Hoffmann-La Roche AG, AstraZeneca plc, Novartis AG, Amgen Inc., Merck KGaA, Regeneron Pharmaceuticals Inc., Astellas Pharma Inc., Chugai Pharmaceutical Co. Ltd., UCB Pharma SA, Swedish Orphan Biovitrum AB(Sobi), Alnylam Pharmaceuticals Inc., BioCryst Pharmaceuticals Inc., Apellis Pharmaceuticals Inc., Omeros Corporation, Dianthus Therapeutics Inc., Kira Pharmaceuticals, Biopharma PEG Scientific Inc., ProbeChem Biochemicals, InflaRx NV, Akari Therapeutics Plc
North America was the largest region in the C5 complement inhibitors market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in this report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the C5 Complement Inhibitors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The C5 complement inhibitors market consists of sales of zilucoplan, cemdisiran, tesidolumab, and biologics. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
C5 Complement Inhibitors Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on c5 complement inhibitors market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for c5 complement inhibitors ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The c5 complement inhibitors market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.