PUBLISHER: The Business Research Company | PRODUCT CODE: 1751082
PUBLISHER: The Business Research Company | PRODUCT CODE: 1751082
Primary immunodeficiency disorders (PIDs) are inherited conditions that impair the immune system, making individuals more susceptible to infections, autoimmune diseases, and certain cancers. Early diagnosis and identification of PIDs are critical for effective treatment, infection prevention, and improving patient health through therapies such as immunoglobulin replacement or bone marrow transplants.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The main types of primary immunodeficiency disorders include antibody deficiencies, cellular immunodeficiencies, innate immune disorders, and others. Antibody deficiencies occur when the immune system is unable to produce sufficient antibodies, which are responsible for detecting and neutralizing harmful pathogens. Treatments available include immunoglobulin replacement therapy, antibiotic treatment, stem cell or bone marrow transplants, gene therapy, and other methods. Diagnostic approaches involve genetic testing, blood tests, flow cytometry, and other techniques, which are typically applied in hospitals, specialty clinics, home care settings, and research institutions.
The primary immunodeficiency disorders market research report is one of a series of new reports from The Business Research Company that provides primary immunodeficiency disorders market statistics, including the primary immunodeficiency disorders industry's global market size, regional shares, competitors with a primary immunodeficiency disorders market share, detailed primary immunodeficiency disorders market segments, market trends and opportunities, and any further data you may need to thrive in the primary immunodeficiency disorders industry. This primary immunodeficiency disorders market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.
The primary immunodeficiency disorders market size has grown strongly in recent years. It will grow from$6.84 billion in 2024 to $7.32 billion in 2025 at a compound annual growth rate (CAGR) of 7.0%. The growth during the historic period can be attributed to the rising incidence of primary immunodeficiency disorders, increased awareness among healthcare professionals, growing demand for effective treatments, higher research funding, and an increased focus on pediatric care.
The primary immunodeficiency disorders market size is expected to see strong growth in the next few years. It will grow to$9.51 billion in 2029 at a compound annual growth rate (CAGR) of 6.8%. The growth in the forecast period can be attributed to the growing adoption of subcutaneous therapies, improved healthcare access, robust research and development, a higher demand for efficient treatments, and an increasing need for immunoglobulin replacement therapy. Major trends in the forecast period include advancements in biotechnology, innovative gene therapies and biologics, progress in genetic testing and personalized medicine, and ongoing advancements in gene therapy and genetic tests.
The increasing prevalence of autoimmune diseases is anticipated to drive the growth of the primary immunodeficiency disorders market. Autoimmune diseases occur when the immune system erroneously attacks the body's healthy cells and tissues, perceiving them as foreign invaders. This misdirected immune response leads to inflammation and damage across various organs and systems. The rise in autoimmune diseases is attributed to a complex mix of environmental factors, genetic predispositions, and lifestyle changes. These diseases can cause primary immunodeficiency disorders by disrupting immune regulation and attacking immune cells, resulting in weakened or impaired immune responses. For example, in November 2024, data from Versorgungsatlas.de, an interactive online platform in Germany, revealed that in 2022, among 73,241,305 insured individuals, 6,304,340 were diagnosed with at least one autoimmune disease, resulting in a raw prevalence rate of 8.61%. This increasing prevalence of autoimmune diseases is a key driver behind the expansion of the primary immunodeficiency disorders market.
Leading companies in the primary immunodeficiency disorders market are focusing on the development of advanced therapies such as intravenous immunoglobulin (IVIG) therapy to enhance patient outcomes by improving immune function. IVIG therapy involves administering immunoglobulins (antibodies) derived from donor plasma directly into a patient's bloodstream through an IV. For instance, in June 2024, Grifols, a healthcare company based in Spain, received FDA approval for Yimmugo, an intravenous immunoglobulin (IVIg) therapy. This new sugar-free, ready-to-use IgG solution, derived from human blood plasma, is intended for intravenous administration. It was approved in the U.S. for substitution therapy in patients with primary antibody deficiency syndromes. Yimmugo provides antibody replacement to support individuals with immune deficiencies, enhancing Grifols' portfolio of plasma-based treatments by offering a safer and more effective solution to protect against infections.
In April 2022, Grifols, S.A., a pharmaceutical company based in Spain, acquired Biotest AG for an undisclosed amount. This acquisition is aimed at accelerating growth and fostering innovation by expanding Grifols' plasma-derived medicines portfolio and strengthening its global market presence. Biotest AG, a biotechnology company based in Germany, specializes in plasma proteins and biological drugs.
Major players in the primary immunodeficiency disorders market are Pfizer Inc., Thermo Fisher Scientific Inc., Takeda Pharmaceuticals, CSL Behring, Baxter International Inc., Grifols SA, Octapharma, Kedrion Biopharma, Miltenyi Biotec, LFB Group, Clinigen Limited, ADMA Biologics Inc., Bio Products Laboratory Ltd, BD Biosciences, Cellectis SA, Florencia Healthcare, X4 Pharmaceuticals Inc., Amber Lifesciences, bluebird bio Inc., and Chengdu Rongsheng Pharmaceutical Co Ltd.
North America was the largest region in the primary immunodeficiency disorders market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in primary immunodeficiency disorders report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the primary immunodeficiency disorders market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The primary immunodeficiency disorders market consists of revenues earned by entities by providing services such as immunoglobulin therapy, rehabilitation and support programs, educational and advocacy services, and personalized treatment plans. The market value includes the value of related goods sold by the service provider or included within the service offering. The primary immunodeficiency disorders market also includes sales of vaccines, antibiotics, antifungals, and small molecule drugs. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Primary Immunodeficiency Disorders Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on primary immunodeficiency disorders market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for primary immunodeficiency disorders ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The primary immunodeficiency disorders market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.