PUBLISHER: The Business Research Company | PRODUCT CODE: 1751094
PUBLISHER: The Business Research Company | PRODUCT CODE: 1751094
Renin-angiotensin system (RAS)-acting agents are a group of medications designed to regulate blood pressure, fluid balance, and vascular resistance by targeting different components of the renin-angiotensin system, which plays a vital role in cardiovascular and renal function. These agents are frequently prescribed for conditions such as hypertension, heart failure, and chronic kidney disease, either by blocking the production of angiotensin II or inhibiting its effects on blood vessels.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The primary classes of drugs in the renin-angiotensin system (RAS)-acting agents include angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), renin inhibitors, aldosterone antagonists, and others. ACE inhibitors are medications that block the enzyme responsible for converting angiotensin I into angiotensin II, a substance that narrows blood vessels and raises blood pressure. They are used for various indications such as hypertension, heart failure, chronic kidney disease, diabetic nephropathy, and coronary artery disease. These drugs are distributed through hospital pharmacies, retail pharmacies, online pharmacies, and specialty clinics, catering to various end users, including hospitals, research institutes, pharmaceutical companies, and others.
The renin-angiotensin-system (RAS)-acting agents market research report is one of a series of new reports from The Business Research Company that provides renin-angiotensin-system (RAS)-acting agents market statistics, including renin-angiotensin-system (RAS)-acting agents industry global market size, regional shares, competitors with a renin-angiotensin-system (RAS)-acting agents market share, detailed renin-angiotensin-system (RAS)-acting agents market segments, market trends and opportunities, and any further data you may need to thrive in the renin-angiotensin-system (RAS)-acting agents industry. This renin-angiotensin-system (RAS)-acting agents market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The renin-angiotensin-system (RAS)-acting agents market size has grown strongly in recent years. It will grow from$5.82 billion in 2024 to $6.17 billion in 2025 at a compound annual growth rate (CAGR) of 6.0%. The growth during the historic period can be attributed to several factors, including the rising prevalence of hypertension, the increasing incidence of cardiovascular diseases, the growing aging population, heightened awareness about blood pressure management, strong support from clinical research, and regulatory approvals for new drugs.
The renin-angiotensin-system (RAS)-acting agents market size is expected to see strong growth in the next few years. It will grow to$7.73 billion in 2029 at a compound annual growth rate (CAGR) of 5.8%. The growth during the forecast period can be attributed to several factors, including an increasing focus on personalized treatment, higher demand for fixed-dose combinations, greater investment in cardiovascular research, expanding healthcare access in emerging markets, and the rising prevalence of lifestyle-related diseases. Key trends during this period include AI-driven drug development, nanotechnology-based drug delivery, advancements in personalized medicine, the use of blockchain for secure clinical data, wearable biosensors for hypertension monitoring, and the application of digital twin technology for patient modeling.
The growing prevalence of hypertension is expected to drive the expansion of the renin-angiotensin system (RAS)-acting agents market in the coming years. Hypertension, or high blood pressure, is a chronic condition in which the force of blood against the artery walls is consistently too high. The rise in hypertension is largely due to unhealthy diets, particularly those rich in salt and processed foods, which contribute to higher blood pressure and increased strain on the cardiovascular system. RAS-acting agents help mitigate hypertension by regulating blood pressure through the inhibition of angiotensin II, a hormone that constricts blood vessels and increases fluid retention. By promoting vasodilation and reducing blood pressure, these agents help manage hypertension. For example, in October 2024, the Australian Bureau of Statistics reported that 11.6% (3.0 million) of Australians had hypertension in 2022, with similar rates observed for males (11.7%) and females (11.6%). Thus, the rising prevalence of hypertension is driving the growth of the RAS-acting agents market.
Key players in the RAS-acting agents market are focusing on developing novel inhibitors, such as angiotensin-converting enzyme (ACE) inhibitors, to improve efficacy, minimize side effects, enhance patient compliance, and address hypertension, heart failure, and kidney diseases. ACE inhibitors work by lowering blood pressure through the blockage of the enzyme responsible for converting angiotensin I to angiotensin II, a substance that narrows blood vessels. For example, in November 2023, Proveca Ltd., a UK-based pharmaceutical company, received a grant from the European Commission for pediatric use marketing authorization (PUMA) for Aqumeldi (enalapril maleate) orodispersible tablets, which are indicated for the treatment of heart failure in children aged from birth to under 18 years. Aqumeldi, an ACE inhibitor, treats pediatric heart failure by preventing the conversion of angiotensin I to angiotensin II, thereby relaxing blood vessels, improving blood flow, and reducing the heart's workload.
In February 2023, AstraZeneca, a UK-based pharmaceutical company, acquired CinCor Pharma for $1.3 billion. Through this acquisition, AstraZeneca aims to strengthen its cardiorenal pipeline by adding CinCor's lead drug, baxdrostat (CIN-107), a selective aldosterone synthase inhibitor (ASI) designed to reduce blood pressure in treatment-resistant hypertension. CinCor Pharma, a U.S.-based biopharmaceutical company, is focused on developing RAS-acting agents, including baxdrostat, which targets resistant hypertension.
Major players in the renin-angiotensin-system (RAS)-acting agents market are Pfizer Inc., Merck And Co. Inc., Bayer AG, Sanofi S.A., Bristol-Myers Squibb Company, AstraZeneca plc, Novartis AG, GSK plc, Teva Pharmaceutical Industries Ltd., Boehringer Ingelheim GmbH, Sandoz International GmbH, Astellas Pharma Inc., Bausch Health Companies Inc., Aurobindo Pharma Limited, Cipla Limited, Dr. Reddy's Laboratories Ltd., Biocon Limited, Daiichi Sankyo Company Limited, Glenmark Pharmaceuticals Ltd., and Torrent Pharmaceuticals Ltd.
North America was the largest region in the renin-angiotensin-system (RAS)-acting agents market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in renin-angiotensin system (RAS)-acting agents report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the renin-angiotensin system (RAS)-acting agents market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The renin-angiotensin system (RAS)-acting agents market consists of sales of enalapril, lisinopril, ramipril, and captopril. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Renin-Angiotensin-System (RAS)-Acting Agents Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on renin-angiotensin-system (ras)-acting agents market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for renin-angiotensin-system (ras)-acting agents ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The renin-angiotensin-system (ras)-acting agents market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.