PUBLISHER: The Business Research Company | PRODUCT CODE: 1769720
PUBLISHER: The Business Research Company | PRODUCT CODE: 1769720
Primary myelofibrosis (PMF) is a rare and chronic bone marrow condition marked by the excessive development of fibrous scar tissue (fibrosis) within the bone marrow. This fibrosis interferes with the normal production of blood cells, resulting in symptoms such as anemia, fatigue, weakness, and an enlarged spleen (splenomegaly). PMF falls under the category of myeloproliferative neoplasms (MPNs) and can also lead to issues like night sweats, unintended weight loss, and bone discomfort.
The major types of primary myelofibrosis include spinocerebellar primary myelofibrosis, primary myelofibrosis-telangiectasia, episodic primary myelofibrosis, and other less common forms. Services provided encompass both diagnosis and treatment, while medication options are offered in multiple dosage forms, including solids, liquids, and other formulations, to cater to various patient needs. This condition can affect individuals of all age groups-children, adults, and the elderly-and is managed in various healthcare environments such as hospitals, clinics, and other care facilities.
The primary myelofibrosis market research report is one of a series of new reports from The Business Research Company that provides primary myelofibrosis market statistics, including the primary myelofibrosis industry global market size, regional shares, competitors with the primary myelofibrosis market share, detailed primary myelofibrosis market segments, market trends, and opportunities, and any further data you may need to thrive in the primary myelofibrosis industry. These primary myelofibrosis market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.
The primary myelofibrosis market size has grown strongly in recent years. It will grow from $0.79 billion in 2024 to $0.84 billion in 2025 at a compound annual growth rate (CAGR) of 6.4%. Growth during the historic period was driven by greater awareness of the disease among healthcare providers, expanded use of JAK inhibitors, improved diagnostic and genetic testing capabilities, enhanced access to hematology care, and a rise in clinical research activity.
The primary myelofibrosis market size is expected to see strong growth in the next few years. It will grow to $1.07 billion in 2029 at a compound annual growth rate (CAGR) of 6.2%. Contributing factors to future growth include the expansion of innovative treatment pipelines, rising demand for therapies that alter disease progression, increasing incidence among elderly populations, a shift toward combination treatment approaches, and higher levels of investment from pharmaceutical and biotechnology companies. Key emerging trends include progress in precision drug development, the use of next-generation sequencing (NGS) in diagnostics, tech-enabled patient monitoring tools, advancements in multi-drug therapy regimens, and improvements in imaging methods for bone marrow fibrosis.
The growing prevalence of myelofibrosis is anticipated to drive the expansion of the primary myelofibrosis market in the coming years. Myelofibrosis is a rare bone marrow cancer that interferes with the normal production of blood cells, leading to significant scarring in the bone marrow, which in turn causes severe anemia, fatigue, weakness, and an enlarged spleen. This condition is increasingly prevalent due to the aging global population, as it most commonly affects individuals over the age of 60. With life expectancy on the rise, the number of diagnosed cases continues to grow. This increase in prevalence supports advancements in primary myelofibrosis management by promoting research, encouraging early diagnosis, expanding treatment options, and refining clinical guidelines and care strategies. For example, in November 2024, the National Institute for Health and Care Excellence, a UK-based independent executive non-departmental public body, reported that myelofibrosis has a prevalence of 3.2 per 100,000 people in the UK and an incidence rate of 0.6 per 100,000. As a result, the increasing number of cases is contributing to the growth of the primary myelofibrosis market.
Key players in the primary myelofibrosis market are emphasizing the development of innovative treatments such as Janus kinase 2 (JAK2) inhibiting tablets to better manage symptoms and slow disease progression. These oral medications work by blocking the JAK2 enzyme, which is involved in abnormal signaling pathways that result in excessive blood cell production in primary myelofibrosis. JAK2 inhibitors help reduce spleen size, relieve fatigue and bone pain, and slow disease progression. For instance, in March 2025, GlaxoSmithKline Korea (GSK Korea) Ltd., a pharmaceutical and biotechnology company based in South Korea, introduced Omjjara (momelotinib), a new treatment for myelofibrosis. Approved by South Korea's Ministry of Food and Drug Safety, Omjjara is designed for adult patients with intermediate- or high-risk primary or secondary myelofibrosis who suffer from moderate to severe anemia. This oral therapy targets JAK1, JAK2, and activin A receptor type 1 (ACVR1), effectively treating symptoms such as anemia, splenomegaly, and fatigue. Clinical trial results showed significant improvements in these areas compared to existing treatments, supporting the drug's approval.
In June 2022, GSK plc, a UK-based pharmaceutical and biotechnology firm, completed the acquisition of Sierra Oncology, Inc. for approximately $1.9 billion. This move was intended to strengthen GSK's oncology pipeline, particularly in the area of hematologic cancers. Sierra Oncology, Inc. is a U.S.-based biopharmaceutical company focused on the development of therapies for primary myelofibrosis.
Major players in the primary myelofibrosis market are Merck & Co. Inc., AbbVie Inc., Bristol-Myers Squibb Company, Sumitomo Pharma Oncology Inc., Incyte Corporation, Nippon Shinyaku Co. Ltd., MorphoSys AG, Keros Therapeutics Inc., Geron Corporation, Lynk Pharmaceuticals Co. Ltd., Pharmaxis Ltd, Kartos Therapeutics Inc., Disc Medicine Inc., Galecto Inc., Cellenkos Inc., Chia Tai Tianqing Pharmaceutical Group Co. Ltd., Taiga Biotechnologies Inc., Suzhou Zelgen Biopharmaceuticals Co. Ltd., Telios Pharma Inc., Samus Therapeutics Inc., Jacobio Pharmaceuticals Co. Ltd.
North America was the largest region in the primary myelofibrosis market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in primary myelofibrosis report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the primary myelofibrosis market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The primary myelofibrosis market consists of revenues earned by entities by providing services such as diagnosis services, medical consultations, treatment services, monitoring and follow-up and supportive care. The market value includes the value of related goods sold by the service provider or included within the service offering. The primary myelofibrosis (PMF) market also includes sales of products including ruxolitinib (Jakafi or Jakavi), erythropoiesis-stimulating agents (ESAs), hydroxyurea, bone marrow or stem cell transplant kits and iron supplements. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Primary Myelofibrosis Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on primary myelofibrosis market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for primary myelofibrosis ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The primary myelofibrosis market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.