PUBLISHER: The Business Research Company | PRODUCT CODE: 1826791
PUBLISHER: The Business Research Company | PRODUCT CODE: 1826791
Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor that arises in the squamous epithelium of the upper aerodigestive tract, affecting areas such as the oral cavity, pharynx, and larynx. It is one of the most common types of head and neck cancer, often associated with risk factors such as tobacco use, alcohol consumption, and infections such as human papillomavirus (HPV).
The main types of head and neck squamous cell carcinoma include salivary gland, oral and oropharyngeal, nasal cavity and paranasal sinuses, nasopharyngeal, laryngeal, and hypopharyngeal cancers. Salivary gland cancers are rare malignancies that develop in the glands producing saliva and are usually treated with surgery, radiation, and targeted therapies. Drug classes used in treatment include epidermal growth factor receptor (EGFR) inhibitors, immune checkpoint inhibitors, and other therapies. These can be administered via intravenous, oral, or other routes. Treatment methods include radiation therapy, chemotherapy, and immunotherapy, with administration across various settings such as hospitals, specialty clinics, and ambulatory surgical centers.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The sharp rise in U.S. tariffs and the resulting trade tensions in spring 2025 are having a significant impact on the healthcare sector, especially in the supply of essential medical devices, diagnostic equipment, and pharmaceuticals. Hospitals and healthcare providers are grappling with higher costs for imported surgical tools, imaging systems, and consumables like syringes and catheters, many of which have limited domestic substitutes. These escalating expenses are putting pressure on healthcare budgets, prompting some providers to delay equipment upgrades or pass increased costs on to patients. Furthermore, tariffs on raw materials and components are disrupting the manufacturing of vital drugs and devices, leading to supply chain delays. In response, the industry is adopting diversified sourcing strategies, expanding local production where feasible, and pushing for tariff exemptions on critical medical products.
The head and neck squamous cell carcinoma market research report is one of a series of new reports from The Business Research Company that provides head and neck squamous cell carcinoma market statistics, including the head and neck squamous cell carcinoma industry global market size, regional shares, competitors with the head and neck squamous cell carcinoma market share, detailed head and neck squamous cell carcinoma market segments, market trends, and opportunities, and any further data you may need to thrive in the head and neck squamous cell carcinoma industry. This head and neck squamous cell carcinoma market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.
The head and neck squamous cell carcinoma market size has grown strongly in recent years. It will grow from $1.81 billion in 2024 to $1.97 billion in 2025 at a compound annual growth rate (CAGR) of 9.1%. The growth in the historic period can be attributed to raise awareness and screening, growth of combination therapies, healthcare infrastructure development, rise in healthcare spending, and rise incidence of head and neck squamous cell carcinoma.
The head and neck squamous cell carcinoma market size is expected to see strong growth in the next few years. It will grow to $2.78 billion in 2029 at a compound annual growth rate (CAGR) of 8.9%. The growth in the forecast period can be attributed to rising tobacco consumption, rising geriatric population, favorable government policies, increasing incidence of cancer, and increasing consumption of alcohol. Major trends in the forecast period include targeted therapy adoption, investment in research, integration of immunotherapy, technological advancements, and advancements in drug formulation.
The forecast of 8.9% growth over the next five years reflects a modest reduction of 0.2% from the previous estimate for this market. This reduction is primarily due to the impact of tariffs between the US and other countries. Trade tensions could hinder U.S. adoption of targeted immunotherapy by inflating prices of PD-1 inhibitors developed in Switzerland and the U.K., resulting in reduced precision therapy access and higher oncology care costs The effect will also be felt more widely due to reciprocal tariffs and the negative effect on the global economy and trade due to increased trade tensions and restrictions.
The growing consumption of tobacco and alcohol is anticipated to drive the expansion of the head and neck squamous cell carcinoma market. This rise is influenced by factors such as cultural norms, social pressures, stress, marketing, and the easy availability of these substances. The consumption of tobacco and alcohol contributes to an increased risk of head and neck squamous cell carcinoma (HNSCC) by causing chronic irritation and damage to the mucosal lining, triggering genetic mutations, and weakening immune responses, all of which promote cancer development in the head and neck area. For example, in September 2024, the Centers for Disease Control and Prevention (CDC) reported that tobacco use remains the leading cause of preventable disease and death in the U.S. In 2022, approximately 49.2 million adults, or 19.8% of the population, used tobacco products. Additionally, data released by the UK's National Health Service in June 2024 indicated that 81% of adults consumed alcohol in the previous year, with 84% of men and 78% of women reporting alcohol use during this period. As such, the increasing use of tobacco and alcohol is contributing to the growth of the head and neck squamous cell carcinoma market.
To foster innovation in cancer treatments, leading companies in the head and neck squamous cell carcinoma field are forming strategic partnerships. These collaborations allow companies to pool resources and expertise, speeding up research and development while boosting innovation. By joining forces, these partnerships also facilitate faster commercialization, helping companies reach broader markets and access new patient groups. For example, in October 2024, Exelixis Inc., a U.S.-based biotech firm, teamed up with Merck & Co. Inc., a U.S.-based pharmaceutical company, to further cancer treatments. This collaboration aims to explore the combination of zanzalintinib with KEYTRUDA and WELIREG, targeting enhanced outcomes for patients with HNSCC and renal cell carcinoma (RCC).
In March 2023, Flamingo Therapeutics NV, a Belgian biotechnology firm, merged with Dynacure SAS in a deal with undisclosed terms. This merger allows the two companies to combine their expertise in RNA-targeting and clinical drug development, creating a prominent oncology entity focused on advancing cutting-edge therapies. This includes Flamingo's danvatirsen program, currently undergoing Phase II trials for head and neck cancer, and the FTX-001 program targeting MALAT-1 in solid tumors. Dynacure SAS is a Belgium-based biotech company specializing in developing therapies for patients with rare and severe orphan diseases.
Major players in the head and neck squamous cell carcinoma market are Pfizer Inc., F. Hoffmann-La Roche Ltd, Merck & Co. Inc., Bayer AG, Sanofi SA, Bristol-Myers Squibb Company, AstraZeneca PLC, Novartis AG, GSK plc, Eli Lilly and Company, Boehringer Ingelheim International GmbH, Rakuten Medical Inc., Exelixis Inc., Akeso Inc., Fortress Biotech Inc., Hookipa Pharma Inc., MacroGenics Inc., Theriva Biologics Inc., Turnstone Biologics Inc., Nykode Therapeutics AS, Immutep Limited, Tizona Therapeutics Inc., Checkpoint Therapeutics Inc., and Zenith Epigenetics Ltd.
North America was the largest region in the head and neck squamous cell carcinoma market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in head and neck squamous cell carcinoma report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the head and neck squamous cell carcinoma market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The head and neck squamous cell carcinoma market consists of revenues earned by entities by providing services such as diagnostic services, treatment services, rehabilitation services, and palliative care. The market value includes the value of related goods sold by the service provider or included within the service offering. The head and neck squamous cell carcinoma market also includes sales of therapeutics, regenerative products, targeted therapy treatments, and supportive care products. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Head And Neck Squamous Cell Carcinoma Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on head and neck squamous cell carcinoma market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for head and neck squamous cell carcinoma ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The head and neck squamous cell carcinoma market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the technological advancements such as AI and automation, Russia-Ukraine war, trade tariffs (government-imposed import/export duties), elevated inflation and interest rates.