PUBLISHER: The Business Research Company | PRODUCT CODE: 1949870
PUBLISHER: The Business Research Company | PRODUCT CODE: 1949870
C5 complement inhibitors represent a category of targeted immunomodulatory biologic drugs that precisely inhibit the cleavage of complement component 5 (C5) into its active fragments C5a and C5b. This action blocks the formation of the membrane attack complex (MAC) and reduces the downstream inflammatory and cytolytic effects stemming from excessive complement system activation. These agents treat complement-driven conditions like paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and select types of generalized myasthenia gravis, in which heightened complement activity drives disease progression.
The primary products in C5 complement inhibitors consist of long-acting C5 inhibitors and short-acting C5 inhibitors. Long-acting C5 complement inhibitors are therapeutic agents engineered to deliver extended suppression of complement component 5 (C5) activity, minimizing administration frequency while ensuring robust management of immune-mediated disorders. The drugs in this category include eculizumab, ravulizumab, and others, administered via routes such as intravenous, subcutaneous, and oral, and distributed through channels like hospital pharmacies, retail pharmacies, and online pharmacies for applications including paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, generalized myasthenia gravis, neuromyelitis optica spectrum disorder, and others.
Tariffs have affected the c5 complement inhibitors market by increasing the cost of imported active pharmaceutical ingredients, biologic intermediates, and specialized manufacturing inputs used in monoclonal antibody production. These impacts have been most pronounced in long-acting inhibitor segments, particularly in north america and europe where biologic supply chains are globally integrated. Asia-pacific manufacturers have faced sourcing challenges and higher production costs due to reliance on imported biologic materials. However, tariffs have encouraged localized biologics manufacturing and regional supply chain investments, supporting long-term supply resilience.
The c5 complement inhibitors market research report is one of a series of new reports from The Business Research Company that provides c5 complement inhibitors market statistics, including c5 complement inhibitors industry global market size, regional shares, competitors with a c5 complement inhibitors market share, detailed c5 complement inhibitors market segments, market trends and opportunities, and any further data you may need to thrive in the c5 complement inhibitors industry. This c5 complement inhibitors market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The c5 complement inhibitors market size has grown rapidly in recent years. It will grow from $7.84 billion in 2025 to $8.93 billion in 2026 at a compound annual growth rate (CAGR) of 13.9%. The growth in the historic period can be attributed to approval of first-in-class complement inhibitors, rising diagnosis of rare hematological disorders, improved clinical awareness of complement pathways, expansion of specialty treatment centers, strong biologics development pipelines.
The c5 complement inhibitors market size is expected to see rapid growth in the next few years. It will grow to $14.93 billion in 2030 at a compound annual growth rate (CAGR) of 13.7%. The growth in the forecast period can be attributed to increasing prevalence of autoimmune and rare diseases, expansion of personalized medicine approaches, pipeline growth of next-generation inhibitors, rising biologics manufacturing capacity, supportive regulatory pathways for orphan drugs. Major trends in the forecast period include growing adoption of targeted immunotherapies, rising use in rare complement-mediated disorders, increasing preference for long-acting formulations, expansion of combination treatment approaches, growing focus on early diagnosis and intervention.
The rising incidence of chronic diseases is anticipated to fuel the expansion of the C5 complement inhibitors market in the future. Chronic diseases represent long-lasting health conditions that develop gradually and endure over time, frequently demanding ongoing medical care and oversight to avert complications. This surge in chronic diseases stems primarily from lifestyle shifts like unhealthy eating, lack of exercise, tobacco use, and chronic stress, all of which lead to sustained health decline. C5 complement inhibitors assist patients with chronic diseases by inhibiting excessive complement system activation, which curbs inflammation, safeguards tissues from harm, and enhances results in disorders like PNH, aHUS, and various complement-driven conditions. For instance, in April 2025, the International Diabetes Federation-a Belgium-based nonprofit-reported that over 9.5 million individuals lived with type 1 diabetes in 2024, including 1.9 million children and adolescents under 20. By 2050, the worldwide diabetes population is projected to reach 853 million. Thus, the growing burden of chronic diseases is propelling the C5 complement inhibitors market forward.
Major companies in the C5 complement inhibitors market are prioritizing the creation of innovative treatments, including self-administered C5 inhibitors, to broaden options for generalized myasthenia gravis patients. A self-administered C5 inhibitor is a precise medication that targets and blocks the complement C5 protein, helping to curb inflammation and immune-related harm; it's formulated for easy patient use in managing diseases like paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. For example, in October 2023, Union Chimique Belge (UCB) SA, a biopharmaceutical firm based in Belgium, revealed that Zilbrysq (zilucoplan) received approval from the Food and Drug Administration (FDA), the U.S. regulatory body, for adults with generalized myasthenia gravis (gMG). This approval targets those who test positive for anti-acetylcholine receptor (AChR) antibodies, a prevalent subtype of the condition. Zilbrysq functions as a once-daily, subcutaneous C5 complement inhibitor that patients can self-administer, providing a fresh choice for gMG management. The endorsement bolsters UCB's neurology offerings, enhancing therapies for people with autoimmune neuromuscular conditions.
In July 2023, Astellas Pharma Inc., a Japanese pharmaceutical company, acquired Iveric Bio Inc. for $5.9 billion. Through this acquisition, Astellas Pharma seeks to bolster its ophthalmology pipeline and grow its footprint in the retinal disease market by obtaining Iveric Bio's lead candidate, Zimura, a promising therapy for geographic atrophy associated with age-related macular degeneration. Iveric Bio Inc. is a U.S.-based biopharmaceutical firm focused on developing a complement C5 inhibitor.
Major companies operating in the c5 complement inhibitors market are AstraZeneca plc, F. Hoffmann-La Roche AG, Chugai Pharmaceutical Co. Ltd., Swedish Orphan Biovitrum AB, Alnylam Pharmaceuticals Inc., BioCryst Pharmaceuticals Inc., Omeros Corporation, Dianthus Therapeutics Inc., Akari Therapeutics Plc, Regeneron Pharmaceuticals Inc., UCB Pharma SA, Astellas Pharma Inc., InflaRx NV, Alexion Pharmaceuticals Inc., Ra Pharmaceuticals Inc., ChemoCentryx Inc., Annexon Biosciences Inc., Iveric Bio Inc., Apellis Pharmaceuticals Inc., Kira Pharmaceuticals Inc.
North America was the largest region in the C5 complement inhibitors market in 2025. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the c5 complement inhibitors market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the c5 complement inhibitors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The C5 complement inhibitors market consists of sales of zilucoplan, cemdisiran, tesidolumab, and biologics. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
C5 Complement Inhibitors Market Global Report 2026 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses c5 complement inhibitors market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for c5 complement inhibitors ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The c5 complement inhibitors market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, total addressable market (TAM), market attractiveness score (MAS), competitive landscape, market shares, company scoring matrix, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
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