PUBLISHER: The Business Research Company | PRODUCT CODE: 1951619
PUBLISHER: The Business Research Company | PRODUCT CODE: 1951619
Claudin 18.2-targeted therapy represents a cutting-edge precision treatment for cancer, honed to zero in on the Claudin 18.2 protein that's unusually abundant on the surface of specific tumor cells. It precisely eliminates cancer cells, boosting treatment effectiveness while minimizing harm to normal tissues.
The primary therapy categories for claudin 18.2 targeted treatments include monoclonal antibodies, bispecific antibodies, antibody-drug conjugates, and additional options. Monoclonal antibodies consist of laboratory-engineered molecules that bind to particular proteins on cancer cells, enabling the immune system to identify and eliminate them. These treatments are chiefly recommended for gastric cancer, pancreatic cancer, esophageal cancer, and various other types, delivered through intravenous, oral, or alternative methods. They are predominantly utilized by end-users such as hospitals, oncology centers, research institutes, and more.
Tariffs are impacting the claudin 18.2 targeted therapy market by increasing costs of imported biologic manufacturing equipment, specialized reagents, cell culture media, and advanced laboratory instruments used in antibody development and production. North America and Europe are most affected due to dependence on cross-border sourcing of bioprocessing inputs, while Asia-Pacific faces higher costs for clinical trial materials and biologics manufacturing components. These tariffs are raising development and production expenses and extending commercialization timelines. However, they are also encouraging localized biologics manufacturing, regional supply chain strengthening, and increased investment in domestic biopharmaceutical infrastructure.
The claudin 18.2 targeted therapy market research report is one of a series of new reports from The Business Research Company that provides claudin 18.2 targeted therapy market statistics, including claudin 18.2 targeted therapy industry global market size, regional shares, competitors with a claudin 18.2 targeted therapy market share, detailed claudin 18.2 targeted therapy market segments, market trends and opportunities, and any further data you may need to thrive in the claudin 18.2 targeted therapy industry. This claudin 18.2 targeted therapy market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The claudin 18.2 targeted therapy market size has grown exponentially in recent years. It will grow from $1.6 billion in 2025 to $1.98 billion in 2026 at a compound annual growth rate (CAGR) of 23.7%. The growth in the historic period can be attributed to increasing prevalence of gastric and gastrointestinal cancers, advancements in antibody engineering technologies, expansion of oncology-focused clinical trials, rising investments in targeted cancer therapies, improved understanding of claudin protein biology.
The claudin 18.2 targeted therapy market size is expected to see exponential growth in the next few years. It will grow to $4.61 billion in 2030 at a compound annual growth rate (CAGR) of 23.5%. The growth in the forecast period can be attributed to increasing regulatory approvals for targeted oncology drugs, rising demand for personalized cancer treatment, expansion of combination therapy approaches, growing oncology pipeline investments, increasing adoption of precision diagnostics. Major trends in the forecast period include increasing focus on biomarker-driven oncology therapies, rising development of claudin 18.2 monoclonal antibodies, growing expansion of indication-specific targeted treatments, enhanced integration of companion diagnostics, increasing strategic collaborations in precision oncology.
The increasing prevalence of gastrointestinal cancers is anticipated to boost the claudin 18.2 targeted therapy market in the future. Gastrointestinal (GI) cancers are malignant tumors that form in any section of the digestive system, ranging from the esophagus to the rectum. This surge in GI cancers stems mainly from poor diets high in processed foods and low in fiber, which foster gut inflammation and elevate cancer risk. Claudin 18.2 targeted therapy addresses these cancers by precisely homing in on the Claudin 18.2 protein, which is overexpressed on tumor cells, allowing drugs or antibodies to destroy cancer cells while preserving healthy tissue and enhancing overall treatment outcomes. For instance, in June 2025, the Centers for Disease Control and Prevention (CDC), a US-based public health organization, reported 147,931 new colorectal cancer cases in 2022 and 53,779 deaths from colorectal cancer in 2023. Thus, the growing incidence of gastrointestinal cancers is fueling expansion in the claudin 18.2 targeted therapy market.
Major companies in the claudin 18.2 targeted therapy market are prioritizing the creation of cutting-edge treatments, like monoclonal antibodies, to precisely target cancer cells expressing claudin 18.2 and improve patient results. A monoclonal antibody is a lab-produced protein engineered to attach specifically to one target, such as a protein on cancer cell surfaces, helping the immune system identify and eliminate those cells. For example, in March 2024, Astellas Pharma Inc., a pharmaceutical firm based in Japan, secured approval from Japan's Ministry of Health, Labour and Welfare for VYLOY (zolbetuximab) to treat patients with CLDN18.2-positive cancer. This targeted treatment for advanced gastric and gastroesophageal junction cancer specifically attaches to the CLDN18.2 protein on tumor cells, triggering the immune system to eliminate them. Clinical studies demonstrated it substantially boosts progression-free and overall survival rates when used alongside chemotherapy, outperforming chemotherapy alone. This breakthrough therapy offers a fresh, potent choice for patients with HER2-negative, CLDN18.2-positive tumors, addressing a critical gap in managing aggressive gastric cancer.
In February 2024, AstraZeneca plc, a UK-based pharmaceutical company, acquired Gracell Biotechnologies Inc. for an undisclosed sum. Through this acquisition, AstraZeneca seeks to speed up its cell therapy strategy by broadening its pipeline with Gracell's cutting-edge CAR-T therapies for blood cancers and autoimmune diseases, utilizing Gracell's FasTCAR platform to enhance treatment effectiveness and production speed. Gracell Biotechnologies Inc. is a China-based clinical-stage biopharmaceutical company that develops claudin 18.2 targeted therapy.
Major companies operating in the claudin 18.2 targeted therapy market are Bristol Myers Squibb Company, Amgen Inc., Astellas Pharma Inc., Jiangsu Hengrui Medicine Co. Ltd., Shanghai Henlius Biotech Inc., Legend Biotech Corporation, Zai Lab Limited, Harbour Biomed Ltd., CARsgen Therapeutics Holdings Limited, Genor Biopharma Co. Ltd., Phanes Therapeutics Inc., Suzhou Zelgen Biopharmaceuticals Co. Ltd., Triumvira Immunologics Inc., SOTIO Biotech a.s., Leap Therapeutics, Allogene Therapeutics, AskGene Pharma Inc., Elpiscience Biopharmaceutical Co. Ltd., I-Mab Biopharma Co. Ltd., Antegene Biopharma Co. Ltd.
Asia-Pacific was the largest region in the claudin 18.2 targeted therapy market in 2025. The regions covered in the claudin 18.2 targeted therapy market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the claudin 18.2 targeted therapy market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The claudin 18.2 targeted therapy market consists of sales of zolbetuximab, CMG901, and bispecific antibodies. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Claudin 18.2 Targeted Therapy Market Global Report 2026 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses claudin 18.2 targeted therapy market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for claudin 18.2 targeted therapy ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The claudin 18.2 targeted therapy market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, total addressable market (TAM), market attractiveness score (MAS), competitive landscape, market shares, company scoring matrix, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
Added Benefits available all on all list-price licence purchases, to be claimed at time of purchase. Customisations within report scope and limited to 20% of content and consultant support time limited to 8 hours.