PUBLISHER: The Business Research Company | PRODUCT CODE: 1955447
PUBLISHER: The Business Research Company | PRODUCT CODE: 1955447
Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer is a form of gastric or gastroesophageal junction cancer in which tumor cells exhibit abnormally high expression of the HER2 protein or amplification of the HER2 gene, leading to enhanced cancer cell growth. This specific subtype can be addressed with targeted treatment options, resulting in improved therapeutic outcomes for suitable patients.
The primary treatment approaches for human epidermal growth factor receptor 2 (HER2)-positive gastric cancer include chemotherapy, immunotherapy, radiation therapy, and targeted therapy. Chemotherapy involves the use of potent drugs that circulate throughout the bloodstream to eliminate rapidly dividing cancer cells, including those associated with HER2-positive gastric cancer. These treatments are applied across multiple disease stages, including stage I, stage II, stage III, and stage IV, and are utilized by various end users such as ambulatory surgery centers, hospitals, specialty clinics, and others.
Tariffs have affected the HER2-positive gastric cancer market by increasing costs for imported targeted therapies, monoclonal antibodies, and advanced diagnostic equipment. Segments such as HER2-targeted therapies and antibody-drug conjugates are particularly impacted, with regions like North America and Europe facing moderate price adjustments due to import duties. While tariffs increase treatment costs and supply chain complexities, they also encourage local production, investment in domestic manufacturing, and the development of alternative therapeutic solutions.
The human epidermal growth factor receptor 2 (her2)-positive gastric cancer market research report is one of a series of new reports from The Business Research Company that provides human epidermal growth factor receptor 2 (her2)-positive gastric cancer market statistics, including human epidermal growth factor receptor 2 (her2)-positive gastric cancer industry global market size, regional shares, competitors with a human epidermal growth factor receptor 2 (her2)-positive gastric cancer market share, detailed human epidermal growth factor receptor 2 (her2)-positive gastric cancer market segments, market trends and opportunities, and any further data you may need to thrive in the human epidermal growth factor receptor 2 (her2)-positive gastric cancer industry. This human epidermal growth factor receptor 2 (her2)-positive gastric cancer market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The human epidermal growth factor receptor 2 (her2)-positive gastric cancer market size has grown steadily in recent years. It will grow from $1.31 billion in 2025 to $1.37 billion in 2026 at a compound annual growth rate (CAGR) of 4.6%. The growth in the historic period can be attributed to limited availability of targeted therapies, reliance on conventional chemotherapy and radiation therapy, low awareness of her2-positive gastric cancer, restricted access to specialty clinics, slow adoption of immunotherapy.
The human epidermal growth factor receptor 2 (her2)-positive gastric cancer market size is expected to see steady growth in the next few years. It will grow to $1.64 billion in 2030 at a compound annual growth rate (CAGR) of 4.6%. The growth in the forecast period can be attributed to development of novel antibody-drug conjugates, increasing clinical trials for her2-targeted therapies, rising healthcare infrastructure in emerging markets, growth in precision medicine and biomarker testing, expanding ambulatory surgery centers and specialty oncology clinics. Major trends in the forecast period include increasing adoption of her2-targeted therapies, rising awareness of gastric cancer subtypes, expansion of immunotherapy and monoclonal antibody usage, growth in personalized treatment approaches, enhanced focus on early detection and diagnostic testing.
The increasing use of targeted cancer therapy is anticipated to drive growth in the human epidermal growth factor receptor 2 (HER2)-positive gastric cancer market in the coming years. Targeted therapy, also referred to as personalized medicine, is a treatment strategy that employs specific drugs or agents to inhibit cancer growth by focusing on particular molecules involved in tumor development. The growth in the adoption of targeted therapies is largely attributed to advances in genetic profiling, which enable more precise treatments tailored to an individual's unique tumor characteristics, resulting in enhanced effectiveness and reduced side effects. In HER2-positive gastric cancer, targeted therapy works by directly targeting the HER2 protein, which is overexpressed in these tumors, thereby slowing disease progression and improving patient outcomes. For example, in February 2024, the Personalized Medicine Coalition, a U.S.-based professional membership organization, reported that the Food and Drug Administration (FDA) approved 16 new personalized medicines in 2023, including 7 for cancer and 3 for other diseases and conditions, up from 6 approvals in 2022. This trend highlights that the increasing adoption of targeted cancer therapy is fueling the growth of the HER2-positive gastric cancer market.
Key players in the human epidermal growth factor receptor 2 (HER2)-positive gastric cancer market are focusing on obtaining approvals for innovative therapies, such as advanced immunotherapy-enhanced combination regimens, which combine immune checkpoint inhibitors with targeted therapy and chemotherapy to substantially improve patient outcomes in first-line treatment settings. These regimens harness the immune system by blocking programmed death (PD)-1 or programmed death ligand (PD-L1) interactions while simultaneously targeting HER2 receptors and employing chemotherapeutic agents, thereby boosting anti-tumor activity and improving survival rates. For instance, in March 2025, Merck & Co., Inc., a U.S.-based biopharmaceutical company, received FDA approval for pembrolizumab (Keytruda) in combination with trastuzumab and chemotherapy as a first-line treatment for adults with HER2-positive unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma whose tumors express PD-L1. This combination therapy demonstrated significant improvements in median progression-free survival and overall survival compared to standard treatments. With an overall response rate of 73% and a longer median duration of response, this therapy represents a major advancement in the management of advanced HER2-positive gastric cancers.
In December 2023, Pfizer Inc., a U.S.-based pharmaceutical company, acquired Seagen Inc. for an undisclosed sum. Through this acquisition, Pfizer aims to expand its oncology portfolio and strengthen its capabilities in targeted cancer therapies. Seagen Inc., a U.S.-based biotechnology company, specializes in treatments for HER2-positive gastric cancer.
Major companies operating in the human epidermal growth factor receptor 2 (her2)-positive gastric cancer market are Pfizer Inc., Roche Holding AG, Merck & Co Inc., Bayer Aktiengesellschaft, Eli Lilly and Company, Bristol-Myers Squibb Company, AstraZeneca PLC, Novartis AG, Amgen Inc., Astellas Pharma Inc., Daiichi Sankyo Company Limited, Genentech Inc., Ono Pharmaceutical Co Ltd., Shanghai Henlius Biotech Inc., MacroGenics Inc., Hutchison Medipharma Limited , ALX Oncology Holdings Inc., Taiho Pharmaceutical Co Ltd., Ambrx Biopharma Inc., LintonPharm Co Ltd.
North America was the largest region in the human epidermal growth factor receptor 2 (HER2)-positive gastric cancer market in 2025. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the human epidermal growth factor receptor 2 (her2)-positive gastric cancer market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the human epidermal growth factor receptor 2 (her2)-positive gastric cancer market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The human epidermal growth factor receptor 2 (HER2)-positive gastric cancer market consists of sales of trastuzumab, pertuzumab, margetuximab, and lapatinib. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastric Cancer Market Global Report 2026 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses human epidermal growth factor receptor 2 (her2)-positive gastric cancer market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for human epidermal growth factor receptor 2 (her2)-positive gastric cancer ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The human epidermal growth factor receptor 2 (her2)-positive gastric cancer market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, total addressable market (TAM), market attractiveness score (MAS), competitive landscape, market shares, company scoring matrix, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
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