PUBLISHER: The Business Research Company | PRODUCT CODE: 1957699
PUBLISHER: The Business Research Company | PRODUCT CODE: 1957699
Programmed death-1 (PD-1) non-small cell lung cancer (NSCLC) refers to a type of lung cancer in which tumors evade immune detection by exploiting the PD-1 pathway, an important immune checkpoint. PD-1 is a receptor on T cells that, when bound by its ligands PD-L1 or PD-L2, suppresses immune responses to prevent tissue damage. In NSCLC, tumors often overexpress PD-L1, allowing them to escape immune surveillance and progress.
The main types of PD-1 NSCLC therapies include monotherapy and combination therapy. Monotherapy involves treating the disease with a single drug, without combining it with other treatments. These therapies are applied across different lines of treatment, including first-line, second-line, and later stages, and are used by a variety of end users, such as hospitals, specialty cancer centers, academic and research institutions, and others.
Tariffs have affected the PD-1 NSCLC market by increasing the cost of imported immunotherapy drugs, biologics, and combination therapy agents, disrupting supply chains and raising treatment costs. Hospitals, specialty cancer centers, and academic institutes in regions like North America and Europe, which rely heavily on imported drugs, are most impacted. However, tariffs have also encouraged local production, research collaborations, and development of cost-optimized PD-1 therapies, potentially improving long-term access and affordability.
The programmed death (pd)-1 non-small cell lung cancer market research report is one of a series of new reports from The Business Research Company that provides programmed death (pd)-1 non-small cell lung cancer market statistics, including programmed death (pd)-1 non-small cell lung cancer industry global market size, regional shares, competitors with a programmed death (pd)-1 non-small cell lung cancer market share, detailed programmed death (pd)-1 non-small cell lung cancer market segments, market trends and opportunities, and any further data you may need to thrive in the programmed death (pd)-1 non-small cell lung cancer industry. This programmed death (pd)-1 non-small cell lung cancer market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The programmed death (pd)-1 non-small cell lung cancer market size has grown strongly in recent years. It will grow from $27.5 billion in 2025 to $29.92 billion in 2026 at a compound annual growth rate (CAGR) of 8.8%. The growth in the historic period can be attributed to limited pd-1 inhibitors approved for nsclc, growing incidence of lung cancer, increasing physician awareness about immune checkpoint therapies, reliance on chemotherapy as standard care, early clinical trial successes of pembrolizumab and nivolumab.
The programmed death (pd)-1 non-small cell lung cancer market size is expected to see strong growth in the next few years. It will grow to $41.45 billion in 2030 at a compound annual growth rate (CAGR) of 8.5%. The growth in the forecast period can be attributed to development of novel combination therapies, expansion of biomarker-driven personalized treatment, increasing adoption of mRNA vaccine-based therapies, growing investment in immuno-oncology research, rising government and private funding for cancer immunotherapy. Major trends in the forecast period include increased adoption of pd-1 monotherapy for nsclc, growth in combination therapies with chemotherapy, ctla-4 inhibitors, and vegf inhibitors, rising investment in targeted therapy and mrna vaccine research, expansion of first-line and second-line treatment options, integration of personalized medicine and biomarker testing in treatment planning.
The increasing adoption of personalized treatments is expected to drive the growth of the programmed death (PD)-1 non-small cell lung cancer market in the coming years. Personalized treatments are medical approaches tailored to an individual's genetic profile, lifestyle, and specific disease characteristics to achieve more effective and targeted outcomes. The rising demand for these treatments is fueled by greater access to genomic profiling and biomarker testing, which help identify specific mutations and biological markers, enabling clinicians to select therapies most likely to be effective. Personalized treatments support PD-1 non-small cell lung cancer (NSCLC) by customizing therapies based on a patient's genetic profile, tumor characteristics, and immune response. For instance, in February 2024, the Personalized Medicine Coalition reported that the U.S. Food and Drug Administration (FDA) approved 16 new personalized treatments for rare diseases in 2023, compared to 6 in 2022. Therefore, the growing adoption of personalized treatments is propelling the PD-1 non-small cell lung cancer market.
Key companies in this market are focusing on clinical trials of innovative therapies, such as monotherapy, to improve patient outcomes. Monotherapy uses a single drug or therapy to treat a condition. For example, in March 2025, Akeso, Inc., a China-based biopharmaceutical company, announced positive results from its Phase III HARMONi-2 trial evaluating Ivonescimab (AK112) in combination with chemotherapy for first-line treatment of advanced NSCLC. The study met its primary endpoint by significantly extending progression-free survival compared to pembrolizumab, highlighting the potential of this dual-targeted bispecific antibody.
In February 2025, BioNTech SE, a Germany-based biotechnology company, acquired Biotheus Inc. for an undisclosed amount. This acquisition gave BioNTech access to Biotheus's lead asset, PM8002, a bispecific antibody targeting PD-L1 and vascular endothelial growth factor (VEGF)-A, currently in late-stage trials for NSCLC and other solid tumors. Biotheus Inc. is a China-based company specializing in multispecific biologics and immuno-oncology candidates, including PD-1 therapies for NSCLC.
Major companies operating in the programmed death (pd)-1 non-small cell lung cancer market are F. Hoffmann-La Roche Ltd, Merck & Co. Inc., Sanofi S.A., Novartis AG, GlaxoSmithKline plc, Regeneron Pharmaceuticals Inc., Incyte Corporation, Ono Pharmaceutical Co. Ltd., BeiGene Ltd., BioNTech SE, Shanghai Junshi Biosciences Co. Ltd., Akeso Inc., Arcus Biosciences Inc., Shandong Boan Biotechnology Co. Ltd., CStone Pharmaceuticals, iTeos Therapeutics Inc., Summit Therapeutics Inc., Shanghai Henlius Biotech Inc.
North America was the largest region in the programmed death (PD)-1 non-small cell lung cancer market in 2025. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the programmed death (pd)-1 non-small cell lung cancer market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the programmed death (pd)-1 non-small cell lung cancer market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The programmed death-1 (PD-1) non-small cell lung cancer market consists of revenues earned by entities by providing services such as clinical oncology services for immunotherapy administration, companion diagnostic testing, and comprehensive patient support services. The market value includes the value of related goods sold by the service provider or included within the service offering. The programmed death-1 (PD-1) non-small cell lung cancer market also includes sales of pembrolizumab (Keytruda), nivolumab (Opdivo), and cemiplimab (Libtayo). Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Programmed Death (PD)-1 Non-Small Cell Lung Cancer Market Global Report 2026 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses programmed death (pd)-1 non-small cell lung cancer market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for programmed death (pd)-1 non-small cell lung cancer ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The programmed death (pd)-1 non-small cell lung cancer market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, total addressable market (TAM), market attractiveness score (MAS), competitive landscape, market shares, company scoring matrix, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
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