PUBLISHER: The Business Research Company | PRODUCT CODE: 2127192
PUBLISHER: The Business Research Company | PRODUCT CODE: 2127192
Alzheimer's agitation non-antipsychotic drug therapy refers to pharmaceutical approaches used to manage agitation, aggression, and associated behavioral symptoms in individuals with Alzheimer's disease without the use of antipsychotic medications. These therapies work by influencing neurotransmitter activity and neurobiological pathways associated with mood, behavior, and cognitive regulation to improve symptom management. Alzheimer's agitation non-antipsychotic drug therapies aim to provide safer treatment alternatives to antipsychotics by minimizing risks such as sedation, cognitive impairment, and cardiovascular complications.
The primary drug classes of Alzheimer's agitation non-antipsychotic drug therapy include N-methyl-D-aspartate receptor antagonists, sigma-one receptor agonists, serotonin modulators, and novel central nervous system targets. N-methyl-D-aspartate receptor antagonists refer to therapeutic agents that regulate glutamate activity in the brain to help manage agitation symptoms associated with Alzheimer's disease. These therapies are designed for patient settings including memory care facilities, home care, assisted living, and hospital inpatient settings and address disease stages such as mild to moderate Alzheimer's and moderate to severe Alzheimer's. They are administered through routes including oral, injectable, transdermal, and intranasal and are utilized by end users including hospitals, neurology clinics, geriatric care centers, rehabilitation centers, and home healthcare providers.
Tariffs are influencing the Alzheimer's agitation non-antipsychotic drug therapy market by increasing the cost of imported active pharmaceutical ingredients, biologic materials, laboratory equipment, and specialized drug manufacturing components required for therapy development and production. This is creating supply chain disruptions and increasing production expenses across pharmaceutical and biotechnology ecosystems, particularly in regions dependent on imported healthcare materials such as North America, Europe, and Asia-Pacific. Drug-intensive segments such as serotonin modulators, sigma-one receptor agonists, and novel central nervous system targets are most affected due to their dependence on globally sourced ingredients and research inputs. However, tariffs are also encouraging local pharmaceutical manufacturing expansion, regional supplier diversification, and increased investments in domestic drug development ecosystems, creating stronger long-term market resilience.
The alzheimer's agitation non-antipsychotic drug therapy market research report is one of a series of new reports from The Business Research Company that provides alzheimer's agitation non-antipsychotic drug therapy market statistics, including alzheimer's agitation non-antipsychotic drug therapy industry global market size, regional shares, competitors with a alzheimer's agitation non-antipsychotic drug therapy market share, detailed alzheimer's agitation non-antipsychotic drug therapy market segments, market trends and opportunities, and any further data you may need to thrive in the alzheimer's agitation non-antipsychotic drug therapy industry. This alzheimer's agitation non-antipsychotic drug therapy market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The alzheimer's agitation non-antipsychotic drug therapy market size has grown rapidly in recent years. It will grow from $5.09 billion in 2025 to $5.85 billion in 2026 at a compound annual growth rate (CAGR) of 14.7%. The growth in the historic period can be attributed to rising prevalence of alzheimer's disease globally, increasing geriatric population growth, growing awareness regarding behavioral symptoms in dementia care, expansion of neurological research activities, increasing concerns regarding antipsychotic related adverse effects.
The alzheimer's agitation non-antipsychotic drug therapy market size is expected to see rapid growth in the next few years. It will grow to $9.98 billion in 2030 at a compound annual growth rate (CAGR) of 14.3%. The growth in the forecast period can be attributed to growing investments in neurodegenerative disease drug development, increasing demand for precision medicine approaches, rising clinical research for novel neurobehavioral therapies, expansion of home based dementia care services, increasing regulatory support for safer treatment alternatives. Major trends in the forecast period include increasing development of safer alternatives to antipsychotic therapies, growing focus on targeted neurobehavioral symptom management, rising adoption of multimodal therapeutic approaches for agitation treatment, increasing research on neurotransmitter pathway modulation therapies, expansion of clinical trials for novel central nervous system therapies.
The increasing prevalence of Alzheimer's disease is expected to drive the growth of the Alzheimer's agitation non-antipsychotic drug therapy market going forward. Alzheimer's disease is a progressive neurodegenerative condition that gradually affects memory, cognitive abilities, and behavior due to the deterioration and loss of brain cells. The growing prevalence of Alzheimer's disease is attributed to rising life expectancy, as an expanding elderly population increases the number of individuals reaching age groups with a higher risk of developing the condition. Alzheimer's agitation non-antipsychotic drug therapy helps manage behavioral and psychological symptoms associated with Alzheimer's disease, enhancing patient care, improving quality of life, and supporting better long-term care outcomes for the increasing patient population. For instance, in December 2025, according to the Australian Government, an Australian-based government department, approximately 25,000 people in Australia were living with dementia, including nearly 266,000 women and 159,000 men, representing around 16 cases per 1,000 Australians (19 per 1,000 women and 12 per 1,000 men). Therefore, the increasing prevalence of Alzheimer's disease is driving the growth of the Alzheimer's agitation non-antipsychotic drug therapy market.
The increasing investments in research and development are expected to drive the growth of the Alzheimer's agitation non-antipsychotic drug therapy market going forward. Research and development investments refer to the allocation of financial resources by governments, pharmaceutical companies, and academic organizations toward the discovery, development, and clinical evaluation of new therapeutic solutions. The growth in R&D investments is primarily fueled by the rising global burden of Alzheimer's disease, as an increasing aging population expands the number of patients requiring targeted therapies, creating greater demand for effective non-antipsychotic treatment approaches. Increased R&D funding supports the discovery and clinical validation of innovative non-antipsychotic compounds that specifically target agitation symptoms in Alzheimer's patients, strengthening the therapeutic pipeline and enabling the introduction of new treatment options. For instance, in February 2025, according to the National Center for Science and Engineering Statistics (NCSES), a US-based government statistical agency, U.S. research and development expenditures increased from $892 billion in 2022 to $940 billion in 2023, representing a rise of $48 billion. Therefore, increasing research and development investments are driving the growth of the Alzheimer's agitation non-antipsychotic drug therapy market.
Major companies operating in the Alzheimer's agitation non-antipsychotic drug therapy market are focusing on developing advanced non-antipsychotic treatments to manage agitation symptoms associated with Alzheimer's disease while reducing the safety risks associated with conventional antipsychotic medications. Non-antipsychotic therapies are treatments that address agitation through alternative neurological pathways without using antipsychotic mechanisms, potentially providing improved safety and tolerability for elderly patients. For instance, in April 2026, Axsome Therapeutics, a US-based biopharmaceutical company, received U.S. FDA approval for Auvelity (dextromethorphan-bupropion) for treating agitation associated with dementia caused by Alzheimer's disease. The approval marked the introduction of the first FDA-approved non-antipsychotic therapy for this indication, providing a new treatment approach for managing agitation symptoms. The therapy acts on NMDA and sigma-1 receptors, expanding available treatment options for patients and caregivers.
Major companies operating in the alzheimer's agitation non-antipsychotic drug therapy market report are Axsome Therapeutics Inc., Bristol Myers Squibb Company, Suven Life Sciences Limited, IGC Pharma Inc., Exciva GmbH, Neumora Therapeutics Inc.
North America was the dominating region in the alzheimer's agitation non-antipsychotic drug therapy market in 2025. Asia-Pacific is expected to be the rapidly growing region in the forecast period. The regions covered in the alzheimer's agitation non-antipsychotic drug therapy market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the alzheimer's agitation non-antipsychotic drug therapy market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The alzheimer's agitation non-antipsychotic drug therapy market consists of sales of mirtazapine, gabapentin, pregabalin, suvorexant, ramelteon, and melatonin. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Alzheimer's Agitation Non-Antipsychotic Drug Therapy Market Global Report 2026 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses alzheimer's agitation non-antipsychotic drug therapy market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for alzheimer's agitation non-antipsychotic drug therapy ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The alzheimer's agitation non-antipsychotic drug therapy market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, total addressable market (TAM), market attractiveness score (MAS), competitive landscape, market shares, company scoring matrix, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
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