PUBLISHER: The Insight Partners | PRODUCT CODE: 1871437
PUBLISHER: The Insight Partners | PRODUCT CODE: 1871437
The therapeutic vaccines market in South and Central America is projected to grow significantly, reaching approximately US$ 6,998.78 thousand by 2031, up from US$ 3,370.35 thousand in 2024, reflecting a compound annual growth rate (CAGR) of 11.0% from 2024 to 2031.
Executive Summary and Market Analysis
The market is divided into key regions: Brazil, Argentina, and the Rest of South and Central America. Growth in this sector is driven by a large population, improving healthcare infrastructure, and an increasing governmental emphasis on healthcare innovation. Additionally, rising healthcare expenditures and a growing demand for treatments due to the prevalence of chronic diseases further stimulate market expansion.
Market Segmentation
The therapeutic vaccines market is categorized by product type, technology, and end user:
Market Outlook
The therapeutic vaccines sector is experiencing robust investment and advancements in vaccine development, driven by the increasing global demand for innovative treatment options. There is a notable rise in clinical candidates advancing through various development stages. Innovative research and development in biotechnology are leading to the creation of advanced therapeutic vaccines targeting a range of diseases, particularly chronic conditions like cancer and newer infections.
For instance, Moderna's mRNA-4157 is currently in phase 2 trials, showing promising results in combination with checkpoint inhibitors for melanoma treatment. The therapeutic vaccine pipeline is also expanding in areas such as autoimmune diseases and infectious diseases, including HIV, HPV, and HBV infections.
Numerous companies are focusing on scientific and technical excellence to develop and launch new therapeutic vaccines. The expanding pipeline of vaccine candidates targeting diverse diseases presents significant opportunities to meet unmet medical needs. Below is a summary of the therapeutic vaccine pipeline:
| Vaccine Type | Vaccine Formulation | Phase/Status | Condition |
|--------------|---------------------|--------------|-----------|
| Bacterial vector vaccine | ADXS11-001 (attenuated live Listeria Encoding HPV 16 E7 vector) | Phase I/II | Cervical carcinoma, Anal cancer, Rectal cancer |
| Peptide/protein vaccine | ISA101 (nine HPV-16 E6 and four HPV-16 E7 synthetic peptides with Montanide ISA51) | Phase II | Solid tumors |
| Personalized peptide vaccine | NeoVax (neoantigen + Poly-ICLC) | Phase I | Kidney cancer |
| mRNA-based neoantigen vaccine | mRNA-4157 (lipid-encapsulated RNA) | Phase I/II | Solid tumors, Melanoma |
| DNA vaccine | VGX-3100 (plasmid encoding E6 and E7 of HPV16/18) | Phase I/II | Head and neck squamous cell cancer, Cervical cancer |
| Virus-like particle | NASVAC (HBsAg, HBcAg) | Phase III | HBV infection |
| Protein vaccine | Theravax (DV-601, consisting of HBsAg, HbcAg, and saponin-based ISCOMATRIX adjuvant) | Phase II | Chronic HBV infection |
| mRNA vaccine | iHIVARNA (consisting of HIV immunogen sequence and a mixture of activation molecules) | Phase I | HIV infection |
| Viral vector vaccines | AdCh3NSmut/Ad6NSmut (encoding HCV proteins) | Phase I | HCV infection |
| DNA vaccine | pNGVL4a-Sig/E7(detox)/HSP70 (HPV16 E7) | Phase I | HPV infection |
With numerous clinical trials underway, the market's future looks promising, offering new treatment options for patients and addressing unmet medical needs in areas where existing treatments fall short. The strong pipeline of therapeutic vaccine candidates indicates substantial growth potential for the market.
Country Insights
The therapeutic vaccines market in South and Central America includes Argentina, Brazil, and the Rest of South and Central America, with Brazil holding the largest market share in 2024. Brazil's market potential is bolstered by its large population, improving healthcare infrastructure, and a governmental focus on healthcare innovation. As of 2022, over 30 million Brazilians were aged 60 and above, a figure expected to rise to nearly 50 million by 2030, representing 24% of the population. The country faces a high incidence of chronic diseases and cancers, creating a significant health burden. According to GLOBOCAN 2020, Brazil reported 592,212 cancer cases, highlighting the need for effective therapeutic vaccines to alleviate this burden. As healthcare professionals become more familiar with personalized medicine and targeted therapies, the demand for therapeutic vaccines is anticipated to grow.
Company Profiles
Key players in the therapeutic vaccines market include CureVac SE, THERAVECTYS SA, Transgene SA, INOVIO Pharmaceuticals Inc, ISA Pharmaceuticals BV, Amgen Inc, Merck & Co Inc, Serum Institute of India Pvt. Ltd, BioNTech SE, and Dendreon. These companies are pursuing various strategies, including expansion, product innovation, and mergers and acquisitions, to enhance their market presence and offer innovative products.