PUBLISHER: AnalystView Market Insights | PRODUCT CODE: 1836233
PUBLISHER: AnalystView Market Insights | PRODUCT CODE: 1836233
Chronic refractory gout market size was valued at US$ 1,804.25 Million in 2024, expanding at a CAGR of 10.23% from 2025 to 2032.
Chronic refractory gout is a severe form of gout in which patients do not respond adequately to standard urate-lowering therapies or cannot tolerate them. It is characterized by persistently high uric acid levels, frequent painful flares, and tophi formation that can damage joints and surrounding tissues. This condition often requires advanced treatments, such as uricase-based therapies or biologics, along with comprehensive management of comorbidities to reduce complications and improve quality of life.
Chronic Refractory Gout Market- Market Dynamics
Increasing burden of gouts across the globe to propel market demand
The rising global burden of gout is driving demand for advanced treatment options. In 2020, an estimated 55.8 million people worldwide were living with gout. Obesity and kidney dysfunction are major contributors to disability from the disease, with high body mass index accounting for 34.3% of years lived with disability (YLDs) due to gout, and kidney dysfunction contributing 11.8%. However, underdiagnosis of these comorbidities often delays appropriate treatment.
In the United States, the Centers for Disease Control and Prevention (CDC) reports that more than 1 in 7 adults have chronic kidney disease. On the positive side, lifestyle interventions targeting obesity can significantly reduce gout severity and progression. Additionally, improving chronic kidney disease (CKD) detection in gout patients could enhance treatment outcomes and help address one of the key underlying drivers of refractory cases.
The Global Chronic Refractory Gout Market is segmented on the basis of Therapy Class, Route of Administration, Disease Burden, Comorbidity Profile, Propulsion, Distribution Channel, and Region.
The market is divided into four categories based on Therapy Class: uricase therapies, IL-1 inhibitors, adjunct anti-inflammatories, and next-generation small molecules. The uricase therapies segment is expected to hold the major market share during the forecast period. This dominance is driven by their unique ability to rapidly and effectively lower serum uric acid levels in patients unresponsive to conventional treatments.
The market is divided into two categories based on Comorbidity Profile: renal impairment and cardiovascular/metabolic conditions. Among these, the renal impairment segment is expected to capture the major market share. Chronic kidney disease is a frequent complication in gout patients, limiting the use of traditional urate-lowering drugs and creating higher reliance on advanced therapies like uricase-based treatments. Renal impairment poses the greatest therapeutic challenge, driving stronger demand for specialized and effective treatment options in this patient group.
Chronic Refractory Gout Market- Geographical Insights
North America cancer biopsy market dominated the global market, and a similar trend is observed in the chronic refractory gout segment due to high disease burden and strong healthcare infrastructure. According to the U.S. Centers for Disease Control and Prevention (CDC), nearly 9.2 million adults in the United States suffer from gout, representing about 3.9% of the adult population.
A significant proportion of these cases develop into chronic and treatment-resistant forms, driving the demand for advanced therapies such as pegloticase. The U.S. Food and Drug Administration (FDA) has prioritized approvals of biologics and novel urate-lowering drugs to address unmet needs in refractory cases. In Europe, the prevalence is also notable, with the UK's National Health Service (NHS) reporting a sharp rise in gout-related hospital admissions over the past decade. Meanwhile, in Asia Pacific, Japan's Ministry of Health and Welfare identifies gout as a growing concern linked to lifestyle diseases, further expanding treatment demand.
Rising prevalence of uncontrolled gout cases is encouraging companies to refine treatment strategies. Competitors are focusing on developing biologics and uricase-based therapies with improved safety and longer durability of response. Many are exploring combination regimens with immunomodulators to reduce antibody formation and enhance effectiveness. Partnerships with research institutes, specialty clinics, and payers aim to expand patient access. In parallel, firms are investing in patient-support programs, infusion services, and digital monitoring tools to strengthen adherence and improve long-term treatment outcomes.
In March 2025, Shanton Pharma announced positive Phase 2b results for SAP-001 in refractory gout patients, showing nearly 100% target achievement versus 10% on conventional therapy, with sustained effects, strong efficacy, and excellent safety across six months of treatment.
Chronic Refractory Gout Market - By Disease Burden