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PUBLISHER: Coherent Market Insights | PRODUCT CODE: 1766587

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PUBLISHER: Coherent Market Insights | PRODUCT CODE: 1766587

Prolia Market, By Indication, By Age Group, By Gender, By End User, By Sales Channel, By Geography

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Prolia Market is estimated to be valued at USD 4,562.1 Mn in 2025 and is expected to reach USD 5,703.2 Mn by 2032, growing at a compound annual growth rate (CAGR) of 3.2% from 2025 to 2032.

Report Coverage Report Details
Base Year: 2024 Market Size in 2025: USD 4,562.1 Mn
Historical Data for: 2020 To 2024 Forecast Period: 2025 To 2032
Forecast Period 2025 to 2032 CAGR: 3.20% 2032 Value Projection: USD 5,703.2 Mn

This steady growth reflects increasing adoption and awareness about Prolia as a treatment option for osteoporosis and related bone disorders, supported by rising prevalence rates and expanding healthcare infrastructure worldwide.

The global Prolia market represents a significant segment within the pharmaceutical industry, focusing on denosumab-based therapeutic solutions primarily designed for treating osteoporosis and other bone-related disorders. Prolia, developed as a RANKL inhibitor, has revolutionized the treatment landscape for postmenopausal women with osteoporosis at high risk for fracture, patients with bone loss due to hormone ablation therapy for cancer, and individuals with glucocorticoid-induced osteoporosis. This innovative biologic therapy works by mimicking the natural process that keeps bones strong, effectively blocking the formation, function, and survival of osteoclasts, the cells responsible for bone destruction. The market encompasses various stakeholders including pharmaceutical manufacturers, healthcare providers, patients, and regulatory bodies, all contributing to the dynamic ecosystem surrounding this critical therapeutic area. As global demographics shift toward an aging population, the prevalence of osteoporosis and related bone disorders continues to rise, creating substantial demand for effective treatment options like Prolia. The market's growth trajectory is influenced by factors such as increasing awareness about bone health, advancing healthcare infrastructure, regulatory approvals across different regions, and the continuous evolution of treatment protocols that incorporate Prolia as a cornerstone therapy for bone loss prevention and management.

Market Dynamics

The global Prolia market growth is driven by several compelling factors that collectively propel its expansion across international healthcare systems. The primary driver stems from the rapidly aging global population, particularly the increasing number of postmenopausal women who face heightened osteoporosis risk, creating a substantial patient pool requiring effective bone protection therapies. Additionally, rising awareness about bone health among healthcare professionals and patients, coupled with improved diagnostic capabilities for osteoporosis detection, significantly contributes to market growth. The superior efficacy profile of Prolia compared to traditional bisphosphonates, demonstrated through reduced fracture rates and improved bone mineral density, drives physician preference and patient adoption. However, the market faces notable restraints including the high cost of Prolia treatment, which limits accessibility in price-sensitive markets and creates reimbursement challenges across various healthcare systems. Safety concerns, particularly regarding osteonecrosis of the jaw and atypical femoral fractures in long-term users, create hesitation among some healthcare providers and patients, potentially limiting market penetration. Regulatory complexities and lengthy approval processes for new indications or geographic expansions also constrain market growth. Nevertheless, significant opportunities exist within emerging markets where healthcare infrastructure improvements and increasing healthcare expenditure create new avenues for market expansion. The potential for label expansion into additional indications, such as treatment of giant cell tumor of bone and hypercalcemia of malignancy, presents substantial growth opportunities. Furthermore, the development of biosimilar versions could democratize access while maintaining market volume, and strategic partnerships between pharmaceutical companies and healthcare systems could enhance market penetration through improved patient access programs and educational initiatives.

Key Features of the Study

  • This report provides in-depth analysis of the global Prolia market, and provides market size (USD Million) and compound annual growth rate (CAGR%) for the forecast period (2025-2032), considering 2024 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approvals, market trends, regional outlook, and competitive strategies adopted by key players
  • It profiles key players in the global Prolia market based on the following parameters - company highlights, products portfolio, key highlights, financial performance, and strategies
  • Key companies covered as a part of this study include Amgen Inc.
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launches, type up-gradation, market expansion, and marketing tactics
  • The global Prolia market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the global Prolia market

Market Segmentation

  • Indication Insights (Revenue, USD Mn, 2020 - 2032)
    • Postmenopausal osteoporosis (high fracture risk)
    • Men's osteoporosis (high fracture risk)
    • Glucocorticoid-induced osteoporosis (high fracture risk)
    • Men on androgen deprivation therapy (high fracture risk)
    • Women on aromatase inhibitor therapy (high fracture risk)
  • Age Group Insights (Revenue, USD Mn, 2020 - 2032)
    • Pediatric
    • Adult
    • Geriatric
  • Gender Insights (Revenue, USD Mn, 2020 - 2032)
    • Male
    • Female
  • End User Insights (Revenue, USD Mn, 2020 - 2032)
    • Hospitals
    • Specialty Clinics
    • Ambulatory Surgical Centers (ASCs)
    • Long-Term Care Facilities
    • Orthopedic Clinics
    • Others (Rehabilitation Centers, etc.)
  • Sales Channel Insights (Revenue, USD Mn, 2020 - 2032)
    • Online
    • Offline
  • Regional Insights (Revenue, USD Mn, 2020 - 2032)
    • North America
    • U.S.
    • Canada
    • Latin America
    • Brazil
    • Argentina
    • Mexico
    • Rest of Latin America
    • Europe
    • Germany
    • U.K.
    • Spain
    • France
    • Italy
    • Russia
    • Rest of Europe
    • Asia Pacific
    • China
    • India
    • Japan
    • Australia
    • South Korea
    • ASEAN
    • Rest of Asia Pacific
    • Middle East
    • GCC Countries
    • Israel
    • Rest of Middle East
    • Africa
    • South Africa
    • North Africa
    • Central Africa
  • Key Players Insights
    • Amgen Inc.
Product Code: CMI8149

Table of Contents

1. Research Objectives and Assumptions

  • Research Objectives
  • Assumptions
  • Abbreviations

2. Market Purview

  • Report Description
    • Market Definition and Scope
  • Executive Summary
    • Global Prolia Market, By Indication
    • Global Prolia Market, By Age Group
    • Global Prolia Market, By Gender
    • Global Prolia Market, By End User
    • Global Prolia Market, By Sales Channel
    • Global Prolia Market, By Region

3. Market Dynamics, Regulations, and Trends Analysis

  • Market Dynamics
  • Driver
  • Restraint
  • Opportunity
  • Impact Analysis
  • Key Developments
  • Regulatory Scenario
  • Product Launches/Approvals
  • PEST Analysis
  • PORTER's Analysis
  • Merger and Acquisition Scenario
  • Industry Trends
  • Epidemiology
    • Adherence
    • Persistence

4. Global Prolia Market, By Indication, 2020-2032, (USD Mn)

  • Introduction
    • Market Share Analysis, 2025 and 2032 (%)
    • Y-o-Y Growth Analysis, 2021 - 2032
    • Segment Trends
  • Postmenopausal osteoporosis (high fracture risk)
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Men's osteoporosis (high fracture risk)
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Glucocorticoid-induced osteoporosis (high fracture risk)
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Men on androgen deprivation therapy (high fracture risk)
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Women on aromatase inhibitor therapy (high fracture risk)
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)

5. Global Prolia Market, By Age Group, 2020-2032, (USD Mn)

  • Introduction
    • Market Share Analysis, 2025 and 2032 (%)
    • Y-o-Y Growth Analysis, 2021 - 2032
    • Segment Trends
  • Pediatric
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Adult
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Geriatric
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)

6. Global Prolia Market, By Gender, 2020-2032, (USD Mn)

  • Introduction
    • Market Share Analysis, 2025 and 2032 (%)
    • Y-o-Y Growth Analysis, 2021 - 2032
    • Segment Trends
  • Male
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Female
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)

7. Global Prolia Market, By End User, 2020-2032, (USD Mn)

  • Introduction
    • Market Share Analysis, 2025 and 2032 (%)
    • Y-o-Y Growth Analysis, 2021 - 2032
    • Segment Trends
  • Hospitals
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Specialty Clinics
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Ambulatory Surgical Centers (ASCs)
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Long-Term Care Facilities
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Orthopedic Clinics
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Others (Rehabilitation Centers, etc.)
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)

8. Global Prolia Market, By Sales Channel, 2020-2032, (USD Mn)

  • Introduction
    • Market Share Analysis, 2025 and 2032 (%)
    • Y-o-Y Growth Analysis, 2021 - 2032
    • Segment Trends
  • Online
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
  • Offline
    • Introduction
    • Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)

9. Global Prolia Market, By Region, 2020 - 2032, Value (USD Mn)

  • Introduction
    • Market Share (%) Analysis, 2025, 2028 & 2032, Value (USD Mn)
    • Market Y-o-Y Growth Analysis (%), 2021 - 2032, Value (USD Mn)
    • Regional Trends
  • North America
    • Introduction
    • Market Size and Forecast, By Indication, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Age Group, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Gender, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By End User, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Sales Channel, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Country, 2020 - 2032, Value (USD Mn)
      • U.S.
      • Canada
  • Latin America
    • Introduction
    • Market Size and Forecast, By Indication, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Age Group, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Gender, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By End User, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Sales Channel, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Country, 2020 - 2032, Value (USD Mn)
      • Brazil
      • Argentina
      • Mexico
      • Rest of Latin America
  • Europe
    • Introduction
    • Market Size and Forecast, By Indication, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Age Group, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Gender, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By End User, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Sales Channel, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Country, 2020 - 2032, Value (USD Mn)
      • Germany
      • U.K.
      • Spain
      • France
      • Italy
      • Russia
      • Rest of Europe
  • Asia Pacific
    • Introduction
    • Market Size and Forecast, By Indication, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Age Group, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Gender, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By End User, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Sales Channel, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Country, 2020 - 2032, Value (USD Mn)
      • China
      • India
      • Japan
      • Australia
      • South Korea
      • ASEAN
      • Rest of Asia Pacific
  • Middle East
    • Introduction
    • Market Size and Forecast, By Indication, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Age Group, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Gender, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By End User, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Sales Channel, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Country, 2020 - 2032, Value (USD Mn)
      • GCC Countries
      • Israel
      • Rest of Middle East
  • Africa
    • Introduction
    • Market Size and Forecast, By Indication, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Age Group, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Gender, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By End User, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Sales Channel, 2020 - 2032, Value (USD Mn)
    • Market Size and Forecast, By Country/Region, 2020 - 2032, Value (USD Mn)
      • South Africa
      • North Africa
      • Central Africa

10. Competitive Landscape

  • Amgen Inc.
    • Company Highlights
    • Product Portfolio
    • Key Developments
    • Financial Performance
    • Strategies

11. Analyst Recommendations

  • Wheel of Fortune
  • Analyst View
  • Coherent Opportunity Map

12. References and Research Methodology

  • References
  • Research Methodology
  • About us
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