PUBLISHER: Coherent Market Insights | PRODUCT CODE: 1789384
PUBLISHER: Coherent Market Insights | PRODUCT CODE: 1789384
Aldosterone Synthase Inhibitors Market, By Drug Type, By Drug, By Indication, By Stage of Development, By Gender, By End User, By Geography
Aldosterone Synthase Inhibitors Market is estimated to be valued at USD 225.9 Mn in 2025 and is expected to reach USD 369.6 Mn by 2032, growing at a compound annual growth rate (CAGR) of 7.3% from 2025 to 2032.
| Report Coverage | Report Details | ||
|---|---|---|---|
| Base Year: | 2024 | Market Size in 2025: | USD 225.9 Mn |
| Historical Data for: | 2020 To 2024 | Forecast Period: | 2025 To 2032 |
| Forecast Period 2025 to 2032 CAGR: | 7.30% | 2032 Value Projection: | USD 369.6 Mn |
The global aldosterone synthase inhibitors market represents a specialized pharmaceutical segment focused on developing therapeutic solutions for cardiovascular and renal diseases associated with aldosterone overproduction. Aldosterone synthase, also known as CYP11B2, is a crucial enzyme responsible for the final step in aldosterone biosynthesis within the adrenal cortex. Inhibitors targeting this enzyme offer promising therapeutic potential for treating conditions such as primary aldosteronism, resistant hypertension, heart failure, and chronic kidney disease. These inhibitors work by selectively blocking aldosterone production while preserving cortisol synthesis, providing a more targeted approach compared to traditional mineralocorticoid receptor antagonists.
The market encompasses various developmental stages, from preclinical research to clinical trials, with several pharmaceutical companies investing significantly in this therapeutic area. The growing understanding of aldosterone's role in cardiovascular pathophysiology and the limitations of current treatment options have intensified research efforts in this field. Market growth is primarily driven by increasing prevalence of cardiovascular diseases, rising awareness about primary aldosteronism, and the need for more effective therapeutic alternatives. The development of selective aldosterone synthase inhibitors represents a significant advancement in precision medicine approaches for managing aldosterone-related disorders.
Market Dynamics
The global aldosterone synthase inhibitors market is experiencing significant growth driven by multiple factors, with the primary driver being the increasing prevalence of cardiovascular diseases worldwide, particularly resistant hypertension and heart failure, which affects millions of patients globally and creates substantial demand for innovative therapeutic solutions. The growing recognition of primary aldosteronism as a more common cause of secondary hypertension than previously thought, affecting approximately 10-15% of hypertensive patients, has intensified research focus on aldosterone synthase inhibitors as targeted therapeutic interventions.
Additionally, the limitations of existing treatments, including side effects associated with mineralocorticoid receptor antagonists such as hyperkalemia and hormonal disturbances, create opportunities for more selective therapeutic approaches. However, the market faces significant restraints including complex regulatory pathways for novel enzyme inhibitors, substantial research and development costs, and lengthy clinical trial processes that can extend over several years before market approval. The technical challenges associated with developing selective inhibitors that effectively target aldosterone synthase while avoiding interference with other steroidogenic enzymes present additional hurdles for pharmaceutical companies. Furthermore, the specialized nature of this therapeutic area requires extensive clinical expertise and infrastructure, limiting the number of companies capable of pursuing these developments.
Despite these challenges, opportunities abound in the form of increasing investment in cardiovascular research, growing partnerships between pharmaceutical companies and academic institutions, expanding understanding of aldosterone's role in various disease states beyond hypertension, and the potential for combination therapies that could enhance treatment efficacy and patient outcomes.
Key Features of the Study
- This report provides in-depth analysis of the global aldosterone synthase inhibitors market, and provides market size (USD Million) and compound annual growth rate (CAGR%) for the forecast period (2025-2032), considering 2024 as the base year.
- It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market.
- This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends, regional outlook, and competitive strategies adopted by key players.
- It profiles key players in the global aldosterone synthase inhibitors market based on the following parameters - company highlights, products portfolio, key highlights, financial performance, and strategies.
- Key companies covered as a part of this study include major pharmaceutical companies, biotechnology firms, and research institutions actively involved in aldosterone synthase inhibitor development.
- Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launches, type up-gradation, market expansion, and marketing tactics.
- The global aldosterone synthase inhibitors market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts.
- Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the global aldosterone synthase inhibitors market.
Market Segmentation
- Drug Type Insights (Revenue, USD Mn, 2020 - 2032)
- Selective Aldosterone Synthase Inhibitors
- Non-Selective CYP11B Inhibitors
- Drug Insights (Revenue, USD Mn, 2020 - 2032)
- Osilodrostat
- Lorundrostat
- Baxdrostat
- Vicadrostat
- Dexfadrostat
- Indication Insights (Revenue, USD Mn, 2020 - 2032)
- Cushing's Syndrome
- Hypertension
- Primary aldosteronism (Conn's syndrome)
- Heart Failure
- Heart Failure with Reduced Ejection Fraction (HFrEF)
- Heart Failure with Preserved Ejection Fraction (HFpEF)
- Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
- Stage of Development Insights (Revenue, USD Mn, 2020 - 2032)
- Preclinical
- Phase I Clinical Trials
- Phase II Clinical Trials
- Phase III Clinical Trials
- Approved or Marketed
- Gender Insights (Revenue, USD Mn, 2020 - 2032)
- Male
- Female
- End User Insights (Revenue, USD Mn, 2020 - 2032)
- Hospitals
- Cardiology Clinics
- Nephrology Clinics
- Research and Academic Institutes
- Contract Research Organizations (CROs)
- Regional Insights (Revenue, USD Mn, 2020 - 2032)
- North America
- U.S.
- Canada
- Latin America
- Brazil
- Argentina
- Mexico
- Rest of Latin America
- Europe
- Germany
- U.K.
- Spain
- France
- Italy
- Russia
- Rest of Europe
- Asia Pacific
- China
- India
- Japan
- Australia
- South Korea
- ASEAN
- Rest of Asia Pacific
- Middle East
- GCC Countries
- Israel
- Rest of Middle East
- Africa
- South Africa
- North Africa
- Central Africa
- Key Players Insights
- Mineralys Therapeutics, Inc.
- AstraZeneca
- Boehringer Ingelheim International GmbH
- DAMIAN PHARMA AG
- CORXEL
- JX09
- Recordati Rare Diseases Inc.
- Other Prominent Players
Table of Contents
1. Research Objectives and Assumptions
- Research Objectives
- Assumptions
- Abbreviations
2. Market Purview
- Report Description
- Market Definition and Scope
- Executive Summary
- Global Aldosterone Synthase Inhibitors Market, By Drug Type
- Global Aldosterone Synthase Inhibitors Market, By Drug
- Global Aldosterone Synthase Inhibitors Market, By Indication
- Global Aldosterone Synthase Inhibitors Market, By Stage of Development
- Global Aldosterone Synthase Inhibitors Market, By Gender
- Global Aldosterone Synthase Inhibitors Market, By End User
- Global Aldosterone Synthase Inhibitors Market, By Region
3. Market Dynamics, Regulations, and Trends Analysis
- Market Dynamics
- Driver
- Restraint
- Opportunity
- Impact Analysis
- Key Developments
- Regulatory Scenario
- Product Launches/Approvals
- PEST Analysis
- PORTER's Analysis
- Merger and Acquisition Scenario
- Industry Trends
- Pipeline Analysis
- Blockade Mapping
- Chessboard Mapping
- Company Positioning Analysis
- Comparative Matrix
4. Global Aldosterone Synthase Inhibitors Market, By Drug Type, 2020-2032, (USD Mn)
- Introduction
- Market Share Analysis, 2025 and 2032 (%)
- Y-o-Y Growth Analysis, 2021 - 2032
- Segment Trends
- Selective Aldosterone Synthase Inhibitors
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Non-Selective CYP11B Inhibitors
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
5. Global Aldosterone Synthase Inhibitors Market, By Drug, 2020-2032, (USD Mn)
- Introduction
- Market Share Analysis, 2025 and 2032 (%)
- Y-o-Y Growth Analysis, 2021 - 2032
- Segment Trends
- Osilodrostat
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Lorundrostat
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Baxdrostat
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Vicadrostat
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Dexfadrostat
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
6. Global Aldosterone Synthase Inhibitors Market, By Indication, 2020-2032, (USD Mn)
- Introduction
- Market Share Analysis, 2025 and 2032 (%)
- Y-o-Y Growth Analysis, 2021 - 2032
- Segment Trends
- Cushing's Syndrome
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Hypertension
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Primary aldosteronism (Conn's syndrome)
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Heart Failure
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Heart Failure with Reduced Ejection Fraction (HFrEF)
- Heart Failure with Preserved Ejection Fraction (HFpEF)
- Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
7. Global Aldosterone Synthase Inhibitors Market, By Stage of Development, 2020-2032, (USD Mn)
- Introduction
- Market Share Analysis, 2025 and 2032 (%)
- Y-o-Y Growth Analysis, 2021 - 2032
- Segment Trends
- Preclinical
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Phase I Clinical Trials
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Phase II Clinical Trials
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Phase III Clinical Trials
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Approved or Marketed
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
8. Global Aldosterone Synthase Inhibitors Market, By Gender, 2020-2032, (USD Mn)
- Introduction
- Market Share Analysis, 2025 and 2032 (%)
- Y-o-Y Growth Analysis, 2021 - 2032
- Segment Trends
- Male
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Female
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
9. Global Aldosterone Synthase Inhibitors Market, By End User, 2020-2032, (USD Mn)
- Introduction
- Market Share Analysis, 2025 and 2032 (%)
- Y-o-Y Growth Analysis, 2021 - 2032
- Segment Trends
- Hospitals
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Cardiology Clinics
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Nephrology Clinics
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Research and Academic Institutes
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
- Contract Research Organizations (CROs)
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Mn)
10. Global Aldosterone Synthase Inhibitors Market, By Region, 2020 - 2032, Value (USD Mn)
- Introduction
- Market Share (%) Analysis, 2025,2028 & 2032, Value (USD Mn)
- Market Y-o-Y Growth Analysis (%), 2021 - 2032, Value (USD Mn)
- Regional Trends
- North America
- Introduction
- Market Size and Forecast, By Drug Type, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Drug, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Indication, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Stage of Development, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Gender, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By End User, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Country, 2021 - 2032, Value (USD Mn)
- U.S.
- Canada
- Latin America
- Introduction
- Market Size and Forecast, By Drug Type, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Drug, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Indication, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Stage of Development, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Gender, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By End User, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Country, 2021 - 2032, Value (USD Mn)
- Brazil
- Argentina
- Mexico
- Rest of Latin America
- Europe
- Introduction
- Market Size and Forecast, By Drug Type, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Drug, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Indication, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Stage of Development, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Gender, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By End User, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Country, 2021 - 2032, Value (USD Mn)
- Germany
- U.K.
- Spain
- France
- Italy
- Russia
- Rest of Europe
- Asia Pacific
- Introduction
- Market Size and Forecast, By Drug Type, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Drug, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Indication, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Stage of Development, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Gender, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By End User, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Country, 2021 - 2032, Value (USD Mn)
- China
- India
- Japan
- Australia
- South Korea
- ASEAN
- Rest of Asia Pacific
- Middle East
- Introduction
- Market Size and Forecast, By Drug Type, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Drug, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Indication, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Stage of Development, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Gender, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By End User, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Country, 2021 - 2032, Value (USD Mn)
- GCC Countries
- Israel
- Rest of Middle East
- Africa
- Introduction
- Market Size and Forecast, By Drug Type, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Drug, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Indication, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Stage of Development, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Gender, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By End User, 2021 - 2032, Value (USD Mn)
- Market Size and Forecast, By Country/Region, 2021 - 2032, Value (USD Mn)
- South Africa
- North Africa
- Central Africa
11. Competitive Landscape
- Mineralys Therapeutics, Inc.
- Company Highlights
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- AstraZeneca
- Company Highlights
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- Boehringer Ingelheim International GmbH
- Company Highlights
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- DAMIAN PHARMA AG
- Company Highlights
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- CORXEL
- Company Highlights
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- JX09
- Company Highlights
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- Recordati Rare Diseases Inc.
- Company Highlights
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- Other Prominent Players
- Company Highlights
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
12. Analyst Recommendations
- Wheel of Fortune
- Analyst View
- Coherent Opportunity Map
13. References and Research Methodology
- References
- Research Methodology
- About us
