PUBLISHER: DelveInsight Business Research LLP | PRODUCT CODE: 1058077
PUBLISHER: DelveInsight Business Research LLP | PRODUCT CODE: 1058077
DelveInsight's "Acromegaly- Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of the Acromegaly, historical and forecasted epidemiology as well as the Acromegaly market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.
The Acromegaly market report provides current treatment practices, emerging drugs, Acromegaly market share of the individual therapies, current and forecasted Acromegaly market Size from 2019 to 2032 segmented by seven major markets. The Report also covers current Acromegaly treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.
The DelveInsight's Acromegaly market report gives a thorough understanding of Acromegaly by including details such as disease definition, symptoms, causes, pathophysiology, diagnosis, and treatment. Acromegaly is a rare, slowly progressive, acquired disorder that affects adults. The pituitary gland produces too much growth hormone (GH). The pituitary gland is a small gland located near the base of the skull that stores several hormones and releases them into the bloodstream as needed by the body. These hormones regulate many different bodily functions. In most patients, acromegaly is caused by the growth of a benign tumor (adenoma) arising from the pituitary gland. Symptoms of acromegaly include abnormal enlargement in bones of the hands, arms, feet, legs, and head. Enlargement of the bones in the jaws and the front of the skull are typically the most apparent bony changes.
Common signs and symptoms of acromegaly are enlarged hands and feet. For example, patients are not able to put on rings that used to fit, and the shoe size has progressively increased. It may also cause gradual changes in the face shape, such as a protruding lower jaw and brow bone, an enlarged nose, thickened lips, and wider spacing between the teeth.
Screening is recommended for all patients presenting with clinical features of acromegaly (such as mass tumor effects, systemic effects of GH/IGF-1 excess, cardiovascular and metabolic features, respiratory and bone/joint manifestations, and/or other endocrine consequences). However, screening may also be considered in patients with several medical conditions associated with acromegaly, such as type 2 diabetes mellitus, carpal tunnel syndrome, debilitating arthritis, hypertension, and sleep apnea. Biochemical screening is the first step for an acromegaly diagnosis. Endocrine Society guidelines and experts' consensus recommend using age- and sex-adjusted IGF-1 levels in combination with GH nadir during an oral glucose tolerance test (OGTT) to diagnose and rule out acromegaly. Measuring serum IGF-1 is usually the initial screening test.
Levels of GH in the blood can change throughout the day. A reliable way to track GH in the body is by measuring the level of IGF-I in the blood. In most cases, a high IGF-I level suggests that a person has acromegaly. An oral glucose tolerance test to confirm the diagnosis. For this test, the patient will drink a sugary liquid. A health professional will then test the blood every half hour for 2 h to measure growth hormone levels. The sugar in the drink will normally cause GH levels to fall. But if the body is making too much of the hormone, these levels will not go down enough-thereby confirming the diagnosis of acromegaly. If the blood tests confirm that the body is making too much GH, the doctor will conduct imaging tests to locate and measure the tumor that may be causing the problem.
Treatment goals in acromegaly include symptom relief, tumor control with the maintenance of pituitary function, biochemical normalization of GH/IGF-1, and reversal of the excess morbidity and mortality associated with the disorder. Current modalities of treatment available include surgery, medical therapy, and radiotherapy. Treatment is complex, and more than one modality is frequently required to achieve treatment goals. The primary treatment for acromegaly is transsphenoidal surgery followed by medicinal treatment. Patients who are not eligible for surgery or non-respondent to the surgery are treated with Somatostatin analogs (octreotide, lanreotide, and pasireotide), dopamine agonists (e.g., cabergoline, bromocriptine), or growth hormone receptor antagonists (pegvisomant), either as monotherapy or in combination.
Surgery is the treatment of choice for all microadenomas as well as macroadenomas, causing a mass effect. Debulking of macroadenomas without mass effect can also be done and has been described as a modality to allow for better response to medical treatment even if a surgical cure is not likely. The best predictors of surgical cure include smaller tumor size, lower levels of GH/IGF-1, and absence of invasion of surrounding structures such as the cavernous sinus. All of these drugs are synthetic somatostatin and bind to somatostatin receptors. This results in suppression of growth hormone secretion from both normal pituitary gland and somatotroph adenomas; it also acts at the level of the liver inhibiting GH action by reducing GH binding to hepatocytes and reducing the production of IGF-1 from the liver. Thus, these drugs control hormonal overproduction as well as tumor growth. Radiotherapy is considered in those patients in whom medical management is ineffective in controlling disease, recurrence after surgery, and again after the failure of medical therapy. The patients treated with radiotherapy need to be closely monitored for hypopituitarism.
The Acromegaly epidemiology section provides insights about historical and current Acromegaly patient pool and forecasted trends for individual seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the report also provides the diagnosed patient pool and their trends along with assumptions undertaken.
In the year 2021, the total diagnosed prevalent cases of Acromegaly was 57,824 cases in the 7MM which are expected to grow during the study period, i.e., 2019-2032.
The disease epidemiology covered in the report provides historical as well as forecasted Acromegaly epidemiology [segmented as Total Diagnosed prevalent Cases of Acromegaly, Total Tumor origin-specific Cases of Acromegaly, Total Gender-specific Cases of Acromegaly, Total Tumor size Cases of Acromegaly, Total Treated Cases of Acromegaly] in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2019 to 2032.
The epidemiology segment also provides the Acromegaly epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
The drug chapter segment of the Acromegaly report encloses the detailed analysis of Acromegaly marketed drugs and late stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the Acromegaly clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.
The report provides the details of the emerging therapies under the late and mid-stage of development for Acromegaly treatment.
The Acromegaly market outlook of the report helps to build the detailed comprehension of the historic, current, and forecasted Acromegaly market trends by analyzing the impact of current therapies on the market, unmet needs, drivers, and barriers and demand of better technology.
This segment gives a thorough detail of Acromegaly market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria's, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.
According to DelveInsight, the Acromegaly market in 7MM is expected to witness a major change in the study period 2019-2032.
The Acromegaly market size in the 7MM is expected to change during the study period 2019-2032. The therapeutic market of Acromegaly in the seven major markets is expected to increase during the study period (2019-2032). In 2021, the total market size of Acromegaly was USD 1,326.6 million which is expected to rise during the study period (2019-2032).
The total market size of Acromegaly in the United States accounted for USD 719.1 million in 2021 which is expected to rise during the study period (2019-2032).
In EU5, the total market size of Acromegaly was USD 423.2 million in 2021, which is expected to rise during the study period (2019-2032).
In Japan, the total market size of Acromegaly was USD 184.3 million in 2021, which is expected to rise during the study period (2019-2032).
This section focuses on the rate of uptake of the potential drugs recently launched in the Acromegaly market or expected to get launched in the market during the study period 2019-2032. The analysis covers Acromegaly market uptake by drugs; patient uptake by therapies; and sales of each drug.
This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs, and allows the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.
The report provides insights into different therapeutic candidates in Phase II, and Phase III stages. It also analyses Acromegaly's key players involved in developing targeted therapeutics.
The report covers the detailed information of collaborations, acquisition, and merger, licensing patent details, and other information for Acromegaly emerging therapies.
Approaching reimbursement proactively can have a positive impact both during the late stages of product development and well after product launch. In a report, we consider reimbursement to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.
To keep up with current market trends, we take KOLs and SMEs ' opinions working in the Acromegaly domain through primary research to fill the data gaps and validate our secondary research. Their opinion helps to understand and validate current and emerging therapies treatment patterns or Acromegaly market trends. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the market and the unmet needs.
We perform Competitively and Market Intelligence analysis of the Acromegaly Market by using various Competitive Intelligence tools that include - SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.