PUBLISHER: DelveInsight | PRODUCT CODE: 1160840
PUBLISHER: DelveInsight | PRODUCT CODE: 1160840
DelveInsight's , "Chronic Rhinosinusitis with Nasal Polyps - Pipeline Insight, 2022," report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Chronic Rhinosinusitis with Nasal Polyps pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a condition that can cause frustrating symptoms, from sinus pain and nose stuffiness to loss of smell. Nasal polyps are growths in the nose or sinuses. They are not cancerous, but they can make you miserable and interfere with your quality of life and make sleeping difficult. Treatment includes nasal or oral medications, biologic injections, and surgery. However, these polyps may grow back. Symptoms include anterior or posterior rhinorrhea, nasal congestion, hyposmia and/or facial pressure or pain that last for greater than 12 weeks duration. Nasal polyps are inflammatory lesions that project into the nasal airway, are typically bilateral, and originate from the ethmoid sinus. Males are more likely to be affected than females but no specific genetic or environmental factors have been strongly linked to the development of this disorder to date. CRSwNP is frequently associated with asthma and allergic rhinitis but the cellular and molecular mechanisms that contribute to the clinical symptoms are not fully understood. Defects in the sinonasal epithelial cell barrier, increased exposure to pathogenic and colonized bacteria, and dysregulation of the host immune system are all thought to play prominent roles in disease pathogenesis. Medical treatment options for patients with CRSwNP remain limited. According to the most recent US guidelines, both topical corticosteroids and nasal saline irrigations are recommended as initial medical therapies for affected patients
"Chronic Rhinosinusitis with Nasal Polyps - Pipeline Insight, 2022" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Chronic Rhinosinusitis with Nasal Polyps pipeline landscape is provided which includes the disease overview and Chronic Rhinosinusitis with Nasal Polyps treatment guidelines. The assessment part of the report embraces, in depth Chronic Rhinosinusitis with Nasal Polyps commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Chronic Rhinosinusitis with Nasal Polyps collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
This segment of the Chronic Rhinosinusitis with Nasal Polyps report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
CM310 recombinant humanized monoclonal antibody injection is an innovative humanized monoclonal antibody self-developed by Keymed Bioscience (Chengdu) Co., Ltd., the first in China targeting human IL-4 receptor alpha subunit (IL-4Rα) and completed Phase II clinical trial. CM310 can selectively combine with IL-4Rα to block out the combination of IL-4Rα and IL-4 as well as IL-13, thus suppressing its bioactivity. Currently, it is in Phase II stage of clinical trial evaluation to treat chronic sinusitis with nasal polyps.
CBP-201 is a human monoclonal antibody targeting IL-4Rα, which we have observed to have dose-dependent and differentiated pharmacokinetics and pharmacodynamics in an early clinical trial. As an inhibitor of IL-4Rα, CBP-201 blocks inflammatory signaling by both IL-4 and IL-13. CBP-201 binds to a region of IL-4Rα that is distinct from that bound by dupilumab (an antibody that targets IL-4Rα and is marketed as Dupixent®). The clinical development program is focused on differentiating CBP-201 in three areas, with the potential to show rapid onset and sustained improvements in clinical outcomes with a convenient dosing frequency.
This segment of the report provides insights about the different Chronic Rhinosinusitis with Nasal Polyps drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 10+ key companies which are developing the therapies for Chronic Rhinosinusitis with Nasal Polyps. The companies which have their Chronic Rhinosinusitis with Nasal Polyps drug candidates in the most advanced stage, i.e. phase II include, Keymed Biosciences.
DelveInsight's report covers around 10+ products under different phases of clinical development like:
Chronic Rhinosinusitis with Nasal Polyps pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as:
Products have been categorized under various Molecule types such as:
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Chronic Rhinosinusitis with Nasal Polyps therapeutic drugs key players involved in developing key drugs.
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Chronic Rhinosinusitis with Nasal Polyps drugs.