PUBLISHER: DelveInsight | PRODUCT CODE: 1286691
PUBLISHER: DelveInsight | PRODUCT CODE: 1286691
DelveInsight's "Perivascular epithelioid cell neoplasm (PEComa) - Epidemiology Forecast - 2032" report delivers an in-depth understanding of the PEComa, historical and forecasted epidemiology in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.
Study Period: 2019-2032
PEComa Disease Understanding
PEComa Overview
Perivascular epithelioid cell neoplasms (PEComas) are rare soft tissue tumors. They often form around small blood vessels (perivascular spaces) in various body parts such as the lungs, GI tract, kidneys, liver, and uterus. PEComas comprise cells with an epithelioid (cuboidal) shape and share some features with melanocytes and smooth muscle cells. Melanocytes are cells normally found in the skin and produce melanin to give skin its color.
PEComa can make some of the same proteins used to create pigment. PEComa also makes some of the same proteins found in smooth muscle cells, which comprise muscles not under one's conscious control, such as the muscles that make up one's internal organs and digestive tract.
According to the WHO classification, in the PEComa NOS, both benign PEComa NOS and clinically challenging tumors with a higher degree of malignancy are included (malignant PEComa NOS). A malignant PEComa encountered by clinical oncologists in their practice is abdominopelvic perivascular epithelioid cell sarcoma - the so-called malignant PEComa.
PEComas are considered a group of tumors. However, within this group are specific tumors with unique features and more likely to form in certain body parts. These specific tumors include:
PEComa Diagnosis
PEComas may be detected by imaging with X-ray, CT scan, or MRI. Once a tumor is detected, a biopsy is needed to examine the cellular makeup and distinguish it from other tumors.
Tissue samples from biopsies will have a characteristic appearance under the microscope to identify tumors as PEComas and differentiate them from other potential tumors.
PEComas typically have mostly epithelioid cells around blood vessels. They also contain protein markers similar to melanocytes (melanin-producing cells) and smooth muscle cells.
Malignant PEComas can be detected from biopsy as well. Malignancy is more likely in larger PEComas, to begin to grow into surrounding tissues, and have a higher percentage of actively growing cells.
Genetic testing is available to identify patients with TSC at an increased risk of developing PEComas.
For patients with LAM, a blood test for detecting increased levels of vascular endothelial growth factor D (VEGF-D) may aid in diagnosing this PEComa subtype. VEGF-D stimulates the growth of new blood vessels, and high levels may be involved in tumor spread.
Further details are provided in the report
As the market is derived using a patient-based model, the PEComa epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by total incident cases of PEComa, PEComa cases by Gender, Stage, Clinical Presentation, and Age in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain) and the United Kingdom, and Japan from 2019 to 2032.
KOL Views
To keep up with current trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry Experts contacted for insights on PEComa evolving diagnostic landscape, include Medical/scientific writers, Medical Oncologists, and Professors, Department of Medical Oncology, Strasbourg-Europe Cancer Institute, Dana-Farber Cancer Institute, and others.
Delveinsight's analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Centers such as MD Anderson Cancer Center, Texas from UT Southwestern Medical Center in Dallas, Cancer Research UK Barts Centre in London, MD Anderson Cancer Center, etc., were contacted. Their opinion helps understand and validate current diagnostic patterns.
Key Questions
Epidemiology Insights: