PUBLISHER: DelveInsight | PRODUCT CODE: 2018985
PUBLISHER: DelveInsight | PRODUCT CODE: 2018985
DelveInsight's "Wet Age-Related Macular Degeneration (Wet AMD) - Market Insights, Epidemiology, and Market Forecast - 2036" report delivers an in-depth understanding of the Wet Age-Related Macular Degeneration (Wet AMD), historical and forecasted epidemiology as well as the Wet Age-Related Macular Degeneration (Wet AMD) market trends in the United States, EU4 and the UK (Germany, France, Italy, Spain) and the United Kingdom, and Japan.
The Wet Age-Related Macular Degeneration (Wet AMD) market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Wet Age-Related Macular Degeneration (Wet AMD) market size from 2022 to 2036. The Report also covers current Wet Age-Related Macular Degeneration (Wet AMD) treatment practice, market drivers, market barriers, SWOT analysis, reimbursement and market access, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
Study Period: 2022-2036
Key Factors Driving the Growth of the Wet AMD Market
Advancements in Diagnostic Technologies: Technological innovations such as optical coherence tomography (OCT), fundus imaging, and AI-based diagnostic tools have significantly enhanced early detection and disease monitoring.
Wet Age-Related Macular Degeneration Treatment Market
Wet Age-Related Macular Degeneration (Wet AMD) Overview
Wet Age-Related Macular Degeneration (Wet AMD) is a chronic eye disorder that results from the abnormal growth of blood vessels beneath the macula, a small area of the retina responsible for central vision. These vessels leak blood and fluid, causing rapid and severe vision loss. The main risk factors include age, genetic predisposition, and lifestyle factors like smoking. Wet AMD is typically more severe than its counterpart, dry AMD, and can lead to permanent central vision impairment.
Wet Age-Related Macular Degeneration (Wet AMD) Diagnosis
Diagnosing wet age-related macular degeneration (AMD) involves several steps. Initial evaluation includes a comprehensive eye exam with dilated fundus photography to visualize the retina and macula. Optical coherence tomography (OCT) is essential for identifying fluid or blood under the retina, indicative of wet AMD. Fluorescein angiography may also be used to detect leaking blood vessels in the macula. Symptoms prompting diagnosis typically include blurred vision, dark spots, or distorted lines in the central vision. Early detection is critical, as prompt treatment can slow disease progression and preserve vision. Patients with wet AMD require ongoing monitoring and care.
Wet Age-Related Macular Degeneration (Wet AMD) Treatment
Treatment for Wet-Age Related Macular Degeneration (Wet-AMD) primarily focuses on halting disease progression and preserving vision. The standard treatment involves the use of anti-VEGF (vascular endothelial growth factor) drugs such as Ranibizumab (Lucentis), Aflibercept (Eylea), and Brolucizumab (Beovu). These are administered via intravitreal injections to reduce new blood vessel growth and fluid leakage in the retina. Some patients may benefit from photodynamic therapy (PDT), which uses light-activated drugs to destroy abnormal blood vessels. Advances in gene therapy and implantable devices are also under investigation to provide longer-lasting treatment solutions and improve patient outcomes.
As the market is derived using a patient-based model, the Wet Age-Related Macular Degeneration (Wet AMD) epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by, Total Prevalent Cases Of Age-Related Macular Degeneration (AMD), Diagnosed Prevalent Cases Of Age-Related Macular Degeneration (AMD), Type-Specific Diagnosed Prevalent Cases Of Age-Related Macular Degeneration (AMD), and Total Age-Specific Cases Of Wet-AMD in the 7MM covering, the United States, EU4 countries (Germany, France, Italy, and Spain), United Kingdom, and Japan from 2022 to 2036.
Wet Age-Related Macular Degeneration (Wet AMD) Recent Developments
The drug chapter segment of the Wet Age-Related Macular Degeneration (Wet AMD) report encloses a detailed analysis of Wet Age-Related Macular Degeneration (Wet AMD) off-label drugs and late-stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the Wet Age-Related Macular Degeneration (Wet AMD) clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.
Wet Age-Related Macular Degeneration Marketed Drugs
BEOVU (Brolucizumab): Novartis
BEOVU (Brolucizumab), developed by Novartis, is a potent anti-VEGF treatment used for Wet Age-Related Macular Degeneration (Wet-AMD). It works by inhibiting vascular endothelial growth factor, reducing abnormal blood vessel growth and fluid leakage in the retina. BEOVU offers a longer dosing interval, allowing up to 12-week dosing schedules.
EYLEA (aflibercept): Regeneron Pharmaceuticals
EYLEA, developed by Regeneron, is used to treat wet age-related macular degeneration (wet-AMD), diabetic eye disease, and other retinal issues. The drug, aflibercept, is an injectable treatment that slows vision loss by blocking abnormal blood vessel growth in the eye. EYLEA works as a soluble decoy receptor, inhibiting VEGF-A and PlGF to prevent abnormal blood vessel formation. The standard dosage is 2 mg every 4 weeks for the first 3 months, then every 8 weeks. Regeneron is currently testing less frequent dosing and higher doses in ongoing phase III trials.
EYLEA (aflibercept) received FDA approval in November 2011 for treating wet-AMD with a dosage of 2 mg every 4 weeks for the first 12 weeks, then every 8 weeks. It was approved by the European Commission in November 2012 and by Japan's MHLW in September 2012 for the same condition.
VABYSMO (faricimab): Roche/ Genentech, Inc.
VABYSMO (faricimab) is the first bispecific antibody designed for the eye. It targets and inhibits two signalling pathways linked to a number of vision-threatening retinal conditions by neutralizing angiopoietin-2 (Ang-2) and vascular endothelial growth factor-A (VEGF-A). Ang-2 and VEGF-A contribute to vision loss by destabilizing blood vessels, causing new leaky blood vessels to form and increasing inflammation. By blocking both pathways involving Ang-2 and VEGF-A, VABYSMO is designed to stabilize blood vessels.
VABYSMO is now approved in the European Union and nine other countries around the world, including the US, Japan, and the UK, for people living with "wet" age-related macular degeneration and diabetic macular edema.
Wet Age-Related Macular Degeneration Emerging Drugs
Ixoberogene soroparvovec (Ixo-vec): Adverum Biotechnologies
Ixoberogene soroparvovec (Ixo-vec, formerly referred to as ADVM-022) is Adverum's clinical-stage gene therapy product candidate being developed for the treatment of wet-AMD. Ixo-vec utilizes a propriety vector capsid, AAV.7m8, carrying an aflibercept coding sequence under the control of a proprietary expression cassette. It is believed that ADVM-022 has the potential to provide a durable, safe and cost-effective in-office treatment option that addresses the needs of the patients, and their families, as well as retina specialists and health systems worldwide. The FDA has granted Fast Track and Regenerative Medicine Advanced Therapy (RMAT) designations for Ixo-vec for the treatment of wet-AMD. Ixo-vec has also received PRIME designation from the EMA and the Innovation Passport from the United Kingdom's Medicines and Healthcare Products Regulatory Agency for the treatment of wet-AMD. Currently, the drug is being investigated in Phase III.
Surabgene lomparvovec (RGX-314): Regenxbio/AbbVie
RGX-314 is being developed as a novel, one-time sub retinal treatment that includes the NAV AAV8 vector containing a gene encoding for a monoclonal antibody fragment. The expressed protein is designed to neutralize VEGF activity, modifying the pathway for the formation of new leaky blood vessels and retinal fluid accumulation. It is a potential one-time gene therapy for the treatment of wet-AMD, diabetic retinopathy, and other chronic retinal diseases. RGX-314 is currently being evaluated in patients with wet-AMD in Phase III and II/III clinical trials. The company anticipates submitting global regulatory applications in the first half of 2026.
OGX-110: Ocugenix
OGX-110 is a novel small molecule therapy in development for wet-AMD, designed to target both abnormal blood vessels and fibrosis, key drivers of disease progression and irreversible blindness. OGX-110 selectively activates the CXCR3 pathway, a natural wound-healing mechanism in the retina, which noncompetitively overrides pro-angiogenic and pro-fibrotic signals (including VEGF), leading to the regression of pathological neovascularization and fibrotic tissue rather than simply controlling edema. As per company's pipeline, the drug is currently active in Phase I clinical trial for wet-AMD.
Wet Age-Related Macular Degeneration (wet AMD) is a progressive eye condition characterized by the growth of abnormal blood vessels beneath the retina, which can lead to severe vision loss. Treatment aims to manage symptoms, slow disease progression, and preserve vision. The primary therapeutic approach for wet AMD is anti-vascular endothelial growth factor (anti-VEGF) therapy. These medications, including ranibizumab (LUCENTIS), aflibercept (EYLEA), and brolucizumab (BEOVU), work by inhibiting VEGF, a protein that promotes the growth of abnormal blood vessels. Administered via intravitreal injections, these drugs reduce fluid leakage and vascular growth, stabilizing or improving vision in many patients.
Another treatment option is photodynamic therapy (PDT), which involves intravenous administration of a light-sensitive drug, verteporfin (Visudyne), followed by the application of a low-level laser to the eye. PDT targets and destroys the abnormal blood vessels without causing significant damage to the surrounding retina. However, its use has declined with the advent of more effective anti-VEGF therapies.
In some cases, thermal laser photocoagulation might be employed to directly destroy the abnormal blood vessels, though this method is less common due to its potential to cause scarring and vision loss. Additionally, recent advancements include the development of sustained-release anti-VEGF delivery systems, such as port delivery systems, which aim to reduce the frequency of injections.
Overall, the choice of treatment depends on the specific characteristics of the AMD and the patient's response to initial therapies. Regular monitoring and individualized treatment plans are crucial to achieving the best outcomes and preserving vision for patients with wet AMD.
This section focuses on the uptake rate of potential drugs expected to launch in the market during 2022-2036. For example, RGX-314 in the US is expected to be launched by 2026 with a peak share of 0.5%. RGX-314 is anticipated to take 6 years to peak with a medium uptake.
Wet Age-Related Macular Degeneration (Wet AMD) Pipeline Development Activities
The report provides insights into different Wet Age-Related Macular Degeneration clinical trials within Phase III, Phase II, and Phase I stage. It also analyzes key players involved in developing targeted therapeutics.
Pipeline Development Activities
The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Wet Age-Related Macular Degeneration (Wet AMD) emerging therapies.
KOL Views
To keep up with current market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate the secondary research. Industry Experts were contacted for insights on Wet Age-Related Macular Degeneration (Wet AMD) evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake along with challenges related to accessibility, including KOL from Cleveland Clinic - Cole Eye Institute, Cleveland, US; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, US; Bascom Palmer Eye Institute/University of Miami Miller School of Medicine, Miami; Thomas Jefferson University, US; University of Louisville School of Medicine, Louisville, US; Department of Ophthalmology, University of Bonn, Germany; Department of Experimental Medicine, University Tor Vergata, Viale Oxford, Rome, Italy; Department of Ophthalmology, Kansai Medical University, Hirakata, Osaka, Japan; and others.
Delveinsight's analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Their opinion helps understand and validate current and emerging therapies, treatment patterns, or Wet Age-Related Macular Degeneration (Wet AMD) market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.
Qualitative Analysis
We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.
Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.
Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Market Access and Reimbursement
The high cost of therapies for the treatment is a major factor restraining the growth of the global drug market. Because of the high cost, the economic burden is increasing, leading the patient to escape from proper treatment.
The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.
Scope of the Wet Age-Related Macular Degeneration Market Report
Wet Age-Related Macular Degeneration Epidemiology Insights
Current Wet Age-Related Macular Degeneration Treatment Scenario, Marketed Drugs, and Emerging Therapies
Reasons to Buy Wet Age-Related Macular Degeneration Market Report