Picture
SEARCH
What are you looking for?
Need help finding what you are looking for? Contact Us
Compare

PUBLISHER: DelveInsight | PRODUCT CODE: 2018996

Cover Image

PUBLISHER: DelveInsight | PRODUCT CODE: 2018996

Multiple System Atrophy - Market Insight, Epidemiology, and Market Forecast - 2036

PUBLISHED:
PAGES: 200 Pages
DELIVERY TIME: 2-10 business days
SELECT AN OPTION
PDF (Single User License)
USD 7990
PDF & Excel (2-3 User License)
USD 9987.50
PDF & Excel (Site License)
USD 13983
PDF & Excel (Global License)
USD 17978

Add to Cart

Key Highlights:

  • In 2025, the market size of MSA across the 7MM was approximately USD 45 million and is projected to grow further by 2036.
  • The US accounted for the largest market share, with a valuation of approximately USD 40 million in 2024.

Multiple System Atrophy Market and Epidemiology Analysis

  • The Multiple System Atrophy Market is poised for steady growth, with a strong compound annual growth rate (CAGR) projected from 2026 to 2036. This expansion across the 7MM will be driven by the launch of innovative therapies, including, Amlenetug (Lu AF82422), Ampreloxetine ATH434, TAK-341/MEDI1341, and Emrusolmin.
  • There are no approved therapies to slow Multiple System Atrophy's neurodegeneration, but symptom management options include levodopa, amantadine, droxidopa, adrenergic receptors agonists, and various off-label therapies that provide relief and help patients cope with the disease's effects.
  • Challenges in accurately diagnosing and defining the condition hinder the advancement of Multiple System Atrophy clinical trials for potential disease-modifying therapies.
  • The rapid progression, severe morbidity, and shortened life expectancy of the disease lead to poor patient outcomes, profoundly affecting the quality of life for individuals and their caregivers, creating significant emotional, physical, and social challenges for both parties.

Multiple System Atrophy Market Size and Forecast

  • 2025 Market Size: USD 44 million in 2025
  • Largest Market: United States

DelveInsight's "Multiple System Atrophy Market Insights, Epidemiology, and Market Forecast - 2036" report delivers an in-depth understanding of Multiple System Atrophy, historical and forecasted epidemiology, as well as the Multiple System Atrophy market trends in the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan.

The Multiple System Atrophy Treatment Market Report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted 7MM Multiple System Atrophy market size from 2022 to 2036. The report also covers Multiple System Atrophy treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the Multiple System Atrophy treatment market potential.

Key Factors Driving the Multiple System Atrophy Market

Increasing Multiple System Atrophy Prevalence

In 2025, the diagnosed prevalent cases of MSA are predicted to be ~72K in the leading markets [the United States, the EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan], projected to increase through 2036. These numbers are increasing due to rising healthcare needs and a growing demand for effective therapies.

Multiple System Atrophy Market Opportunities for Key Companies

With limited FDA-approved disease-modifying treatments currently available for MSA, the field presents a significant opportunity for innovation. Existing options, such as LEVODOPA, provide limited relief, highlighting a clear pathway for novel, targeted therapies to transform patient outcomes and redefine the treatment landscape. Other than that, the companies working in the MSA clinical trial landscape are H Lundbeck A/S, Brain Neurotherapy Bio, Inc., Asklepios BioPharmaceutical, Inc., Theravance Biopharma, Ono Pharmaceutical Co. Ltd, Ionis Pharmaceuticals, Inc., Biogen, Alterity Therapeutics, Teva Pharmaceutical, MODAG GmbH, and others.

Increasing Multiple System Atrophy Clinical Trial Activities

Promising multiple system atrophy drugs in clinical trials include Ampreloxetine (Theravance Biopharma), Amlenetug (H Lundbeck A/S), Emrusolmin (Teva Pharmaceutical/MODAG GmBH), TAK-341/MEDI1341 (AstraZeneca/Takeda Pharma), ATH434 (Alterity Therapeutics), and others.

Multiple System Atrophy Disease Understanding

Multiple System Atrophy overview

Multiple System Atrophy is a progressive neurodegenerative disease marked by symptoms affecting movement and the autonomic nervous system. Its cause remains unknown, and most cases are sporadic. A hallmark of Multiple System Atrophy is the accumulation of alpha-synuclein in oligodendroglial cells, which produce myelin, essential for efficient nerve signal transmission. In 1969, the term Multiple System Atrophy was introduced to combine three previously recognized neurological conditions: Shy-Drager syndrome (focused on autonomic dysfunction), Striatonigral Degeneration (emphasizing Parkinsonian symptoms), and sporadic Olivopontocerebellar Atrophy (highlighting cerebellar symptoms). This unification helped categorize overlapping clinical features under a single diagnosis.

Early symptoms of Multiple System Atrophy include bradykinesia, tremors, stiffness, and lack of coordination. Diagnostic subtypes are Multiple System Atrophy-P, resembling Parkinson's disease with Parkinsonian features, and Multiple System Atrophy-C, distinguished by cerebellar dysfunction, primarily presenting as ataxia and impaired balance, reflecting the diverse neurological impacts of this progressive disorder. Multiple System Atrophy is divided into two main subtypes: Multiple System Atrophy with predominant Parkinsonism (Multiple System Atrophy-P) and Multiple System Atrophy with predominant cerebellar ataxia (Multiple System Atrophy-C). However, these classifications are flexible, as a patient's symptoms can shift between the two over time.

Multiple System Atrophy diagnosis

Diagnosing of Multiple System Atrophy is challenging, especially in its early stages, as it shares symptoms with Parkinson's disease. Diagnostic methods may include autonomic testing (e.g., blood pressure and heart rate monitoring), bladder function assessment, and neuroimaging techniques like MRI or PET scans.

Multiple System Atrophy treatment

Pharmacological treatments for Multiple System Atrophy target Parkinsonism, autonomic dysfunction, cerebellar ataxia, and sleep issues. Levodopa is the first-line treatment for Parkinsonism, with temporary benefits, while dopamine agonists and amantadine offer alternative options but may cause more side effects.

Multiple System Atrophy Epidemiology

As Multiple System Atrophy market is derived using a patient-based model, the Multiple System Atrophy epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Diagnosed Prevalence Cases of Multiple System Atrophy, Gender-specific Diagnosed Prevalent Cases of Multiple System Atrophy, Age-specific Diagnosed Prevalent Cases of Multiple System Atrophy, Type-specific Diagnosed Prevalent Cases of Multiple System Atrophy in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain), the United Kingdom, and Japan from 2022 to 2036.

Key Findings from Multiple System Atrophy Epidemiological Analyses and Forecast

  • According to DelveInsight's analysis, in 2025, the US had the highest number of diagnosed prevalent cases of MSA among the 7MM, with more than 43,000 cases, followed by Japan with nearly 17,000 cases.
  • MSA is divided into six stages: Stage 0, Stage 1, Stage 2, Stage 3, Stage 4, and Stage 5. In 2025, Stage 3 had the highest diagnosed prevalent, with around 4,000 cases reported in EU4 and the UK.
  • In the UK, the 70 years and above age group reported the highest number of MSA around 1,200 cases in 2025, surpassing other age groups such as 50-59 and 60-69, with projections indicating an increase by 2036.

Multiple System Atrophy Epidemiology Segmentation

  • Diagnosed Prevalence Cases of Multiple System Atrophy
  • Gender-specific Diagnosed Prevalent Cases of Multiple System Atrophy
  • Age-specific Diagnosed Prevalent Cases of Multiple System Atrophy
  • Type-specific Diagnosed Prevalent Cases of Multiple System Atrophy

Multiple System Atrophy Recent Developments and Breakthroughs

  • In March 2026, Lundbeck announced ahead-of-schedule completion of patient randomization in the Phase III MASCOT trial of amlenetug for MSA, with results expected in Q3 2027 and potential launch in Q1 2029.
  • In December 2025, Lundbeck announced it will showcase the design of its Phase 3 MASCOT trial at the 2025 International Congress of Parkinson's Disease and Movement Disorders. The trial evaluates amlenetug, an investigational monoclonal antibody targeting alpha-synuclein, for the treatment of Multiple System Atrophy (MSA). MSA is a rare, aggressive neurodegenerative disorder with no current disease-modifying treatments. The MASCOT study aims to determine if amlenetug can slow disease progression by preventing the aggregation of toxic proteins in the brain. This presentation will provide the medical community with key insights into the study's methodology and its potential impact on MSA patients.
  • In December 2025,Asklepios BioPharmaceutical (AskBio), a subsidiary of Bayer, has completed enrollment for its Phase 1 clinical trial of AB-1005 for Multiple System Atrophy-Parkinsonian type (MSA-P). AB-1005 is an investigational gene therapy that uses an AAV2 vector to deliver the GDNF gene directly to the brain. This approach is intended to support the survival of neurons and potentially slow the progression of the disease. The study focuses on the safety and tolerability of the surgical delivery method. This milestone is a critical step in determining if gene therapy can offer a neuroprotective benefit for patients with this rapidly progressing condition.
  • In December 2025, Teva Pharmaceutical Industries announced that the U.S. FDA has granted Fast Track Designation to emrusolmin for the treatment of Multiple System Atrophy (MSA). Emrusolmin is an oral small molecule designed to inhibit the aggregation of alpha-synuclein, a key driver of MSA pathology. Fast Track status is intended to expedite the development and review of drugs for serious conditions with unmet medical needs. This designation allows Teva to have more frequent interactions with the FDA and potentially qualify for Priority Review. The news marks a significant advancement in the effort to bring a disease-modifying therapy to the MSA community.
  • In September 2025, Teva Pharmaceutical (NYSE:TEVA) announced that its investigational MSA treatment, emrusolmin, received Fast Track designation from the U.S. FDA. The drug is currently in Phase 2 development for Multiple System Atrophy.
  • In August 2025, Tiziana Life Sciences received FDA clearance of its IND for a Phase 2a trial of intranasal foralumab in patients with Multiple System Atrophy (MSA), a rare neurodegenerative disease with no approved therapies. The six-month open-label study will evaluate microglial activation, clinical outcomes, and safety of the fully human anti-CD3 monoclonal antibody delivered via nasal spray.
  • In July 2025, NKGen Biotech received FDA authorization for an Expanded Access Program (EAP) to use its NK cell therapy, troculeucel, in multiple neurodegenerative diseases-including Alzheimer's, Parkinson's, ALS, MSA, PSP, FTD, CBD, MS, and Lewy Body Dementia-beyond its current Phase 2a trial in moderate-stage Alzheimer's disease.
  • In May 2025, Alterity Therapeutics announced that the FDA has granted Fast Track designation for ATH434, its investigational treatment for Multiple System Atrophy (MSA). This designation aims to expedite the development and review of ATH434, recognizing its potential to address the significant unmet need in MSA, a condition currently without an approved therapy.
  • In February 2025, Alterity Therapeutics' ATH434 showed promising Phase 2 results in a randomized, double-blind trial for early-stage multiple system atrophy (Multiple System Atrophy). The treatment, particularly at a 50 mg dose, was well-tolerated and demonstrated both clinical and biomarker-based benefits.

Multiple System Atrophy Drug Analysis

The drug chapter segment of the Multiple System Atrophy report encloses a detailed analysis of Multiple System Atrophy early and mid to late-stage (Phase III and Phase II) pipeline drugs. It also helps understand the Multiple System Atrophy clinical trials details, expressive pharmacological action, agreements and collaborations, advantages and disadvantages of each included drug, and the latest news and press releases.

Multiple System Atrophy Emerging Drugs

Emrusolmin (TEV-56286, Anle-138b): Teva Pharmaceutical/MODAG GmBH

TEV-56286 also known as anle138b is a small molecule designed to specifically target toxic oligomeric structures of alpha-synuclein, the primary aggregating protein involved in neurodegenerative disorders. By binding to these toxic oligomers, anle138b dissolves them and prevents the formation of new ones, addressing the underlying cause of the disease.

Amlenetug (Lu AF82422): H. Lundbeck A/S/Genmab

Amlenetug (Lu AF82422) is a human IgG1 monoclonal antibody targeting extracellular a-synuclein to block aggregation and enhance microglial clearance, developed by Lundbeck in collaboration with Genmab.

ONO-2808: Deciphera Pharmaceuticals/ONO PHARMA

ONO-2808 is an orally available, selective sphingosine-1-phosphate receptor-5 (S1P5) agonist discovered by ONO. The ONO-2808-03 study is a multicenter, randomized Phase II trial evaluating early-stage MSA patients within five years of symptom onset in Japan and the US. It is currently being evaluated in the Phase II for MSA.

Multiple System Atrophy Drug Class Analysis

Multiple System Atrophy treatment primarily focuses on symptom management, as there is no cure. Pharmacological therapies, such as levodopa for Parkinsonism and other medications for autonomic dysfunction, cerebellar ataxia, and sleep disturbances, are commonly used. Immunotherapy is not typically part of Multiple System Atrophy treatment, as it targets underlying protein aggregation rather than immune response.

Emerging therapies include Amlenetug, Ampreloxetine, ATH434, TAK-341/MEDI1341 and Emrusolmin (Anle138b).

Amlenetug

developed by H. Lundbeck A/S and Genmab, is a monoclonal antibody targeting toxic alpha-synuclein in Multiple System Atrophy, aiming to slow progression, now in Phase III.

Ampreloxetine

A norepinephrine reuptake inhibitor for symptomatic neurogenic orthostatic hypotension in Multiple System Atrophy is in Phase III trials with ODD status. Emrusolmin (Anle138b), is a small molecule targeting toxic alpha-synuclein oligomers to halt disease progression. It is orally administered, crosses the blood-brain barrier, and received orphan drug designation for Multiple System Atrophy, currently in Phase II trials.

Multiple System Atrophy Market Outlook

Multiple System Atrophy is a rare neurodegenerative disorder that typically begins in adulthood, usually after age 30. It shares symptoms with Parkinson's disease, such as Parkinsonism, but also includes additional features like cerebellar ataxia and autonomic dysfunction, affecting involuntary processes such as heart rate and blood pressure. Multiple System Atrophy is classified as Multiple System Atrophy-P when Parkinsonism predominates, and Multiple System Atrophy-C when cerebellar symptoms are more prominent. Currently, no disease-modifying treatments are approved for Multiple System Atrophy, offering a significant opportunity for pharmaceutical Multiple System Atrophy companies to develop the first effective therapies. Existing Parkinson's treatments like levodopa have limited effectiveness, underscoring the need for targeted treatments for Multiple System Atrophy.

Currently, no disease-modifying treatments are approved for Multiple System Atrophy in the 7MM, creating a significant opportunity for pharmaceutical Multiple System Atrophy companies to develop the first approved therapy. While Parkinson's drugs like levodopa are used, their effectiveness varies. northera (droxidopa) is commonly prescribed for neurogenic orthostatic hypotension (nOH), a common Multiple System Atrophy symptom. Approved in 2014, northera addresses nOH but lost market exclusivity in 2021, despite its impact on Multiple System Atrophy-related disability and injury risk.

Pharmacological treatments for Multiple System Atrophy focus on Parkinsonism, autonomic dysfunction, cerebellar ataxia, and sleep issues. Levodopa is the first-line treatment for Parkinsonism, providing temporary relief, especially in Multiple System Atrophy-P patients. While effective, its benefits are limited, and side effects like orthostatic hypotension require management. Dopamine agonists and amantadine may offer alternatives, though they are less preferred due to side effects.

Currently, there are no approved therapies to slow neurodegeneration in Multiple System Atrophy. However, symptom management includes options like Levodopa, Amantadine, Droxidopa, Anticholinergic agents, and off-label treatments to help patients cope. Potential future therapies for Multiple System Atrophy include Lu AF82422 (H. Lundbeck A/S/Genmab), Ampreloxetine (Theravance Biopharma), Emrusolmin (Teva Pharmaceutical/MODAG GmbH), and others.

  • In 2025, the market size of MSA across the 7MM was approximately USD 45 million and is projected to grow further by 2036.
  • The US accounted for the largest market share, with a valuation of approximately USD 40 million in 2024.
  • Within EU4 and the UK, Germany had the highest market size at approximately USD 1 million in 2024.
  • Meanwhile, Japan's market size for MSA stood at approximately USD 3 million in 2025, slightly lower compared to other 7MM countries, with expectations of significant growth by 2036.

Multiple System Atrophy Drugs Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the Multiple System Atrophy market during 2022-2036.

Multiple System Atrophy Pipeline Development Activities

The report provides insights into different Multiple System Atrophy clinical trials within Phase III, Phase II, and Phase I. It also analyzes key players involved in developing targeted therapeutics.

Pipeline development activities

The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for emerging therapies for Multiple System Atrophy.

Latest KOL Views on Multiple System Atrophy

To keep up with current Multiple System Atrophy market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry Experts contacted for insights on Multiple System Atrophy evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake, along with challenges related to accessibility, including Medical/scientific writers, Medical Professionals, Professors, Directors, and Others.

DelveInsight's analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Centers like the University of California, the US, University of Maryland School of Medicine, the US, University of Texas Southwestern, the US, University Medical Center, Johannes-Gutenberg-University, Germany, Department of Neurology Center Hospitalier de la Cote Basque Bayonne, France, University of Pisa, Italy, Barcelona Clinical Hospital, Spain, University of Aberdeen, the UK, Hyogo College of Medicine, Japan, among others, were contacted. Their opinion helps understand and validate current and emerging therapy treatment patterns or Multiple System Atrophy market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the Multiple System Atrophy therapeutics market and the unmet needs.

Physician's View

As per the KOLs from the US, The diagnosis of Multiple System Atrophy is complicated, and this is mostly due to the overlap with other similar Parkinsonian syndromes. It was found that some cases are misdiagnosed as other clinical syndromes when there is no severe dysautonomia or cerebellar dysfunction (like cerebellar ataxia or dysarthria). Importantly, there are not great treatment options for the autonomic and cerebellar symptoms in patients with Multiple System Atrophy clinical phenotype, but there are many Multiple System Atrophy clinical trials still in progress to find treatments for these aspects.

As per the KOLs from Germany, The Multiple System Atrophy distinction into Multiple System Atrophy-P and Multiple System Atrophy-C is based on the predominant clinical features. Multiple System Atrophy-P is more common in most of the countries, with the exception of Japan, where Multiple System Atrophy-C is the predominant phenotype. Patients with Multiple System Atrophy have an early, usually transient, and in general poorer, response to L-Dopa compared to patients with Parkinson's disease.

As per the KOLs from Japan, Distinguishing Multiple System Atrophy from other neurodegenerative parkinsonisms, such as Parkinson's disease, dementia with Lewy bodies, and progressive supranuclear palsy, can be challenging. However, advancements in imaging techniques, like [123I]-Meta-iodo Benzyl Guanidine (MIBG) myocardial scintigraphy, have shown promise in helping differentiate PD from other Parkinsonian syndromes, improving diagnosis and treatment strategies for Multiple System Atrophy.

Multiple System Atrophy Report Qualitative Analysis

We perform Qualitative and Multiple System Atrophy treatment market Intelligence analysis using various approaches, such as SWOT and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.

Conjoint Analysis analyzes multiple emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy. To analyze the effectiveness of these therapies, have calculated their attributed analysis by giving them scores based on their ability to improve atrial and ventricular dimension/function and ability to regulate heart rate.

Further, the therapies' safety is evaluated wherein the adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials, which directly affects the safety of the molecule in the upcoming trials. It sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Multiple System Atrophy Market Access and Reimbursement

The National Institute of Neurological Disorders and Stroke (NINDS).

The National Institute of Neurological Disorders and Stroke (NINDS), part of the NIH, is crucial in advancing Multiple System Atrophy research. By funding top medical institutions, NINDS supports studies to better understand and treat Multiple System Atrophy. In 2007, NINDS held a global consensus conference to improve diagnostic criteria, aiding quicker and more accurate diagnoses. Ongoing research aims to uncover the mechanisms behind synuclein buildup in Multiple System Atrophy and Parkinson's disease, with the goal of developing preventative and therapeutic approaches for these neurodegenerative conditions. Further details will be provided in the report.

The report provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenarios, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Scope of the Multiple System Atrophy Market Report

  • The report covers a segment of key events, an executive summary, and a descriptive overview of multiple system atrophy, explaining its causes, signs and symptoms, pathogenesis, and emerging therapies.
  • Comprehensive insight into the epidemiology segments and forecasts, the future growth potential of diagnosis rate, disease progression, and treatment guidelines have been provided.
  • Additionally, an all-inclusive account of the emerging therapies and the elaborative profiles of late-stage and prominent therapies will impact the current treatment landscape.
  • A detailed review of the multiple system atrophy therapeutics market, historical and forecasted Multiple System Atrophy market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help shape and drive the 7MM multiple system atrophy.

Multiple System Atrophy Market Report Insights

  • Patient Population
  • Therapeutic Approaches
  • Multiple System Atrophy Pipeline Analysis
  • Multiple System Atrophy Market Size and Multiple System Atrophy Therapeutics Market
  • Existing and Future Multiple System Atrophy Market Opportunity

Multiple System Atrophy Market Report Key Strengths

  • 11 years Forecast
  • The 7MM Coverage
  • Multiple System Atrophy Epidemiology Segmentation
  • Key Cross Competition
  • Attribute Analysis
  • Drugs Uptake and Key Multiple System Atrophy Market Forecast Assumptions

Multiple System Atrophy Market Report Assessment

  • Current Treatment Practices
  • Unmet Needs
  • Pipeline Product Profiles
  • Market Attractiveness
  • Qualitative Analysis (SWOT and Attribute Analysis)

Key Questions Answered in the Multiple System Atrophy Market

Multiple System Atrophy Market Insights

  • What was the total Multiple System Atrophy market size of multiple system atrophy, the market size of multiple system atrophy by therapies, and market share (%) distribution in 2022, and what would it look like by 2036? What are the contributing factors for this growth?
  • How will amlenetug (Lu AF82422) affect the Multiple System Atrophy treatment market of multiple system atrophy?
  • What would be the multiple system atrophy market growth till 2036 and what will be the resultant market size in the year 2036?
  • Which drug is going to be the largest contributor by 2036?
  • What are the key findings pertaining to the market across the 7MM and which country will have the largest multiple system atrophy market size during the forecast period (2026-2036)?
  • How would future opportunities affect the market dynamics and subsequent analysis of the associated trends?

Multiple System Atrophy Epidemiology Insights

  • What are the disease risks, burdens, and unmet needs of multiple system atrophy? What will be the growth opportunities across the 7MM with respect to the patient population pertaining to multiple system atrophy?
  • What is the historical and forecasted multiple system atrophy patient pool in the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan?
  • Out of the countries mentioned above, which country would have the highest diagnosed prevalent cases of multiple system atrophy population during the forecast period (2026-2036)?
  • What factors are contributing to the growth of multiple system atrophy cases?

Current Treatment Scenario, Marketed Drugs, and Emerging Therapies

  • What are the current options for the treatment of multiple system atrophy? What are the current clinical and treatment guidelines for treating multiple system atrophy?
  • How many Multiple System Atrophy companies are developing therapies for the treatment of multiple system atrophy?
  • How many emerging therapies are in the mid-stage and late stage of development for treating multiple system atrophy?
  • What are the recent novel therapies, targets, mechanisms of action, and technologies developed to overcome the challenges of multiple system atrophy?
  • What is the cost burden of current treatment on the patient?
  • Patient acceptability in terms of preferred treatment options as per real-world scenarios?
  • What are the accessibility issues of approved therapy in the US?
  • What is the 7MM historical and forecasted market of multiple system atrophy?

Reasons to Buy the Multiple System Atrophy Market Report

  • The report will help develop business strategies by understanding the latest trends and changing treatment dynamics driving the multiple system atrophy market.
  • Insights on patient burden/disease prevalence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing Multiple System Atrophy treatment market opportunities in varying geographies and the growth potential over the coming years.
  • The distribution of historical and current patient share is based on real-world prescription data in the US, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan.
  • Identifying upcoming solid players in the Multiple System Atrophy therapeutics market will help devise strategies to help get ahead of competitors.
  • Detailed analysis and ranking of class-wise potential current and emerging therapies under the conjoint analysis section to provide visibility around leading classes.
  • Highlights of Multiple System Atrophy therapeutics market access and reimbursement policies for multiple system atrophy, barriers to accessibility of approved therapy, and patient assistance programs.
  • To understand key opinion leaders' perspectives around the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights on the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.
Product Code: DIMI0748

Table of Contents

1. Key Insights

2. Report Introduction

3. MSA Market Overview at a Glance

  • 3.1. Market Share (%) Distribution of MSA by Therapies in 2022
  • 3.2. Market Share (%) Distribution of MSA by Therapies in 2036

4. Epidemiology and Market Forecast Methodology

5. Key Events

6. Executive Summary

7. Disease Background and Overview: MSA

  • 7.1. Introduction
  • 7.2. Subtypes of MSA
    • 7.2.1. MSA-P
    • 7.2.2. MSA-C
  • 7.3. Etiology of MSA
  • 7.4. Signs and symptoms of MSA
  • 7.5. The Neuropathology of MSA
  • 7.6. Pathogenesis of MSA
  • 7.7. Biomarkers
  • 7.8. Diagnosis of MSA
  • 7.9. Diagnostic guidelines for MSA
  • 7.10. Diagnostic algorithm for MSA
  • 7.11. Treatment for MSA

8. Patient Journey

9. Epidemiology and Patient Population

  • 9.1. Key Findings
  • 9.2. Assumptions and Rationale: the 7MM
    • 9.2.1. Diagnosed Prevalent Cases of MSA
    • 9.2.2. Gender-specific Diagnosed Prevalent Cases of MSA
    • 9.2.3. Age-specific Diagnosed Prevalent Cases of MSA
    • 9.2.4. Type-specific Diagnosed Prevalent Cases of MSA
    • 9.2.5. Stage-specific Diagnosed Prevalent Cases of MSA
    • 9.2.6. nOH Symptomatic Cases of MSA
  • 9.3. Total Diagnosed Prevalent Cases of MSA in the 7MM
  • 9.4. The United States
    • 9.4.1. Diagnosed Prevalent Cases of MSA in the US
    • 9.4.2. Gender-specific Diagnosed Prevalent Cases of MSA in the US
    • 9.4.3. Age-specific Diagnosed Prevalent Cases of MSA in the US
    • 9.4.4. Type-specific Diagnosed Prevalent Cases of MSA in the US
    • 9.4.5. Stage-specific Diagnosed Prevalent Cases of MSA in the US
    • 9.4.6. nOH Symptomatic Cases of MSA in the US
  • 9.5. EU4 and the UK
    • 9.5.1. Diagnosed Prevalent Cases of MSA in EU4 and the UK
    • 9.5.2. Gender-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK
    • 9.5.3. Age-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK
    • 9.5.4. Type-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK
    • 9.5.5. Stage-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK
    • 9.5.6. nOH Symptomatic Cases of MSA in EU4 and the UK
  • 9.6. Japan
    • 9.6.1. Diagnosed Prevalent Cases of MSA in Japan
    • 9.6.2. Gender-specific Diagnosed Prevalent Cases of MSA in Japan
    • 9.6.3. Age-specific Diagnosed Prevalent Cases of MSA in Japan
    • 9.6.4. Type-specific Diagnosed Prevalent Cases of MSA in Japan
    • 9.6.5. Stage-specific Diagnosed Prevalent Cases of MSA in Japan
    • 9.6.6. nOH Symptomatic Cases of MSA

10. Emerging Drugs

  • 10.1. Key Cross Competition
  • 10.2. Lu AF82422: H Lundbeck A/S
    • 10.2.1. Product Description
    • 10.2.2. Other Development Activities
    • 10.2.3. Clinical Trial Information
    • 10.2.4. Safety and Efficacy
    • 10.2.5. Analyst's Views
  • 10.3. AAV2-GDNF Gene Therapy: Brain Neurotherapy Bio, Inc./ Asklepios BioPharmaceutical, Inc.
    • 10.3.1. Product Description
    • 10.3.2. Other Development Activities
    • 10.3.3. Clinical Trial Information
    • 10.3.4. Safety and Efficacy
    • 10.3.5. Analyst's Views
  • 10.4. Ampreloxetine (TD-9855): Theravance Biopharma
    • 10.4.1. Product Description
    • 10.4.2. Other Development Activities
    • 10.4.3. Clinical Trial Information
    • 10.4.4. Safety and Efficacy
    • 10.4.5. Analyst's Views
  • 10.5. ONO-2808: Ono Pharmaceutical Co. Ltd
    • 10.5.1. Product Description
    • 10.5.2. Other Development Activities
    • 10.5.3. Clinical Trial Information
    • 10.5.4. Safety and Efficacy
    • 10.5.5. Analyst's Views
  • 10.6. ION464: Ionis Pharmaceuticals, Inc. /Biogen
    • 10.6.1. Product Description
    • 10.6.2. Other Development Activities
    • 10.6.3. Clinical Trial Information
    • 10.6.4. Safety and Efficacy
    • 10.6.5. Analyst's Views
  • 10.7. ATH434: Alterity Therapeutics
    • 10.7.1. Product Description
    • 10.7.2. Other Development Activities
    • 10.7.3. Clinical Trial Information
    • 10.7.4. Safety and Efficacy
    • 10.7.5. Analyst's Views
  • 10.8. Emrusolmin: Teva Pharmaceutical/ MODAG GmbH
    • 10.8.1. Product Description
    • 10.8.2. Other Development Activities
    • 10.8.3. Clinical Trial Information
    • 10.8.4. Safety and Efficacy
    • 10.8.5. Analyst's Views

11. MSA: Seven Major Market Analysis

  • 11.1. Key Findings
  • 11.2. Key Market Forecast Assumptions
    • 12.2.1. Cost Assumptions and Rebates
    • 12.2.2. Pricing Trends
    • 12.2.3. Analogue Assessment
    • 12.2.4. Launch Year and Therapy Uptake
  • 11.3. Market Outlook
  • 11.4. Conjoint Analysis
  • 11.5. Total Market Size of MSA in the 7MM
  • 11.6. Market Size of MSA by Therapies in the 7MM
  • 11.7. United States
    • 11.7.1. Total Market Size of MSA
    • 11.7.2. Market Size of MSA by Therapies
  • 11.8. EU4 and the UK
    • 11.8.1. Total Market Size of MSA
    • 11.8.2. Market Size of MSA by Therapies
  • 11.9. Japan
    • 11.9.1. Total Market Size of MSA
    • 11.9.2. Market Size of MSA by Therapies

13. KOL Opinion Leaders' Views

14. SWOT Analysis

15. Unmet Needs

16. Market Access and Reimbursement

  • 16.1. The United States
    • 16.1.1. Centre for Medicare & Medicaid Services (CMS)
  • 16.2. In EU4 and the UK
    • 16.2.1. Germany
    • 16.2.2. France
    • 16.2.3. Italy
    • 16.2.4. Spain
    • 16.2.5. The United Kingdom
  • 16.3. Japan
    • 16.3.1. MHLW

17. Appendix

  • 17.1. Bibliography
  • 17.2. Acronyms and Abbreviations

18. Report Methodology

19. DelveInsight Capabilities

20. Disclaimer

Product Code: DIMI0748

List of Tables

  • Table 1: Key Events
  • Table 2: Summary of MSA Market and Epidemiology (2022-2036)
  • Table 3: Current Consensus Criteria for the Diagnosis of MSA
  • Table 4: Criteria for Possible MSA
  • Table 5: Additional Features of Possible MSA
  • Table 6: Criteria for the Diagnosis of Probable MSA
  • Table 7: Features Supporting and not Supporting a Diagnosis of MSA
  • Table 8: Total Diagnosed Prevalent cases of MSA in the 7MM (2022-2036)
  • Table 9: Diagnosed Prevalent Cases of MSA in the US (2022-2036)
  • Table 10: Gender-specific Diagnosed Prevalent Cases of MSA in the US (2022-2036)
  • Table 11: Age-specific Diagnosed Prevalent Cases of MSA in the US (2022-2036)
  • Table 12: Type-specific Diagnosed Prevalent Cases of MSA in the US (2022-2036)
  • Table 13: Stage-specific Diagnosed Prevalent Cases of MSA in the US (2022-2036)
  • Table 14: nOH Symptomatic Cases of MSA in the US (2022-2036)
  • Table 15: Diagnosed Prevalent Cases of MSA in EU4 and the UK (2022-2036)
  • Table 16: Gender-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK (2022-2036)
  • Table 17: Age-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK (2022-2036)
  • Table 18: Type-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK (2022-2036)
  • Table 19: Stage-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK (2022-2036)
  • Table 20: nOH Symptomatic Cases of MSA in EU4 and the UK (2022-2036)
  • Table 21: Diagnosed Prevalent Cases of MSA in Japan (2022-2036)
  • Table 22: Gender-specific Diagnosed Prevalent Cases of MSA in Japan (2022-2036)
  • Table 23: Age-specific Diagnosed Prevalent Cases of MSA in Japan (2022-2036)
  • Table 24: Type-specific Diagnosed Prevalent Cases of MSA in Japan (2022-2036)
  • Table 25: Stage-specific Diagnosed Prevalent Cases of MSA in Japan (2022-2036)
  • Table 26: nOH Symptomatic Cases of MSA in Japan (2022-2036)
  • Table 27: Comparison of Emerging Drugs Under Development
  • Table 28: Lu AF82422, Clinical Trial Description, 2025
  • Table 29: AAV2-GDNF Gene Therapy, Clinical Trial Description, 2025
  • Table 30: Ampreloxetine (TD-9855), Clinical Trial Description, 2025
  • Table 31: ONO-2808, Clinical Trial Description, 2025
  • Table 32: ION464, Clinical Trial Description, 2025
  • Table 33: ATH434, Clinical Trial Description, 2025
  • Table 34: Emrusolmin, Clinical Trial Description, 2025
  • Table 35: Key Market Forecast Assumptions for TD-9855
  • Table 36: Market Size of MSA in the 7MM, in USD Million (2022-2036)
  • Table 37: Market Size of MSA by Therapies, in the 7MM in USD Million (2022-2036)
  • Table 38: Total Market Size of MSA in the US, in USD Million (2022-2036)
  • Table 39: Market Size of MSA by Therapies in the US, in USD Million (2022-2036)
  • Table 40: Total Market Size of MSA in EU4 and the UK, in USD Million (2022-2036)
  • Table 41: Market Size of MSA by Therapies in EU4 and the UK, in USD Million (2022-2036)
  • Table 42: Total Market Size of MSA in Japan, in USD Million (2022-2036)
  • Table 43: Market Size of MSA by Therapies in Japan, in USD Million (2022-2036)

List of Figures

  • Figure 1: Neurological entities describing MSA
  • Figure 2: Sub-Types of Multiple System Atrophy
  • Figure 3: Clinical Presentations in MSA Patients
  • Figure 4: Neuropathology of MSA and cell-to-cell propagation of a-syn
  • Figure 5: Alpha-synuclein in the pathogenesis of MSA
  • Figure 6: Mitochondria in the pathogenesis of MSA
  • Figure 7: Available Models of MSA
  • Figure 8: Current and future diagnostic biomarkers of MSA
  • Figure 9: 2022 MDS criteria for clinically diagnosed MSA
  • Figure 10: Diagnostic scheme for MSA according to the current consensus diagnostic criteria
  • Figure 11: Treatment and Management of Multiple System Atrophy
  • Figure 12: Patient Journey
  • Figure 13: Total Diagnosed Prevalent Cases of MSA in the 7MM (2022-2036)
  • Figure 14: Diagnosed Prevalent Cases of MSA in the US (2022-2036)
  • Figure 15: Gender-specific Diagnosed Prevalent Cases of MSA in the US (2022-2036)
  • Figure 16: Age-specific Diagnosed Prevalent Cases of MSA in the US (2022-2036)
  • Figure 17: Type-specific Diagnosed Prevalent Cases of MSA in the US (2022-2036)
  • Figure 18: Stage-specific Diagnosed Prevalent Cases of MSA in the US (2022-2036)
  • Figure 19: nOH Symptomatic Cases of MSA in the US (2022-2036)
  • Figure 20: Diagnosed Prevalent Cases of MSA in EU4 and the UK (2022-2036)
  • Figure 21: Gender-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK (2022-2036)
  • Figure 22: Age-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK (2022-2036)
  • Figure 23: Type-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK (2022-2036)
  • Figure 24: Stage-specific Diagnosed Prevalent Cases of MSA in EU4 and the UK (2022-2036)
  • Figure 25: nOH Symptomatic Cases of MSA in EU4 and the UK (2022-2036)
  • Figure 26: Diagnosed Prevalent Cases of MSA in Japan (2022-2036)
  • Figure 27: Gender-specific Diagnosed Prevalent Cases of MSA in Japan (2022-2036)
  • Figure 28: Age-specific Diagnosed Prevalent Cases of MSA in Japan (2022-2036)
  • Figure 29: Type-specific Diagnosed Prevalent Cases of MSA in Japan (2022-2036)
  • Figure 30: Stage-specific Diagnosed Prevalent Cases of MSA in Japan (2022-2036)
  • Figure 31: nOH Symptomatic Cases of MSA in Japan (2022-2036)
  • Figure 32: Patient Journey
  • Figure 33: Market Size of MSA in the 7MM, in USD Million (2022-2036)
  • Figure 34: Market Size of MSA by Therapies, in the 7MM in USD Million (2022-2036)
  • Figure 35: Total Market Size of MSA in the US, in USD Million (2022-2036)
  • Figure 36: Market Size of MSA by Therapies in the US, in USD Million (2022-2036)
  • Figure 37: Total Market Size of MSA in EU4 and the UK, in USD Million (2022-2036)
  • Figure 38: Market Size of MSA by Therapies in EU4 and the UK, in USD Million (2022-2036)
  • Figure 39: Total Market Size of MSA in Japan, in USD Million (2022-2036)
  • Figure 40: Market Size of MSA by Therapies in Japan, in USD Million (2022-2036)
  • Figure 41: Unmet Needs
  • Figure 42: SWOT Analysis
  • Figure 43: Total Market Size of MSA in the US, in USD Million (2022-2036)
  • Figure 44: Market Size of MSA by Therapies in the US, in USD Million (2022-2036)
  • Figure 45: Total Market Size of MSA in EU4 and the UK, in USD Million (2022-2036)
  • Figure 46: Health Technology Assessment
  • Figure 47: Reimbursement Process in the United States
  • Figure 48: Reimbursement Process in Germany
  • Figure 49: Reimbursement Process in France
  • Figure 50: Reimbursement Process in Spain
  • Figure 51: Reimbursement Process in the United Kingdom
  • Figure 52: Reimbursement Process in Japan
Have a question?
Picture

Jeroen Van Heghe

Manager - EMEA

+32-2-535-7543

Picture

Christine Sirois

Manager - Americas

+1-860-674-8796

Questions? Please give us a call or visit the contact form.
Hi, how can we help?
Contact us!