PUBLISHER: DelveInsight | PRODUCT CODE: 2018996
PUBLISHER: DelveInsight | PRODUCT CODE: 2018996
Multiple System Atrophy Market and Epidemiology Analysis
Multiple System Atrophy Market Size and Forecast
DelveInsight's "Multiple System Atrophy Market Insights, Epidemiology, and Market Forecast - 2036" report delivers an in-depth understanding of Multiple System Atrophy, historical and forecasted epidemiology, as well as the Multiple System Atrophy market trends in the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan.
The Multiple System Atrophy Treatment Market Report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted 7MM Multiple System Atrophy market size from 2022 to 2036. The report also covers Multiple System Atrophy treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the Multiple System Atrophy treatment market potential.
Key Factors Driving the Multiple System Atrophy Market
Increasing Multiple System Atrophy Prevalence
In 2025, the diagnosed prevalent cases of MSA are predicted to be ~72K in the leading markets [the United States, the EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan], projected to increase through 2036. These numbers are increasing due to rising healthcare needs and a growing demand for effective therapies.
Multiple System Atrophy Market Opportunities for Key Companies
With limited FDA-approved disease-modifying treatments currently available for MSA, the field presents a significant opportunity for innovation. Existing options, such as LEVODOPA, provide limited relief, highlighting a clear pathway for novel, targeted therapies to transform patient outcomes and redefine the treatment landscape. Other than that, the companies working in the MSA clinical trial landscape are H Lundbeck A/S, Brain Neurotherapy Bio, Inc., Asklepios BioPharmaceutical, Inc., Theravance Biopharma, Ono Pharmaceutical Co. Ltd, Ionis Pharmaceuticals, Inc., Biogen, Alterity Therapeutics, Teva Pharmaceutical, MODAG GmbH, and others.
Increasing Multiple System Atrophy Clinical Trial Activities
Promising multiple system atrophy drugs in clinical trials include Ampreloxetine (Theravance Biopharma), Amlenetug (H Lundbeck A/S), Emrusolmin (Teva Pharmaceutical/MODAG GmBH), TAK-341/MEDI1341 (AstraZeneca/Takeda Pharma), ATH434 (Alterity Therapeutics), and others.
Multiple System Atrophy Disease Understanding
Multiple System Atrophy overview
Multiple System Atrophy is a progressive neurodegenerative disease marked by symptoms affecting movement and the autonomic nervous system. Its cause remains unknown, and most cases are sporadic. A hallmark of Multiple System Atrophy is the accumulation of alpha-synuclein in oligodendroglial cells, which produce myelin, essential for efficient nerve signal transmission. In 1969, the term Multiple System Atrophy was introduced to combine three previously recognized neurological conditions: Shy-Drager syndrome (focused on autonomic dysfunction), Striatonigral Degeneration (emphasizing Parkinsonian symptoms), and sporadic Olivopontocerebellar Atrophy (highlighting cerebellar symptoms). This unification helped categorize overlapping clinical features under a single diagnosis.
Early symptoms of Multiple System Atrophy include bradykinesia, tremors, stiffness, and lack of coordination. Diagnostic subtypes are Multiple System Atrophy-P, resembling Parkinson's disease with Parkinsonian features, and Multiple System Atrophy-C, distinguished by cerebellar dysfunction, primarily presenting as ataxia and impaired balance, reflecting the diverse neurological impacts of this progressive disorder. Multiple System Atrophy is divided into two main subtypes: Multiple System Atrophy with predominant Parkinsonism (Multiple System Atrophy-P) and Multiple System Atrophy with predominant cerebellar ataxia (Multiple System Atrophy-C). However, these classifications are flexible, as a patient's symptoms can shift between the two over time.
Multiple System Atrophy diagnosis
Diagnosing of Multiple System Atrophy is challenging, especially in its early stages, as it shares symptoms with Parkinson's disease. Diagnostic methods may include autonomic testing (e.g., blood pressure and heart rate monitoring), bladder function assessment, and neuroimaging techniques like MRI or PET scans.
Multiple System Atrophy treatment
Pharmacological treatments for Multiple System Atrophy target Parkinsonism, autonomic dysfunction, cerebellar ataxia, and sleep issues. Levodopa is the first-line treatment for Parkinsonism, with temporary benefits, while dopamine agonists and amantadine offer alternative options but may cause more side effects.
As Multiple System Atrophy market is derived using a patient-based model, the Multiple System Atrophy epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Diagnosed Prevalence Cases of Multiple System Atrophy, Gender-specific Diagnosed Prevalent Cases of Multiple System Atrophy, Age-specific Diagnosed Prevalent Cases of Multiple System Atrophy, Type-specific Diagnosed Prevalent Cases of Multiple System Atrophy in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain), the United Kingdom, and Japan from 2022 to 2036.
Key Findings from Multiple System Atrophy Epidemiological Analyses and Forecast
Multiple System Atrophy Recent Developments and Breakthroughs
Multiple System Atrophy Drug Analysis
The drug chapter segment of the Multiple System Atrophy report encloses a detailed analysis of Multiple System Atrophy early and mid to late-stage (Phase III and Phase II) pipeline drugs. It also helps understand the Multiple System Atrophy clinical trials details, expressive pharmacological action, agreements and collaborations, advantages and disadvantages of each included drug, and the latest news and press releases.
Multiple System Atrophy Emerging Drugs
Emrusolmin (TEV-56286, Anle-138b): Teva Pharmaceutical/MODAG GmBH
TEV-56286 also known as anle138b is a small molecule designed to specifically target toxic oligomeric structures of alpha-synuclein, the primary aggregating protein involved in neurodegenerative disorders. By binding to these toxic oligomers, anle138b dissolves them and prevents the formation of new ones, addressing the underlying cause of the disease.
Amlenetug (Lu AF82422): H. Lundbeck A/S/Genmab
Amlenetug (Lu AF82422) is a human IgG1 monoclonal antibody targeting extracellular a-synuclein to block aggregation and enhance microglial clearance, developed by Lundbeck in collaboration with Genmab.
ONO-2808: Deciphera Pharmaceuticals/ONO PHARMA
ONO-2808 is an orally available, selective sphingosine-1-phosphate receptor-5 (S1P5) agonist discovered by ONO. The ONO-2808-03 study is a multicenter, randomized Phase II trial evaluating early-stage MSA patients within five years of symptom onset in Japan and the US. It is currently being evaluated in the Phase II for MSA.
Multiple System Atrophy Drug Class Analysis
Multiple System Atrophy treatment primarily focuses on symptom management, as there is no cure. Pharmacological therapies, such as levodopa for Parkinsonism and other medications for autonomic dysfunction, cerebellar ataxia, and sleep disturbances, are commonly used. Immunotherapy is not typically part of Multiple System Atrophy treatment, as it targets underlying protein aggregation rather than immune response.
Emerging therapies include Amlenetug, Ampreloxetine, ATH434, TAK-341/MEDI1341 and Emrusolmin (Anle138b).
Amlenetug
developed by H. Lundbeck A/S and Genmab, is a monoclonal antibody targeting toxic alpha-synuclein in Multiple System Atrophy, aiming to slow progression, now in Phase III.
Ampreloxetine
A norepinephrine reuptake inhibitor for symptomatic neurogenic orthostatic hypotension in Multiple System Atrophy is in Phase III trials with ODD status. Emrusolmin (Anle138b), is a small molecule targeting toxic alpha-synuclein oligomers to halt disease progression. It is orally administered, crosses the blood-brain barrier, and received orphan drug designation for Multiple System Atrophy, currently in Phase II trials.
Multiple System Atrophy is a rare neurodegenerative disorder that typically begins in adulthood, usually after age 30. It shares symptoms with Parkinson's disease, such as Parkinsonism, but also includes additional features like cerebellar ataxia and autonomic dysfunction, affecting involuntary processes such as heart rate and blood pressure. Multiple System Atrophy is classified as Multiple System Atrophy-P when Parkinsonism predominates, and Multiple System Atrophy-C when cerebellar symptoms are more prominent. Currently, no disease-modifying treatments are approved for Multiple System Atrophy, offering a significant opportunity for pharmaceutical Multiple System Atrophy companies to develop the first effective therapies. Existing Parkinson's treatments like levodopa have limited effectiveness, underscoring the need for targeted treatments for Multiple System Atrophy.
Currently, no disease-modifying treatments are approved for Multiple System Atrophy in the 7MM, creating a significant opportunity for pharmaceutical Multiple System Atrophy companies to develop the first approved therapy. While Parkinson's drugs like levodopa are used, their effectiveness varies. northera (droxidopa) is commonly prescribed for neurogenic orthostatic hypotension (nOH), a common Multiple System Atrophy symptom. Approved in 2014, northera addresses nOH but lost market exclusivity in 2021, despite its impact on Multiple System Atrophy-related disability and injury risk.
Pharmacological treatments for Multiple System Atrophy focus on Parkinsonism, autonomic dysfunction, cerebellar ataxia, and sleep issues. Levodopa is the first-line treatment for Parkinsonism, providing temporary relief, especially in Multiple System Atrophy-P patients. While effective, its benefits are limited, and side effects like orthostatic hypotension require management. Dopamine agonists and amantadine may offer alternatives, though they are less preferred due to side effects.
Currently, there are no approved therapies to slow neurodegeneration in Multiple System Atrophy. However, symptom management includes options like Levodopa, Amantadine, Droxidopa, Anticholinergic agents, and off-label treatments to help patients cope. Potential future therapies for Multiple System Atrophy include Lu AF82422 (H. Lundbeck A/S/Genmab), Ampreloxetine (Theravance Biopharma), Emrusolmin (Teva Pharmaceutical/MODAG GmbH), and others.
This section focuses on the uptake rate of potential drugs expected to be launched in the Multiple System Atrophy market during 2022-2036.
Multiple System Atrophy Pipeline Development Activities
The report provides insights into different Multiple System Atrophy clinical trials within Phase III, Phase II, and Phase I. It also analyzes key players involved in developing targeted therapeutics.
Pipeline development activities
The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for emerging therapies for Multiple System Atrophy.
Latest KOL Views on Multiple System Atrophy
To keep up with current Multiple System Atrophy market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry Experts contacted for insights on Multiple System Atrophy evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake, along with challenges related to accessibility, including Medical/scientific writers, Medical Professionals, Professors, Directors, and Others.
DelveInsight's analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Centers like the University of California, the US, University of Maryland School of Medicine, the US, University of Texas Southwestern, the US, University Medical Center, Johannes-Gutenberg-University, Germany, Department of Neurology Center Hospitalier de la Cote Basque Bayonne, France, University of Pisa, Italy, Barcelona Clinical Hospital, Spain, University of Aberdeen, the UK, Hyogo College of Medicine, Japan, among others, were contacted. Their opinion helps understand and validate current and emerging therapy treatment patterns or Multiple System Atrophy market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the Multiple System Atrophy therapeutics market and the unmet needs.
Physician's View
As per the KOLs from the US, The diagnosis of Multiple System Atrophy is complicated, and this is mostly due to the overlap with other similar Parkinsonian syndromes. It was found that some cases are misdiagnosed as other clinical syndromes when there is no severe dysautonomia or cerebellar dysfunction (like cerebellar ataxia or dysarthria). Importantly, there are not great treatment options for the autonomic and cerebellar symptoms in patients with Multiple System Atrophy clinical phenotype, but there are many Multiple System Atrophy clinical trials still in progress to find treatments for these aspects.
As per the KOLs from Germany, The Multiple System Atrophy distinction into Multiple System Atrophy-P and Multiple System Atrophy-C is based on the predominant clinical features. Multiple System Atrophy-P is more common in most of the countries, with the exception of Japan, where Multiple System Atrophy-C is the predominant phenotype. Patients with Multiple System Atrophy have an early, usually transient, and in general poorer, response to L-Dopa compared to patients with Parkinson's disease.
As per the KOLs from Japan, Distinguishing Multiple System Atrophy from other neurodegenerative parkinsonisms, such as Parkinson's disease, dementia with Lewy bodies, and progressive supranuclear palsy, can be challenging. However, advancements in imaging techniques, like [123I]-Meta-iodo Benzyl Guanidine (MIBG) myocardial scintigraphy, have shown promise in helping differentiate PD from other Parkinsonian syndromes, improving diagnosis and treatment strategies for Multiple System Atrophy.
Multiple System Atrophy Report Qualitative Analysis
We perform Qualitative and Multiple System Atrophy treatment market Intelligence analysis using various approaches, such as SWOT and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.
Conjoint Analysis analyzes multiple emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy. To analyze the effectiveness of these therapies, have calculated their attributed analysis by giving them scores based on their ability to improve atrial and ventricular dimension/function and ability to regulate heart rate.
Further, the therapies' safety is evaluated wherein the adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials, which directly affects the safety of the molecule in the upcoming trials. It sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Multiple System Atrophy Market Access and Reimbursement
The National Institute of Neurological Disorders and Stroke (NINDS).
The National Institute of Neurological Disorders and Stroke (NINDS), part of the NIH, is crucial in advancing Multiple System Atrophy research. By funding top medical institutions, NINDS supports studies to better understand and treat Multiple System Atrophy. In 2007, NINDS held a global consensus conference to improve diagnostic criteria, aiding quicker and more accurate diagnoses. Ongoing research aims to uncover the mechanisms behind synuclein buildup in Multiple System Atrophy and Parkinson's disease, with the goal of developing preventative and therapeutic approaches for these neurodegenerative conditions. Further details will be provided in the report.
The report provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenarios, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.
Scope of the Multiple System Atrophy Market Report
Key Questions Answered in the Multiple System Atrophy Market
Multiple System Atrophy Market Insights
Multiple System Atrophy Epidemiology Insights
Current Treatment Scenario, Marketed Drugs, and Emerging Therapies
Reasons to Buy the Multiple System Atrophy Market Report